Q5RL73 (RBM48_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding protein 48

Gene names

Name:	RBM48
Synonyms:	C7orf64
ORF Names:	HSPC304

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the RBM48 family. Contains 1 RRM (RNA recognition motif) domain.

Sequence caution

The sequence AAH33561.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB70806.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB66554.1 differs from that shown. Reason: Frameshift at position 341. The sequence CAI45942.1 differs from that shown. Reason: Erroneous translation. The protein sequence does not correspond to the translation of the nucleic acid sequence. The sequence EAL24148.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	RNA-binding protein 48		PRO_0000321514
Regions
	Domain	46 – 124	79	RRM
Experimental info
	Sequence conflict	8	1	L → P in CAB66554. Ref.1
	Sequence conflict	229	1	R → K in BAB70806. Ref.4
	Sequence conflict	359	1	H → R in BAB70806. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q5RL73 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: BD42E7ACCDCE9B96	FASTA	367	41,808
	10 20 30 40 50 60 MASSGGELGS LFDHHVQRAV CDTRAKYREG RRPRAVKVYT INLESQYLLI QGVPAVGVMK 70 80 90 100 110 120 ELVERFALYG AIEQYNALDE YPAEDFTEVY LIKFMNLQSA RTAKRKMDEQ SFFGGLLHVC 130 140 150 160 170 180 YAPEFETVEE TRKKLQMRKA YVVKTTENKD HYVTKKKLVT EHKDTEDFRQ DFHSEMSGFC 190 200 210 220 230 240 KAALNTSAGN SNPYLPYSCE LPLCYFSSKC MCSSGGPVDR APDSSKDGRN HHKTMGHYNH 250 260 270 280 290 300 NDSLRKTQIN SLKNSVACPG AQKAITSSEA VDRFMPRTTQ LQERKRRRED DRKLGTFLQT 310 320 330 340 350 360 NPTGNEIMIG PLLPDISKVD MHDDSLNTTA NLIRHKLKEV ISSVPKPPED KPEDVHTSHP LKQRRRI

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Endometrial adenocarcinoma.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lung and Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-367. Tissue: Cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136619 mRNA. Translation: CAB66554.1. Frameshift. CR933641 mRNA. Translation: CAI45942.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76839.1. CH236949 Genomic DNA. Translation: EAL24148.1. Sequence problems. BC033561 mRNA. Translation: AAH33561.1. Different initiation. BC044570 mRNA. Translation: AAH44570.1. BC104865 mRNA. Translation: AAI04866.1. BC104867 mRNA. Translation: AAI04868.1. BC143576 mRNA. Translation: AAI43577.1. AK054777 mRNA. Translation: BAB70806.1. Different initiation.
IPI	IPI00549763.
RefSeq	NP_115496.2. NM_032120.2.
UniGene	Hs.21590.
3D structure databases
ProteinModelPortal	Q5RL73.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5RL73. 42 interactions.
MINT	MINT-3979239.
PTM databases
PhosphoSite	Q5RL73.
Polymorphism databases
DMDM	74736145.
Proteomic databases
PaxDb	Q5RL73.
PRIDE	Q5RL73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265732; ENSP00000265732; ENSG00000127993.
GeneID	84060.
KEGG	hsa:84060.
UCSC	uc003ulz.3. human.
Organism-specific databases
CTD	84060.
GeneCards	GC07P092159.
HGNC	HGNC:21785. RBM48.
HPA	HPA021777. HPA025306.
neXtProt	NX_Q5RL73.
PharmGKB	PA164717383.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150976.
HOGENOM	HOG000082399.
HOVERGEN	HBG054270.
InParanoid	Q5RL73.
OrthoDB	EOG4RBQKJ.
Gene expression databases
ArrayExpress	Q5RL73.
Bgee	Q5RL73.
CleanEx	HS_C7orf64.
Genevestigator	Q5RL73.
Family and domain databases
PROSITE	PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RBM48. human.
GenomeRNAi	84060.
NextBio	73212.

Entry information

Entry name

RBM48_HUMAN

Accession

Primary (citable) accession number: Q5RL73
Secondary accession number(s): B7ZL51 , Q5H9T2, Q8IYW7, Q96NS0, Q9H0V7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.