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Protein

Host cell factor 2

Gene

Hcfc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Host cell factor 2
Short name:
HCF-2
Alternative name(s):
C2 factor
Gene namesi
Name:Hcfc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307385 Hcfc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190741 – 723Host cell factor 2Add BLAST723

Proteomic databases

PaxDbiQ5RKG2
PRIDEiQ5RKG2

PTM databases

PhosphoSitePlusiQ5RKG2

Interactioni

Subunit structurei

Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014951

Structurei

3D structure databases

ProteinModelPortaliQ5RKG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 79Kelch 1Add BLAST46
Repeati83 – 130Kelch 2Add BLAST48
Repeati207 – 255Kelch 3Add BLAST49
Repeati257 – 305Kelch 4Add BLAST49
Domaini357 – 436Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST80
Domaini516 – 606Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini608 – 720Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4152 Eukaryota
ENOG410Y5AC LUCA
HOGENOMiHOG000021205
HOVERGENiHBG051889
InParanoidiQ5RKG2
KOiK14966

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.120.10.80, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR037932 HCFC2
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PANTHERiPTHR23244:SF325 PTHR23244:SF325, 2 hits
PfamiView protein in Pfam
PF01344 Kelch_1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

Sequencei

Sequence statusi: Complete.

Q5RKG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH
60 70 80 90 100
VYNTVTNQWF LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL
110 120 130 140 150
YELQASRWLW KKVKPQPPPS GLPPCPRLGH SFSLYGNKCY LFAGLANESE
160 170 180 190 200
DSNNNVPRYL NDFYELELQH GSGVVGWSVP ATKGTVPSPR ESHTAVIYCK
210 220 230 240 250
RDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT VPLPRSLHTA
260 270 280 290 300
SVIGNKMYIF GGWVPHKGEN TENSPHDCEW RCTSSFSYLN LDTAEWTTLV
310 320 330 340 350
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW
360 370 380 390 400
YLDTEKPPAP SQVQLIKATT NSFHVKWDEV PTVEGYLLQL NTDLTHQAAS
410 420 430 440 450
PDASAAPNTL GGRTDPHRQG SNSILHNSVS DPANCTKPEH TAVAARGMSL
460 470 480 490 500
KSKPDSRAAD SSVALHSPLA PNTSNNNSCM ADMLWKSEVD EICALPATKI
510 520 530 540 550
SRVEAHAAAT PFSKETPSNP VAILKAEQWC DVGIFKNNTA LVSQFYLLPK
560 570 580 590 600
GKQSMSKVGN ADVPDYSLLK KQDLVPGTVY KFRVAAINGC GIGPFSKLSE
610 620 630 640 650
FKTCIPGFPG APSTVRISKN VEGIHLSWEP PTSPSGNILE YSAYLAIRTA
660 670 680 690 700
QVQDNPSQLV FMRIYCGLKT SCIVTAGQLA NAHIDYTSRP AIVFRISAKN
710 720
EKGYGPATQV RWLQGNSKKA PLS
Length:723
Mass (Da):79,149
Last modified:December 21, 2004 - v1
Checksum:iFC09D7455BEEAD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085951 mRNA Translation: AAH85951.1
RefSeqiNP_001008358.1, NM_001008357.1
UniGeneiRn.90662

Genome annotation databases

GeneIDi314704
KEGGirno:314704
UCSCiRGD:1307385 rat

Similar proteinsi

Entry informationi

Entry nameiHCFC2_RAT
AccessioniPrimary (citable) accession number: Q5RKG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health