Reviewed,
UniProtKB/Swiss-Prot Q5RLY7 (CDO_AJECA)
Last modified
November 25, 2008.
Version 23.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cysteine dioxygenase Short name=CDO EC=1.13.11.20 | ||
| Gene names |
| ||
| Organism | Ajellomyces capsulata (Histoplasma capsulatum) | ||
| Taxonomic identifier | 5037 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces |
Protein attributes
| Sequence length | 213 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-cysteine + O(2) = 3-sulfinoalanine. |
| Cofactor | Binds 1 iron ion per subunit By similarity. |
| Pathway | Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. |
| Post-translational modification | The thioether cross-link between Cys-107 and Tyr-177 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity. |
| Sequence similarities | Belongs to the cysteine dioxygenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Thioether bond |
Gene Ontology (GO) | |
| Biological process | L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cysteine dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 213 | 213 | Cysteine dioxygenase | PRO_0000206614 | |||||||
Sites | |||||||||||
| Metal binding | 100 | 1 | Iron; catalytic By similarity | ||||||||
| Metal binding | 102 | 1 | Iron; catalytic By similarity | ||||||||
| Metal binding | 160 | 1 | Iron; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 107 ↔ 177 | 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity | |||||||||
Sequences
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References
| [1] | "Isolation and characterization of the cysteine dioxygenase gene (CDO1) from the dimorphic pathogenic fungus Histoplasma capsulatum." Hasler S., Shearer G. Jr. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 26029 / G186A. |
Cross-references
Sequence databases | |
|---|---|
| AY804144 mRNA. Translation: AAV66535.1. | |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR010300. Cys_dOase_I. [Graphical view] |
| Pfam | PF05995. CDO_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDO_AJECA | ||||||||
| Accession | Primary (citable) accession number: Q5RLY7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


