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Protein

Heat shock protein beta-1

Gene

HSPB1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in stress resistance and actin organization.By similarity

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-SSC-4420097. VEGFA-VEGFR2 Pathway.
R-SSC-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-1
Short name:
HspB1
Alternative name(s):
Heat shock 27 kDa protein
Short name:
HSP 27
Gene namesi
Name:HSPB1
Synonyms:HSP27
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Heat shock protein beta-1PRO_0000125929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei15 – 151Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei80 – 801Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity
Modified residuei84 – 841Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei88 – 881PhosphoserineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei125 – 1251N6-acetyllysineBy similarity
Modified residuei176 – 1761PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphoserineBy similarity
Modified residuei201 – 2011PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress leads to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5S1U1.
PeptideAtlasiQ5S1U1.

PTM databases

iPTMnetiQ5S1U1.

Expressioni

Gene expression databases

BgeeiENSSSCG00000024482.
GenevisibleiQ5S1U1. SS.

Interactioni

Subunit structurei

Associates with alpha- and beta-tubulin, microtubules and CRYAB. Interacts with HSPB8, HSPBAP1 and TGFB1I1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008216.

Structurei

3D structure databases

ProteinModelPortaliQ5S1U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 207136Interaction with TGFB1I1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ5S1U1.
KOiK04455.
OMAiDQSFGMP.
OrthoDBiEOG091G0USC.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 2 hits.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5S1U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERRVPFSL LRSPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS
60 70 80 90 100
GWPGYVRPLP PPAIEGPAAV AAPAYSRLLS RQLSSGVSEI QQTADRWRVS
110 120 130 140 150
LDVNHFAPEE LTVKTKDGVV EITGKHEERQ DEHGFISRCF TRKYTLPPGV
160 170 180 190 200
DPTQVSSSLS PEGTLSVEAP LPKPATQSAE ITIPVTFEAR AQLGGTEAGK

SEKPGTK
Length:207
Mass (Da):22,942
Last modified:December 21, 2004 - v1
Checksum:iB2B5E955AAA70D69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY789513 mRNA. Translation: AAV54182.1.
RefSeqiNP_001007519.1. NM_001007518.1.
UniGeneiSsc.5832.

Genome annotation databases

EnsembliENSSSCT00000008434; ENSSSCP00000008215; ENSSSCG00000024482.
ENSSSCT00000008435; ENSSSCP00000008216; ENSSSCG00000028568.
GeneIDi493184.
KEGGissc:493184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY789513 mRNA. Translation: AAV54182.1.
RefSeqiNP_001007519.1. NM_001007518.1.
UniGeneiSsc.5832.

3D structure databases

ProteinModelPortaliQ5S1U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008216.

PTM databases

iPTMnetiQ5S1U1.

Proteomic databases

PaxDbiQ5S1U1.
PeptideAtlasiQ5S1U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008434; ENSSSCP00000008215; ENSSSCG00000024482.
ENSSSCT00000008435; ENSSSCP00000008216; ENSSSCG00000028568.
GeneIDi493184.
KEGGissc:493184.

Organism-specific databases

CTDi3315.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ5S1U1.
KOiK04455.
OMAiDQSFGMP.
OrthoDBiEOG091G0USC.
TreeFamiTF105049.

Enzyme and pathway databases

ReactomeiR-SSC-4420097. VEGFA-VEGFR2 Pathway.
R-SSC-5687128. MAPK6/MAPK4 signaling.

Gene expression databases

BgeeiENSSSCG00000024482.
GenevisibleiQ5S1U1. SS.

Family and domain databases

Gene3Di2.60.40.790. 2 hits.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB1_PIG
AccessioniPrimary (citable) accession number: Q5S1U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.