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Q5RLY7 (CDO_AJECG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Post-translational modification

The thioether cross-link between Cys-107 and Tyr-177 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Cysteine dioxygenase
PRO_0000206614

Sites

Metal binding1001Iron; catalytic By similarity
Metal binding1021Iron; catalytic By similarity
Metal binding1601Iron; catalytic By similarity

Amino acid modifications

Cross-link107 ↔ 1773'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Experimental info

Sequence conflict1461K → E in AAV66535. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q5RLY7 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 62C0639517F657FB

FASTA21323,768
        10         20         30         40         50         60 
MPYLENSESS PDPTPLDAFH CLVQDINKVL GPSSGLDSDD VDPMDIQKLM EDYTSNESEW 

        70         80         90        100        110        120 
ERYAFGDAGR AYTRNLVDEG NGKCNLLILV WSPGKGSAIH DHANAHCVMK VLKGSLRETL 

       130        140        150        160        170        180 
YGWPESDKVQ KGEPSPLTVT RDKVYKEGQV TYMSDKLGLH KISNPDPTNF AISLHLYTPP 

       190        200        210 
NAAHYGFSLF DEKTGKSRHV KQSVLFSRKG HKL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the cysteine dioxygenase gene (CDO1) from the dimorphic pathogenic fungus Histoplasma capsulatum."
Hasler S., Shearer G. Jr.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Ajellomyces capsulatus strain G186AR."
Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J. expand/collapse author list , Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G., San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY804144 mRNA. Translation: AAV66535.1.
GG663372 Genomic DNA. Translation: EEH05017.1.

3D structure databases

ProteinModelPortalQ5RLY7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7Q5HQR.

Enzyme and pathway databases

UniPathwayUPA00012; UER00537.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDO_AJECG
AccessionPrimary (citable) accession number: Q5RLY7
Secondary accession number(s): C0NUD7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 16, 2009
Last modified: January 22, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways