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Protein

Solute carrier family 35 member F6

Gene

Slc35f6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F6
Alternative name(s):
ANT2-binding protein
Short name:
ANT2BP
Transport and Golgi organization 9 homolog
Gene namesi
Name:Slc35f6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1309228. Slc35f6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31220HelicalSequence analysisAdd
BLAST
Transmembranei320 – 33617HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 372354Solute carrier family 35 member F6PRO_0000232517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Modified residuei366 – 3661PhosphothreonineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5RKH7.
PRIDEiQ5RKH7.

Expressioni

Gene expression databases

GenevisibleiQ5RKH7. RN.

Interactioni

Subunit structurei

Interacts with SLC25A5.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012558.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16056EamAAdd
BLAST

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated
Contains 1 EamA domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3912. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000017237.
HOGENOMiHOG000210249.
HOVERGENiHBG057690.
InParanoidiQ5RKH7.
OMAiKYQDNQC.
OrthoDBiEOG7JHM60.
PhylomeDBiQ5RKH7.
TreeFamiTF105890.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]
PIRSFiPIRSF036436. UCP036436. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RKH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FEAEGCGGSQ EHSFKHPFVQ
60 70 80 90 100
AVGMFLGEFS CLAAFYLLKC RARRQSDSSV EPRQPFNALL FLPPALCDMT
110 120 130 140 150
GTSIMYVALN MTSASSFQML RGAVIIFTGL FSVAFLDRRL VPSQWLGILI
160 170 180 190 200
TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD LLIIMAQIII AIQMVLEEKF
210 220 230 240 250
VYKHNIHPLQ AVGIEGFFGF VILSLLLVPM YYIPTASFSG NPRGVLEDAL
260 270 280 290 300
DAFCQVGRQP LIALALLGNI SSIAFFNFSG ISVTKELSAT TRMVLDTLRT
310 320 330 340 350
VVIWAFTLAL GWEVFHPLQI LGFLILLMGT ALYNGLHRPL LACLSRRWRH
360 370
PTQEGEQERL LGDSRTPINE TS
Length:372
Mass (Da):41,092
Last modified:December 21, 2004 - v1
Checksum:i47649083703DC568
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085904 mRNA. Translation: AAH85904.1.
RefSeqiNP_001017451.1. NM_001017451.1.
UniGeneiRn.41348.

Genome annotation databases

EnsembliENSRNOT00000012558; ENSRNOP00000012558; ENSRNOG00000009459.
GeneIDi298851.
KEGGirno:298851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085904 mRNA. Translation: AAH85904.1.
RefSeqiNP_001017451.1. NM_001017451.1.
UniGeneiRn.41348.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012558.

Proteomic databases

PaxDbiQ5RKH7.
PRIDEiQ5RKH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012558; ENSRNOP00000012558; ENSRNOG00000009459.
GeneIDi298851.
KEGGirno:298851.

Organism-specific databases

CTDi54978.
RGDi1309228. Slc35f6.

Phylogenomic databases

eggNOGiKOG3912. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000017237.
HOGENOMiHOG000210249.
HOVERGENiHBG057690.
InParanoidiQ5RKH7.
OMAiKYQDNQC.
OrthoDBiEOG7JHM60.
PhylomeDBiQ5RKH7.
TreeFamiTF105890.

Miscellaneous databases

NextBioi644393.
PROiQ5RKH7.

Gene expression databases

GenevisibleiQ5RKH7. RN.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]
PIRSFiPIRSF036436. UCP036436. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiS35F6_RAT
AccessioniPrimary (citable) accession number: Q5RKH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.