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Protein

Probable RNA-binding protein EIF1AD

Gene

Eif1ad

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein EIF1AD
Alternative name(s):
Eukaryotic translation initiation factor 1A domain-containing protein
Gene namesi
Name:Eif1ad
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1304686. Eif1ad.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Probable RNA-binding protein EIF1ADPRO_0000314155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphothreonineBy similarity
Modified residuei131 – 1311PhosphoserineBy similarity
Modified residuei135 – 1351PhosphoserineCombined sources
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei159 – 1591PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5RKI6.
PRIDEiQ5RKI6.

PTM databases

iPTMnetiQ5RKI6.
PhosphoSiteiQ5RKI6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020463.
GenevisibleiQ5RKI6. RN.

Interactioni

Subunit structurei

Interacts with GAPDH and STAT1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027752.

Structurei

3D structure databases

ProteinModelPortaliQ5RKI6.
SMRiQ5RKI6. Positions 16-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8985S1-likePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi6 – 127Nuclear localization signalSequence analysis
Motifi56 – 6510Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 16512Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the EIF1AD family.Curated
Contains 1 S1-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2925. Eukaryota.
ENOG4111N6Z. LUCA.
GeneTreeiENSGT00390000011180.
HOGENOMiHOG000007486.
HOVERGENiHBG097893.
InParanoidiQ5RKI6.
KOiK15025.
OMAiHRQYHES.
OrthoDBiEOG091G0TN4.
PhylomeDBiQ5RKI6.
TreeFamiTF314439.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
[Graphical view]
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RKI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQASKRKHV VQEVLGEHMV PSDQQQIVKV LRTPGNNLHE VETAQGQRFL
60 70 80 90 100
VSMPSKYRKN IWIKRGDFLI VDPIEEGEKV KAEISFVLCK NHVRSLQKEG
110 120 130 140 150
HWPEAFSEVA EKQNNVNRES QPELPAEPQL SGEGSGSEDD SDLFVNTNHR
160
QYHESEEESE EEEEEAA
Length:167
Mass (Da):19,076
Last modified:December 21, 2004 - v1
Checksum:i855E53D9A5D4D8D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085818 mRNA. Translation: AAH85818.1.
RefSeqiNP_001008306.1. NM_001008305.1.
UniGeneiRn.4163.

Genome annotation databases

EnsembliENSRNOT00000027753; ENSRNOP00000027752; ENSRNOG00000020463.
GeneIDi293673.
KEGGirno:293673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085818 mRNA. Translation: AAH85818.1.
RefSeqiNP_001008306.1. NM_001008305.1.
UniGeneiRn.4163.

3D structure databases

ProteinModelPortaliQ5RKI6.
SMRiQ5RKI6. Positions 16-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027752.

PTM databases

iPTMnetiQ5RKI6.
PhosphoSiteiQ5RKI6.

Proteomic databases

PaxDbiQ5RKI6.
PRIDEiQ5RKI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027753; ENSRNOP00000027752; ENSRNOG00000020463.
GeneIDi293673.
KEGGirno:293673.

Organism-specific databases

CTDi84285.
RGDi1304686. Eif1ad.

Phylogenomic databases

eggNOGiKOG2925. Eukaryota.
ENOG4111N6Z. LUCA.
GeneTreeiENSGT00390000011180.
HOGENOMiHOG000007486.
HOVERGENiHBG097893.
InParanoidiQ5RKI6.
KOiK15025.
OMAiHRQYHES.
OrthoDBiEOG091G0TN4.
PhylomeDBiQ5RKI6.
TreeFamiTF314439.

Miscellaneous databases

PROiQ5RKI6.

Gene expression databases

BgeeiENSRNOG00000020463.
GenevisibleiQ5RKI6. RN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
[Graphical view]
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF1A_RAT
AccessioniPrimary (citable) accession number: Q5RKI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.