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Q5SE95 (Q5SE95_ASPFM) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

L-ornithine N5-oxygenase EMBL AAX40989.1
Gene names
Name:sidA EMBL AAT84594.1
OrganismNeosartorya fumigata (Aspergillus fumigatus) EMBL AAT84594.1
Taxonomic identifier746128 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding49 – 502FAD PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63 PDB 4B69
Nucleotide binding83 – 853FAD PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63 PDB 4B69
Nucleotide binding90 – 912FAD PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63 PDB 4B69
Nucleotide binding100 – 1023NADP PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63
Nucleotide binding254 – 2607NADP PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63
Nucleotide binding323 – 3253NADP PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63
Nucleotide binding466 – 4683FAD PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63 PDB 4B69
Region126 – 1327Sulfate 2 binding PDB 4B68 PDB 4B65 PDB 4B67 PDB 4B66
Region328 – 3303Sulfate 1 binding PDB 4B66
Region367 – 3682Sulfate 4 binding PDB 4B67 PDB 4B69

Sites

Binding site1021FAD; via amide nitrogen PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63 PDB 4B69
Binding site1391Sulfate 3 PDB 4B64 PDB 4B63
Binding site1441NADP PDB 4B64 PDB 4B63
Binding site1681FAD; via amide nitrogen and carbonyl oxygen PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63 PDB 4B69
Binding site2151NADP PDB 4B65 PDB 4B66
Binding site2791NADP PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B66 PDB 4B63
Binding site3281Sulfate 3 PDB 4B64 PDB 4B63
Binding site4041NADP; via carbonyl oxygen PDB 4B68 PDB 4B65 PDB 4B64 PDB 4B67 PDB 4B63

Sequences

Sequence LengthMass (Da)Tools
Q5SE95 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: DD1D4DEDD2509506

FASTA50156,877
        10         20         30         40         50         60 
MESVERKSES SYLGMRNMQP EQRLSLDPPR LRSTPQDELH DLLCVGFGPA SLAIAIALHD 

        70         80         90        100        110        120 
ALDPRLNKSA SNIHAQPKIC FLERQKQFAW HSGMLVPGSK MQISFIKDLA TLRDPRSSFT 

       130        140        150        160        170        180 
FLNYLHQKGR LIHFTNLSTF LPARLEFEDY MRWCAQQFSD VVAYGEEVVE VIPGKSDPSS 

       190        200        210        220        230        240 
SVVDFFTVRS RNVETGEISA RRTRKVVIAI GGTAKMPSGL PQDPRIIHSS KYCTTLPALL 

       250        260        270        280        290        300 
KDKSKPYNIA VLGSGQSAAE IFHDLQKRYP NSRTTLIMRD SAMRPSDDSP FVNEIFNPER 

       310        320        330        340        350        360 
VDKFYSQSAA ERQRSLLADK ATNYSVVRLE LIEEIYNDMY LQRVKNPDET QWQHRILPER 

       370        380        390        400        410        420 
KITRVEHHGP QSRMRIHLKS SKPESEGAAN DVKETLEVDA LMVATGYNRN AHERLLSKVQ 

       430        440        450        460        470        480 
HLRPTGQDQW KPHRDYRVEM DPSKVSSEAG IWLQGCNERT HGLSDSLLSV LAVRGGEMVQ 

       490        500 
SIFGEQLERA AVQGHQLRAM L 

« Hide

References

[1]"Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence."
Schrettl M., Bignell E., Kragl C., Joechl C., Rogers T., Arst H.N. Jr, Haynes K., Haas H.
J. Exp. Med. 200:1213-1219(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence."
Hissen A.H., Wan A.N., Warwas M.L., Pinto L.J., Moore M.M.
Infect. Immun. 73:5493-5503(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases."
Franceschini S., Fedkenheuer M., Vogelaar N.J., Robinson H.H., Sobrado P., Mattevi A.
Biochemistry 51:7043-7045(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH FAD; NADP AND SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY586511 Genomic DNA. Translation: AAT84594.1.
AY819708 Genomic DNA. Translation: AAX40989.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B63X-ray1.90A1-501[»]
4B64X-ray2.28A1-501[»]
4B65X-ray2.32A1-501[»]
4B66X-ray2.90A1-501[»]
4B67X-ray2.75A1-501[»]
4B68X-ray2.29A1-501[»]
4B69X-ray2.30A1-501[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000237193.

Family and domain databases

InterProIPR025700. Lys/Orn_oxygenase.
[Graphical view]
PfamPF13434. K_oxygenase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5SE95_ASPFM
AccessionPrimary (citable) accession number: Q5SE95
Secondary accession number(s): Q4X250
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)