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Protein

Macrophage erythroblast attacher

Gene

Maea

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage erythroblast attacher
Gene namesi
Name:Maea
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1309877 Maea

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849401 – 396Macrophage erythroblast attacherAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5RKJ1
PRIDEiQ5RKJ1

Expressioni

Gene expression databases

BgeeiENSRNOG00000005397
GenevisibleiQ5RKJ1 RN

Interactioni

Subunit structurei

Forms a complex with F-actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007181

Structurei

3D structure databases

ProteinModelPortaliQ5RKJ1
SMRiQ5RKJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 153LisHPROSITE-ProRule annotationAdd BLAST33
Domaini159 – 216CTLHPROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 124Extracellular and involved in cell to cell contactBy similarityAdd BLAST124

Phylogenomic databases

eggNOGiKOG0396 Eukaryota
ENOG410XPGU LUCA
GeneTreeiENSGT00720000108841
HOGENOMiHOG000241232
HOVERGENiHBG053270
InParanoidiQ5RKJ1
KOiK18624
OMAiYAHHTKS
OrthoDBiEOG091G0E8J
PhylomeDBiQ5RKJ1
TreeFamiTF314273

Family and domain databases

InterProiView protein in InterPro
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR027714 Fyv10/EMP
IPR006594 LisH
PANTHERiPTHR12170:SF2 PTHR12170:SF2, 1 hit
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RKJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQESAAQL SMTLKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV
60 70 80 90 100
VAELEKTLSS CPAVDSVVSL LDGVVEKLSV LKRKAVESIQ AEDESAKLCK
110 120 130 140 150
RRIEHLKEHS SDQPAAASMW KRKRMDRMMV EHLLRCGYYN TAVKLARQSG
160 170 180 190 200
IEDLVNIEMF LTAKEVEESL ERRETATCLA WCHDNKSRLR KMKSCLEFSL
210 220 230 240 250
RIQEFIELVR QNKRLDAVRH ARKHFSQAEG SQLDEVRQVM GMLAFPPDTH
260 270 280 290 300
ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNSSVFTLTL QAGLSAIKTP
310 320 330 340 350
QCYKEDGSSK SPDCPVCSRS LNKLAQPLPM AHCANSRLVC KISGDVMNEN
360 370 380 390
NPPMMLPNGY VYGYNSLLSI RQDDKVVCPR TKEVFHFSQA EKVYIM
Length:396
Mass (Da):45,336
Last modified:May 1, 2007 - v2
Checksum:i686F1E086742B99B
GO

Sequence cautioni

The sequence AAH85770 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085770 mRNA Translation: AAH85770.1 Different initiation.
RefSeqiNP_001008320.2, NM_001008319.2
UniGeneiRn.101181

Genome annotation databases

EnsembliENSRNOT00000007181; ENSRNOP00000007181; ENSRNOG00000005397
GeneIDi298982
KEGGirno:298982
UCSCiRGD:1309877 rat

Similar proteinsi

Entry informationi

Entry nameiMAEA_RAT
AccessioniPrimary (citable) accession number: Q5RKJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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