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Q5S255 (Q5S255_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Bruton agammaglobulinemia tyrosine kinase EMBL AAV52921.1
Gene names
Name:Btk EMBL AAV52921.1 RGD 1359683
OrganismRattus norvegicus (Rat) EMBL AAV52921.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266

Sequence similarities

Contains 1 PH domain. RuleBase RU003350 SAAS SAAS000980

Contains 1 SH2 domain. SAAS SAAS008266

Contains 1 SH3 domain. RuleBase RU003338 SAAS SAAS008266

Contains 1 protein kinase domain. SAAS SAAS008266

Sequences

Sequence LengthMass (Da)Tools
Q5S255 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: D4D7566203ADB11D

FASTA66076,403
        10         20         30         40         50         60 
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK 

        70         80         90        100        110        120 
ITCVETVVPE KNPPPERQIP VPRGEESSEM EQISIIERFP YPFQVVYDEG PLYVFSPTEE 

       130        140        150        160        170        180 
LRKRWIHQLK NVIRYNSDLV QKYHPCFWID GQYLCCSQTA KNAMGCQILE NRNGSLKPGS 

       190        200        210        220        230        240 
SHRKTKKPLP PTPEEDQILK KPLPPEPTAA PISTSELKKV VALYDYMPMN ANDLQLRKGE 

       250        260        270        280        290        300 
EYFILEESNL PWWRARDKNG QEGYIPSNYV TEAEDSIEMY EWYSKHMTRS QAEQLLKQEG 

       310        320        330        340        350        360 
KEGGFIVRDS SKAGKYTVSV FAKSTGEPQG VIRHYVVCST PQSQYYLAEK HLFSTIPELI 

       370        380        390        400        410        420 
NYHQHNSAGL ISRLKYPVSK QNKNAPSTAG LGYGSWEIDP KDLTFLKELG TGQFGVVKYG 

       430        440        450        460        470        480 
KWRGQYDVAI KMIREGSMSE DEFIEEAKVM MNLSHEKLVQ LYGVCTKQRP IFIITEYMAN 

       490        500        510        520        530        540 
GCLLNYLREM RHRFQTQQLL EMCKDVCEAM EYLESKQFLH RDLAARNCLV NDQGVVKVSD 

       550        560        570        580        590        600 
FGLSRYVLDD EYTSSVGSKF PVRWSPPEVL MYSKFSSKSD IWAFGVLMWE IYSLGKIPYE 

       610        620        630        640        650        660 
RFTNSETAEH IAQGLRLYRP HLASDRVYTI MYSCWHEKAD ERPSFKILLS NILDVMDEES

« Hide

References

[1]Blomberg K.E.M., Nore B.F., Lindvall J.M., Smith C.I.E.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling."
Lindvall J.M., Blomberg K.E., Valiaho J., Vargas L., Heinonen J.E., Berglof A., Mohamed A.J., Nore B.F., Vihinen M., Smith C.I.
Immunol. Rev. 203:200-215(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY787790 mRNA. Translation: AAV52921.1.
IPIIPI00361631.
RefSeqNP_001007799.1. NM_001007798.1.
UniGeneRn.26996.

3D structure databases

ProteinModelPortalQ5S255.
SMRQ5S255. Positions 2-171, 212-388, 398-655.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000059788.
Q5S255.

PTM databases

PhosphoSiteQ5S255.

Proteomic databases

PaxDbQ5S255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID367901.
KEGGrno:367901.

Organism-specific databases

CTD695.
RGD1359683. Btk.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233859.
HOVERGENHBG008761.
InParanoidQ5S255.
KOK07370.

Gene expression databases

GenevestigatorQ5S255.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00402. TECBTKDOMAIN.
PR00109. TYRKINASE.
SMARTSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio691818.

Entry information

Entry nameQ5S255_RAT
AccessionPrimary (citable) accession number: Q5S255
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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