ID   Q5S007_HUMAN PRELIMINARY;      PRT;  2527 AA.
AC   Q5S007;
DT   01-FEB-2005 (TrEMBLrel. 29, Created)
DT   01-FEB-2005 (TrEMBLrel. 29, Last sequence update)
DT   01-FEB-2005 (TrEMBLrel. 29, Last annotation update)
DE   Leucine-rich repeat kinase 2.
GN   Name=LRRK2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RA   Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M.,
RA   Lincoln S., Kachergus J., Hulihan M., Uitti R.J., Calne D.B.,
RA   Stoessl J., Pfeiffer R.F., Patenge N., Carballo I., Vieregge P.,
RA   Asmus F., Mueller-Myhsok B., Meitinger T., Strom T.M., Wszolek Z.,
RA   Gasser T.;
RT   "Mutations in a large multifunctional protein (LRRK2) cause autosomal
RT   dominant parkinsonism with pleiomorphic a-synuclein and tau-pathology
RT   (PARK8).";
RL   Neuron 0:0-0(2004).
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DR   EMBL; AY792511; AAV63975.1; -; mRNA.
DR   GO; GO:0005524; F:ATP binding; IEA.
DR   GO; GO:0005525; F:GTP binding; IEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA.
DR   GO; GO:0004713; F:protein-tyrosine kinase activity; IEA.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA.
DR   GO; GO:0015031; P:protein transport; IEA.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA.
DR   InterPro; IPR003579; GTPase_Rab.
DR   InterPro; IPR001611; LRR.
DR   InterPro; IPR003591; LRR_typ.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR001806; Ras_trnsfrmng.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR005225; Small_GTP.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   Pfam; PF00560; LRR_1; 10.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00369; LRR_TYP; 7.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS00626; RCC1_2; UNKNOWN_1.
KW   Kinase.
SQ   SEQUENCE   2527 AA;  286055 MW;  6F6070F2437B9C06 CRC64;
     MASGSCQGCE EDEETLKKLI VRLNNVQEGK QIETLVQILE DLLVFTYSEH ASKLFQGKNI
     HVPLLIVLDS YMRVASVQQV GWSLLCKLIE VCPGTMQSLM GPQDVGNDWE VLGVHQLILK
     MLTVHNASVN LSVIGLKTLD LLLTSGKITL LILDEESDIF MLIFDAMHSF PANDEVQKLG
     CKALHVLFER VSEEQLTEFV ENKDYMILLS ASTNFKDEEE IVLHVLHCLH SLAIPCNNVE
     VLMSGNVRCY NIVVEAMKAF PMSERIQEVS CCLLHRLTLG NFFNILVLNE VHEFVVKAVQ
     QYPENAALQI SALSCLALLT ETIFLNQDLE EKNENQENDD EGEEDKLFWL EACYKALTWH
     RKNKHVQEAA CWALNNLLMY QNSLHEKIGD EDGHFPAHRE VMLSMLMHSS SKEVFQASAN
     ALSTLLEQNV NFRKILLSKG IHLNVLELMQ KHIHSPEVAE SGCKMLNHLF EGSNTSLDIM
     AAVVPKILTV MKRHETSLPV QLEALRAILH FIVPGMPEES REDTEFHHKL NMVKKQCFKN
     DIHKLVLAAL NRFIGNPGIQ KCGLKVISSI VHFPDALEML SLEGAMDSVL HTLQMYPDDQ
     EIQCLGLSLI GYLITKKNVF IGTGHLLAKI LVSSLYRFKD VAEIQTKGFQ TILAILKLSA
     SFSKLLVHHS FDLVIFHQMS SNIMEQKDQQ FLNLCCKCFA KVAMDDYLKN VMLERACDQN
     NSIMVECLLL LGADANQAKE GSSLICQVCE KESSPKLVEL LLNSGSREQD VRKALTISIG
     KGDSQIISLL LRRLALDVAN NSICLGGFCI GKVEPSWLGP LFPDKTSNLR KQTNIASTLA
     RMVIRYQMKS AVEEGTASGS DGNFSEDVLS KFDEWTFIPD SSMDSVFAQS DDLDSEGSEG
     SFLVKKKSNS ISVGEFYRDA VLQRCSPNLQ RHSNSLGPIF DHEDLLKRKR KILSSDDSLR
     SSKLQSHMRH SDSISSLASE REYITSLDLS ANELRDIDAL SQKCCISVHL EHLEKLELHQ
     NALTSFPQQL CETLKSLTHL DLHSNKFTSF PSYLLKMSCI ANLDVSRNDI GPSVVLDPTV
     KCPTLKQFNL SYNQLSFVPE NLTDVVEKLE QLILEGNKIS GICSPLRLKE LKILNLSKNH
     ISSLSENFLE ACPKVESFSA RMNFLAAMPF LPPSMTILKL SQNKFSCIPE AILNLPHLRS
     LDMSSNDIQY LPGPAHWKSL NLRELLFSHN QISILDLSEK AYLWSRVEKL HLSHNKLKEI
     PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD ELHLNFDFKH IGCKAKDIIR
     FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLMKTKKS DLGMQSATVG IDVKDWPIQI
     RDKRKRDLVL NVWDFAGREE FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA
     RASSSPVILV GTHLDVSDEK QRKACMSKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL
     RKTIINESLN FKIRDQLVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVREN
     QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKIMAQI LTVKVEGCPK
     HPKGIISRRD VEKFLSKKRK FPKNYMSQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI
     ELPHCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPYML SGRERALRPN RMYWRQGIYL
     NWSPEAYCLV GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI
     CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI PISQIAPDLI
     LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRAAYEG EEVAVKIFNK HTSLRLLRQE
     LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ QDKASLTRTL QHRIALHVAD
     GLRYLHSAMI IYRDLKPHNV LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA
     PEVARGNVIY NQQADVYSFG LLLYDILTTG GRIVEGLKFP NEFDELEIQG KLPDPVKEYG
     CAPWPMVEKL IKQCLKENPQ ERPTSAQVFD ILNSAELVCL TRRILLPKNV IVECMVATHH
     NSRNASIWLG CGHTDRGQLS FLDLNTEGYT SEEVADSRIL CLALVHLPVE KESWIVSGTQ
     SGTLLVINTE DGKKRHTLEK MTDSVTCLYC NSFSKQSKQK NFLLVGTADG KLAIFEDKTV
     KLKGAAPLKI LNIGNVSTPL MCLSESTNST ERNVMWGGCG TKIFSFSNDF TIQKLIETRT
     SQLFSYAAFS DSNIITVVVD TALYIAKQNS PVVEVWDKKT EKLCGLIDCV HFLREVMVKE
     NKESKHKMSY SGRVKTLCLQ KNTALWIGTG GGHILLLDLS TRRLIRVIYN FCNSVRVMMT
     AQLGSLKNVM LVLGYNRKNT EGTQKQKEIQ SCLTVWDINL PHEVQNLEKH IEVRKELAEK
     MRRTSVE
//