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Q5SE95

- Q5SE95_ASPFM

UniProt

Q5SE95 - Q5SE95_ASPFM

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Protein
Submitted name:

L-ornithine N5 monooxygenase

Gene

sidA

Organism
Neosartorya fumigata (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021FAD; via amide nitrogenImported
Binding sitei144 – 1441NADP
Binding sitei168 – 1681FAD; via amide nitrogen and carbonyl oxygenImported
Binding sitei215 – 2151NADPImported
Binding sitei279 – 2791NADP
Binding sitei404 – 4041NADP; via carbonyl oxygenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 502FADImported
Nucleotide bindingi83 – 853FADImported
Nucleotide bindingi90 – 912FADImported
Nucleotide bindingi100 – 1023NADP
Nucleotide bindingi254 – 2607NADP
Nucleotide bindingi323 – 3253NADP
Nucleotide bindingi466 – 4683FADImported

GO - Molecular functioni

  1. monooxygenase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseImported, Oxidoreductase

Keywords - Ligandi

FADImported, Flavoprotein, NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
L-ornithine N5 monooxygenaseImported
Submitted name:
L-ornithine N5-oxygenaseImported
Gene namesi
Name:sidAImported
OrganismiNeosartorya fumigata (Aspergillus fumigatus)Imported
Taxonomic identifieri746128 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B63X-ray1.90A1-501[»]
4B64X-ray2.28A1-501[»]
4B65X-ray2.32A1-501[»]
4B66X-ray2.90A1-501[»]
4B67X-ray2.75A1-501[»]
4B68X-ray2.29A1-501[»]
4B69X-ray2.30A1-501[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000237193.

Family and domain databases

InterProiIPR025700. Lys/Orn_oxygenase.
[Graphical view]
PfamiPF13434. K_oxygenase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SE95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESVERKSES SYLGMRNMQP EQRLSLDPPR LRSTPQDELH DLLCVGFGPA
60 70 80 90 100
SLAIAIALHD ALDPRLNKSA SNIHAQPKIC FLERQKQFAW HSGMLVPGSK
110 120 130 140 150
MQISFIKDLA TLRDPRSSFT FLNYLHQKGR LIHFTNLSTF LPARLEFEDY
160 170 180 190 200
MRWCAQQFSD VVAYGEEVVE VIPGKSDPSS SVVDFFTVRS RNVETGEISA
210 220 230 240 250
RRTRKVVIAI GGTAKMPSGL PQDPRIIHSS KYCTTLPALL KDKSKPYNIA
260 270 280 290 300
VLGSGQSAAE IFHDLQKRYP NSRTTLIMRD SAMRPSDDSP FVNEIFNPER
310 320 330 340 350
VDKFYSQSAA ERQRSLLADK ATNYSVVRLE LIEEIYNDMY LQRVKNPDET
360 370 380 390 400
QWQHRILPER KITRVEHHGP QSRMRIHLKS SKPESEGAAN DVKETLEVDA
410 420 430 440 450
LMVATGYNRN AHERLLSKVQ HLRPTGQDQW KPHRDYRVEM DPSKVSSEAG
460 470 480 490 500
IWLQGCNERT HGLSDSLLSV LAVRGGEMVQ SIFGEQLERA AVQGHQLRAM

L
Length:501
Mass (Da):56,877
Last modified:December 21, 2004 - v1
Checksum:iDD1D4DEDD2509506
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY586511 Genomic DNA. Translation: AAT84594.1.
AY819708 Genomic DNA. Translation: AAX40989.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY586511 Genomic DNA. Translation: AAT84594.1 .
AY819708 Genomic DNA. Translation: AAX40989.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B63 X-ray 1.90 A 1-501 [» ]
4B64 X-ray 2.28 A 1-501 [» ]
4B65 X-ray 2.32 A 1-501 [» ]
4B66 X-ray 2.90 A 1-501 [» ]
4B67 X-ray 2.75 A 1-501 [» ]
4B68 X-ray 2.29 A 1-501 [» ]
4B69 X-ray 2.30 A 1-501 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000237193.

Family and domain databases

InterProi IPR025700. Lys/Orn_oxygenase.
[Graphical view ]
Pfami PF13434. K_oxygenase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence."
    Schrettl M., Bignell E., Kragl C., Joechl C., Rogers T., Arst H.N. Jr, Haynes K., Haas H.
    J. Exp. Med. 200:1213-1219(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence."
    Hissen A.H., Wan A.N., Warwas M.L., Pinto L.J., Moore M.M.
    Infect. Immun. 73:5493-5503(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases."
    Franceschini S., Fedkenheuer M., Vogelaar N.J., Robinson H.H., Sobrado P., Mattevi A.
    Biochemistry 51:7043-7045(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH FAD AND NADP.

Entry informationi

Entry nameiQ5SE95_ASPFM
AccessioniPrimary (citable) accession number: Q5SE95
Secondary accession number(s): Q4X250
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3