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Q5S006

- LRRK2_MOUSE

UniProt

Q5S006 - LRRK2_MOUSE

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Protein

Leucine-rich repeat serine/threonine-protein kinase 2

Gene

Lrrk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. May also have GTPase activity (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1906 – 19061ATPPROSITE-ProRule annotation
Active sitei1994 – 19941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1341 – 13488GTPPROSITE-ProRule annotation
Nucleotide bindingi1885 – 18939ATPPROSITE-ProRule annotation
Nucleotide bindingi2098 – 212124GTPPROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi2295 – 22984GTPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTPase activator activity Source: UniProtKB-KW
  3. GTPase activity Source: Ensembl
  4. GTP binding Source: MGI
  5. GTP-dependent protein kinase activity Source: MGI
  6. identical protein binding Source: IntAct
  7. kinase activity Source: UniProtKB
  8. MAP kinase kinase activity Source: Ensembl
  9. protein kinase A binding Source: ParkinsonsUK-UCL
  10. Rho GTPase binding Source: BHF-UCL

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. autophagy Source: UniProtKB-KW
  3. cellular protein localization Source: ParkinsonsUK-UCL
  4. cellular response to organic cyclic compound Source: Ensembl
  5. determination of adult lifespan Source: Ensembl
  6. intracellular distribution of mitochondria Source: Ensembl
  7. intracellular signal transduction Source: ParkinsonsUK-UCL
  8. locomotory exploration behavior Source: ParkinsonsUK-UCL
  9. negative regulation of GTPase activity Source: MGI
  10. negative regulation of protein binding Source: Ensembl
  11. negative regulation of protein phosphorylation Source: ParkinsonsUK-UCL
  12. neuromuscular junction development Source: Ensembl
  13. neuron death Source: Ensembl
  14. neuron projection morphogenesis Source: UniProtKB
  15. peptidyl-serine phosphorylation Source: Ensembl
  16. peptidyl-threonine phosphorylation Source: Ensembl
  17. positive regulation of autophagy Source: BHF-UCL
  18. positive regulation of dopamine receptor signaling pathway Source: Ensembl
  19. positive regulation of programmed cell death Source: Ensembl
  20. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  21. positive regulation of protein ubiquitination Source: Ensembl
  22. protein autophosphorylation Source: MGI
  23. protein phosphorylation Source: MGI
  24. regulation of branching morphogenesis of a nerve Source: Ensembl
  25. regulation of dendritic spine morphogenesis Source: ParkinsonsUK-UCL
  26. regulation of dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
  27. regulation of excitatory postsynaptic membrane potential Source: ParkinsonsUK-UCL
  28. regulation of kidney size Source: BHF-UCL
  29. regulation of locomotion Source: Ensembl
  30. regulation of mitochondrial depolarization Source: Ensembl
  31. regulation of neuroblast proliferation Source: Ensembl
  32. regulation of neuron death Source: Ensembl
  33. regulation of neuron maturation Source: Ensembl
  34. regulation of protein kinase A signaling Source: ParkinsonsUK-UCL
  35. regulation of synaptic transmission, glutamatergic Source: ParkinsonsUK-UCL
  36. regulation of synaptic vesicle exocytosis Source: Ensembl
  37. regulation of synaptic vesicle transport Source: ParkinsonsUK-UCL
  38. response to oxidative stress Source: Ensembl
  39. small GTPase mediated signal transduction Source: InterPro
  40. tangential migration from the subventricular zone to the olfactory bulb Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Autophagy, Differentiation

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 2 (EC:2.7.11.1)
Gene namesi
Name:Lrrk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1913975. Lrrk2.

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity. Perikaryon By similarity. Cell projectionaxon By similarity. Cell projectiondendrite By similarity. Golgi apparatus 1 Publication. Endoplasmic reticulum 1 Publication. Cytoplasmic vesicle 1 Publication. Endosome 1 Publication. Lysosome 1 Publication. Mitochondrion outer membrane 1 Publication. Mitochondrion inner membrane 1 Publication. Mitochondrion matrix 1 Publication
Note: Localized in the cytoplasm and associated with cellular membrane structures. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes (By similarity). Predominantly associated with intracytoplasmic vesicular and membranous structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria.By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cytoplasmic side of mitochondrial outer membrane Source: Ensembl
  3. cytoplasmic vesicle Source: UniProtKB
  4. cytosol Source: Ensembl
  5. dendrite Source: ParkinsonsUK-UCL
  6. dendrite cytoplasm Source: Ensembl
  7. endoplasmic reticulum Source: UniProtKB
  8. endosome Source: UniProtKB
  9. extracellular space Source: Ensembl
  10. extracellular vesicular exosome Source: Ensembl
  11. Golgi apparatus Source: UniProtKB
  12. inclusion body Source: Ensembl
  13. lysosome Source: UniProtKB
  14. membrane raft Source: MGI
  15. mitochondrial inner membrane Source: UniProtKB
  16. mitochondrial matrix Source: UniProtKB
  17. mitochondrial outer membrane Source: UniProtKB
  18. perikaryon Source: UniProtKB
  19. plasma membrane Source: MGI
  20. synapse Source: MGI
  21. synaptic vesicle Source: MGI
  22. terminal bouton Source: ParkinsonsUK-UCL
  23. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25272527Leucine-rich repeat serine/threonine-protein kinase 2PRO_0000086239Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5S006.
PaxDbiQ5S006.
PRIDEiQ5S006.

PTM databases

PhosphoSiteiQ5S006.

Expressioni

Tissue specificityi

Expressed in the brain (at protein level). Detected throughout the adult brain. Expressed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. Highly expressed in the striatum, cortex and olfactory tubercle. Little or no expression in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson disease. Expression is particularly high in brain dopaminoceptive areas. High and strikingly specific expression in striatum and parts of cortex and no signals in dopamine neurons.4 Publications

Gene expression databases

BgeeiQ5S006.
CleanExiMM_LRRK2.
GenevestigatoriQ5S006.

Interactioni

Subunit structurei

Homodimer. Interacts with PARK2, PRDX3 and TPCN2 (By similarity). Interacts with VPS35 and RAB29.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2693710,EBI-2693710
Arfgap1Q9EPJ93EBI-2693710,EBI-6288020
Dnm1lQ8K1M64EBI-2693710,EBI-2365792
MSNP260382EBI-2693710,EBI-528768From a different organism.
NsfP464603EBI-2693710,EBI-398006
Prkar2bP313243EBI-2693710,EBI-455340
YwhabQ9CQV83EBI-2693710,EBI-771608
YwhaeP622593EBI-2693710,EBI-356480
YwhagP619827EBI-2693710,EBI-359843
YwhahP685104EBI-2693710,EBI-444641
YwhaqP682543EBI-2693710,EBI-400675
YwhazP631014EBI-2693710,EBI-354751

Protein-protein interaction databases

BioGridi211674. 24 interactions.
DIPiDIP-58648N.
IntActiQ5S006. 65 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5S006.
SMRiQ5S006. Positions 1335-1512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati983 – 100422LRR 1Add
BLAST
Repeati1012 – 103322LRR 2Add
BLAST
Repeati1036 – 105722LRR 3Add
BLAST
Repeati1059 – 108022LRR 4Add
BLAST
Repeati1084 – 110522LRR 5Add
BLAST
Repeati1108 – 112922LRR 6Add
BLAST
Repeati1130 – 115122LRR 7Add
BLAST
Repeati1174 – 119522LRR 8Add
BLAST
Repeati1197 – 121822LRR 9Add
BLAST
Repeati1221 – 124222LRR 10Add
BLAST
Repeati1246 – 126722LRR 11Add
BLAST
Repeati1269 – 129123LRR 12Add
BLAST
Domaini1328 – 1511184RocPROSITE-ProRule annotationAdd
BLAST
Domaini1879 – 2146268Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili9 – 3325Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 167Poly-Glu
Compositional biasi728 – 7314Poly-Leu
Compositional biasi971 – 9766Poly-Ser

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 Roc domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063477.
HOGENOMiHOG000293315.
HOVERGENiHBG081937.
InParanoidiQ5S006.
KOiK08844.
OMAiFKIRDQP.
OrthoDBiEOG7R56RK.
TreeFamiTF313679.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.20. 1 hit.
2.130.10.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_GTPase.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF08477. Miro. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00248. ANK. 2 hits.
SM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5S006-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGACQGCE EEEEEEALKK LIVRLNNVQE GKQIETLLQL LEDMLVFTYS
60 70 80 90 100
DRASKLFEDK NFHVPLLIVL DSYMRVASVQ QAGWSLLCKL IEVCPGTLQS
110 120 130 140 150
LIGPQDIGND WEVLGIHRLI LKMLTVHHAN VNLSIVGLKA LDLLLDSGKL
160 170 180 190 200
TLLILDEECD IFLLIFDAMH RYSANDEVQK LGCKALHVLF ERVSEEQLTE
210 220 230 240 250
FVENKDYTIL LSTFGSFRRD KEIVYHVLCC LHSLAVTCSN VEVLMSGNVR
260 270 280 290 300
CYNLVVEAMK AFPTNENIQE VSCSLFQKLT LGNFFNILVL NEVHVFVVKA
310 320 330 340 350
VRQYPENAAL QISALSCLAL LTETIFLNQD LEERSETQEQ SEEEDSEKLF
360 370 380 390 400
WLEPCYKALV RHRKDKHVQE AACWALNNLL MYQNSLHEKI GDEDGQFPAH
410 420 430 440 450
REVMLSMLMH SSSKDVFQAA AHALSTLLEQ NVNFRKILLA KGVYLNVLEL
460 470 480 490 500
MQKHAHAPEV AESGCKMLSH LFEGSNPSLD TMAAVVPKIL TVMKAHGTSL
510 520 530 540 550
SVQLEALRAI LHFVVPGLLE ESREDSQCRP NVLRKQCFRT DIHKLVLVAL
560 570 580 590 600
NRFIGNPGIQ KCGLKVISSL AHLPDATETL SLQGAVDSVL HTLQMYPDDQ
610 620 630 640 650
EIQCLGLHLM GCLMTKKNFC IGTGHLLAKI LASTLQRFKD VAEVQTTGLQ
660 670 680 690 700
TTLSILELSV SFSKLLVHYS FDVVIFHQMS SSVVEQKDEQ FLNLCCKCFA
710 720 730 740 750
KVAVDDELKN TMLERACDQN NSIMVECLLL LGADANQVKG ATSLIYQVCE
760 770 780 790 800
KESSPKLVEL LLNGGCREQD VRKALTVSIQ KGDSQVISLL LRKLALDLAN
810 820 830 840 850
NSICLGGFGI GKIDPSWLGP LFPDKSSNLR KQTNTGSVLA RKVLRYQMRN
860 870 880 890 900
TLQEGVASGS DGKFSEDALA KFGEWTFIPD SSMDSVFGQS DDLDSEGSES
910 920 930 940 950
SFLVKRKSNS ISVGEVYRDL ALQRCSPNAQ RHSNSLGPVF DHEDLLRRKR
960 970 980 990 1000
KILSSDESLR SSRLPSHMRQ SDSSSSLASE REHITSLDLS ANELKDIDAL
1010 1020 1030 1040 1050
SQKCCLSSHL EHLTKLELHQ NSLTSFPQQL CETLKCLIHL DLHSNKFTSF
1060 1070 1080 1090 1100
PSFVLKMPRI TNLDASRNDI GPTVVLDPAM KCPSLKQLNL SYNQLSSIPE
1110 1120 1130 1140 1150
NLAQVVEKLE QLLLEGNKIS GICSPLSLKE LKILNLSKNH IPSLPGDFLE
1160 1170 1180 1190 1200
ACSKVESFSA RMNFLAAMPA LPSSITSLKL SQNSFTCIPE AIFSLPHLRS
1210 1220 1230 1240 1250
LDMSHNNIEC LPGPAHWKSL NLRELIFSKN QISTLDFSEN PHVWSRVEKL
1260 1270 1280 1290 1300
HLSHNKLKEI PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD
1310 1320 1330 1340 1350
GLHLNFDFKH VGCKAKDIIR FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL
1360 1370 1380 1390 1400
LQQLMKMKKP ELGMQGATVG IDVRDWSIQI RGKRRKDLVL NVWDFAGREE
1410 1420 1430 1440 1450
FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASSSPVILV
1460 1470 1480 1490 1500
GTHLDVSDEK QRKACISKIT KELLNKRGFP TIRDYHFVNA TEESDALAKL
1510 1520 1530 1540 1550
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKA VPTEFPVINR
1560 1570 1580 1590 1600
KHLLQLVNEH QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP
1610 1620 1630 1640 1650
KWLCKVMAQI LTVKVDGCLK HPKGIISRRD VEKFLSKKKR FPKNYMMQYF
1660 1670 1680 1690 1700
KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF
1710 1720 1730 1740 1750
PMGFWSRLIN RLLEISPFML SGRERALRPN RMYWRQGIYL NWSPEAYCLV
1760 1770 1780 1790 1800
GSEVLDNRPE SFLKITVPSC RKGCILLGRV VDHIDSLMEE WFPGLLEIDI
1810 1820 1830 1840 1850
CGEGETLLKK WALYSFNDGE EHQKILLDEL MKKAEEGDLL INPDQPRLTI
1860 1870 1880 1890 1900
PISQIAPDLI LADLPRNIML NNDELEFEEA PEFLLGDGSF GSVYRAAYEG
1910 1920 1930 1940 1950
EEVAVKIFNK HTSLRLLRQE LVVLCHLHHP SLISLLAAGI RPRMLVMELA
1960 1970 1980 1990 2000
SKGSLDRLLQ QDKASLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV
2010 2020 2030 2040 2050
LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY
2060 2070 2080 2090 2100
NQQADVYSFG LLLHDIWTTG SRIMEGLRFP NEFDELAIQG KLPDPVKEYG
2110 2120 2130 2140 2150
CAPWPMVEKL ITKCLKENPQ ERPTSAQVFD ILNSAELICL MRHILIPKNI
2160 2170 2180 2190 2200
IVECMVATNL NSKSATLWLG CGNTEKGQLS LFDLNTERYS YEEVADSRIL
2210 2220 2230 2240 2250
CLALVHLAAE KESWVVCGTQ SGALLVINVE EETKRHTLEK MTDSVTCLHC
2260 2270 2280 2290 2300
NSLAKQSKQS NFLLVGTADG NLMIFEDKAV KCKGAAPLKT LHIGDVSTPL
2310 2320 2330 2340 2350
MCLSESLNSS ERHITWGGCG TKVFSFSNDF TIQKLIETKT NQLFSYAAFS
2360 2370 2380 2390 2400
DSNIIALAVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLKEVMVKL
2410 2420 2430 2440 2450
NKESKHQLSY SGRVKALCLQ KNTALWIGTG GGHILLLDLS TRRVIRTIHN
2460 2470 2480 2490 2500
FCDSVRAMAT AQLGSLKNVM LVLGYKRKST EGIQEQKEIQ SCLSIWDLNL
2510 2520
PHEVQNLEKH IEVRTELADK MRKTSVE
Length:2,527
Mass (Da):284,732
Last modified:July 27, 2011 - v2
Checksum:i706E25C173E36F98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431E → K in BAC35052. (PubMed:16141072)Curated
Sequence conflicti777 – 7771V → I in AAV63976. (PubMed:15541309)Curated
Sequence conflicti863 – 8631K → N in AAV63976. (PubMed:15541309)Curated
Sequence conflicti925 – 9251C → Y in AAV63976. (PubMed:15541309)Curated
Sequence conflicti1705 – 17073WSR → GQD in BAC28700. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY792512 mRNA. Translation: AAV63976.1.
AC099704 Genomic DNA. No translation available.
AC158752 Genomic DNA. No translation available.
AK052591 mRNA. Translation: BAC35052.1.
AK034413 mRNA. Translation: BAC28700.1.
BC034074 mRNA. Translation: AAH34074.1.
BC035949 mRNA. Translation: AAH35949.1.
CCDSiCCDS37180.1.
RefSeqiNP_080006.3. NM_025730.3.
UniGeneiMm.37558.

Genome annotation databases

EnsembliENSMUST00000060642; ENSMUSP00000052584; ENSMUSG00000036273.
GeneIDi66725.
KEGGimmu:66725.
UCSCiuc007xhz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY792512 mRNA. Translation: AAV63976.1 .
AC099704 Genomic DNA. No translation available.
AC158752 Genomic DNA. No translation available.
AK052591 mRNA. Translation: BAC35052.1 .
AK034413 mRNA. Translation: BAC28700.1 .
BC034074 mRNA. Translation: AAH34074.1 .
BC035949 mRNA. Translation: AAH35949.1 .
CCDSi CCDS37180.1.
RefSeqi NP_080006.3. NM_025730.3.
UniGenei Mm.37558.

3D structure databases

ProteinModelPortali Q5S006.
SMRi Q5S006. Positions 1335-1512.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211674. 24 interactions.
DIPi DIP-58648N.
IntActi Q5S006. 65 interactions.

Chemistry

ChEMBLi CHEMBL2010622.

PTM databases

PhosphoSitei Q5S006.

Proteomic databases

MaxQBi Q5S006.
PaxDbi Q5S006.
PRIDEi Q5S006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060642 ; ENSMUSP00000052584 ; ENSMUSG00000036273 .
GeneIDi 66725.
KEGGi mmu:66725.
UCSCi uc007xhz.1. mouse.

Organism-specific databases

CTDi 120892.
MGIi MGI:1913975. Lrrk2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063477.
HOGENOMi HOG000293315.
HOVERGENi HBG081937.
InParanoidi Q5S006.
KOi K08844.
OMAi FKIRDQP.
OrthoDBi EOG7R56RK.
TreeFami TF313679.

Miscellaneous databases

NextBioi 322485.
PROi Q5S006.
SOURCEi Search...

Gene expression databases

Bgeei Q5S006.
CleanExi MM_LRRK2.
Genevestigatori Q5S006.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
1.25.40.20. 1 hit.
2.130.10.10. 2 hits.
3.40.50.300. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020859. ROC_GTPase.
IPR008271. Ser/Thr_kinase_AS.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF08477. Miro. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00248. ANK. 2 hits.
SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51450. LRR. 11 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS51424. ROC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-946 AND 1162-1707.
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1688-2527.
    Strain: FVB/N.
    Tissue: Kidney.
  5. Cited for: TISSUE SPECIFICITY.
  6. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain."
    Simon-Sanchez J., Herranz-Perez V., Olucha-Bordonau F., Perez-Tur J.
    Eur. J. Neurosci. 23:659-666(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Anatomical localization of leucine-rich repeat kinase 2 in mouse brain."
    Melrose H., Lincoln S., Tyndall G., Dickson D., Farrer M.
    Neuroscience 139:791-794(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
    MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
    Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VPS35 AND RAB29.

Entry informationi

Entry nameiLRRK2_MOUSE
AccessioniPrimary (citable) accession number: Q5S006
Secondary accession number(s): E9QNJ2
, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3