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Protein

Solute carrier family 7 member 13

Gene

Slc7a13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 7 member 13
Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1
Gene namesi
Name:Slc7a13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311633. Slc7a13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini36 – 4712ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini69 – 8921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini111 – 12919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini151 – 16515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini187 – 20822ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini230 – 24213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini264 – 28926ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini311 – 33828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini360 – 3601ExtracellularSequence Analysis
Transmembranei361 – 38121Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini382 – 39615CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei397 – 41721Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini418 – 4236ExtracellularSequence Analysis
Transmembranei424 – 44421Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini445 – 47935CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Solute carrier family 7 member 13PRO_0000330727Add
BLAST

Proteomic databases

PRIDEiQ5RKI7.

PTM databases

PhosphoSiteiQ5RKI7.

Expressioni

Gene expression databases

GenevisibleiQ5RKI7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032751.

Structurei

3D structure databases

ProteinModelPortaliQ5RKI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ5RKI7.
KOiK13870.
OMAiKCLALAM.
OrthoDBiEOG7Z3F48.
PhylomeDBiQ5RKI7.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RKI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDIEKKIY LKRQLGYFWG TNFLIINIIG AGIFVSPKGV LQYSSMNVGV
60 70 80 90 100
SLCVWVFCAV LSMTSTLCAA EIGITFPYTV AHYYFLKRCF GPFVAFLRLW
110 120 130 140 150
TSLFTGPGVL ASQALLLAEY GIQPFYPSCS APAVPKKCLA LAMLWIVGIL
160 170 180 190 200
NSRGVKELSW LQTVSMVLKM GILSFISLSG LFLLVTGRKE NVRRLQNAFD
210 220 230 240 250
AEFPEVSRLI EAIFQGYFAF SGGGSFTYVA GELKEPSKTI PRCIFTALPL
260 270 280 290 300
VTVVYLLANL SYLTVLSPQE LLSSDAVALT WTDRVIPQLT WSVPFAISAS
310 320 330 340 350
LFSNLVTSVF ETSRTSYIAS RNGQLPLLCS TLNVHSSPFI AVLLDVSMGS
360 370 380 390 400
IAIVLTNLIE LINYLFFVFS IWTVLSVIGI LKLRYQEPNL HRPYKVFSPF
410 420 430 440 450
LFITAAISLS MVLIPLIKSP KMQYIYVFLF FLGGLLFYVP LIHFKLKLIW
460 470
FQKLTCYLQL LFNICIPDVS DEHVAEEES
Length:479
Mass (Da):53,551
Last modified:December 21, 2004 - v1
Checksum:i9EDA418E533B2B96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085796 mRNA. Translation: AAH85796.1.
RefSeqiNP_001012100.1. NM_001012100.1.
UniGeneiRn.22708.

Genome annotation databases

EnsembliENSRNOT00000035685; ENSRNOP00000032751; ENSRNOG00000024903.
GeneIDi313089.
KEGGirno:313089.
UCSCiRGD:1311633. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085796 mRNA. Translation: AAH85796.1.
RefSeqiNP_001012100.1. NM_001012100.1.
UniGeneiRn.22708.

3D structure databases

ProteinModelPortaliQ5RKI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032751.

PTM databases

PhosphoSiteiQ5RKI7.

Proteomic databases

PRIDEiQ5RKI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035685; ENSRNOP00000032751; ENSRNOG00000024903.
GeneIDi313089.
KEGGirno:313089.
UCSCiRGD:1311633. rat.

Organism-specific databases

CTDi157724.
RGDi1311633. Slc7a13.

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ5RKI7.
KOiK13870.
OMAiKCLALAM.
OrthoDBiEOG7Z3F48.
PhylomeDBiQ5RKI7.
TreeFamiTF313355.

Miscellaneous databases

NextBioi665628.
PROiQ5RKI7.

Gene expression databases

GenevisibleiQ5RKI7. RN.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS7A13_RAT
AccessioniPrimary (citable) accession number: Q5RKI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.