Q5RKQ4 (Q5RKQ4_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone deacetylase PIRNR PIRNR037913
EC=3.5.1.98 PIRNR PIRNR037913

Gene names

Name:

hdac1 EMBL AAH85375.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAH85375.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913
Subcellular location	Nucleus By similarity PIRNR PIRNR037913.
Sequence similarities	Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
Biological process	Transcription Transcription regulation PIRNR PIRNR037913
Cellular component	Nucleus PIRNR PIRNR037913
Molecular function	Chromatin regulator PIRNR PIRNR037913 Hydrolase PIRNR PIRNR037913 SAAS SAAS000286
Gene Ontology (GO)
Biological process	convergent extension involved in axis elongation Inferred from mutant phenotype. Source: ZFIN determination of dorsal identity Inferred from mutant phenotype. Source: ZFIN digestive tract development Inferred from mutant phenotype. Source: ZFIN exocrine pancreas development Inferred from mutant phenotype. Source: ZFIN facial nucleus development Inferred from mutant phenotype. Source: ZFIN hemopoietic stem cell differentiation Inferred from mutant phenotype. Source: ZFIN liver development Inferred from mutant phenotype. Source: ZFIN melanocyte differentiation Inferred from mutant phenotype. Source: ZFIN negative regulation of cell proliferation Inferred from mutant phenotype. Source: ZFIN neuron migration Inferred from mutant phenotype. Source: ZFIN oligodendrocyte differentiation Inferred from mutant phenotype. Source: ZFIN positive regulation of neurogenesis Inferred from mutant phenotype. Source: ZFIN regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW rostrocaudal neural tube patterning Inferred from mutant phenotype. Source: ZFIN transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC histone deacetylase activity (H3-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5RKQ4 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 101246F3EBF86BF0	FASTA	480	54,725
	10 20 30 40 50 60 MALSSQGTKK KVCYYYDGDV GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 70 80 90 100 110 120 NAEEMTKYHS DDYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSAGGSVA 130 140 150 160 170 180 GAVKLNKQQT DIAINWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 190 200 210 220 230 240 GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNYPLR DGIDDESYEA 250 260 270 280 290 300 IFKPIMSKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTIK GHAKCVEYMK SFNLPLLMLG 310 320 330 340 350 360 GGGYTIRNVA RCWTFETAVA LDSTIPNELP YSDYFEYFGP DFKLHISPSN MTNQNTNDYL 370 380 390 400 410 420 EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV QEDSGDEEDD PDKRISIRAH DKRIACDEEF 430 440 450 460 470 480 SDSEDEGQGG RRNAANYKKP KRVKTEEEKD GEEKKDVKEE EKASEEKMDT KGPKEELKTV

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo EMBL AAH85375.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085375 mRNA. Translation: AAH85375.1.
IPI	IPI00503694.
UniGene	Dr.31752.
3D structure databases
ProteinModelPortal	Q5RKQ4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5RKQ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ZFIN	ZDB-GENE-020419-32. hdac1.
Phylogenomic databases
eggNOG	fiNOG13777.
HOGENOM	HBG396919.
HOVERGEN	HBG057112.
InParanoid	Q5RKQ4.
OrthoDB	EOG4868CH.
PhylomeDB	Q5RKQ4.
Gene expression databases
ArrayExpress	Q5RKQ4.
Bgee	Q5RKQ4.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

Q5RKQ4_DANRE

Accession

Primary (citable) accession number: Q5RKQ4

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	October 19, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)