Serine/threonine-protein kinase PRP4 homolog

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Q5RKH1 (PRP4B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PRP4 homolog
EC=2.7.11.1

Alternative name(s):
PRP4 pre-mRNA-processing factor 4 homolog

Gene names

Name:

Prpf4b

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1007 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Identified in the spliceosome C complex By similarity. Interacts with Clk1 C-terminus By similarity.
Subcellular location	Nucleus By similarity.
Post-translational modification	Phosphorylated by Clk1 By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	catalytic step 2 spliceosome Inferred from electronic annotation. Source: Compara chromosome Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1007

1007

Serine/threonine-protein kinase PRP4 homolog

PRO_0000326140

Regions

Domain

687 – 1003

317

Protein kinase

Nucleotide binding

693 – 701

ATP By similarity

Compositional bias

40 – 496

457

Arg/Lys-rich (basic)

Compositional bias

41 – 78

His-rich

Sites

Active site

815

Proton acceptor By similarity

Binding site

717

ATP By similarity

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

141

Phosphotyrosine By similarity

Modified residue

143

Phosphoserine By similarity

Modified residue

145

Phosphoserine By similarity

Modified residue

240

Phosphoserine By similarity

Modified residue

242

Phosphoserine By similarity

Modified residue

258

Phosphoserine By similarity

Modified residue

278

Phosphoserine By similarity

Modified residue

292

Phosphoserine By similarity

Modified residue

294

Phosphoserine By similarity

Modified residue

328

Phosphoserine By similarity

Modified residue

354

Phosphoserine By similarity

Modified residue

356

Phosphoserine By similarity

Modified residue

366

Phosphoserine By similarity

Modified residue

368

Phosphoserine By similarity

Modified residue

385

Phosphothreonine By similarity

Modified residue

387

Phosphoserine By similarity

Modified residue

427

Phosphoserine By similarity

Modified residue

431

Phosphoserine By similarity

Modified residue

437

Phosphoserine By similarity

Modified residue

518

Phosphoserine By similarity

Modified residue

519

Phosphoserine By similarity

Modified residue

520

Phosphoserine By similarity

Modified residue

565

Phosphoserine By similarity

Modified residue

569

Phosphoserine By similarity

Modified residue

576

Phosphoserine By similarity

Modified residue

578

Phosphoserine By similarity

Modified residue

580

Phosphoserine By similarity

Modified residue

717

N6-acetyllysine By similarity

Modified residue

849

Phosphotyrosine By similarity

Modified residue

852

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q5RKH1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 310085987BA1549A
Show »

FASTA

1,007

117,007

        10         20         30         40         50         60 
MAATEPPSLR EQPEMDDADN SEKSVNEENG EVSEDQSQNK HSRHKKKKHK HRSKHKKHKH 

        70         80         90        100        110        120 
SSEEDRDKKH KHKHKHKKHK RKEVLDASDK EGLSPAKRTK LDDLALLEDL EKQRALIKAE 

       130        140        150        160        170        180 
LDNELMEGKV QSGMGLILQG YESGSEEEGE IHEKARNGNR SSTRSSSTRG KLEITDNKNS 

       190        200        210        220        230        240 
AKKRSKSRSK ERTRHRSDKR KSKGAVEMMR EKANRSKSKE RRKSKSPSKR SKSQDQARKS 

       250        260        270        280        290        300 
KSPTLRRRSQ EKVGKARSPA DEKIKSEEKG KIKDRKKSPI VNERSRDRSK KSKSPVDLRD 

       310        320        330        340        350        360 
KSKDRRSRSK ERKSKRSEID KEKKPIKSPS KDASSGKENR SPSRRPGRSP KRRSLSPKQR 

       370        380        390        400        410        420 
DKSRRSRSPL LNDRRSKQSK SPSRTLSPGR RAKSRSLERK RREPERRRLS SPRTRPRDDI 

       430        440        450        460        470        480 
LGRCERSKDA SPINRWSPSR RRSRSPIRRR SRSPLRRSRS PRRRSRSPRR RDRSRRSRSR 

       490        500        510        520        530        540 
LRRRSRSRGG HRRRSRSKVK EDKFKGSLSE GMKVEQESSS DDNLEDFDVE EEDEEAVIEQ 

       550        560        570        580        590        600 
RRIQRQAIVQ KYKYLAEDSN ISVPSEPSSP QSSTRSRSPS PDDILERVAA DVKEYERENV 

       610        620        630        640        650        660 
DTFEASVKAK HNLMTVEQNN GSSQKKLLAP DMFTESDDMF AAYFDSARLR AAGIGKDFKE 

       670        680        690        700        710        720 
NPNLRDNWTD AEGYYRVNIG EVLDKRYNVY GYTGQGVFSN VVRARDNARA NQEVAVKIIR 

       730        740        750        760        770        780 
NNELMQKTGL KELEFLKKLN DADPDDKFHC LRLFRHFYHK QHLCLVFEPL SMNLREVLKK 

       790        800        810        820        830        840 
YGKDVGLHIK AVRSYSQQLF LALKLLKRCN ILHADIKPDN ILVNESKTIL KLCDFGSASH 

       850        860        870        880        890        900 
VADNDITPYL VSRFYRAPEI IIGKSYDYGI DMWSVGCTLY ELYTGKILFP GKTNNHMLKL 

       910        920        930        940        950        960 
AMDLKGKMPN KMIRKGVFKD QHFDQNLNFM YIEVDKVTER EKVTVMSTIN PTKDLLADLI 

       970        980        990       1000 
GCQRLPEDQR KKVHQLKDLL DQILMLDPAK RISINQALQH AFIQEKI

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References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085927 mRNA. Translation: AAH85927.1.
IPI	IPI00362970.
RefSeq	NP_001011923.1. NM_001011923.1.
UniGene	Rn.32654.
3D structure databases
HSSP	HSSP built from PDB template 1Q99 based on UniProtKB Q03656.
ProteinModelPortal	Q5RKH1.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022902.
PTM databases
PhosphoSite	Q5RKH1.
Proteomic databases
PaxDb	Q5RKH1.
PRIDE	Q5RKH1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022902; ENSRNOP00000022902; ENSRNOG00000016705.
GeneID	291078.
KEGG	rno:291078.
UCSC	RGD:1307784. rat.
Organism-specific databases
CTD	8899.
RGD	1307784. Prpf4b.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00580000081366.
HOGENOM	HOG000043099.
HOVERGEN	HBG055182.
InParanoid	Q5RKH1.
KO	K08827.
OrthoDB	EOG4DV5KR.
Gene expression databases
ArrayExpress	Q5RKH1.
Genevestigator	Q5RKH1.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	632083.

Entry information

Entry name

PRP4B_RAT

Accession

Primary (citable) accession number: Q5RKH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents