Q5RKI7 (S7A13_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 7 member 13

Alternative name(s):
Sodium-independent aspartate/glutamate transporter 1

Gene names

Name:

Slc7a13

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	amino acid transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Solute carrier family 7 member 13		PRO_0000330727
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 35	21	Helical; Name=1; Potential
	Topological domain	36 – 47	12	Extracellular Potential
	Transmembrane	48 – 68	21	Helical; Name=2; Potential
	Topological domain	69 – 89	21	Cytoplasmic Potential
	Transmembrane	90 – 110	21	Helical; Name=3; Potential
	Topological domain	111 – 129	19	Extracellular Potential
	Transmembrane	130 – 150	21	Helical; Name=4; Potential
	Topological domain	151 – 165	15	Cytoplasmic Potential
	Transmembrane	166 – 186	21	Helical; Name=5; Potential
	Topological domain	187 – 208	22	Extracellular Potential
	Transmembrane	209 – 229	21	Helical; Name=6; Potential
	Topological domain	230 – 242	13	Cytoplasmic Potential
	Transmembrane	243 – 263	21	Helical; Name=7; Potential
	Topological domain	264 – 289	26	Extracellular Potential
	Transmembrane	290 – 310	21	Helical; Name=8; Potential
	Topological domain	311 – 338	28	Cytoplasmic Potential
	Transmembrane	339 – 359	21	Helical; Name=9; Potential
	Topological domain	360	1	Extracellular Potential
	Transmembrane	361 – 381	21	Helical; Name=10; Potential
	Topological domain	382 – 396	15	Cytoplasmic Potential
	Transmembrane	397 – 417	21	Helical; Name=11; Potential
	Topological domain	418 – 423	6	Extracellular Potential
	Transmembrane	424 – 444	21	Helical; Name=12; Potential
	Topological domain	445 – 479	35	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5RKI7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 9EDA418E533B2B96	FASTA	479	53,551
	10 20 30 40 50 60 MAMDIEKKIY LKRQLGYFWG TNFLIINIIG AGIFVSPKGV LQYSSMNVGV SLCVWVFCAV 70 80 90 100 110 120 LSMTSTLCAA EIGITFPYTV AHYYFLKRCF GPFVAFLRLW TSLFTGPGVL ASQALLLAEY 130 140 150 160 170 180 GIQPFYPSCS APAVPKKCLA LAMLWIVGIL NSRGVKELSW LQTVSMVLKM GILSFISLSG 190 200 210 220 230 240 LFLLVTGRKE NVRRLQNAFD AEFPEVSRLI EAIFQGYFAF SGGGSFTYVA GELKEPSKTI 250 260 270 280 290 300 PRCIFTALPL VTVVYLLANL SYLTVLSPQE LLSSDAVALT WTDRVIPQLT WSVPFAISAS 310 320 330 340 350 360 LFSNLVTSVF ETSRTSYIAS RNGQLPLLCS TLNVHSSPFI AVLLDVSMGS IAIVLTNLIE 370 380 390 400 410 420 LINYLFFVFS IWTVLSVIGI LKLRYQEPNL HRPYKVFSPF LFITAAISLS MVLIPLIKSP 430 440 450 460 470 KMQYIYVFLF FLGGLLFYVP LIHFKLKLIW FQKLTCYLQL LFNICIPDVS DEHVAEEES

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085796 mRNA. Translation: AAH85796.1.
IPI	IPI00388452.
RefSeq	NP_001012100.1. NM_001012100.1.
UniGene	Rn.22708.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000032751.
PTM databases
PhosphoSite	Q5RKI7.
Proteomic databases
PRIDE	Q5RKI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000035685; ENSRNOP00000032751; ENSRNOG00000024903.
GeneID	313089.
KEGG	rno:313089.
UCSC	RGD:1311633. rat.
Organism-specific databases
CTD	157724.
RGD	1311633. Slc7a13.
Phylogenomic databases
eggNOG	COG0531.
GeneTree	ENSGT00690000101896.
HOGENOM	HOG000098892.
HOVERGEN	HBG000476.
InParanoid	Q5RKI7.
KO	K13870.
OMA	PFYPSCS.
OrthoDB	EOG4K9BC9.
Gene expression databases
Genevestigator	Q5RKI7.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. [Graphical view]
PANTHER	PTHR11785. PTHR11785. 1 hit.
PIRSF	PIRSF006060. AA_transporter. 1 hit.
ProtoNet	Search...
Other
NextBio	665628.

Entry information

Entry name

S7A13_RAT

Accession

Primary (citable) accession number: Q5RKI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program