Q5RJY4 (DRS7B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dehydrogenase/reductase SDR family member 7B
EC=1.1.-.-

Gene names

Name:

Dhrs7b

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative oxidoreductase Potential.
Subcellular location	Peroxisome membrane; Single-pass type II membrane protein Potential Ref.1.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Membrane Peroxisome
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peroxisomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5RJY4-1)

Also known as: Dhrs7b.1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5RJY4-2)

Also known as: Dhrs7b.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Dehydrogenase/reductase SDR family member 7B		PRO_0000312108
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	39 – 325	287	Peroxisomal Potential
	Nucleotide binding	56 – 80	25	NAD or NADP By similarity
Sites
	Active site	207	1	Proton acceptor By similarity
	Binding site	194	1	Substrate Potential
Natural variations
	Alternative sequence	1 – 9	9	Missing in isoform 2.		VSP_029700

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Dhrs7b.1) [UniParc]. Last modified December 21, 2004. Version 1. Checksum: AFC1DEA2610F2D2D	FASTA	325	35,342
	10 20 30 40 50 60 MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL RNAVVVVTGA 70 80 90 100 110 120 TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS SSQGQTHQPC VVTFDLADPG 130 140 150 160 170 180 AIAPAAAEIL QCFGYVDILI NNAGISYRGA ISDTIVDVDR KVMEINYFGP VALTKALLPS 190 200 210 220 230 240 MVERKRGHIV AISSIQGKIS IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI 250 260 270 280 290 300 HTNLSVNAVT ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI 310 320 RTLAPRLFFR IMASRARKER KSKNS
	Isoform 2 (Dhrs7b.2) [UniParc]. Checksum: 86AF3BA9E8C29D78	FASTA	316	34,398
	10 20 30 40 50 60 MLKERAMDLV TQTTILPLLF GCLGIFSLFR LLQRTRSKAY LRNAVVVVTG ATSGLGKECA 70 80 90 100 110 120 RVFHAAGAKV VLCGRNVKAL EEFTRELADS SSSQGQTHQP CVVTFDLADP GAIAPAAAEI 130 140 150 160 170 180 LQCFGYVDIL INNAGISYRG AISDTIVDVD RKVMEINYFG PVALTKALLP SMVERKRGHI 190 200 210 220 230 240 VAISSIQGKI SIPFRSAYAA SKHATQAFFD CLRAEMKDSD IEVTVISPGY IHTNLSVNAV 250 260 270 280 290 300 TADGSRYGAL DKNTAQGRSA VEVAQDIFDA VGKKKKDVLL TDFLPTMAVY IRTLAPRLFF 310 RIMASRARKE RKSKNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rat liver peroxisomes after fibrate treatment: a survey using quantitative mass spectrometry." Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A. J. Biol. Chem. 282:23055-23069(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF445633 mRNA. Translation: ABO31120.1. BC086453 mRNA. Translation: AAH86453.1.
IPI	IPI00369545. IPI00877375.
RefSeq	NP_001008507.1. NM_001008507.1.
UniGene	Rn.203124.
3D structure databases
HSSP	HSSP built from PDB template 1XU9 based on UniProtKB P28845.
ProteinModelPortal	Q5RJY4.
ModBase	Search...
Proteomic databases
PaxDb	Q5RJY4.
PRIDE	Q5RJY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360.
GeneID	287380.
KEGG	rno:287380.
UCSC	RGD:1311243. rat.
Organism-specific databases
CTD	25979.
RGD	1311243. Dhrs7b.
Phylogenomic databases
eggNOG	COG1028.
GeneTree	ENSGT00650000092907.
HOVERGEN	HBG107825.
InParanoid	Q5RJY4.
KO	K11166.
Gene expression databases
ArrayExpress	Q5RJY4.
Genevestigator	Q5RJY4.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	625993.

Entry information

Entry name

DRS7B_RAT

Accession

Primary (citable) accession number: Q5RJY4
Secondary accession number(s): A4GWE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program