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Protein

Putative oxidoreductase GLYR1

Gene

glyr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of mapk14 and specifically regulating mapk14 signaling (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei270 – 2701NADBy similarity
Binding sitei414 – 4141NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 19315NADBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative oxidoreductase GLYR1 (EC:1.-.-.-)
Alternative name(s):
Glyoxylate reductase 1 homolog
Nuclear protein NP60
Gene namesi
Name:glyr1
Synonyms:np60
ORF Names:zgc:103629
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041121-5. glyr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Putative oxidoreductase GLYR1PRO_0000312126Add
BLAST

Proteomic databases

PRIDEiQ5RKN4.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5RKN4.
SMRiQ5RKN4. Positions 170-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 6659PWWPPROSITE-ProRule annotationAdd
BLAST

Domaini

The PWWP domain probably mediates the binding to H3K36me3.By similarity

Sequence similaritiesi

Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000219609.
InParanoidiQ5RKN4.
PhylomeDBiQ5RKN4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR000313. PWWP_dom.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RKN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVHLRIGD LVWGKLGRYP PWPGKVVSPP KDLKKPRGKK CFFVKFFGTE
60 70 80 90 100
DHAWIKVEQL KPYHPHKEEM IKVNKGKRFQ QAVDAVEEYL KKAKGKDQSH
110 120 130 140 150
SDDKSKSDKG RKAAKPMKII EEDDEDAFKG GSSDKPASSM EPITKRLKII
160 170 180 190 200
EEDTRSTSIQ AADSTAINGS ITPTDKRIGF LGLGLMGSGV VSNLLKMGHV
210 220 230 240 250
VTVWNRTAEK CDLFIQEGAR LGRTPAEVVS MCDITFSCVS DPKAARDLVL
260 270 280 290 300
GPSGVLQGIR PGKCYVEMST VDPETITELS QVITSRGGRF LEAPVSGSQQ
310 320 330 340 350
LSNDGMLVIV AAGDRSVYED CSSCFQAMGK TSFFIAGEAG NAARMMLILN
360 370 380 390 400
MVQGSFMATI AEGLTLAQAT GQSQQTFLDI LCQGQMASTF VDQKCQNILQ
410 420 430 440 450
GNFKPDYYLK HIQKDLRLAI SMGDSVNHPT PMAAAANEVY KRAKALDQSD
460
NDMSAVYRAY IH
Length:462
Mass (Da):50,601
Last modified:December 21, 2004 - v1
Checksum:i8B5A17C1E9D270E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085567 mRNA. Translation: AAH85567.1.
RefSeqiNP_001007772.1. NM_001007771.1.
UniGeneiDr.77851.

Genome annotation databases

GeneIDi493611.
KEGGidre:493611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085567 mRNA. Translation: AAH85567.1.
RefSeqiNP_001007772.1. NM_001007771.1.
UniGeneiDr.77851.

3D structure databases

ProteinModelPortaliQ5RKN4.
SMRiQ5RKN4. Positions 170-462.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5RKN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493611.
KEGGidre:493611.

Organism-specific databases

CTDi84656.
ZFINiZDB-GENE-041121-5. glyr1.

Phylogenomic databases

HOGENOMiHOG000219609.
InParanoidiQ5RKN4.
PhylomeDBiQ5RKN4.

Miscellaneous databases

NextBioi20865422.
PROiQ5RKN4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR000313. PWWP_dom.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larva.

Entry informationi

Entry nameiGLYR1_DANRE
AccessioniPrimary (citable) accession number: Q5RKN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The conserved NAD-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.