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Protein
Submitted name:

Dimethylglycine dehydrogenase

Gene

Dmgdh

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6798163. Choline catabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Dimethylglycine dehydrogenaseImported
Submitted name:
Dimethylglycine dehydrogenase, mitochondrialImported
Gene namesi
Name:DmgdhImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620453. Dmgdh.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023588.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030481.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 407DAOInterPro annotationAdd BLAST363
Domaini410 – 463FAO_MInterPro annotationAdd BLAST54
Domaini473 – 737GCV_TInterPro annotationAdd BLAST265
Domaini746 – 837GCV_T_CInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2844. Eukaryota.
COG0404. LUCA.
COG0665. LUCA.
GeneTreeiENSGT00530000063120.
HOVERGENiHBG081945.
KOiK00315.
TreeFamiTF314735.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR032503. FAO_M.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16350. FAO_M. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
SSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5RKL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLGALRLR GLALRSSQGR PSSAGLREGQ ESPPSPPEWK DRAETVIIGG
60 70 80 90 100
GCVGVSLAYH LAKAGMRDVV LLEKSELTAG STWHAAGLTT YFHPGINLKK
110 120 130 140 150
IHYDSIKLYE RLEEETGQVV GFHQPGSIRL ATTPERVDEF KYQMTRTNWH
160 170 180 190 200
ATEQYIIEPE KIHELFPLLN MDKILAGLYN PGDGHIDPYS LTMALATGAR
210 220 230 240 250
KYGALLKYPA PVTSLKPRPD GTWDVETPQG SVRANRIVNA AGFWAREVGK
260 270 280 290 300
MIGLDHPLIP VQHQYVITST IPEVKALKRE LPVLRDLEGS YYLRQERDGL
310 320 330 340 350
LFGPYESQEK MKLQASWVAH GVPPGFGKEL FESDLDRITE HVEAAMEMVP
360 370 380 390 400
VLKKADIINI VNGPITYSPD ILPMVGPHQG VRNYWVAIGF GYGIIHAGGV
410 420 430 440 450
GTYLSDWILH GEPPFDLIEL DPNRYGKWTT TQYTEAKARE SYGFNNIVGY
460 470 480 490 500
PKEERFAGRP TQRVSGLYKI LESKCSMGFH AGWEQPHWFY KPGQDTQYRP
510 520 530 540 550
SFRRTNWFEP VGSEYKQVMQ RVGVIDLSPF GKFNIKGQDS TQLLDHLCAN
560 570 580 590 600
VIPKVGFTNI SHMLTPRGRV YAELTVSHQS PGEFLLITGS GSELHDLRWI
610 620 630 640 650
EEAAVRGGYD VEIRNITDEL GVLGVAGPYA RRVLQKLTSE DLSDDVFKFL
660 670 680 690 700
QTKSLKISDI PVTAIRISYT GELGWELYHR REDSAALYER IMNAGQEEGI
710 720 730 740 750
DNFGTYALNA LRLEKAFRAW GSEMNCDTNP LEAGLDYFIK LNKPANFTGK
760 770 780 790 800
QALKQIKAKG LKRRLVCLTL ATDNVDPEGN ESVWYKGKVI GNTTSGSYSY
810 820 830 840 850
SIQKSLAFAY VPVELSEVGQ QVEVELLGKN YPATIIQEPL VLTEPTRTRL

QKDGRKS
Length:857
Mass (Da):95,977
Last modified:December 21, 2004 - v1
Checksum:iD7E356645C8AA69F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07007675 Genomic DNA. No translation available.
AABR07007676 Genomic DNA. No translation available.
BC085697 mRNA. Translation: AAH85697.1.
RefSeqiNP_620802.2. NM_139102.2.
UniGeneiRn.3646.

Genome annotation databases

EnsembliENSRNOT00000032783; ENSRNOP00000030481; ENSRNOG00000023588.
GeneIDi245961.
KEGGirno:245961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07007675 Genomic DNA. No translation available.
AABR07007676 Genomic DNA. No translation available.
BC085697 mRNA. Translation: AAH85697.1.
RefSeqiNP_620802.2. NM_139102.2.
UniGeneiRn.3646.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032783; ENSRNOP00000030481; ENSRNOG00000023588.
GeneIDi245961.
KEGGirno:245961.

Organism-specific databases

CTDi29958.
RGDi620453. Dmgdh.

Phylogenomic databases

eggNOGiKOG2844. Eukaryota.
COG0404. LUCA.
COG0665. LUCA.
GeneTreeiENSGT00530000063120.
HOVERGENiHBG081945.
KOiK00315.
TreeFamiTF314735.

Enzyme and pathway databases

ReactomeiR-RNO-6798163. Choline catabolism.

Gene expression databases

BgeeiENSRNOG00000023588.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR032503. FAO_M.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16350. FAO_M. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
SSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5RKL4_RAT
AccessioniPrimary (citable) accession number: Q5RKL4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.