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Q5RLY7

- CDO_AJECG

UniProt

Q5RLY7 - CDO_AJECG

Protein

Cysteine dioxygenase

Gene

CDO1

Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi100 – 1001Iron; catalyticBy similarity
    Metal bindingi102 – 1021Iron; catalyticBy similarity
    Metal bindingi160 – 1601Iron; catalyticBy similarity

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. L-cysteine metabolic process Source: InterPro
    2. taurine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00012; UER00537.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase (EC:1.13.11.20)
    Short name:
    CDO
    Gene namesi
    Name:CDO1
    ORF Names:HCBG_06968
    OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
    Taxonomic identifieri447093 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000001631: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Cysteine dioxygenasePRO_0000206614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki107 ↔ 1773'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

    Post-translational modificationi

    The thioether cross-link between Cys-107 and Tyr-177 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

    Keywords - PTMi

    Thioether bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RLY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    OrthoDBiEOG7Q5HQR.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5RLY7-1 [UniParc]FASTAAdd to Basket

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    MPYLENSESS PDPTPLDAFH CLVQDINKVL GPSSGLDSDD VDPMDIQKLM    50
    EDYTSNESEW ERYAFGDAGR AYTRNLVDEG NGKCNLLILV WSPGKGSAIH 100
    DHANAHCVMK VLKGSLRETL YGWPESDKVQ KGEPSPLTVT RDKVYKEGQV 150
    TYMSDKLGLH KISNPDPTNF AISLHLYTPP NAAHYGFSLF DEKTGKSRHV 200
    KQSVLFSRKG HKL 213
    Length:213
    Mass (Da):23,768
    Last modified:June 16, 2009 - v2
    Checksum:i62C0639517F657FB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461K → E in AAV66535. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY804144 mRNA. Translation: AAV66535.1.
    GG663372 Genomic DNA. Translation: EEH05017.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY804144 mRNA. Translation: AAV66535.1 .
    GG663372 Genomic DNA. Translation: EEH05017.1 .

    3D structure databases

    ProteinModelPortali Q5RLY7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7Q5HQR.

    Enzyme and pathway databases

    UniPathwayi UPA00012 ; UER00537 .

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the cysteine dioxygenase gene (CDO1) from the dimorphic pathogenic fungus Histoplasma capsulatum."
      Hasler S., Shearer G. Jr.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G186AR / H82 / ATCC MYA-2454 / RMSCC 2432.

    Entry informationi

    Entry nameiCDO_AJECG
    AccessioniPrimary (citable) accession number: Q5RLY7
    Secondary accession number(s): C0NUD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3