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Protein

Ribosome maturation protein SBDS

Gene

Sbds

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SBDS
Alternative name(s):
Shwachman-Bodian-Diamond syndrome protein homolog
Gene namesi
Name:Sbds
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311043. Sbds.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity
  • Nucleusnucleoplasm By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: Primarily detected in the cytoplasm, and at low levels in nucleus. Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 250249Ribosome maturation protein SBDSPRO_0000304733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei238 – 2381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RK30.
PRIDEiQ5RK30.

PTM databases

iPTMnetiQ5RK30.

Expressioni

Gene expression databases

GenevisibleiQ5RK30. RN.

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex consisting of 60S ribosomal subunit, SBDS and EFL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001190.

Structurei

3D structure databases

ProteinModelPortaliQ5RK30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

eggNOGiKOG2917. Eukaryota.
COG1500. LUCA.
GeneTreeiENSGT00390000008135.
HOGENOMiHOG000216685.
HOVERGENiHBG039762.
InParanoidiQ5RK30.
KOiK14574.
OMAiTIDSETR.
OrthoDBiEOG7XWPPD.
PhylomeDBiQ5RK30.
TreeFamiTF300881.

Family and domain databases

Gene3Di3.30.1250.10. 1 hit.
InterProiIPR018978. Ribosome_mat_SBDS_C.
IPR018023. Ribosome_mat_SBDS_CS.
IPR019783. Ribosome_mat_SBDS_N.
IPR002140. Sdo1/SBDS.
[Graphical view]
PfamiPF01172. SBDS. 1 hit.
PF09377. SBDS_C. 1 hit.
[Graphical view]
SUPFAMiSSF89895. SSF89895. 1 hit.
TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
PROSITEiPS01267. UPF0023. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RK30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFTPTNQI RLTNVAVVRM KRGGKRFEIA CYKNKVVGWR SGVEKDLDEV
60 70 80 90 100
LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER
110 120 130 140 150
HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKPNKST
160 170 180 190 200
KQQALEVIKQ LKEKMKIERA HMRLRFLLPV NEGKKLKEKL KPLMKVVESE
210 220 230 240 250
DYSQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLSLK DVEEGDEKFE
Length:250
Mass (Da):28,752
Last modified:December 21, 2004 - v1
Checksum:i31339F6BB478740A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086335 mRNA. Translation: AAH86335.1.
RefSeqiNP_001008290.1. NM_001008289.1.
UniGeneiRn.107123.

Genome annotation databases

EnsembliENSRNOT00000001190; ENSRNOP00000001190; ENSRNOG00000000888.
GeneIDi288615.
KEGGirno:288615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086335 mRNA. Translation: AAH86335.1.
RefSeqiNP_001008290.1. NM_001008289.1.
UniGeneiRn.107123.

3D structure databases

ProteinModelPortaliQ5RK30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001190.

PTM databases

iPTMnetiQ5RK30.

Proteomic databases

PaxDbiQ5RK30.
PRIDEiQ5RK30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001190; ENSRNOP00000001190; ENSRNOG00000000888.
GeneIDi288615.
KEGGirno:288615.

Organism-specific databases

CTDi51119.
RGDi1311043. Sbds.

Phylogenomic databases

eggNOGiKOG2917. Eukaryota.
COG1500. LUCA.
GeneTreeiENSGT00390000008135.
HOGENOMiHOG000216685.
HOVERGENiHBG039762.
InParanoidiQ5RK30.
KOiK14574.
OMAiTIDSETR.
OrthoDBiEOG7XWPPD.
PhylomeDBiQ5RK30.
TreeFamiTF300881.

Miscellaneous databases

PROiQ5RK30.

Gene expression databases

GenevisibleiQ5RK30. RN.

Family and domain databases

Gene3Di3.30.1250.10. 1 hit.
InterProiIPR018978. Ribosome_mat_SBDS_C.
IPR018023. Ribosome_mat_SBDS_CS.
IPR019783. Ribosome_mat_SBDS_N.
IPR002140. Sdo1/SBDS.
[Graphical view]
PfamiPF01172. SBDS. 1 hit.
PF09377. SBDS_C. 1 hit.
[Graphical view]
SUPFAMiSSF89895. SSF89895. 1 hit.
TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
PROSITEiPS01267. UPF0023. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiSBDS_RAT
AccessioniPrimary (citable) accession number: Q5RK30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.