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Protein

Testis-specific H1 histone

Gene

H1fnt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, DNA condensation, Spermatogenesis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific H1 histone
Alternative name(s):
Haploid germ cell-specific nuclear protein 1
Histone H1t2
Gene namesi
Name:H1fnt
Synonyms:Hanp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1560024. H1fnt.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Testis-specific H1 histonePRO_0000343416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5RKG3.
PRIDEiQ5RKG3.

PTM databases

iPTMnetiQ5RKG3.
PhosphoSiteiQ5RKG3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046187.

Structurei

3D structure databases

ProteinModelPortaliQ5RKG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili292 – 33039Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 286150Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IX90. Eukaryota.
ENOG4111BIG. LUCA.
GeneTreeiENSGT00730000111596.
HOVERGENiHBG097311.
InParanoidiQ5RKG3.
OMAiGAELTIQ.
OrthoDBiEOG71K64P.
TreeFamiTF338403.

Sequencei

Sequence statusi: Complete.

Q5RKG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAQPTGE SQGAELTIQI QQPVERALRT PVRRGAQSVL RVSQLLLRAI
60 70 80 90 100
AGHQRLTLAA LKKELGNAGY EVRRKISSHQ AGDSTRSEKY TLLRVSGSDA
110 120 130 140 150
AGYFRVWKIS KPRRKAPRSR LTLGSHSHGK TVLKSPRPLR PRSRRKAAKK
160 170 180 190 200
AREVWRRKAR ALKARSRRAR SLARSMVRSR ASSRASSRAR SRARSRARSR
210 220 230 240 250
ARSRARSRAS SRARSSARSS ARSSARSSVR SSVRSSARSS ARSSIRSRAR
260 270 280 290 300
SRARTRARSR AKDLVRSKAR EQARTRAREQ AHARARTHDC VRAKAQEYVR
310 320 330 340 350
AKEQQYVSAK EQEYVRTKEQ ECAKAREQMR IGAMEEARIK AIDNRVQTTM
360 370 380 390 400
EDTSPWSTDE MRSRTKPREE KRQEPERPVK QTNQKPAVVK VDNAPSRQGK
410
TCTKSSTKSG HPGCSGTS
Length:418
Mass (Da):47,073
Last modified:December 21, 2004 - v1
Checksum:i9E66642D9B838588
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085950 mRNA. Translation: AAH85950.1.
RefSeqiNP_001019527.1. NM_001024356.1.
UniGeneiRn.123328.

Genome annotation databases

EnsembliENSRNOT00000046402; ENSRNOP00000046187; ENSRNOG00000029545.
GeneIDi500928.
KEGGirno:500928.
UCSCiRGD:1560024. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085950 mRNA. Translation: AAH85950.1.
RefSeqiNP_001019527.1. NM_001024356.1.
UniGeneiRn.123328.

3D structure databases

ProteinModelPortaliQ5RKG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046187.

PTM databases

iPTMnetiQ5RKG3.
PhosphoSiteiQ5RKG3.

Proteomic databases

PaxDbiQ5RKG3.
PRIDEiQ5RKG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046402; ENSRNOP00000046187; ENSRNOG00000029545.
GeneIDi500928.
KEGGirno:500928.
UCSCiRGD:1560024. rat.

Organism-specific databases

CTDi341567.
RGDi1560024. H1fnt.

Phylogenomic databases

eggNOGiENOG410IX90. Eukaryota.
ENOG4111BIG. LUCA.
GeneTreeiENSGT00730000111596.
HOVERGENiHBG097311.
InParanoidiQ5RKG3.
OMAiGAELTIQ.
OrthoDBiEOG71K64P.
TreeFamiTF338403.

Miscellaneous databases

NextBioi707692.
PROiQ5RKG3.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH1FNT_RAT
AccessioniPrimary (citable) accession number: Q5RKG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.