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Q5RL73 (RBM48_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding protein 48
Gene names
Name:RBM48
Synonyms:C7orf64
ORF Names:HSPC304
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the RBM48 family.

Contains 1 RRM (RNA recognition motif) domain.

Sequence caution

The sequence AAH33561.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB70806.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAB66554.1 differs from that shown. Reason: Frameshift at position 341.

The sequence CAI45942.1 differs from that shown. Reason: Erroneous translation. The protein sequence does not correspond to the translation of the nucleic acid sequence.

The sequence EAL24148.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   LigandRNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay. Source: HPA

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367RNA-binding protein 48
PRO_0000321514

Regions

Domain46 – 12479RRM

Experimental info

Sequence conflict81L → P in CAB66554. Ref.1
Sequence conflict2291R → K in BAB70806. Ref.4
Sequence conflict3591H → R in BAB70806. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q5RL73 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: BD42E7ACCDCE9B96

FASTA36741,808
        10         20         30         40         50         60 
MASSGGELGS LFDHHVQRAV CDTRAKYREG RRPRAVKVYT INLESQYLLI QGVPAVGVMK 

        70         80         90        100        110        120 
ELVERFALYG AIEQYNALDE YPAEDFTEVY LIKFMNLQSA RTAKRKMDEQ SFFGGLLHVC 

       130        140        150        160        170        180 
YAPEFETVEE TRKKLQMRKA YVVKTTENKD HYVTKKKLVT EHKDTEDFRQ DFHSEMSGFC 

       190        200        210        220        230        240 
KAALNTSAGN SNPYLPYSCE LPLCYFSSKC MCSSGGPVDR APDSSKDGRN HHKTMGHYNH 

       250        260        270        280        290        300 
NDSLRKTQIN SLKNSVACPG AQKAITSSEA VDRFMPRTTQ LQERKRRRED DRKLGTFLQT 

       310        320        330        340        350        360 
NPTGNEIMIG PLLPDISKVD MHDDSLNTTA NLIRHKLKEV ISSVPKPPED KPEDVHTSHP 


LKQRRRI 

« Hide

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Endometrial adenocarcinoma.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lung and Testis.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-367.
Tissue: Cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136619 mRNA. Translation: CAB66554.1. Frameshift.
CR933641 mRNA. Translation: CAI45942.1. Sequence problems.
CH471091 Genomic DNA. Translation: EAW76839.1.
CH236949 Genomic DNA. Translation: EAL24148.1. Sequence problems.
BC033561 mRNA. Translation: AAH33561.1. Different initiation.
BC044570 mRNA. Translation: AAH44570.1.
BC104865 mRNA. Translation: AAI04866.1.
BC104867 mRNA. Translation: AAI04868.1.
BC143576 mRNA. Translation: AAI43577.1.
AK054777 mRNA. Translation: BAB70806.1. Different initiation.
CCDSCCDS43615.1.
RefSeqNP_115496.2. NM_032120.2.
UniGeneHs.21590.

3D structure databases

ProteinModelPortalQ5RL73.
SMRQ5RL73. Positions 45-123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123855. 48 interactions.
IntActQ5RL73. 48 interactions.
MINTMINT-3979239.

PTM databases

PhosphoSiteQ5RL73.

Polymorphism databases

DMDM74736145.

Proteomic databases

MaxQBQ5RL73.
PaxDbQ5RL73.
PRIDEQ5RL73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265732; ENSP00000265732; ENSG00000127993.
GeneID84060.
KEGGhsa:84060.
UCSCuc003ulz.3. human.

Organism-specific databases

CTD84060.
GeneCardsGC07P092159.
HGNCHGNC:21785. RBM48.
HPAHPA021777.
HPA025306.
neXtProtNX_Q5RL73.
PharmGKBPA164717383.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150976.
HOGENOMHOG000082399.
HOVERGENHBG054270.
InParanoidQ5RL73.
PhylomeDBQ5RL73.
TreeFamTF328457.

Gene expression databases

ArrayExpressQ5RL73.
BgeeQ5RL73.
CleanExHS_C7orf64.
GenevestigatorQ5RL73.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSRBM48. human.
GenomeRNAi84060.
NextBio73212.
PROQ5RL73.

Entry information

Entry nameRBM48_HUMAN
AccessionPrimary (citable) accession number: Q5RL73
Secondary accession number(s): B7ZL51 expand/collapse secondary AC list , Q5H9T2, Q8IYW7, Q96NS0, Q9H0V7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM