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Q5SGD2

- PPM1L_HUMAN

UniProt

Q5SGD2 - PPM1L_HUMAN

Protein

Protein phosphatase 1L

Gene

PPM1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi128 – 1281Manganese 1By similarity
    Metal bindingi128 – 1281Manganese 2By similarity
    Metal bindingi129 – 1291Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi302 – 3021Manganese 2By similarity
    Metal bindingi342 – 3421Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: Reactome

    GO - Biological processi

    1. MAPK cascade Source: Ensembl
    2. protein dephosphorylation Source: InterPro
    3. small molecule metabolic process Source: Reactome
    4. sphingolipid biosynthetic process Source: Reactome
    5. sphingolipid metabolic process Source: Reactome
    6. transmembrane receptor protein serine/threonine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BRENDAi3.1.3.16. 2681.
    ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1L (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 1-like
    Protein phosphatase 2C isoform epsilon
    Short name:
    PP2C-epsilon
    Gene namesi
    Name:PPM1L
    Synonyms:PP2CE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16381. PPM1L.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Protein phosphatase 1LPRO_0000057754Add
    BLAST

    Proteomic databases

    MaxQBiQ5SGD2.
    PaxDbiQ5SGD2.
    PRIDEiQ5SGD2.

    PTM databases

    PhosphoSiteiQ5SGD2.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.1 Publication

    Gene expression databases

    BgeeiQ5SGD2.
    CleanExiHS_PPM1L.
    GenevestigatoriQ5SGD2.

    Organism-specific databases

    HPAiHPA019891.
    HPA019953.

    Interactioni

    Subunit structurei

    Interacts with MAP3K7/TAK1 By similarity. Interacts with MAP3K5.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi127400. 2 interactions.
    STRINGi9606.ENSP00000417659.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SGD2.
    SMRiQ5SGD2. Positions 93-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 360318CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4217HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 344254PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    HOVERGENiHBG079483.
    InParanoidiQ5SGD2.
    KOiK17506.
    OMAiTERIVAC.
    OrthoDBiEOG74J98W.
    PhylomeDBiQ5SGD2.
    TreeFamiTF332888.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SGD2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK    50
    SSRDAVKMVK GKVAEIMQND RLGGLDVLEA EFSKTWEFKN HNVAVYSIQG 100
    RRDHMEDRFE VLTDLANKTH PSIFGIFDGH GGETAAEYVK SRLPEALKQH 150
    LQDYEKDKEN SVLSYQTILE QQILSIDREM LEKLTVSYDE AGTTCLIALL 200
    SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK RIKRAGGFIS 250
    FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300
    SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK 350
    FRNSSKTEEQ 360
    Length:360
    Mass (Da):41,053
    Last modified:December 21, 2004 - v1
    Checksum:i08212E7BA32AFE2B
    GO
    Isoform 2 (identifier: Q5SGD2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-179: Missing.

    Show »
    Length:181
    Mass (Da):20,324
    Checksum:i74F07366F3C3FB4B
    GO
    Isoform 3 (identifier: Q5SGD2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.
         128-133: DGHGGE → MPAFST

    Show »
    Length:233
    Mass (Da):26,363
    Checksum:i5522C3B41C506168
    GO
    Isoform 4 (identifier: Q5SGD2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         192-194: GTT → VTF
         195-360: Missing.

    Show »
    Length:194
    Mass (Da):22,475
    Checksum:iBD4465CB810BCBB9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621A → S.
    Corresponds to variant rs13326359 [ dbSNP | Ensembl ].
    VAR_050622

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 179179Missing in isoform 2. 1 PublicationVSP_016927Add
    BLAST
    Alternative sequencei1 – 127127Missing in isoform 3. 1 PublicationVSP_037552Add
    BLAST
    Alternative sequencei128 – 1336DGHGGE → MPAFST in isoform 3. 1 PublicationVSP_037553
    Alternative sequencei192 – 1943GTT → VTF in isoform 4. 1 PublicationVSP_037554
    Alternative sequencei195 – 360166Missing in isoform 4. 1 PublicationVSP_037555Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY337264 mRNA. Translation: AAR00269.1.
    AK055115 mRNA. Translation: BAB70856.1.
    BC104885 mRNA. Translation: AAI04886.1.
    BC104887 mRNA. Translation: AAI04888.1.
    BC110801 mRNA. No translation available.
    CCDSiCCDS33886.1. [Q5SGD2-1]
    RefSeqiNP_640338.2. NM_139245.2. [Q5SGD2-1]
    UniGeneiHs.389027.

    Genome annotation databases

    EnsembliENST00000295839; ENSP00000295839; ENSG00000163590. [Q5SGD2-3]
    ENST00000464260; ENSP00000420746; ENSG00000163590. [Q5SGD2-2]
    ENST00000497343; ENSP00000420354; ENSG00000163590. [Q5SGD2-4]
    ENST00000498165; ENSP00000417659; ENSG00000163590. [Q5SGD2-1]
    GeneIDi151742.
    KEGGihsa:151742.
    UCSCiuc003fdr.3. human. [Q5SGD2-1]
    uc003fdt.3. human. [Q5SGD2-3]

    Polymorphism databases

    DMDMi74743437.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY337264 mRNA. Translation: AAR00269.1 .
    AK055115 mRNA. Translation: BAB70856.1 .
    BC104885 mRNA. Translation: AAI04886.1 .
    BC104887 mRNA. Translation: AAI04888.1 .
    BC110801 mRNA. No translation available.
    CCDSi CCDS33886.1. [Q5SGD2-1 ]
    RefSeqi NP_640338.2. NM_139245.2. [Q5SGD2-1 ]
    UniGenei Hs.389027.

    3D structure databases

    ProteinModelPortali Q5SGD2.
    SMRi Q5SGD2. Positions 93-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127400. 2 interactions.
    STRINGi 9606.ENSP00000417659.

    PTM databases

    PhosphoSitei Q5SGD2.

    Polymorphism databases

    DMDMi 74743437.

    Proteomic databases

    MaxQBi Q5SGD2.
    PaxDbi Q5SGD2.
    PRIDEi Q5SGD2.

    Protocols and materials databases

    DNASUi 151742.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295839 ; ENSP00000295839 ; ENSG00000163590 . [Q5SGD2-3 ]
    ENST00000464260 ; ENSP00000420746 ; ENSG00000163590 . [Q5SGD2-2 ]
    ENST00000497343 ; ENSP00000420354 ; ENSG00000163590 . [Q5SGD2-4 ]
    ENST00000498165 ; ENSP00000417659 ; ENSG00000163590 . [Q5SGD2-1 ]
    GeneIDi 151742.
    KEGGi hsa:151742.
    UCSCi uc003fdr.3. human. [Q5SGD2-1 ]
    uc003fdt.3. human. [Q5SGD2-3 ]

    Organism-specific databases

    CTDi 151742.
    GeneCardsi GC03P160473.
    HGNCi HGNC:16381. PPM1L.
    HPAi HPA019891.
    HPA019953.
    MIMi 611931. gene.
    neXtProti NX_Q5SGD2.
    PharmGKBi PA134871016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    HOVERGENi HBG079483.
    InParanoidi Q5SGD2.
    KOi K17506.
    OMAi TERIVAC.
    OrthoDBi EOG74J98W.
    PhylomeDBi Q5SGD2.
    TreeFami TF332888.

    Enzyme and pathway databases

    BRENDAi 3.1.3.16. 2681.
    Reactomei REACT_115810. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    GenomeRNAii 151742.
    NextBioi 86779.
    PROi Q5SGD2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SGD2.
    CleanExi HS_PPM1L.
    Genevestigatori Q5SGD2.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon)."
      Jin F., Ji C., Liu L., Dai J., Gu S., Sun X., Xie Y., Mao Y.
      Mol. Biol. Rep. 31:197-202(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Brain.
    4. "Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon."
      Saito J., Toriumi S., Awano K., Ichijo H., Sasaki K., Kobayashi T., Tamura S.
      Biochem. J. 405:591-596(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MAP3K5.

    Entry informationi

    Entry nameiPPM1L_HUMAN
    AccessioniPrimary (citable) accession number: Q5SGD2
    Secondary accession number(s): Q2M3J2, Q96NM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3