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Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

Abcb8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi489 – 4968ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial
Gene namesi
Name:Abcb8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1307655. Abcb8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei178 – 19821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei278 – 29821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei365 – 38521HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionBy similarityAdd
BLAST
Chaini39 – 714676ATP-binding cassette sub-family B member 8, mitochondrialPRO_0000356235Add
BLAST

Proteomic databases

PaxDbiQ5RKI8.
PRIDEiQ5RKI8.

PTM databases

iPTMnetiQ5RKI8.
PhosphoSiteiQ5RKI8.

Expressioni

Tissue specificityi

Strong expression is found in the heart, brain and testis. In the testis, expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes). Also expressed in the lung, liver, intestine and kidney.1 Publication

Gene expression databases

ExpressionAtlasiQ5RKI8. baseline.
GenevisibleiQ5RKI8. RN.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012222.

Structurei

3D structure databases

ProteinModelPortaliQ5RKI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 419290ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 691238ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ5RKI8.
KOiK05655.
OMAiDIPVATH.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ5RKI8.
TreeFamiTF105196.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RKI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVHLFRVGI RGGPVPRWSL QSLRFQTFSA ARSSDDQFSS CLLRAVAQLR
60 70 80 90 100
SQLRAHLPRS PPASHRSTSA WCWVGGTLVV PAVLWQHPRF CLIALCEAKG
110 120 130 140 150
SPPAQPTRAR ELRFKWKLFW HFLHPHLLAL GLAIVLALGA ALVNVQIPLL
160 170 180 190 200
LGQLVEIVAK YTREHVGSFV SESRRLSIQL LLLYGVQGLL TFGYLVLLSH
210 220 230 240 250
MGERMAMDMR KALFSSLLRQ DIAFFDAKKT GQLVSRLTTD VQEFKSSFKL
260 270 280 290 300
VISQGLRSST QVIGSLMTLS ILSPRLTLML AVVTPALMGV GTLMGSGLRK
310 320 330 340 350
LSRQCQEQIA RATGVADEAL GSVRTVRAFA MEKREEERYQ AELESCCCKA
360 370 380 390 400
EELGRGIALF QGLSNIAFNC MVLGTLFIGG SLVAGQQLKG GDLMSFLVAS
410 420 430 440 450
QTVQRSMASL SVLFGQVVRG LSAGARVFEY MSLSPVIPLT GGYSIPSKDL
460 470 480 490 500
RGSITFQNVS FSYPCRPGFN VLKNFTLKLP PGKIVALVGQ SGGGKTTVAS
510 520 530 540 550
LLERFYDPTA GVVTLDGHDL RTLDPSWLRG QVIGFISQEP VLFATTIMEN
560 570 580 590 600
IRFGKLDASD EEVYTAARKA NAHEFISSFP DGYSTVVGER GTTLSGGQKQ
610 620 630 640 650
RLAIARALIK RPTVLILDEA TSALDAESER IVQEALDRAS AGRTVLVIAH
660 670 680 690 700
RLSTVRAAHS IIVMANGQVC EAGTHEELLQ KGGLYAELIR RQALDASLPS
710
APPAEKPEDH RSCQ
Length:714
Mass (Da):77,770
Last modified:December 21, 2004 - v1
Checksum:iA77B4362C41C9C5C
GO

Sequence cautioni

The sequence ABB71108.1 differs from that shown. Reason: Frameshift at positions 397, 399 and 406. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti540 – 5401P → T in ABB71108 (PubMed:16390497).Curated
Sequence conflicti578 – 5781S → C in ABB71108 (PubMed:16390497).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ233644 mRNA. Translation: ABB71108.1. Frameshift.
CH474020 Genomic DNA. Translation: EDL99373.1.
BC085781 mRNA. Translation: AAH85781.1.
RefSeqiNP_001007797.1. NM_001007796.1.
UniGeneiRn.79339.

Genome annotation databases

EnsembliENSRNOT00000089817; ENSRNOP00000071952; ENSRNOG00000008557.
GeneIDi362302.
KEGGirno:362302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ233644 mRNA. Translation: ABB71108.1. Frameshift.
CH474020 Genomic DNA. Translation: EDL99373.1.
BC085781 mRNA. Translation: AAH85781.1.
RefSeqiNP_001007797.1. NM_001007796.1.
UniGeneiRn.79339.

3D structure databases

ProteinModelPortaliQ5RKI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012222.

PTM databases

iPTMnetiQ5RKI8.
PhosphoSiteiQ5RKI8.

Proteomic databases

PaxDbiQ5RKI8.
PRIDEiQ5RKI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089817; ENSRNOP00000071952; ENSRNOG00000008557.
GeneIDi362302.
KEGGirno:362302.

Organism-specific databases

CTDi11194.
RGDi1307655. Abcb8.

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ5RKI8.
KOiK05655.
OMAiDIPVATH.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ5RKI8.
TreeFamiTF105196.

Miscellaneous databases

PROiQ5RKI8.

Gene expression databases

ExpressionAtlasiQ5RKI8. baseline.
GenevisibleiQ5RKI8. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis."
    Melaine N., Satie A.-P., Lassurguere J., Desmots S., Jegou B., Samson M.
    Int. J. Androl. 29:392-399(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiABCB8_RAT
AccessioniPrimary (citable) accession number: Q5RKI8
Secondary accession number(s): Q0QVT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.