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Protein

Glutathione S-transferase C-terminal domain-containing protein

Gene

Gstcd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase C-terminal domain-containing protein
Gene namesi
Name:Gstcd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914803 Gstcd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169541 – 634Glutathione S-transferase C-terminal domain-containing proteinAdd BLAST634

Proteomic databases

PaxDbiQ5RL51
PeptideAtlasiQ5RL51
PRIDEiQ5RL51

PTM databases

PhosphoSitePlusiQ5RL51

Expressioni

Gene expression databases

BgeeiENSMUSG00000028018
GenevisibleiQ5RL51 MM

Interactioni

Protein-protein interaction databases

IntActiQ5RL51, 1 interactor
MINTiQ5RL51
STRINGi10090.ENSMUSP00000029651

Structurei

3D structure databases

ProteinModelPortaliQ5RL51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 333GST C-terminalAdd BLAST203

Sequence similaritiesi

Belongs to the GSTCD family.Curated

Phylogenomic databases

eggNOGiENOG410IDXE Eukaryota
ENOG410ZVJE LUCA
GeneTreeiENSGT00390000004446
HOVERGENiHBG107970
InParanoidiQ5RL51
OMAiNFCRAGL
OrthoDBiEOG091G098R
PhylomeDBiQ5RL51
TreeFamiTF324238

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR025714 Methyltranfer_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF13679 Methyltransf_32, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RL51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGIKKSPTE ESLYLEYSHQ TEGCIFPLHT SVTLFLLSYC ECKVFNVCLV
60 70 80 90 100
LTEESTDTSD TSFLKEALPQ DLEIQVISKQ ALPPIVQNCC LPAVVDQPDV
110 120 130 140 150
FCRAGLAVVL RHIIQKSYEA EPSRKEILEL LGFKKTCLKA CAEVSQWTRL
160 170 180 190 200
CELTIPLAVE NFLQESSEHP PTIPEEILEL ERKLSEPVRV HNDDKLRRQK
210 220 230 240 250
LKQQKAAGSE PPSGKGKAKS KASAQKTPKD LAAPSKSLEL KVAFSKLTVQ
260 270 280 290 300
EDAAASNREP SHIRKAKAAD LPPLEHVFAE GLYFTLADIV LLPCIHHFLV
310 320 330 340 350
IICKKFSEKL EQFPLLTSWY QRIQEVPKVK TAASKCGIYF LYLPELLNSA
360 370 380 390 400
RKQPVNSDEV AAVDEQSDPL FIGGPRPTMT KLMEKGIEAM FSPHPCPAWT
410 420 430 440 450
LDWSSLPAAV SPKEGKMSTD RALRKQQQLN NLVYLVLNQA KPGDRIVDFC
460 470 480 490 500
SGGGHVGIVL AHMLPSCQVT LIENKELSLI RAKKRSDELG LSNIWFIQAN
510 520 530 540 550
MEYFTGMFNI GVALHACGVA TDMVIEHCIQ TRASFITCPC CYGFIQNTSK
560 570 580 590 600
FNFPKSEKFK KTLSYKEHML LCRFADQTAV QLPPERRLIG KQCMGLVDLD
610 620 630
RAAAAGEHGY SVQVISMEPE SCSPKNNMIV GVPL
Length:634
Mass (Da):70,618
Last modified:December 21, 2004 - v1
Checksum:iA895253353135EE8
GO
Isoform 2 (identifier: Q5RL51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-542: VALHACGVATDMVIEHCIQTRASFITCPCCY → PNRPTTDVQCRDDKMFERAVMCDTVLTFSPH
     543-634: Missing.

Show »
Length:542
Mass (Da):60,617
Checksum:i7A17C6478393FC49
GO
Isoform 3 (identifier: Q5RL51-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-378: Missing.

Show »
Length:256
Mass (Da):28,416
Checksum:i83D6F940F3195121
GO
Isoform 4 (identifier: Q5RL51-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-330: IICKKFSEKLEQFPLLTSWYQRIQEVPKVK → RMCLQSSCYYAFQFDKLLGFVFGSQQISCL
     331-634: Missing.

Show »
Length:330
Mass (Da):36,862
Checksum:i0132E96F9DB16212
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198R → I in AAH61240 (PubMed:15489334).Curated1
Sequence conflicti414E → G in BAB29091 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0308231 – 378Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_030824301 – 330IICKK…VPKVK → RMCLQSSCYYAFQFDKLLGF VFGSQQISCL in isoform 4. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_030825331 – 634Missing in isoform 4. 1 PublicationAdd BLAST304
Alternative sequenceiVSP_030826512 – 542VALHA…CPCCY → PNRPTTDVQCRDDKMFERAV MCDTVLTFSPH in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_030827543 – 634Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037169 mRNA Translation: BAC29731.1
AK013967 mRNA Translation: BAB29091.1
AK017059 mRNA Translation: BAB30574.2
AK020021 mRNA Translation: BAB31969.1
AK044441 mRNA Translation: BAC31921.1
BC047136 mRNA Translation: AAH47136.1
BC061240 mRNA Translation: AAH61240.1
CCDSiCCDS17847.1 [Q5RL51-1]
RefSeqiNP_080507.2, NM_026231.2 [Q5RL51-1]
XP_006502001.1, XM_006501938.3 [Q5RL51-2]
UniGeneiMm.304899

Genome annotation databases

EnsembliENSMUST00000029651; ENSMUSP00000029651; ENSMUSG00000028018 [Q5RL51-1]
ENSMUST00000080583; ENSMUSP00000079421; ENSMUSG00000028018 [Q5RL51-1]
GeneIDi67553
KEGGimmu:67553
UCSCiuc008rkg.1 mouse [Q5RL51-1]
uc008rki.1 mouse [Q5RL51-4]
uc012cxx.1 mouse [Q5RL51-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGSTCD_MOUSE
AccessioniPrimary (citable) accession number: Q5RL51
Secondary accession number(s): Q6P8I1
, Q8BXR2, Q8BYY6, Q9CTV2, Q9CUA9, Q9CXU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health