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Protein

WD repeat-containing protein 1

Gene

Wdr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Gene namesi
Name:Wdr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1305789. Wdr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 606605WD repeat-containing protein 1PRO_0000271365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei81 – 811N6-acetyllysineBy similarity
Modified residuei95 – 951N6-acetyllysineBy similarity
Modified residuei115 – 1151N6-acetyllysineBy similarity
Modified residuei238 – 2381PhosphotyrosineBy similarity
Modified residuei480 – 4801N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RKI0.
PRIDEiQ5RKI0.

2D gel databases

World-2DPAGE0004:Q5RKI0.

PTM databases

iPTMnetiQ5RKI0.
PhosphoSiteiQ5RKI0.
SwissPalmiQ5RKI0.

Expressioni

Gene expression databases

GenevisibleiQ5RKI0. RN.

Interactioni

Protein-protein interaction databases

BioGridi262322. 2 interactions.
STRINGi10116.ENSRNOP00000024012.

Structurei

3D structure databases

ProteinModelPortaliQ5RKI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati56 – 9540WD 1Add
BLAST
Repeati100 – 14344WD 2Add
BLAST
Repeati144 – 18441WD 3Add
BLAST
Repeati187 – 22640WD 4Add
BLAST
Repeati232 – 27140WD 5Add
BLAST
Repeati318 – 35942WD 6Add
BLAST
Repeati363 – 40139WD 7Add
BLAST
Repeati443 – 48240WD 8Add
BLAST
Repeati487 – 52640WD 9Add
BLAST
Repeati530 – 56940WD 10Add
BLAST
Repeati574 – 60633WD 11Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiQ5RKI0.
OMAiWDVGANS.
OrthoDBiEOG7TXKG1.
PhylomeDBiQ5RKI0.
TreeFamiTF300821.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RKI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KILGGDPKGD NFLYTNGKCV ILRNIDNPAV
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHILKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDTGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQNRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIFIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY
310 320 330 340 350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFS GKGHTNQVSR MTVDESGQLV SCSMDDTVRY TNLTLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AVGGSDGNVR VYSILGATLK DEGKLLEAKG PVTDLAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,181
Last modified:January 23, 2007 - v3
Checksum:i9A3A08A7235EE993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY986483 mRNA. Translation: AAX94056.1.
BC085864 mRNA. Translation: AAH85864.1.
RefSeqiNP_001014157.1. NM_001014135.1.
UniGeneiRn.3168.

Genome annotation databases

EnsembliENSRNOT00000024012; ENSRNOP00000024012; ENSRNOG00000028498.
GeneIDi360950.
KEGGirno:360950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY986483 mRNA. Translation: AAX94056.1.
BC085864 mRNA. Translation: AAH85864.1.
RefSeqiNP_001014157.1. NM_001014135.1.
UniGeneiRn.3168.

3D structure databases

ProteinModelPortaliQ5RKI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262322. 2 interactions.
STRINGi10116.ENSRNOP00000024012.

PTM databases

iPTMnetiQ5RKI0.
PhosphoSiteiQ5RKI0.
SwissPalmiQ5RKI0.

2D gel databases

World-2DPAGE0004:Q5RKI0.

Proteomic databases

PaxDbiQ5RKI0.
PRIDEiQ5RKI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024012; ENSRNOP00000024012; ENSRNOG00000028498.
GeneIDi360950.
KEGGirno:360950.

Organism-specific databases

CTDi9948.
RGDi1305789. Wdr1.

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiQ5RKI0.
OMAiWDVGANS.
OrthoDBiEOG7TXKG1.
PhylomeDBiQ5RKI0.
TreeFamiTF300821.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PROiQ5RKI0.

Gene expression databases

GenevisibleiQ5RKI0. RN.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human WDR1 interacts with actin and is involved in cell attachment and cytoskeletal rearrangement."
    Noone T.E., Hubberstey A.V.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 44-81; 127-147; 162-180; 204-219; 290-306 AND 490-534, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.
  4. "Subcellular localization of WD40 repeat 1 protein in PC12 rat pheochromocytoma cells."
    Shin D.H., Lee E., Chung Y.H., Mun G.H., Park J., Lomax M.I., Oh S.H.
    Neurosci. Lett. 367:399-403(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiWDR1_RAT
AccessioniPrimary (citable) accession number: Q5RKI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.