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Q5S006

- LRRK2_MOUSE

UniProt

Q5S006 - LRRK2_MOUSE

Protein

Leucine-rich repeat serine/threonine-protein kinase 2

Gene

Lrrk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. May also have GTPase activity By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1906 – 19061ATPPROSITE-ProRule annotation
    Active sitei1994 – 19941Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1341 – 13488GTPPROSITE-ProRule annotation
    Nucleotide bindingi1885 – 18939ATPPROSITE-ProRule annotation
    Nucleotide bindingi2098 – 212124GTPPROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi2295 – 22984GTPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. GTPase activator activity Source: UniProtKB-KW
    3. GTPase activity Source: Ensembl
    4. GTP binding Source: MGI
    5. GTP-dependent protein kinase activity Source: MGI
    6. identical protein binding Source: IntAct
    7. kinase activity Source: UniProtKB
    8. MAP kinase kinase activity Source: Ensembl
    9. protein binding Source: IntAct
    10. protein kinase A binding Source: ParkinsonsUK-UCL
    11. Rho GTPase binding Source: BHF-UCL

    GO - Biological processi

    1. activation of MAPKK activity Source: Ensembl
    2. autophagy Source: UniProtKB-KW
    3. cellular protein localization Source: ParkinsonsUK-UCL
    4. cellular response to organic cyclic compound Source: Ensembl
    5. determination of adult lifespan Source: Ensembl
    6. intracellular distribution of mitochondria Source: Ensembl
    7. intracellular signal transduction Source: ParkinsonsUK-UCL
    8. locomotory exploration behavior Source: ParkinsonsUK-UCL
    9. negative regulation of branching morphogenesis of a nerve Source: Ensembl
    10. negative regulation of dendritic spine morphogenesis Source: Ensembl
    11. negative regulation of GTPase activity Source: MGI
    12. negative regulation of neuroblast proliferation Source: Ensembl
    13. negative regulation of neuron maturation Source: Ensembl
    14. negative regulation of protein phosphorylation Source: ParkinsonsUK-UCL
    15. neuromuscular junction development Source: Ensembl
    16. neuron death Source: Ensembl
    17. neuron projection morphogenesis Source: UniProtKB
    18. peptidyl-serine phosphorylation Source: Ensembl
    19. peptidyl-threonine phosphorylation Source: Ensembl
    20. positive regulation of autophagy Source: BHF-UCL
    21. positive regulation of dopamine receptor signaling pathway Source: Ensembl
    22. positive regulation of programmed cell death Source: Ensembl
    23. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    24. positive regulation of protein ubiquitination Source: Ensembl
    25. protein autophosphorylation Source: MGI
    26. protein phosphorylation Source: MGI
    27. regulation of dendritic spine morphogenesis Source: ParkinsonsUK-UCL
    28. regulation of dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
    29. regulation of excitatory postsynaptic membrane potential Source: ParkinsonsUK-UCL
    30. regulation of kidney size Source: BHF-UCL
    31. regulation of locomotion Source: Ensembl
    32. regulation of protein kinase A signaling Source: ParkinsonsUK-UCL
    33. regulation of synaptic transmission, glutamatergic Source: ParkinsonsUK-UCL
    34. regulation of synaptic vesicle transport Source: ParkinsonsUK-UCL
    35. response to oxidative stress Source: Ensembl
    36. small GTPase mediated signal transduction Source: InterPro
    37. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl

    Keywords - Molecular functioni

    GTPase activation, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Autophagy, Differentiation

    Keywords - Ligandi

    ATP-binding, GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat serine/threonine-protein kinase 2 (EC:2.7.11.1)
    Gene namesi
    Name:Lrrk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913975. Lrrk2.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity. Perikaryon By similarity. Cell projectionaxon By similarity. Cell projectiondendrite By similarity. Golgi apparatus 1 Publication. Endoplasmic reticulum 1 Publication. Cytoplasmic vesicle 1 Publication. Endosome 1 Publication. Lysosome 1 Publication. Mitochondrion outer membrane 1 Publication. Mitochondrion inner membrane 1 Publication. Mitochondrion matrix 1 Publication
    Note: Localized in the cytoplasm and associated with cellular membrane structures. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes By similarity. Predominantly associated with intracytoplasmic vesicular and membranous structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cytoplasmic side of mitochondrial outer membrane Source: Ensembl
    3. cytoplasmic vesicle Source: UniProtKB
    4. dendrite Source: ParkinsonsUK-UCL
    5. dendrite cytoplasm Source: Ensembl
    6. endoplasmic reticulum Source: UniProtKB
    7. endosome Source: UniProtKB
    8. Golgi apparatus Source: UniProtKB
    9. lysosome Source: UniProtKB
    10. membrane raft Source: MGI
    11. mitochondrial inner membrane Source: UniProtKB
    12. mitochondrial matrix Source: UniProtKB
    13. mitochondrial outer membrane Source: UniProtKB
    14. perikaryon Source: UniProtKB
    15. plasma membrane Source: MGI
    16. synapse Source: MGI
    17. synaptic vesicle Source: MGI
    18. terminal bouton Source: ParkinsonsUK-UCL
    19. trans-Golgi network Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 25272527Leucine-rich repeat serine/threonine-protein kinase 2PRO_0000086239Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5S006.
    PaxDbiQ5S006.
    PRIDEiQ5S006.

    PTM databases

    PhosphoSiteiQ5S006.

    Expressioni

    Tissue specificityi

    Expressed in the brain (at protein level). Detected throughout the adult brain. Expressed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. Highly expressed in the striatum, cortex and olfactory tubercle. Little or no expression in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson disease. Expression is particularly high in brain dopaminoceptive areas. High and strikingly specific expression in striatum and parts of cortex and no signals in dopamine neurons.4 Publications

    Gene expression databases

    BgeeiQ5S006.
    CleanExiMM_LRRK2.
    GenevestigatoriQ5S006.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with PARK2, PRDX3 and TPCN2 By similarity. Interacts with VPS35 and RAB29.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-2693710,EBI-2693710
    Arfgap1Q9EPJ93EBI-2693710,EBI-6288020
    Dnm1lQ8K1M64EBI-2693710,EBI-2365792
    NsfP464603EBI-2693710,EBI-398006
    Prkar2bP313243EBI-2693710,EBI-455340
    YwhabQ9CQV83EBI-2693710,EBI-771608
    YwhaeP622593EBI-2693710,EBI-356480
    YwhagP619827EBI-2693710,EBI-359843
    YwhahP685104EBI-2693710,EBI-444641
    YwhaqP682543EBI-2693710,EBI-400675
    YwhazP631014EBI-2693710,EBI-354751

    Protein-protein interaction databases

    BioGridi211674. 24 interactions.
    DIPiDIP-58648N.
    IntActiQ5S006. 62 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5S006.
    SMRiQ5S006. Positions 1335-1512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati983 – 100422LRR 1Add
    BLAST
    Repeati1012 – 103322LRR 2Add
    BLAST
    Repeati1036 – 105722LRR 3Add
    BLAST
    Repeati1059 – 108022LRR 4Add
    BLAST
    Repeati1084 – 110522LRR 5Add
    BLAST
    Repeati1108 – 112922LRR 6Add
    BLAST
    Repeati1130 – 115122LRR 7Add
    BLAST
    Repeati1174 – 119522LRR 8Add
    BLAST
    Repeati1197 – 121822LRR 9Add
    BLAST
    Repeati1221 – 124222LRR 10Add
    BLAST
    Repeati1246 – 126722LRR 11Add
    BLAST
    Repeati1269 – 129123LRR 12Add
    BLAST
    Domaini1328 – 1511184RocPROSITE-ProRule annotationAdd
    BLAST
    Domaini1879 – 2146268Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili9 – 3325Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 167Poly-Glu
    Compositional biasi728 – 7314Poly-Leu
    Compositional biasi971 – 9766Poly-Ser

    Sequence similaritiesi

    Contains 12 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 Roc domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00530000063477.
    HOGENOMiHOG000293315.
    HOVERGENiHBG081937.
    InParanoidiQ5S006.
    KOiK08844.
    OMAiFKIRDQP.
    OrthoDBiEOG7R56RK.
    TreeFamiTF313679.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    1.25.40.20. 1 hit.
    2.130.10.10. 2 hits.
    3.40.50.300. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR020859. ROC_GTPase.
    IPR008271. Ser/Thr_kinase_AS.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF08477. Miro. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00248. ANK. 2 hits.
    SM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF48403. SSF48403. 1 hit.
    SSF50978. SSF50978. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51450. LRR. 11 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS51424. ROC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5S006-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGACQGCE EEEEEEALKK LIVRLNNVQE GKQIETLLQL LEDMLVFTYS     50
    DRASKLFEDK NFHVPLLIVL DSYMRVASVQ QAGWSLLCKL IEVCPGTLQS 100
    LIGPQDIGND WEVLGIHRLI LKMLTVHHAN VNLSIVGLKA LDLLLDSGKL 150
    TLLILDEECD IFLLIFDAMH RYSANDEVQK LGCKALHVLF ERVSEEQLTE 200
    FVENKDYTIL LSTFGSFRRD KEIVYHVLCC LHSLAVTCSN VEVLMSGNVR 250
    CYNLVVEAMK AFPTNENIQE VSCSLFQKLT LGNFFNILVL NEVHVFVVKA 300
    VRQYPENAAL QISALSCLAL LTETIFLNQD LEERSETQEQ SEEEDSEKLF 350
    WLEPCYKALV RHRKDKHVQE AACWALNNLL MYQNSLHEKI GDEDGQFPAH 400
    REVMLSMLMH SSSKDVFQAA AHALSTLLEQ NVNFRKILLA KGVYLNVLEL 450
    MQKHAHAPEV AESGCKMLSH LFEGSNPSLD TMAAVVPKIL TVMKAHGTSL 500
    SVQLEALRAI LHFVVPGLLE ESREDSQCRP NVLRKQCFRT DIHKLVLVAL 550
    NRFIGNPGIQ KCGLKVISSL AHLPDATETL SLQGAVDSVL HTLQMYPDDQ 600
    EIQCLGLHLM GCLMTKKNFC IGTGHLLAKI LASTLQRFKD VAEVQTTGLQ 650
    TTLSILELSV SFSKLLVHYS FDVVIFHQMS SSVVEQKDEQ FLNLCCKCFA 700
    KVAVDDELKN TMLERACDQN NSIMVECLLL LGADANQVKG ATSLIYQVCE 750
    KESSPKLVEL LLNGGCREQD VRKALTVSIQ KGDSQVISLL LRKLALDLAN 800
    NSICLGGFGI GKIDPSWLGP LFPDKSSNLR KQTNTGSVLA RKVLRYQMRN 850
    TLQEGVASGS DGKFSEDALA KFGEWTFIPD SSMDSVFGQS DDLDSEGSES 900
    SFLVKRKSNS ISVGEVYRDL ALQRCSPNAQ RHSNSLGPVF DHEDLLRRKR 950
    KILSSDESLR SSRLPSHMRQ SDSSSSLASE REHITSLDLS ANELKDIDAL 1000
    SQKCCLSSHL EHLTKLELHQ NSLTSFPQQL CETLKCLIHL DLHSNKFTSF 1050
    PSFVLKMPRI TNLDASRNDI GPTVVLDPAM KCPSLKQLNL SYNQLSSIPE 1100
    NLAQVVEKLE QLLLEGNKIS GICSPLSLKE LKILNLSKNH IPSLPGDFLE 1150
    ACSKVESFSA RMNFLAAMPA LPSSITSLKL SQNSFTCIPE AIFSLPHLRS 1200
    LDMSHNNIEC LPGPAHWKSL NLRELIFSKN QISTLDFSEN PHVWSRVEKL 1250
    HLSHNKLKEI PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD 1300
    GLHLNFDFKH VGCKAKDIIR FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL 1350
    LQQLMKMKKP ELGMQGATVG IDVRDWSIQI RGKRRKDLVL NVWDFAGREE 1400
    FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASSSPVILV 1450
    GTHLDVSDEK QRKACISKIT KELLNKRGFP TIRDYHFVNA TEESDALAKL 1500
    RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKA VPTEFPVINR 1550
    KHLLQLVNEH QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP 1600
    KWLCKVMAQI LTVKVDGCLK HPKGIISRRD VEKFLSKKKR FPKNYMMQYF 1650
    KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF 1700
    PMGFWSRLIN RLLEISPFML SGRERALRPN RMYWRQGIYL NWSPEAYCLV 1750
    GSEVLDNRPE SFLKITVPSC RKGCILLGRV VDHIDSLMEE WFPGLLEIDI 1800
    CGEGETLLKK WALYSFNDGE EHQKILLDEL MKKAEEGDLL INPDQPRLTI 1850
    PISQIAPDLI LADLPRNIML NNDELEFEEA PEFLLGDGSF GSVYRAAYEG 1900
    EEVAVKIFNK HTSLRLLRQE LVVLCHLHHP SLISLLAAGI RPRMLVMELA 1950
    SKGSLDRLLQ QDKASLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV 2000
    LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY 2050
    NQQADVYSFG LLLHDIWTTG SRIMEGLRFP NEFDELAIQG KLPDPVKEYG 2100
    CAPWPMVEKL ITKCLKENPQ ERPTSAQVFD ILNSAELICL MRHILIPKNI 2150
    IVECMVATNL NSKSATLWLG CGNTEKGQLS LFDLNTERYS YEEVADSRIL 2200
    CLALVHLAAE KESWVVCGTQ SGALLVINVE EETKRHTLEK MTDSVTCLHC 2250
    NSLAKQSKQS NFLLVGTADG NLMIFEDKAV KCKGAAPLKT LHIGDVSTPL 2300
    MCLSESLNSS ERHITWGGCG TKVFSFSNDF TIQKLIETKT NQLFSYAAFS 2350
    DSNIIALAVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLKEVMVKL 2400
    NKESKHQLSY SGRVKALCLQ KNTALWIGTG GGHILLLDLS TRRVIRTIHN 2450
    FCDSVRAMAT AQLGSLKNVM LVLGYKRKST EGIQEQKEIQ SCLSIWDLNL 2500
    PHEVQNLEKH IEVRTELADK MRKTSVE 2527
    Length:2,527
    Mass (Da):284,732
    Last modified:July 27, 2011 - v2
    Checksum:i706E25C173E36F98
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti343 – 3431E → K in BAC35052. (PubMed:16141072)Curated
    Sequence conflicti777 – 7771V → I in AAV63976. (PubMed:15541309)Curated
    Sequence conflicti863 – 8631K → N in AAV63976. (PubMed:15541309)Curated
    Sequence conflicti925 – 9251C → Y in AAV63976. (PubMed:15541309)Curated
    Sequence conflicti1705 – 17073WSR → GQD in BAC28700. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY792512 mRNA. Translation: AAV63976.1.
    AC099704 Genomic DNA. No translation available.
    AC158752 Genomic DNA. No translation available.
    AK052591 mRNA. Translation: BAC35052.1.
    AK034413 mRNA. Translation: BAC28700.1.
    BC034074 mRNA. Translation: AAH34074.1.
    BC035949 mRNA. Translation: AAH35949.1.
    CCDSiCCDS37180.1.
    RefSeqiNP_080006.3. NM_025730.3.
    UniGeneiMm.37558.

    Genome annotation databases

    EnsembliENSMUST00000060642; ENSMUSP00000052584; ENSMUSG00000036273.
    GeneIDi66725.
    KEGGimmu:66725.
    UCSCiuc007xhz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY792512 mRNA. Translation: AAV63976.1 .
    AC099704 Genomic DNA. No translation available.
    AC158752 Genomic DNA. No translation available.
    AK052591 mRNA. Translation: BAC35052.1 .
    AK034413 mRNA. Translation: BAC28700.1 .
    BC034074 mRNA. Translation: AAH34074.1 .
    BC035949 mRNA. Translation: AAH35949.1 .
    CCDSi CCDS37180.1.
    RefSeqi NP_080006.3. NM_025730.3.
    UniGenei Mm.37558.

    3D structure databases

    ProteinModelPortali Q5S006.
    SMRi Q5S006. Positions 1335-1512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211674. 24 interactions.
    DIPi DIP-58648N.
    IntActi Q5S006. 62 interactions.

    Chemistry

    ChEMBLi CHEMBL2010622.

    PTM databases

    PhosphoSitei Q5S006.

    Proteomic databases

    MaxQBi Q5S006.
    PaxDbi Q5S006.
    PRIDEi Q5S006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060642 ; ENSMUSP00000052584 ; ENSMUSG00000036273 .
    GeneIDi 66725.
    KEGGi mmu:66725.
    UCSCi uc007xhz.1. mouse.

    Organism-specific databases

    CTDi 120892.
    MGIi MGI:1913975. Lrrk2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00530000063477.
    HOGENOMi HOG000293315.
    HOVERGENi HBG081937.
    InParanoidi Q5S006.
    KOi K08844.
    OMAi FKIRDQP.
    OrthoDBi EOG7R56RK.
    TreeFami TF313679.

    Miscellaneous databases

    NextBioi 322485.
    PROi Q5S006.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5S006.
    CleanExi MM_LRRK2.
    Genevestigatori Q5S006.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    1.25.40.20. 1 hit.
    2.130.10.10. 2 hits.
    3.40.50.300. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR020859. ROC_GTPase.
    IPR008271. Ser/Thr_kinase_AS.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF08477. Miro. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00248. ANK. 2 hits.
    SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF48403. SSF48403. 1 hit.
    SSF50978. SSF50978. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51450. LRR. 11 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS51424. ROC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-946 AND 1162-1707.
      Strain: C57BL/6J.
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1688-2527.
      Strain: FVB/N.
      Tissue: Kidney.
    5. Cited for: TISSUE SPECIFICITY.
    6. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain."
      Simon-Sanchez J., Herranz-Perez V., Olucha-Bordonau F., Perez-Tur J.
      Eur. J. Neurosci. 23:659-666(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Anatomical localization of leucine-rich repeat kinase 2 in mouse brain."
      Melrose H., Lincoln S., Tyndall G., Dickson D., Farrer M.
      Neuroscience 139:791-794(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
      MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
      Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VPS35 AND RAB29.

    Entry informationi

    Entry nameiLRRK2_MOUSE
    AccessioniPrimary (citable) accession number: Q5S006
    Secondary accession number(s): E9QNJ2
    , Q8BWG7, Q8BZJ6, Q8CI84, Q8K062
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3