Q5SE95 (Q5SE95_ASPFM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
L-ornithine N5 monooxygenase EMBL AAT84594.1

Submitted name:
L-ornithine N5-oxygenase EMBL AAX40989.1

Gene names

Name:

sidA EMBL AAT84594.1

Organism

Neosartorya fumigata (Aspergillus fumigatus) EMBL AAT84594.1

Taxonomic identifier

746128 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Monooxygenase EMBL AAT84594.1 Oxidoreductase
Technical term	3D-structure PDB 4B68 PDB 4B69 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63
Gene Ontology (GO)
Molecular_function	monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5SE95 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: DD1D4DEDD2509506	FASTA	501	56,877
	10 20 30 40 50 60 MESVERKSES SYLGMRNMQP EQRLSLDPPR LRSTPQDELH DLLCVGFGPA SLAIAIALHD 70 80 90 100 110 120 ALDPRLNKSA SNIHAQPKIC FLERQKQFAW HSGMLVPGSK MQISFIKDLA TLRDPRSSFT 130 140 150 160 170 180 FLNYLHQKGR LIHFTNLSTF LPARLEFEDY MRWCAQQFSD VVAYGEEVVE VIPGKSDPSS 190 200 210 220 230 240 SVVDFFTVRS RNVETGEISA RRTRKVVIAI GGTAKMPSGL PQDPRIIHSS KYCTTLPALL 250 260 270 280 290 300 KDKSKPYNIA VLGSGQSAAE IFHDLQKRYP NSRTTLIMRD SAMRPSDDSP FVNEIFNPER 310 320 330 340 350 360 VDKFYSQSAA ERQRSLLADK ATNYSVVRLE LIEEIYNDMY LQRVKNPDET QWQHRILPER 370 380 390 400 410 420 KITRVEHHGP QSRMRIHLKS SKPESEGAAN DVKETLEVDA LMVATGYNRN AHERLLSKVQ 430 440 450 460 470 480 HLRPTGQDQW KPHRDYRVEM DPSKVSSEAG IWLQGCNERT HGLSDSLLSV LAVRGGEMVQ 490 500 SIFGEQLERA AVQGHQLRAM L

References

[1]	"Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence." Schrettl M., Bignell E., Kragl C., Joechl C., Rogers T., Arst H.N. Jr, Haynes K., Haas H. J. Exp. Med. 200:1213-1219(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence." Hissen A.H., Wan A.N., Warwas M.L., Pinto L.J., Moore M.M. Infect. Immun. 73:5493-5503(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases." Franceschini S., Fedkenheuer M., Vogelaar N.J., Robinson H.H., Sobrado P., Mattevi A. Biochemistry 51:7043-7045(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY586511 Genomic DNA. Translation: AAT84594.1.
AY819708 Genomic DNA. Translation: AAX40989.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4B63	X-ray	1.90	A	1-501	[»]
4B64	X-ray	2.28	A	1-501	[»]
4B65	X-ray	2.32	A	1-501	[»]
4B66	X-ray	2.90	A	1-501	[»]
4B67	X-ray	2.75	A	1-501	[»]
4B68	X-ray	2.29	A	1-501	[»]
4B69	X-ray	2.30	A	1-501	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOGENOM

HOG000237193.

OrthoDB

EOG4JWZNW.

Family and domain databases

InterPro

IPR025700. Lys/Orn_oxygenase.
[Graphical view]

Pfam

PF13434. K_oxygenase. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q5SE95_ASPFM

Accession

Primary (citable) accession number: Q5SE95
Secondary accession number(s): Q4X250

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)