SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5SDA5

- GUC2F_MOUSE

UniProt

Q5SDA5 - GUC2F_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Retinal guanylyl cyclase 2

Gene
Gucy2f
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction By similarity.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Enzyme regulationi

Activated by GCAP-1; inhibited by calcium By similarity.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. guanylate cyclase activity Source: UniProtKB-EC
  4. protein kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis, Sensory transduction, Vision

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal guanylyl cyclase 2 (EC:4.6.1.2)
Gene namesi
Name:Gucy2f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:105119. Gucy2f.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini51 – 469419Extracellular Reviewed predictionAdd
BLAST
Transmembranei470 – 49021Helical; Reviewed predictionAdd
BLAST
Topological domaini491 – 1108618Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050 Reviewed predictionAdd
BLAST
Chaini51 – 11081058Retinal guanylyl cyclase 2PRO_0000280445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 132 By similarity
Disulfide bondi452 – 452Interchain By similarity
Disulfide bondi460 – 460Interchain By similarity

Post-translational modificationi

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds By similarity.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ5SDA5.

PTM databases

PhosphoSiteiQ5SDA5.

Expressioni

Gene expression databases

BgeeiQ5SDA5.
CleanExiMM_GUCY2F.
GenevestigatoriQ5SDA5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044521.

Structurei

3D structure databases

ProteinModelPortaliQ5SDA5.
SMRiQ5SDA5. Positions 75-246, 596-855, 884-1060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini532 – 812281Protein kinaseAdd
BLAST
Domaini884 – 1014131Guanylate cyclaseAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110520.
HOGENOMiHOG000293307.
HOVERGENiHBG098487.
InParanoidiQ5SDA5.
KOiK12321.
OMAiNSIYFIA.
OrthoDBiEOG7QVM1V.
PhylomeDBiQ5SDA5.
TreeFamiTF106338.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SDA5-1 [UniParc]FASTAAdd to Basket

« Hide

MFLGPWPFSR LLSWFAISSR LSGQHGLPSS KFLRCLCLLA LLPLLRWGQA     50
LPYKIGVIGP WTCDPFFSKA LPEVAAALAI ERISRDKTFD RSYSFEYVIL 100
NEDCQTSKAL ASFISHQQMA SGFVGPANPG FCEAASLLGT SWDKGIFSWA 150
CVNHELDNKH SFPTFSRTLP SPIRVLVTVM KYFQWAHAGV ISSDEDIWMH 200
TANRVSSALR SQGLPVGVVL TSGRDSQSIQ KALQQIRQAD RIRIIIMCMH 250
SALIGGETQT HFLELAHDLK MTDGTYVFVP YDVLLYSLPY KHSPYQVLRN 300
NPKLREAYDA VLTITVESHE KTFYEAYAEA AARGEIPEKP DSNQVSPLFG 350
TIYNSIYFIA QAMNNAMKKN GRASAASLVQ HSRNMQFYGF NQLIKTDSNG 400
NGISEYVILD TNGKEWELRG TYTVDMETEL LRFRGTPIHF PGGRPTSADA 450
KCWFAERKIC QGGIDPALAM MVCFALLIAL LSINGFAYFI RRRINKIQLI 500
KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQIISEVQS GRSPRLSFSS 550
GSLTPATYEN SNIAIYEGDW VWLKKFPPGD FGDIKSIKSS ASDVFEMMKD 600
LRHENVNPLL GFFYDSGMFA IVSEFCSRRS LEDILTNDDV KLDWMFKSSL 650
LLDLIKGMKY LHHREFIHGR LKSRNCVVDG RFVLKVTDYG FNDILEMLRL 700
SEEEPSEEEL LWTAPELLRA PGGIRLGSFA GDVYSFAIIM QEVMVRGAPF 750
CMMDLPAKEI IDRLKMPPPV YRPVVSPEYA PAECLQLMKQ CWAEASEQRP 800
TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR ERTEELEIEK 850
QKTEKLLTQM LPLSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS 900
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA 950
AEIANMSLDI LSSVGTFKMR HMPEVPVRIR IGLHSGPVVA GVVGLTMPRY 1000
CLFGDTVNTA SRMESTGLPY RIHVSLSTVT ILQTLSEGYE VELRGRTELK 1050
GKGTEETFWL VGKKGFTKPL PVPPPVGKDG QVGHGLQPAE IAAFQRRKAE 1100
RQLVRNKP 1108
Length:1,108
Mass (Da):124,425
Last modified:December 21, 2004 - v1
Checksum:i8A1456FCB384FA90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY651761 mRNA. Translation: AAV54098.1.
AL671916, BX324191 Genomic DNA. Translation: CAM19986.1.
BX324191, AL671916 Genomic DNA. Translation: CAM24899.1.
BC115714 mRNA. Translation: AAI15715.1.
AK044234 mRNA. Translation: BAC31833.1.
CCDSiCCDS30446.1.
RefSeqiNP_001007577.1. NM_001007576.2.
XP_006528904.1. XM_006528841.1.
UniGeneiMm.208511.

Genome annotation databases

EnsembliENSMUST00000042530; ENSMUSP00000044521; ENSMUSG00000042282.
GeneIDi245650.
KEGGimmu:245650.
UCSCiuc009ulq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY651761 mRNA. Translation: AAV54098.1 .
AL671916 , BX324191 Genomic DNA. Translation: CAM19986.1 .
BX324191 , AL671916 Genomic DNA. Translation: CAM24899.1 .
BC115714 mRNA. Translation: AAI15715.1 .
AK044234 mRNA. Translation: BAC31833.1 .
CCDSi CCDS30446.1.
RefSeqi NP_001007577.1. NM_001007576.2.
XP_006528904.1. XM_006528841.1.
UniGenei Mm.208511.

3D structure databases

ProteinModelPortali Q5SDA5.
SMRi Q5SDA5. Positions 75-246, 596-855, 884-1060.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044521.

PTM databases

PhosphoSitei Q5SDA5.

Proteomic databases

PRIDEi Q5SDA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042530 ; ENSMUSP00000044521 ; ENSMUSG00000042282 .
GeneIDi 245650.
KEGGi mmu:245650.
UCSCi uc009ulq.2. mouse.

Organism-specific databases

CTDi 2986.
MGIi MGI:105119. Gucy2f.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110520.
HOGENOMi HOG000293307.
HOVERGENi HBG098487.
InParanoidi Q5SDA5.
KOi K12321.
OMAi NSIYFIA.
OrthoDBi EOG7QVM1V.
PhylomeDBi Q5SDA5.
TreeFami TF106338.

Enzyme and pathway databases

Reactomei REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi 386884.
PROi Q5SDA5.
SOURCEi Search...

Gene expression databases

Bgeei Q5SDA5.
CleanExi MM_GUCY2F.
Genevestigatori Q5SDA5.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Application of functional genomic technologies in a mouse model of retinal degeneration."
    Shearstone J.R., Wang Y.E., Clement A., Allaire N.E., Yang C., Worley D.S., Carulli J.P., Perrin S.
    Genomics 85:309-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-846.
    Strain: C57BL/6J.
    Tissue: Retina.

Entry informationi

Entry nameiGUC2F_MOUSE
AccessioniPrimary (citable) accession number: Q5SDA5
Secondary accession number(s): Q8BLL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi