Q5SCZ2 (NU1C_HUPLU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 1
Short name=NDH subunit 1
NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Huperzia lucidula (Shining clubmoss) (Lycopodium lucidulum)

Taxonomic identifier

37429 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Lycopodiophyta › Lycopodiopsida › Lycopodiales › Lycopodiaceae › Huperzia

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01350
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000240022
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	270 – 290	21	Helical; Potential
	Transmembrane	306 – 326	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5SCZ2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 0F5F97D5CCF7C452	FASTA	369	40,331
	10 20 30 40 50 60 MVINKNLEEQ VIDLFYKLGF PKDLFGFIWI ITPILTYTLG VTIGISVIVW LERKISAGVQ 70 80 90 100 110 120 QRIGPEHAGP LGIIQALADG AKLLSKEDII PSRGDSFLFN VGPVMVVVPV FLSYLVIPLG 130 140 150 160 170 180 HGIILADLDI GVFFWIAVSS VAPLGLLTAG YGSNNKYSSL GGLRAAAQSI SYEIPLALCV 190 200 210 220 230 240 LSVSPLSNSL STVDIVEAQS KYGFWGWNSW RQPIGFVAFF ISSLAECERL PFDLPEAEEE 250 260 270 280 290 300 LVAGYQTEYS GIKFGLFYVA SHPNLLTSSL SATILYLGGW NSPIPFLFLP KFDRLGWNST 310 320 330 340 350 360 DETSEVISIT IAIIITLAKA YSFLFISIAT RWTLPRVRMD QLLDLGWKSL LPVALGNSLP TASFQLSSP

References

[1]

"The first complete chloroplast genome sequence of a lycophyte, Huperzia lucidula (Lycopodiaceae)." Wolf P.G., Karol K.G., Mandoli D.F., Kuehl J.V., Arumuganathan K., Ellis M.W., Mishler B.D., Kelch D.G., Olmstead R.G., Boore J.L. Gene 350:117-128(2005) [PubMed: 15788152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY660566 Genomic DNA. Translation: AAT80758.1.
RefSeq	YP_209562.1. NC_006861.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3283827.
Phylogenomic databases
ProtClustDB	CHL00032.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_HUPLU

Accession

Primary (citable) accession number: Q5SCZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	December 21, 2004
Last modified:	June 28, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program