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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941SubstrateSequence Analysis
Active sitei207 – 2071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 1By similarity
Gene namesi
Name:Dhrs7b
Synonyms:Sdr32c1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1311243. Dhrs7b.

Subcellular locationi

Endoplasmic reticulum membrane 2 Publications; Single-pass type II membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini39 – 325287LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Dehydrogenase/reductase SDR family member 7BPRO_0000312108Add
BLAST

Proteomic databases

PaxDbiQ5RJY4.
PRIDEiQ5RJY4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5RJY4. baseline.
GenevestigatoriQ5RJY4.

Interactioni

Protein-protein interaction databases

BioGridi252129. 1 interaction.
IntActiQ5RJY4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5RJY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00770000120481.
HOVERGENiHBG107825.
InParanoidiQ5RJY4.
KOiK11166.
OrthoDBiEOG7W6WM5.
PhylomeDBiQ5RJY4.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RJY4-1) [UniParc]FASTAAdd to basket

Also known as: Dhrs7b.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS
110 120 130 140 150
SSQGQTHQPC VVTFDLADPG AIAPAAAEIL QCFGYVDILI NNAGISYRGA
160 170 180 190 200
ISDTIVDVDR KVMEINYFGP VALTKALLPS MVERKRGHIV AISSIQGKIS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI HTNLSVNAVT
260 270 280 290 300
ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI
310 320
RTLAPRLFFR IMASRARKER KSKNS
Length:325
Mass (Da):35,342
Last modified:December 21, 2004 - v1
Checksum:iAFC1DEA2610F2D2D
GO
Isoform 2 (identifier: Q5RJY4-2) [UniParc]FASTAAdd to basket

Also known as: Dhrs7b.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:316
Mass (Da):34,398
Checksum:i86AF3BA9E8C29D78
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99Missing in isoform 2. 1 PublicationVSP_029700

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF445633 mRNA. Translation: ABO31120.1.
BC086453 mRNA. Translation: AAH86453.1.
RefSeqiNP_001008507.1. NM_001008507.1. [Q5RJY4-1]
XP_006246534.1. XM_006246472.2. [Q5RJY4-2]
XP_006246535.1. XM_006246473.2. [Q5RJY4-2]
XP_006246536.1. XM_006246474.2. [Q5RJY4-2]
XP_008766008.1. XM_008767786.1. [Q5RJY4-2]
UniGeneiRn.203124.

Genome annotation databases

EnsembliENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360. [Q5RJY4-2]
GeneIDi287380.
KEGGirno:287380.
UCSCiRGD:1311243. rat. [Q5RJY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF445633 mRNA. Translation: ABO31120.1.
BC086453 mRNA. Translation: AAH86453.1.
RefSeqiNP_001008507.1. NM_001008507.1. [Q5RJY4-1]
XP_006246534.1. XM_006246472.2. [Q5RJY4-2]
XP_006246535.1. XM_006246473.2. [Q5RJY4-2]
XP_006246536.1. XM_006246474.2. [Q5RJY4-2]
XP_008766008.1. XM_008767786.1. [Q5RJY4-2]
UniGeneiRn.203124.

3D structure databases

ProteinModelPortaliQ5RJY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252129. 1 interaction.
IntActiQ5RJY4. 1 interaction.

Proteomic databases

PaxDbiQ5RJY4.
PRIDEiQ5RJY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360. [Q5RJY4-2]
GeneIDi287380.
KEGGirno:287380.
UCSCiRGD:1311243. rat. [Q5RJY4-1]

Organism-specific databases

CTDi25979.
RGDi1311243. Dhrs7b.

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00770000120481.
HOVERGENiHBG107825.
InParanoidiQ5RJY4.
KOiK11166.
OrthoDBiEOG7W6WM5.
PhylomeDBiQ5RJY4.
TreeFamiTF313474.

Miscellaneous databases

NextBioi625993.
PROiQ5RJY4.

Gene expression databases

ExpressionAtlasiQ5RJY4. baseline.
GenevestigatoriQ5RJY4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rat liver peroxisomes after fibrate treatment: a survey using quantitative mass spectrometry."
    Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A.
    J. Biol. Chem. 282:23055-23069(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  3. "Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily."
    Keller B., Meier M., Adamski J.
    Mol. Cell. Endocrinol. 301:43-46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDRS7B_RAT
AccessioniPrimary (citable) accession number: Q5RJY4
Secondary accession number(s): A4GWE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: April 1, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.