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Protein

Leucine-rich repeat serine/threonine-protein kinase 2

Gene

Lrrk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. Has GTPase activity (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1906 – 19061ATPPROSITE-ProRule annotation
Active sitei1994 – 19941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1341 – 13488GTPPROSITE-ProRule annotation
Nucleotide bindingi1885 – 18939ATPPROSITE-ProRule annotation
Nucleotide bindingi2098 – 212124GTPPROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi2295 – 22984GTPPROSITE-ProRule annotation

GO - Molecular functioni

  1. actin binding Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. clathrin binding Source: MGI
  4. glycoprotein binding Source: MGI
  5. GTPase activator activity Source: MGI
  6. GTPase activity Source: MGI
  7. GTP binding Source: MGI
  8. GTP-dependent protein kinase activity Source: MGI
  9. identical protein binding Source: IntAct
  10. ion channel binding Source: MGI
  11. kinase activity Source: UniProtKB
  12. MAP kinase kinase activity Source: MGI
  13. peroxidase inhibitor activity Source: MGI
  14. protein homodimerization activity Source: MGI
  15. protein kinase A binding Source: ParkinsonsUK-UCL
  16. protein kinase activity Source: MGI
  17. protein serine/threonine kinase activity Source: MGI
  18. Rho GTPase binding Source: BHF-UCL
  19. SNARE binding Source: MGI
  20. syntaxin-1 binding Source: MGI
  21. tubulin binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. activation of MAPKK activity Source: MGI
  3. autophagy Source: UniProtKB-KW
  4. cellular protein localization Source: ParkinsonsUK-UCL
  5. cellular response to dopamine Source: MGI
  6. cellular response to manganese ion Source: MGI
  7. cellular response to oxidative stress Source: MGI
  8. determination of adult lifespan Source: MGI
  9. endocytosis Source: MGI
  10. exploration behavior Source: MGI
  11. Golgi organization Source: MGI
  12. intracellular distribution of mitochondria Source: MGI
  13. intracellular signal transduction Source: ParkinsonsUK-UCL
  14. locomotory exploration behavior Source: ParkinsonsUK-UCL
  15. MAPK cascade Source: MGI
  16. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
  17. negative regulation of GTPase activity Source: MGI
  18. negative regulation of hydrogen peroxide-induced cell death Source: MGI
  19. negative regulation of neuron death Source: MGI
  20. negative regulation of peroxidase activity Source: MGI
  21. negative regulation of protein binding Source: MGI
  22. negative regulation of protein phosphorylation Source: ParkinsonsUK-UCL
  23. negative regulation of protein processing Source: MGI
  24. negative regulation of protein targeting to mitochondrion Source: MGI
  25. negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation Source: MGI
  26. neuromuscular junction development Source: MGI
  27. neuron death Source: MGI
  28. neuron projection morphogenesis Source: UniProtKB
  29. olfactory bulb development Source: MGI
  30. peptidyl-serine phosphorylation Source: MGI
  31. peptidyl-threonine phosphorylation Source: MGI
  32. positive regulation of autophagy Source: BHF-UCL
  33. positive regulation of dopamine receptor signaling pathway Source: MGI
  34. positive regulation of GTPase activity Source: MGI
  35. positive regulation of programmed cell death Source: MGI
  36. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  37. positive regulation of protein autoubiquitination Source: MGI
  38. positive regulation of protein binding Source: MGI
  39. positive regulation of protein phosphorylation Source: MGI
  40. positive regulation of protein ubiquitination Source: MGI
  41. protein autophosphorylation Source: MGI
  42. protein phosphorylation Source: MGI
  43. reactive oxygen species metabolic process Source: MGI
  44. regulation of branching morphogenesis of a nerve Source: MGI
  45. regulation of dendritic spine morphogenesis Source: ParkinsonsUK-UCL
  46. regulation of dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
  47. regulation of excitatory postsynaptic membrane potential Source: ParkinsonsUK-UCL
  48. regulation of kidney size Source: BHF-UCL
  49. regulation of locomotion Source: MGI
  50. regulation of membrane potential Source: MGI
  51. regulation of mitochondrial depolarization Source: MGI
  52. regulation of neuroblast proliferation Source: MGI
  53. regulation of neuron death Source: MGI
  54. regulation of neuron maturation Source: MGI
  55. regulation of protein kinase A signaling Source: ParkinsonsUK-UCL
  56. regulation of synaptic transmission, glutamatergic Source: ParkinsonsUK-UCL
  57. regulation of synaptic vesicle exocytosis Source: MGI
  58. regulation of synaptic vesicle transport Source: ParkinsonsUK-UCL
  59. response to oxidative stress Source: MGI
  60. small GTPase mediated signal transduction Source: InterPro
  61. synaptic vesicle recycling Source: ParkinsonsUK-UCL
  62. tangential migration from the subventricular zone to the olfactory bulb Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Autophagy, Differentiation

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 2 (EC:2.7.11.1)
Gene namesi
Name:Lrrk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913975. Lrrk2.

Subcellular locationi

  1. Membrane By similarity; Peripheral membrane protein By similarity
  2. Cytoplasm By similarity
  3. Perikaryon By similarity
  4. Cell projectionaxon By similarity
  5. Cell projectiondendrite By similarity
  6. Golgi apparatus 1 Publication
  7. Endoplasmic reticulum 1 Publication
  8. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity1 Publication; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  9. Endosome 1 Publication
  10. Lysosome 1 Publication
  11. Mitochondrion outer membrane 1 Publication
  12. Mitochondrion inner membrane 1 Publication
  13. Mitochondrion matrix 1 Publication

  14. Note: Localized in the cytoplasm and associated with cellular membrane structures. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes (By similarity). Predominantly associated with intracytoplasmic vesicular and membranous structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria.By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: MGI
  4. cytoplasmic side of mitochondrial outer membrane Source: MGI
  5. cytoplasmic vesicle Source: UniProtKB
  6. cytosol Source: MGI
  7. dendrite Source: ParkinsonsUK-UCL
  8. dendrite cytoplasm Source: MGI
  9. endoplasmic reticulum Source: UniProtKB
  10. endosome Source: UniProtKB
  11. extracellular space Source: MGI
  12. extracellular vesicular exosome Source: MGI
  13. Golgi apparatus Source: UniProtKB
  14. inclusion body Source: MGI
  15. lysosome Source: UniProtKB
  16. membrane raft Source: MGI
  17. mitochondrial inner membrane Source: UniProtKB
  18. mitochondrial matrix Source: UniProtKB
  19. mitochondrial membrane Source: MGI
  20. mitochondrial outer membrane Source: UniProtKB
  21. mitochondrion Source: MGI
  22. neuronal cell body Source: MGI
  23. neuron projection Source: MGI
  24. perikaryon Source: UniProtKB
  25. plasma membrane Source: MGI
  26. ribonucleoprotein complex Source: MGI
  27. synapse Source: MGI
  28. synaptic vesicle Source: MGI
  29. synaptic vesicle membrane Source: UniProtKB-SubCell
  30. terminal bouton Source: ParkinsonsUK-UCL
  31. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25272527Leucine-rich repeat serine/threonine-protein kinase 2PRO_0000086239Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5S006.
PaxDbiQ5S006.
PRIDEiQ5S006.

PTM databases

PhosphoSiteiQ5S006.

Expressioni

Tissue specificityi

Expressed in the brain (at protein level). Detected throughout the adult brain. Expressed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. Highly expressed in the striatum, cortex and olfactory tubercle. Little or no expression in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson disease. Expression is particularly high in brain dopaminoceptive areas. High and strikingly specific expression in striatum and parts of cortex and no signals in dopamine neurons.4 Publications

Gene expression databases

BgeeiQ5S006.
CleanExiMM_LRRK2.
GenevestigatoriQ5S006.

Interactioni

Subunit structurei

Homodimer. Interacts with PARK2, PRDX3 and TPCN2 (By similarity). Interacts with VPS35 and RAB29.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2693710,EBI-2693710
Arfgap1Q9EPJ93EBI-2693710,EBI-6288020
Dnm1lQ8K1M64EBI-2693710,EBI-2365792
MSNP260382EBI-2693710,EBI-528768From a different organism.
NsfP464603EBI-2693710,EBI-398006
Prkar2bP313243EBI-2693710,EBI-455340
YwhabQ9CQV83EBI-2693710,EBI-771608
YwhaeP622593EBI-2693710,EBI-356480
YwhagP619827EBI-2693710,EBI-359843
YwhahP685104EBI-2693710,EBI-444641
YwhaqP682543EBI-2693710,EBI-400675
YwhazP631014EBI-2693710,EBI-354751

Protein-protein interaction databases

BioGridi211674. 24 interactions.
DIPiDIP-58648N.
IntActiQ5S006. 67 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5S006.
SMRiQ5S006. Positions 1335-1512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati983 – 100422LRR 1Add
BLAST
Repeati1012 – 103322LRR 2Add
BLAST
Repeati1036 – 105722LRR 3Add
BLAST
Repeati1059 – 108022LRR 4Add
BLAST
Repeati1084 – 110522LRR 5Add
BLAST
Repeati1108 – 112922LRR 6Add
BLAST
Repeati1130 – 115122LRR 7Add
BLAST
Repeati1174 – 119522LRR 8Add
BLAST
Repeati1197 – 121822LRR 9Add
BLAST
Repeati1221 – 124222LRR 10Add
BLAST
Repeati1246 – 126722LRR 11Add
BLAST
Repeati1269 – 129123LRR 12Add
BLAST
Domaini1328 – 1511184RocPROSITE-ProRule annotationAdd
BLAST
Domaini1879 – 2146268Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati2139 – 218345WD 1Add
BLAST
Repeati2188 – 222841WD 2Add
BLAST
Repeati2233 – 227644WD 3Add
BLAST
Repeati2281 – 232747WD 4Add
BLAST
Repeati2333 – 237745WD 5Add
BLAST
Repeati2402 – 243837WD 6Add
BLAST
Repeati2443 – 249755WD 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili9 – 3325Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 167Poly-Glu
Compositional biasi728 – 7314Poly-Leu
Compositional biasi971 – 9766Poly-Ser

Domaini

The seven-bladed WD repeat region is critical for synaptic vesicle trafficking and mediates interaction with multiple vesicle-associated presynaptic proteins.By similarity
The Roc domain mediates homodimerization and regulates kinase activity.By similarity

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation
Contains 7 WD repeats.

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063477.
HOGENOMiHOG000293315.
HOVERGENiHBG081937.
InParanoidiQ5S006.
KOiK08844.
OMAiFKIRDQP.
OrthoDBiEOG7R56RK.
TreeFamiTF313679.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.20. 1 hit.
2.130.10.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_GTPase.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF08477. Miro. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00248. ANK. 2 hits.
SM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5S006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGACQGCE EEEEEEALKK LIVRLNNVQE GKQIETLLQL LEDMLVFTYS
60 70 80 90 100
DRASKLFEDK NFHVPLLIVL DSYMRVASVQ QAGWSLLCKL IEVCPGTLQS
110 120 130 140 150
LIGPQDIGND WEVLGIHRLI LKMLTVHHAN VNLSIVGLKA LDLLLDSGKL
160 170 180 190 200
TLLILDEECD IFLLIFDAMH RYSANDEVQK LGCKALHVLF ERVSEEQLTE
210 220 230 240 250
FVENKDYTIL LSTFGSFRRD KEIVYHVLCC LHSLAVTCSN VEVLMSGNVR
260 270 280 290 300
CYNLVVEAMK AFPTNENIQE VSCSLFQKLT LGNFFNILVL NEVHVFVVKA
310 320 330 340 350
VRQYPENAAL QISALSCLAL LTETIFLNQD LEERSETQEQ SEEEDSEKLF
360 370 380 390 400
WLEPCYKALV RHRKDKHVQE AACWALNNLL MYQNSLHEKI GDEDGQFPAH
410 420 430 440 450
REVMLSMLMH SSSKDVFQAA AHALSTLLEQ NVNFRKILLA KGVYLNVLEL
460 470 480 490 500
MQKHAHAPEV AESGCKMLSH LFEGSNPSLD TMAAVVPKIL TVMKAHGTSL
510 520 530 540 550
SVQLEALRAI LHFVVPGLLE ESREDSQCRP NVLRKQCFRT DIHKLVLVAL
560 570 580 590 600
NRFIGNPGIQ KCGLKVISSL AHLPDATETL SLQGAVDSVL HTLQMYPDDQ
610 620 630 640 650
EIQCLGLHLM GCLMTKKNFC IGTGHLLAKI LASTLQRFKD VAEVQTTGLQ
660 670 680 690 700
TTLSILELSV SFSKLLVHYS FDVVIFHQMS SSVVEQKDEQ FLNLCCKCFA
710 720 730 740 750
KVAVDDELKN TMLERACDQN NSIMVECLLL LGADANQVKG ATSLIYQVCE
760 770 780 790 800
KESSPKLVEL LLNGGCREQD VRKALTVSIQ KGDSQVISLL LRKLALDLAN
810 820 830 840 850
NSICLGGFGI GKIDPSWLGP LFPDKSSNLR KQTNTGSVLA RKVLRYQMRN
860 870 880 890 900
TLQEGVASGS DGKFSEDALA KFGEWTFIPD SSMDSVFGQS DDLDSEGSES
910 920 930 940 950
SFLVKRKSNS ISVGEVYRDL ALQRCSPNAQ RHSNSLGPVF DHEDLLRRKR
960 970 980 990 1000
KILSSDESLR SSRLPSHMRQ SDSSSSLASE REHITSLDLS ANELKDIDAL
1010 1020 1030 1040 1050
SQKCCLSSHL EHLTKLELHQ NSLTSFPQQL CETLKCLIHL DLHSNKFTSF
1060 1070 1080 1090 1100
PSFVLKMPRI TNLDASRNDI GPTVVLDPAM KCPSLKQLNL SYNQLSSIPE
1110 1120 1130 1140 1150
NLAQVVEKLE QLLLEGNKIS GICSPLSLKE LKILNLSKNH IPSLPGDFLE
1160 1170 1180 1190 1200
ACSKVESFSA RMNFLAAMPA LPSSITSLKL SQNSFTCIPE AIFSLPHLRS
1210 1220 1230 1240 1250
LDMSHNNIEC LPGPAHWKSL NLRELIFSKN QISTLDFSEN PHVWSRVEKL
1260 1270 1280 1290 1300
HLSHNKLKEI PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD
1310 1320 1330 1340 1350
GLHLNFDFKH VGCKAKDIIR FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL
1360 1370 1380 1390 1400
LQQLMKMKKP ELGMQGATVG IDVRDWSIQI RGKRRKDLVL NVWDFAGREE
1410 1420 1430 1440 1450
FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASSSPVILV
1460 1470 1480 1490 1500
GTHLDVSDEK QRKACISKIT KELLNKRGFP TIRDYHFVNA TEESDALAKL
1510 1520 1530 1540 1550
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKA VPTEFPVINR
1560 1570 1580 1590 1600
KHLLQLVNEH QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP
1610 1620 1630 1640 1650
KWLCKVMAQI LTVKVDGCLK HPKGIISRRD VEKFLSKKKR FPKNYMMQYF
1660 1670 1680 1690 1700
KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF
1710 1720 1730 1740 1750
PMGFWSRLIN RLLEISPFML SGRERALRPN RMYWRQGIYL NWSPEAYCLV
1760 1770 1780 1790 1800
GSEVLDNRPE SFLKITVPSC RKGCILLGRV VDHIDSLMEE WFPGLLEIDI
1810 1820 1830 1840 1850
CGEGETLLKK WALYSFNDGE EHQKILLDEL MKKAEEGDLL INPDQPRLTI
1860 1870 1880 1890 1900
PISQIAPDLI LADLPRNIML NNDELEFEEA PEFLLGDGSF GSVYRAAYEG
1910 1920 1930 1940 1950
EEVAVKIFNK HTSLRLLRQE LVVLCHLHHP SLISLLAAGI RPRMLVMELA
1960 1970 1980 1990 2000
SKGSLDRLLQ QDKASLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV
2010 2020 2030 2040 2050
LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY
2060 2070 2080 2090 2100
NQQADVYSFG LLLHDIWTTG SRIMEGLRFP NEFDELAIQG KLPDPVKEYG
2110 2120 2130 2140 2150
CAPWPMVEKL ITKCLKENPQ ERPTSAQVFD ILNSAELICL MRHILIPKNI
2160 2170 2180 2190 2200
IVECMVATNL NSKSATLWLG CGNTEKGQLS LFDLNTERYS YEEVADSRIL
2210 2220 2230 2240 2250
CLALVHLAAE KESWVVCGTQ SGALLVINVE EETKRHTLEK MTDSVTCLHC
2260 2270 2280 2290 2300
NSLAKQSKQS NFLLVGTADG NLMIFEDKAV KCKGAAPLKT LHIGDVSTPL
2310 2320 2330 2340 2350
MCLSESLNSS ERHITWGGCG TKVFSFSNDF TIQKLIETKT NQLFSYAAFS
2360 2370 2380 2390 2400
DSNIIALAVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLKEVMVKL
2410 2420 2430 2440 2450
NKESKHQLSY SGRVKALCLQ KNTALWIGTG GGHILLLDLS TRRVIRTIHN
2460 2470 2480 2490 2500
FCDSVRAMAT AQLGSLKNVM LVLGYKRKST EGIQEQKEIQ SCLSIWDLNL
2510 2520
PHEVQNLEKH IEVRTELADK MRKTSVE
Length:2,527
Mass (Da):284,732
Last modified:July 27, 2011 - v2
Checksum:i706E25C173E36F98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431E → K in BAC35052 (PubMed:16141072).Curated
Sequence conflicti777 – 7771V → I in AAV63976 (PubMed:15541309).Curated
Sequence conflicti863 – 8631K → N in AAV63976 (PubMed:15541309).Curated
Sequence conflicti925 – 9251C → Y in AAV63976 (PubMed:15541309).Curated
Sequence conflicti1705 – 17073WSR → GQD in BAC28700 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY792512 mRNA. Translation: AAV63976.1.
AC099704 Genomic DNA. No translation available.
AC158752 Genomic DNA. No translation available.
AK052591 mRNA. Translation: BAC35052.1.
AK034413 mRNA. Translation: BAC28700.1.
BC034074 mRNA. Translation: AAH34074.1.
BC035949 mRNA. Translation: AAH35949.1.
CCDSiCCDS37180.1.
RefSeqiNP_080006.3. NM_025730.3.
UniGeneiMm.37558.

Genome annotation databases

EnsembliENSMUST00000060642; ENSMUSP00000052584; ENSMUSG00000036273.
GeneIDi66725.
KEGGimmu:66725.
UCSCiuc007xhz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY792512 mRNA. Translation: AAV63976.1.
AC099704 Genomic DNA. No translation available.
AC158752 Genomic DNA. No translation available.
AK052591 mRNA. Translation: BAC35052.1.
AK034413 mRNA. Translation: BAC28700.1.
BC034074 mRNA. Translation: AAH34074.1.
BC035949 mRNA. Translation: AAH35949.1.
CCDSiCCDS37180.1.
RefSeqiNP_080006.3. NM_025730.3.
UniGeneiMm.37558.

3D structure databases

ProteinModelPortaliQ5S006.
SMRiQ5S006. Positions 1335-1512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211674. 24 interactions.
DIPiDIP-58648N.
IntActiQ5S006. 67 interactions.

Chemistry

ChEMBLiCHEMBL2010622.

PTM databases

PhosphoSiteiQ5S006.

Proteomic databases

MaxQBiQ5S006.
PaxDbiQ5S006.
PRIDEiQ5S006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060642; ENSMUSP00000052584; ENSMUSG00000036273.
GeneIDi66725.
KEGGimmu:66725.
UCSCiuc007xhz.1. mouse.

Organism-specific databases

CTDi120892.
MGIiMGI:1913975. Lrrk2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063477.
HOGENOMiHOG000293315.
HOVERGENiHBG081937.
InParanoidiQ5S006.
KOiK08844.
OMAiFKIRDQP.
OrthoDBiEOG7R56RK.
TreeFamiTF313679.

Miscellaneous databases

NextBioi322485.
PROiQ5S006.
SOURCEiSearch...

Gene expression databases

BgeeiQ5S006.
CleanExiMM_LRRK2.
GenevestigatoriQ5S006.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.20. 1 hit.
2.130.10.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_GTPase.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF08477. Miro. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00248. ANK. 2 hits.
SM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-946 AND 1162-1707.
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1688-2527.
    Strain: FVB/N.
    Tissue: Kidney.
  5. Cited for: TISSUE SPECIFICITY.
  6. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain."
    Simon-Sanchez J., Herranz-Perez V., Olucha-Bordonau F., Perez-Tur J.
    Eur. J. Neurosci. 23:659-666(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Anatomical localization of leucine-rich repeat kinase 2 in mouse brain."
    Melrose H., Lincoln S., Tyndall G., Dickson D., Farrer M.
    Neuroscience 139:791-794(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
    MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
    Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VPS35 AND RAB29.

Entry informationi

Entry nameiLRRK2_MOUSE
AccessioniPrimary (citable) accession number: Q5S006
Secondary accession number(s): E9QNJ2
, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.