Reviewed, UniProtKB/Swiss-Prot Q5RLY7 (CDO_AJECA)

Names and origin

Protein names

Recommended name:
    Cysteine dioxygenase
      Short name=CDO
    EC=1.13.11.20

Gene names

Name:

CDO1

Organism

Ajellomyces capsulata (Histoplasma capsulatum)

Taxonomic identifier

5037 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-cysteine + O(2) = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-107 and Tyr-177 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Gene Ontology (GO)
Biological process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Cysteine dioxygenase		PRO_0000206614
Sites
	Metal binding	100	1	Iron; catalytic By similarity
	Metal binding	102	1	Iron; catalytic By similarity
	Metal binding	160	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	107 ↔ 177		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RLY7-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 54C0639D3FD65FD3	FASTA	213	23,769
	10 20 30 40 50 60 MPYLENSESS PDPTPLDAFH CLVQDINKVL GPSSGLDSDD VDPMDIQKLM EDYTSNESEW 70 80 90 100 110 120 ERYAFGDAGR AYTRNLVDEG NGKCNLLILV WSPGKGSAIH DHANAHCVMK VLKGSLRETL 130 140 150 160 170 180 YGWPESDKVQ KGEPSPLTVT RDKVYEEGQV TYMSDKLGLH KISNPDPTNF AISLHLYTPP 190 200 210 NAAHYGFSLF DEKTGKSRHV KQSVLFSRKG HKL

References

[1]	"Isolation and characterization of the cysteine dioxygenase gene (CDO1) from the dimorphic pathogenic fungus Histoplasma capsulatum." Hasler S., Shearer G. Jr. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 26029 / G186A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY804144 mRNA. Translation: AAV66535.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR010300. Cys_dOase_I. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDO_AJECA

Accession

Primary (citable) accession number: Q5RLY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)