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Protein

Macrophage erythroblast attacher

Gene

Maea

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Erythrocyte maturation

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage erythroblast attacher
Gene namesi
Name:Maea
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1309877. Maea.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Macrophage erythroblast attacherPRO_0000284940Add
BLAST

Proteomic databases

PaxDbiQ5RKJ1.
PRIDEiQ5RKJ1.

Expressioni

Gene expression databases

GenevisibleiQ5RKJ1. RN.

Interactioni

Subunit structurei

Forms a complex with F-actin.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007181.

Structurei

3D structure databases

ProteinModelPortaliQ5RKJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 15333LisHPROSITE-ProRule annotationAdd
BLAST
Domaini159 – 21658CTLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 124124Extracellular and involved in cell to cell contactBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0396. Eukaryota.
ENOG410XPGU. LUCA.
GeneTreeiENSGT00720000108841.
HOGENOMiHOG000241232.
HOVERGENiHBG053270.
InParanoidiQ5RKJ1.
KOiK18624.
OMAiRQETATC.
OrthoDBiEOG722J8H.
PhylomeDBiQ5RKJ1.
TreeFamiTF314273.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RKJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQESAAQL SMTLKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV
60 70 80 90 100
VAELEKTLSS CPAVDSVVSL LDGVVEKLSV LKRKAVESIQ AEDESAKLCK
110 120 130 140 150
RRIEHLKEHS SDQPAAASMW KRKRMDRMMV EHLLRCGYYN TAVKLARQSG
160 170 180 190 200
IEDLVNIEMF LTAKEVEESL ERRETATCLA WCHDNKSRLR KMKSCLEFSL
210 220 230 240 250
RIQEFIELVR QNKRLDAVRH ARKHFSQAEG SQLDEVRQVM GMLAFPPDTH
260 270 280 290 300
ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNSSVFTLTL QAGLSAIKTP
310 320 330 340 350
QCYKEDGSSK SPDCPVCSRS LNKLAQPLPM AHCANSRLVC KISGDVMNEN
360 370 380 390
NPPMMLPNGY VYGYNSLLSI RQDDKVVCPR TKEVFHFSQA EKVYIM
Length:396
Mass (Da):45,336
Last modified:May 1, 2007 - v2
Checksum:i686F1E086742B99B
GO

Sequence cautioni

The sequence AAH85770.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085770 mRNA. Translation: AAH85770.1. Different initiation.
RefSeqiNP_001008320.2. NM_001008319.2.
UniGeneiRn.101181.

Genome annotation databases

EnsembliENSRNOT00000007181; ENSRNOP00000007181; ENSRNOG00000005397.
GeneIDi298982.
KEGGirno:298982.
UCSCiRGD:1309877. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085770 mRNA. Translation: AAH85770.1. Different initiation.
RefSeqiNP_001008320.2. NM_001008319.2.
UniGeneiRn.101181.

3D structure databases

ProteinModelPortaliQ5RKJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007181.

Proteomic databases

PaxDbiQ5RKJ1.
PRIDEiQ5RKJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007181; ENSRNOP00000007181; ENSRNOG00000005397.
GeneIDi298982.
KEGGirno:298982.
UCSCiRGD:1309877. rat.

Organism-specific databases

CTDi10296.
RGDi1309877. Maea.

Phylogenomic databases

eggNOGiKOG0396. Eukaryota.
ENOG410XPGU. LUCA.
GeneTreeiENSGT00720000108841.
HOGENOMiHOG000241232.
HOVERGENiHBG053270.
InParanoidiQ5RKJ1.
KOiK18624.
OMAiRQETATC.
OrthoDBiEOG722J8H.
PhylomeDBiQ5RKJ1.
TreeFamiTF314273.

Miscellaneous databases

NextBioi644618.
PROiQ5RKJ1.

Gene expression databases

GenevisibleiQ5RKJ1. RN.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiMAEA_RAT
AccessioniPrimary (citable) accession number: Q5RKJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.