Q5S8D1 (Q5S8D1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cacna1c protein EMBL AAI38032.1

Submitted name:
Neuronal voltage-gated calcium channel alpha 1C subunit EMBL AAV59464.1

Gene names

Name:

Cacna1c MGI 103013 EMBL AAV59464.1

Organism

Mus musculus (Mouse) EMBL AAV59464.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2139 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ionic channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Biological process	adult walking behavior Inferred from genetic interaction. Source: MGI calcium ion-dependent exocytosis Inferred from mutant phenotype. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype. Source: MGI glucose homeostasis Inferred from mutant phenotype. Source: MGI growth hormone secretion Inferred from direct assay. Source: MGI insulin secretion Inferred from mutant phenotype. Source: MGI regulation of blood pressure Inferred from mutant phenotype. Source: MGI regulation of organ growth Inferred from mutant phenotype. Source: MGI regulation of vasoconstriction Inferred from mutant phenotype. Source: MGI smooth muscle contraction involved in micturition Inferred from mutant phenotype. Source: MGI synaptic transmission Inferred from mutant phenotype. Source: MGI visual learning Inferred from mutant phenotype. Source: MGI
Cellular component	T-tubule Traceable author statement. Source: MGI caveolar macromolecular signaling complex Inferred from direct assay. Source: MGI dendritic shaft Inferred from direct assay. Source: MGI membrane fraction Inferred from direct assay. Source: MGI neuronal cell body Inferred from direct assay. Source: MGI voltage-gated calcium channel complex Traceable author statement. Source: MGI
Molecular function	protein binding Inferred from physical interaction. Source: MGI voltage-gated calcium channel activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5S8D1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 0FE57B1EDA910DDD	FASTA	2,139	240,141
	10 20 30 40 50 60 MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR 70 80 90 100 110 120 QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI 130 140 150 160 170 180 VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF TVEAFLKVIA 190 200 210 220 230 240 YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR 250 260 270 280 290 300 VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 310 320 330 340 350 360 QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI 370 380 390 400 410 420 TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV LGVLSGEFSK EREKAKARGD 430 440 450 460 470 480 FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNMSMPTSE TESVNTENVA 490 500 510 520 530 540 GGDIEGENCG ARLAHRISKS KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT 550 560 570 580 590 600 IASEHYNQPH WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI 610 620 630 640 650 660 LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS IASLLLLLFL 670 680 690 700 710 720 FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF QILTGEDWNS VMYDGIMAYG 730 740 750 760 770 780 GPSFPGMLVC IYFIILFICG NYILLNVFLA IAVDNLADAE SLTSAQKEEE EEKERKKLAR 790 800 810 820 830 840 TASPEKKQEV MEKPAVEESK EEKIELKSIT ADGESPPTTK INMDDLQPSE NEDKSPHSNP 850 860 870 880 890 900 DTAGEEDEEE PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSPNNRFR LQCHRIVNDT 910 920 930 940 950 960 IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL KMTAYGAFLH 970 980 990 1000 1010 1020 KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ 1030 1040 1050 1060 1070 1080 CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE 1090 1100 1110 1120 1130 1140 VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV 1150 1160 1170 1180 1190 1200 EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELDKNQRQCV EYALKARPLR 1210 1220 1230 1240 1250 1260 RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA MNILNMLFTG 1270 1280 1290 1300 1310 1320 LFTVEMILKL IAFKPKHYFC DAWNTFDALI VVGSIVDIAI TEVHPAEHTQ CSPSMSAEEN 1330 1340 1350 1360 1370 1380 SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML FFIYAVIGMQ 1390 1400 1410 1420 1430 1440 VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS 1450 1460 1470 1480 1490 1500 TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI 1510 1520 1530 1540 1550 1560 WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA 1570 1580 1590 1600 1610 1620 TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA 1630 1640 1650 1660 1670 1680 TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS GDLTAEEELD 1690 1700 1710 1720 1730 1740 KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY QSDSRGNFPQ TFATQRPLHI NKTGNNQADT 1750 1760 1770 1780 1790 1800 ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRFPH PAGYSSTVST VEGHGPPLSP 1810 1820 1830 1840 1850 1860 AVRVQEAAWK LSSKRCHSRE SQGATVNQEI FPDETRSVRM SEEAEYCSEP SLLSTDMFSY 1870 1880 1890 1900 1910 1920 QEDEHRQLTC PEEDKREIQP SPKRSFLRSA SLGRRASFHL ECLKRQKDQG GDISQKTALP 1930 1940 1950 1960 1970 1980 LHLVHHQALA VAGLSPLLQR SHSPTTFPRP CPTPPVTPGS RGRPLRPIPT LRLEGAESSE 1990 2000 2010 2020 2030 2040 KLNSSFPSIH CSSWSEETTA CSGSSSMARR ARPVSLTVPS QAGAPGRQFH GSASSLVEAV 2050 2060 2070 2080 2090 2100 LISEGLGQFA QDPKFIEVTT QELADACDMT IEEMENAADN ILSGGAQQSP NGTLLPFVNC 2110 2120 2130 RDPGQDRAVV PEDESCAYAL GRGRSEEALA DSRSYVSNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neuronal L-type calcium channels open quickly and are inhibited slowly." Helton T.D., Xu W., Lipscombe D. J. Neurosci. 25:10247-10251(2005) [PubMed: 16267232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/c EMBL AAV59464.1. Tissue: Whole brain EMBL AAV59464.1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI38032.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC138031 mRNA. Translation: AAI38032.1. BC145105 mRNA. Translation: AAI45106.1. AY728090 mRNA. Translation: AAV59464.1.
IPI	IPI00277044.
RefSeq	NP_001153006.1. NM_001159534.1.
UniGene	Mm.436656.
3D structure databases
ProteinModelPortal	Q5S8D1.
SMR	Q5S8D1. Positions 1612-1640.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5S8D1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12288.
KEGG	mmu:12288.
UCSC	uc009dlt.2. mouse.
Organism-specific databases
CTD	775.
MGI	MGI:103013. Cacna1c.
Phylogenomic databases
GeneTree	ENSGT00590000082785.
HOVERGEN	HBG050763.
Gene expression databases
ArrayExpress	Q5S8D1.
Genevestigator	Q5S8D1.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
KO	K04850.
PANTHER	PTHR10037:SF47. LVDCCAlpha1C. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q5S8D1_MOUSE

Accession

Primary (citable) accession number: Q5S8D1

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)