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Protein

Connector enhancer of kinase suppressor of ras 3

Gene

Cnksr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Connector enhancer of kinase suppressor of ras 3
Short name:
Connector enhancer of KSR 3
Alternative name(s):
CNK homolog protein 3
Short name:
CNK3
Maguin-like protein
Parturition-related protein 4
Gene namesi
Name:Cnksr3
Synonyms:Prp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307544. Cnksr3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003111071 – 555Connector enhancer of kinase suppressor of ras 3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei381PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SGD7.
PRIDEiQ5SGD7.

PTM databases

iPTMnetiQ5SGD7.
PhosphoSitePlusiQ5SGD7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018052.
ExpressionAtlasiQ5SGD7. baseline and differential.
GenevisibleiQ5SGD7. RN.

Interactioni

Protein-protein interaction databases

BioGridi258906. 1 interactor.
STRINGi10116.ENSRNOP00000024418.

Structurei

3D structure databases

ProteinModelPortaliQ5SGD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 72SAMPROSITE-ProRule annotationAdd BLAST66
Domaini80 – 174CRICPROSITE-ProRule annotationAdd BLAST95
Domaini211 – 293PDZPROSITE-ProRule annotationAdd BLAST83
Domaini325 – 546DUF1170Add BLAST222

Sequence similaritiesi

Belongs to the CNKSR family.Curated
Contains 1 CRIC domain.PROSITE-ProRule annotation
Contains 1 DUF1170 domain.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1738. Eukaryota.
ENOG41104C7. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000015752.
HOVERGENiHBG051040.
InParanoidiQ5SGD7.
OMAiVLPTKMR.
OrthoDBiEOG091G037J.
PhylomeDBiQ5SGD7.
TreeFamiTF326495.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR010599. CNKSR2.
IPR017874. CRIC_domain.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF10534. CRIC_ras_sig. 1 hit.
PF06663. DUF1170. 1 hit.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51290. CRIC. 1 hit.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SGD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVTKWSPK QVVDWTRGLD DCLQPYVHKF EREKIDGEQL LKISHQDLEE
60 70 80 90 100
LGVTRIGHQE LVLEAVDLLC ALNYGLETDN MKNLVLKLRA SSHNLQNYIS
110 120 130 140 150
SRRKSPAYDG NTSRKPPNEF LTSVVELIGA AKALLAWLDR APFTGITDLS
160 170 180 190 200
VTKNKIIQLC LDLTTAVQKD CLVAEMEDKV LNVVKVLNGI CDKMMHSTTD
210 220 230 240 250
PVMSQCACLE EVHLPNVRPG EGLGMYIKST YDGLHVITGT TENSPADRSQ
260 270 280 290 300
KIHAGDEVIQ VNRQTVVGWQ LKNLVKKLRE NPTGVVLLLK KRPTGSFSFT
310 320 330 340 350
PAPLKNLRWK PPLVQTSPPP TTTQSPESTM DASLKKEKPA ILDLYIPPPP
360 370 380 390 400
AVPYSPRDEN VSFSYRGHTK SKQPLPGRKG SESPNSFLDQ ESQRRRFTIT
410 420 430 440 450
DSDQLPGYSV GTNILPIKMR GKTPSYGKPR PLSMPADGNW MGIVDPFAKP
460 470 480 490 500
RGHGRKGEDA LCRYFSNERI TPIIEESASP VYRFSRPLTE RHLVRGADYI
510 520 530 540 550
RGSRCYINSD LHSSATIPFQ EEGPKKKSAS SSAKASSGEP SLLVSWLTRL

KLLTH
Length:555
Mass (Da):61,851
Last modified:December 21, 2004 - v1
Checksum:i9427AEB3FF48626D
GO

Sequence cautioni

The sequence AAR01114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358D → Y in AAR01114 (Ref. 2) Curated1
Sequence conflicti456K → KG in AAR01114 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY328890 mRNA. Translation: AAQ92305.1.
AY333962 mRNA. Translation: AAR01114.1. Different initiation.
RefSeqiNP_001012061.1. NM_001012061.1.
UniGeneiRn.137681.

Genome annotation databases

EnsembliENSRNOT00000024418; ENSRNOP00000024418; ENSRNOG00000018052.
GeneIDi308113.
KEGGirno:308113.
UCSCiRGD:1307544. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY328890 mRNA. Translation: AAQ92305.1.
AY333962 mRNA. Translation: AAR01114.1. Different initiation.
RefSeqiNP_001012061.1. NM_001012061.1.
UniGeneiRn.137681.

3D structure databases

ProteinModelPortaliQ5SGD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi258906. 1 interactor.
STRINGi10116.ENSRNOP00000024418.

PTM databases

iPTMnetiQ5SGD7.
PhosphoSitePlusiQ5SGD7.

Proteomic databases

PaxDbiQ5SGD7.
PRIDEiQ5SGD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024418; ENSRNOP00000024418; ENSRNOG00000018052.
GeneIDi308113.
KEGGirno:308113.
UCSCiRGD:1307544. rat.

Organism-specific databases

CTDi154043.
RGDi1307544. Cnksr3.

Phylogenomic databases

eggNOGiKOG1738. Eukaryota.
ENOG41104C7. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000015752.
HOVERGENiHBG051040.
InParanoidiQ5SGD7.
OMAiVLPTKMR.
OrthoDBiEOG091G037J.
PhylomeDBiQ5SGD7.
TreeFamiTF326495.

Miscellaneous databases

PROiQ5SGD7.

Gene expression databases

BgeeiENSRNOG00000018052.
ExpressionAtlasiQ5SGD7. baseline and differential.
GenevisibleiQ5SGD7. RN.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR010599. CNKSR2.
IPR017874. CRIC_domain.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF10534. CRIC_ras_sig. 1 hit.
PF06663. DUF1170. 1 hit.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51290. CRIC. 1 hit.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNKR3_RAT
AccessioniPrimary (citable) accession number: Q5SGD7
Secondary accession number(s): Q6VPP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.