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Protein

Tripartite motif-containing protein 35

Gene

Trim35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 6141RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri96 – 13742B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 35
Gene namesi
Name:Trim35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1564642. Trim35.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Tripartite motif-containing protein 35PRO_0000345147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RKG6.
PRIDEiQ5RKG6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012528.

Structurei

3D structure databases

ProteinModelPortaliQ5RKG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini284 – 495212B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili209 – 25244Sequence analysisAdd
BLAST

Domaini

The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.By similarity

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 6141RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri96 – 13742B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDQ6. Eukaryota.
ENOG410YB4K. LUCA.
HOGENOMiHOG000124586.
HOVERGENiHBG098569.
InParanoidiQ5RKG6.
KOiK12012.
PhylomeDBiQ5RKG6.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RKG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGPSVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRRCVSGCWE
60 70 80 90 100
VQTTPSCPVC KERAVPGELR TNHTLNNLVE TLLREEAEGA RWTGRRSPRP
110 120 130 140 150
CRAHRAPLTL FCVEDKELLC CACQADARHQ EHRVQPIKDT AQDFRAKCKN
160 170 180 190 200
MEHVLREKAK SFWALRRTYE AIAKHNEVQT TWLEGRIRDE FDKLRDFLRV
210 220 230 240 250
EEQATVDAMK EESRKKHLLA EEKMKQLAEQ TEALAREIER LQMEMKEDDM
260 270 280 290 300
TFLMKHKSRK RRLFCTVEPA PLQPGLLMDA CKYLESLQYR VWKKMLGSVE
310 320 330 340 350
SVPFSLDPNT AAGWLKVADD LTSVINHGYR VQVENPERFS SAPCLLGSQV
360 370 380 390 400
FSKGSHSWEV DVGGLPSWRV GVVRVQAHAQ AQAQADVGGE GHSHSCYHDT
410 420 430 440 450
RSGFWYLCRT QGVDGDHCMT SDTATAPLVQ AMPRRLRVEL ECEEGELSFY
460 470 480 490 500
DSERHCHLYT FHAHFGEVRP YFYLGASRGD GPPEPLRICH LRVSIKEELD

I
Length:501
Mass (Da):57,304
Last modified:December 21, 2004 - v1
Checksum:i5C3D6B7E051D82D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085942 mRNA. Translation: AAH85942.1.
BC094955 mRNA. Translation: AAH94955.1.
RefSeqiNP_001020313.2. NM_001025142.2.
UniGeneiRn.153980.

Genome annotation databases

GeneIDi498538.
KEGGirno:498538.
UCSCiRGD:1564642. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085942 mRNA. Translation: AAH85942.1.
BC094955 mRNA. Translation: AAH94955.1.
RefSeqiNP_001020313.2. NM_001025142.2.
UniGeneiRn.153980.

3D structure databases

ProteinModelPortaliQ5RKG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012528.

Proteomic databases

PaxDbiQ5RKG6.
PRIDEiQ5RKG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi498538.
KEGGirno:498538.
UCSCiRGD:1564642. rat.

Organism-specific databases

CTDi23087.
RGDi1564642. Trim35.

Phylogenomic databases

eggNOGiENOG410KDQ6. Eukaryota.
ENOG410YB4K. LUCA.
HOGENOMiHOG000124586.
HOVERGENiHBG098569.
InParanoidiQ5RKG6.
KOiK12012.
PhylomeDBiQ5RKG6.

Miscellaneous databases

NextBioi700099.
PROiQ5RKG6.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiTRI35_RAT
AccessioniPrimary (citable) accession number: Q5RKG6
Secondary accession number(s): Q4VBW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.