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Protein

Transmembrane protease serine 11E

Gene

Tmprss11e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.1 Publication

Enzyme regulationi

Inhibited by SERPINA5.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei232Charge relay systemBy similarity1
Active sitei277Charge relay systemBy similarity1
Active sitei373Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: UniProtKB

GO - Biological processi

  • cognition Source: MGI
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11E (EC:3.4.21.-)
Alternative name(s):
Serine protease DESC1
Cleaved into the following 2 chains:
Gene namesi
Name:Tmprss11e
Synonyms:Desc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3513175. Tmprss11e.

Subcellular locationi

Chain Transmembrane protease serine 11E catalytic chain :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini40 – 423ExtracellularSequence analysisAdd BLAST384

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000278931 – 191Transmembrane protease serine 11E non-catalytic chainSequence analysisAdd BLAST191
ChainiPRO_0000027894192 – 423Transmembrane protease serine 11E catalytic chainSequence analysisAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi176 ↔ 297Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi217 ↔ 233PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi342 ↔ 358PROSITE-ProRule annotation
Disulfide bondi369 ↔ 398PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ5S248.
PRIDEiQ5S248.

PTM databases

iPTMnetiQ5S248.
PhosphoSitePlusiQ5S248.

Expressioni

Tissue specificityi

Expressed in epidermal, oral and male reproductive tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000054537.
CleanExiMM_TMPRSS11E.
GenevisibleiQ5S248. MM.

Interactioni

Subunit structurei

Forms a heterodimer with SERPINA5 and SERPINE1.

Binary interactionsi

WithEntry#Exp.IntActNotes
Serpina5P704582EBI-490889,EBI-490966
Serpine1P227772EBI-490889,EBI-490898

Protein-protein interaction databases

BioGridi232483. 2 interactors.
IntActiQ5S248. 2 interactors.
STRINGi10090.ENSMUSP00000124534.

Structurei

3D structure databases

ProteinModelPortaliQ5S248.
SMRiQ5S248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 166SEAPROSITE-ProRule annotationAdd BLAST119
Domaini192 – 422Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ5S248.
KOiK09642.
OMAiAHMLLIF.
OrthoDBiEOG091G0DF7.
TreeFamiTF351684.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5S248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRSCVVRAR KRTCVEPWVI GIISFLSLIV LAVCIGLTVH YVRYNHRRTY
60 70 80 90 100
NYYSTLSFTS DKLYSEFGRE ASKNFTEMSQ RIETMVKHAF HKSPLRGQLV
110 120 130 140 150
KAHIIKFSKE DDGVLAHMLL IFRIRSTEDP ETVHKIIEYV LHEKLKYATG
160 170 180 190 200
PPNVDPESVK IKKINKTESD NYFNHCCGTR RNKSTVQTSV RIVGGTPVEE
210 220 230 240 250
EEWPWQSSLR WDGSHRCGAT LINNTWLVTA AHCFRTHKDP SRWSATFGAT
260 270 280 290 300
LQPRKLTTGI RRIIVHEKYK YPSHDYDIAL AELSKPVPCT NAVHKVCLPD
310 320 330 340 350
ANHEFQPGQR MFVTGFGALK NDGFTQNNLR QVQVDYIDTQ TCNQPQSYNG
360 370 380 390 400
AITPRMLCAG FLKGEKDACQ GDSGGPLVTA DVRDIWYLAG VVSWGDECGQ
410 420
PNKPGVYTRV TAFRHWIASN TGI
Length:423
Mass (Da):48,065
Last modified:June 28, 2011 - v2
Checksum:iD71BF4F0283BB896
GO

Sequence cautioni

The sequence AAV52922 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY787860 mRNA. Translation: AAV52922.1. Different initiation.
AK037235 mRNA. Translation: BAC29770.1.
BC115432 mRNA. Translation: AAI15433.1.
BC115433 mRNA. Translation: AAI15434.1.
CCDSiCCDS51533.1.
RefSeqiNP_766468.1. NM_172880.2.
UniGeneiMm.130801.

Genome annotation databases

EnsembliENSMUST00000161306; ENSMUSP00000124534; ENSMUSG00000054537.
GeneIDi243084.
KEGGimmu:243084.
UCSCiuc008xxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY787860 mRNA. Translation: AAV52922.1. Different initiation.
AK037235 mRNA. Translation: BAC29770.1.
BC115432 mRNA. Translation: AAI15433.1.
BC115433 mRNA. Translation: AAI15434.1.
CCDSiCCDS51533.1.
RefSeqiNP_766468.1. NM_172880.2.
UniGeneiMm.130801.

3D structure databases

ProteinModelPortaliQ5S248.
SMRiQ5S248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232483. 2 interactors.
IntActiQ5S248. 2 interactors.
STRINGi10090.ENSMUSP00000124534.

Protein family/group databases

MEROPSiS01.021.

PTM databases

iPTMnetiQ5S248.
PhosphoSitePlusiQ5S248.

Proteomic databases

PaxDbiQ5S248.
PRIDEiQ5S248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161306; ENSMUSP00000124534; ENSMUSG00000054537.
GeneIDi243084.
KEGGimmu:243084.
UCSCiuc008xxv.1. mouse.

Organism-specific databases

CTDi28983.
MGIiMGI:3513175. Tmprss11e.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ5S248.
KOiK09642.
OMAiAHMLLIF.
OrthoDBiEOG091G0DF7.
TreeFamiTF351684.

Miscellaneous databases

PROiQ5S248.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054537.
CleanExiMM_TMPRSS11E.
GenevisibleiQ5S248. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM11E_MOUSE
AccessioniPrimary (citable) accession number: Q5S248
Secondary accession number(s): A4FUP5, Q8BM10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.