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Q5SE95

- Q5SE95_ASPFM

UniProt

Q5SE95 - Q5SE95_ASPFM

Protein
Submitted name:

L-ornithine N5 monooxygenase

Gene

sidA

Organism
Neosartorya fumigata (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021FAD; via amide nitrogenImported
    Binding sitei144 – 1441NADP
    Binding sitei168 – 1681FAD; via amide nitrogen and carbonyl oxygenImported
    Binding sitei215 – 2151NADPImported
    Binding sitei279 – 2791NADP
    Binding sitei404 – 4041NADP; via carbonyl oxygenImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 502FADImported
    Nucleotide bindingi83 – 853FADImported
    Nucleotide bindingi90 – 912FADImported
    Nucleotide bindingi100 – 1023NADP
    Nucleotide bindingi254 – 2607NADP
    Nucleotide bindingi323 – 3253NADP
    Nucleotide bindingi466 – 4683FADImported

    GO - Molecular functioni

    1. monooxygenase activity Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    MonooxygenaseImported, Oxidoreductase

    Keywords - Ligandi

    FADImported, Flavoprotein, NADPImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    L-ornithine N5 monooxygenaseImported
    Submitted name:
    L-ornithine N5-oxygenaseImported
    Gene namesi
    Name:sidAImported
    OrganismiNeosartorya fumigata (Aspergillus fumigatus)Imported
    Taxonomic identifieri746128 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B63X-ray1.90A1-501[»]
    4B64X-ray2.28A1-501[»]
    4B65X-ray2.32A1-501[»]
    4B66X-ray2.90A1-501[»]
    4B67X-ray2.75A1-501[»]
    4B68X-ray2.29A1-501[»]
    4B69X-ray2.30A1-501[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000237193.

    Family and domain databases

    InterProiIPR025700. Lys/Orn_oxygenase.
    [Graphical view]
    PfamiPF13434. K_oxygenase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SE95-1 [UniParc]FASTAAdd to Basket

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    MESVERKSES SYLGMRNMQP EQRLSLDPPR LRSTPQDELH DLLCVGFGPA    50
    SLAIAIALHD ALDPRLNKSA SNIHAQPKIC FLERQKQFAW HSGMLVPGSK 100
    MQISFIKDLA TLRDPRSSFT FLNYLHQKGR LIHFTNLSTF LPARLEFEDY 150
    MRWCAQQFSD VVAYGEEVVE VIPGKSDPSS SVVDFFTVRS RNVETGEISA 200
    RRTRKVVIAI GGTAKMPSGL PQDPRIIHSS KYCTTLPALL KDKSKPYNIA 250
    VLGSGQSAAE IFHDLQKRYP NSRTTLIMRD SAMRPSDDSP FVNEIFNPER 300
    VDKFYSQSAA ERQRSLLADK ATNYSVVRLE LIEEIYNDMY LQRVKNPDET 350
    QWQHRILPER KITRVEHHGP QSRMRIHLKS SKPESEGAAN DVKETLEVDA 400
    LMVATGYNRN AHERLLSKVQ HLRPTGQDQW KPHRDYRVEM DPSKVSSEAG 450
    IWLQGCNERT HGLSDSLLSV LAVRGGEMVQ SIFGEQLERA AVQGHQLRAM 500
    L 501
    Length:501
    Mass (Da):56,877
    Last modified:December 21, 2004 - v1
    Checksum:iDD1D4DEDD2509506
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY586511 Genomic DNA. Translation: AAT84594.1.
    AY819708 Genomic DNA. Translation: AAX40989.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY586511 Genomic DNA. Translation: AAT84594.1 .
    AY819708 Genomic DNA. Translation: AAX40989.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B63 X-ray 1.90 A 1-501 [» ]
    4B64 X-ray 2.28 A 1-501 [» ]
    4B65 X-ray 2.32 A 1-501 [» ]
    4B66 X-ray 2.90 A 1-501 [» ]
    4B67 X-ray 2.75 A 1-501 [» ]
    4B68 X-ray 2.29 A 1-501 [» ]
    4B69 X-ray 2.30 A 1-501 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000237193.

    Family and domain databases

    InterProi IPR025700. Lys/Orn_oxygenase.
    [Graphical view ]
    Pfami PF13434. K_oxygenase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence."
      Schrettl M., Bignell E., Kragl C., Joechl C., Rogers T., Arst H.N. Jr, Haynes K., Haas H.
      J. Exp. Med. 200:1213-1219(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence."
      Hissen A.H., Wan A.N., Warwas M.L., Pinto L.J., Moore M.M.
      Infect. Immun. 73:5493-5503(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases."
      Franceschini S., Fedkenheuer M., Vogelaar N.J., Robinson H.H., Sobrado P., Mattevi A.
      Biochemistry 51:7043-7045(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH FAD AND NADP.

    Entry informationi

    Entry nameiQ5SE95_ASPFM
    AccessioniPrimary (citable) accession number: Q5SE95
    Secondary accession number(s): Q4X250
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3