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Q5RJY4 (DRS7B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dehydrogenase/reductase SDR family member 7B

EC=1.1.-.-
Gene names
Name:Dhrs7b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative oxidoreductase Potential.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein Ref.1 Ref.3.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

peroxisomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5RJY4-1)

Also known as: Dhrs7b.1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5RJY4-2)

Also known as: Dhrs7b.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Dehydrogenase/reductase SDR family member 7B
PRO_0000312108

Regions

Topological domain1 – 1717Cytoplasmic Potential
Transmembrane18 – 3821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain39 – 325287Lumenal Potential
Nucleotide binding56 – 8025NAD or NADP By similarity

Sites

Active site2071Proton acceptor By similarity
Binding site1941Substrate Potential

Natural variations

Alternative sequence1 – 99Missing in isoform 2.
VSP_029700

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Dhrs7b.1) [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: AFC1DEA2610F2D2D

FASTA32535,342
        10         20         30         40         50         60 
MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL RNAVVVVTGA 

        70         80         90        100        110        120 
TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS SSQGQTHQPC VVTFDLADPG 

       130        140        150        160        170        180 
AIAPAAAEIL QCFGYVDILI NNAGISYRGA ISDTIVDVDR KVMEINYFGP VALTKALLPS 

       190        200        210        220        230        240 
MVERKRGHIV AISSIQGKIS IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI 

       250        260        270        280        290        300 
HTNLSVNAVT ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI 

       310        320 
RTLAPRLFFR IMASRARKER KSKNS 

« Hide

Isoform 2 (Dhrs7b.2) [UniParc].

Checksum: 86AF3BA9E8C29D78
Show »

FASTA31634,398

References

« Hide 'large scale' references
[1]"Rat liver peroxisomes after fibrate treatment: a survey using quantitative mass spectrometry."
Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A.
J. Biol. Chem. 282:23055-23069(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary.
[3]"Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily."
Keller B., Meier M., Adamski J.
Mol. Cell. Endocrinol. 301:43-46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF445633 mRNA. Translation: ABO31120.1.
BC086453 mRNA. Translation: AAH86453.1.
RefSeqNP_001008507.1. NM_001008507.1. [Q5RJY4-1]
XP_006246532.1. XM_006246470.1. [Q5RJY4-2]
XP_006246533.1. XM_006246471.1. [Q5RJY4-2]
XP_006246534.1. XM_006246472.1. [Q5RJY4-2]
XP_006246535.1. XM_006246473.1. [Q5RJY4-2]
XP_006246536.1. XM_006246474.1. [Q5RJY4-2]
UniGeneRn.203124.

3D structure databases

ProteinModelPortalQ5RJY4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid252129. 1 interaction.
IntActQ5RJY4. 1 interaction.

Proteomic databases

PaxDbQ5RJY4.
PRIDEQ5RJY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360. [Q5RJY4-2]
GeneID287380.
KEGGrno:287380.
UCSCRGD:1311243. rat. [Q5RJY4-1]

Organism-specific databases

CTD25979.
RGD1311243. Dhrs7b.

Phylogenomic databases

eggNOGCOG1028.
GeneTreeENSGT00740000115336.
HOVERGENHBG107825.
InParanoidQ5RJY4.
KOK11166.
OrthoDBEOG7W6WM5.
PhylomeDBQ5RJY4.
TreeFamTF313474.

Gene expression databases

GenevestigatorQ5RJY4.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio625993.
PROQ5RJY4.

Entry information

Entry nameDRS7B_RAT
AccessionPrimary (citable) accession number: Q5RJY4
Secondary accession number(s): A4GWE3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families