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Q5RKI7 (S7A13_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
Gene names
Name:Slc7a13
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionamino acid transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Solute carrier family 7 member 13
PRO_0000330727

Regions

Topological domain1 – 1414Cytoplasmic Potential
Transmembrane15 – 3521Helical; Name=1; Potential
Topological domain36 – 4712Extracellular Potential
Transmembrane48 – 6821Helical; Name=2; Potential
Topological domain69 – 8921Cytoplasmic Potential
Transmembrane90 – 11021Helical; Name=3; Potential
Topological domain111 – 12919Extracellular Potential
Transmembrane130 – 15021Helical; Name=4; Potential
Topological domain151 – 16515Cytoplasmic Potential
Transmembrane166 – 18621Helical; Name=5; Potential
Topological domain187 – 20822Extracellular Potential
Transmembrane209 – 22921Helical; Name=6; Potential
Topological domain230 – 24213Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=7; Potential
Topological domain264 – 28926Extracellular Potential
Transmembrane290 – 31021Helical; Name=8; Potential
Topological domain311 – 33828Cytoplasmic Potential
Transmembrane339 – 35921Helical; Name=9; Potential
Topological domain3601Extracellular Potential
Transmembrane361 – 38121Helical; Name=10; Potential
Topological domain382 – 39615Cytoplasmic Potential
Transmembrane397 – 41721Helical; Name=11; Potential
Topological domain418 – 4236Extracellular Potential
Transmembrane424 – 44421Helical; Name=12; Potential
Topological domain445 – 47935Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RKI7 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 9EDA418E533B2B96

FASTA47953,551
        10         20         30         40         50         60 
MAMDIEKKIY LKRQLGYFWG TNFLIINIIG AGIFVSPKGV LQYSSMNVGV SLCVWVFCAV 

        70         80         90        100        110        120 
LSMTSTLCAA EIGITFPYTV AHYYFLKRCF GPFVAFLRLW TSLFTGPGVL ASQALLLAEY 

       130        140        150        160        170        180 
GIQPFYPSCS APAVPKKCLA LAMLWIVGIL NSRGVKELSW LQTVSMVLKM GILSFISLSG 

       190        200        210        220        230        240 
LFLLVTGRKE NVRRLQNAFD AEFPEVSRLI EAIFQGYFAF SGGGSFTYVA GELKEPSKTI 

       250        260        270        280        290        300 
PRCIFTALPL VTVVYLLANL SYLTVLSPQE LLSSDAVALT WTDRVIPQLT WSVPFAISAS 

       310        320        330        340        350        360 
LFSNLVTSVF ETSRTSYIAS RNGQLPLLCS TLNVHSSPFI AVLLDVSMGS IAIVLTNLIE 

       370        380        390        400        410        420 
LINYLFFVFS IWTVLSVIGI LKLRYQEPNL HRPYKVFSPF LFITAAISLS MVLIPLIKSP 

       430        440        450        460        470 
KMQYIYVFLF FLGGLLFYVP LIHFKLKLIW FQKLTCYLQL LFNICIPDVS DEHVAEEES 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085796 mRNA. Translation: AAH85796.1.
RefSeqNP_001012100.1. NM_001012100.1.
UniGeneRn.22708.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000032751.

PTM databases

PhosphoSiteQ5RKI7.

Proteomic databases

PRIDEQ5RKI7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000035685; ENSRNOP00000032751; ENSRNOG00000024903.
GeneID313089.
KEGGrno:313089.
UCSCRGD:1311633. rat.

Organism-specific databases

CTD157724.
RGD1311633. Slc7a13.

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00730000110456.
HOGENOMHOG000098892.
HOVERGENHBG000476.
InParanoidQ5RKI7.
KOK13870.
OMACSAEISI.
OrthoDBEOG7Z3F48.
PhylomeDBQ5RKI7.
TreeFamTF313355.

Gene expression databases

GenevestigatorQ5RKI7.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

NextBio665628.
PROQ5RKI7.

Entry information

Entry nameS7A13_RAT
AccessionPrimary (citable) accession number: Q5RKI7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families