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Q5RJY4

- DRS7B_RAT

UniProt

Q5RJY4 - DRS7B_RAT

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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941SubstrateSequence Analysis
Active sitei207 – 2071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Gene namesi
Name:Dhrs7b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1311243. Dhrs7b.

Subcellular locationi

Endoplasmic reticulum membrane 2 Publications; Single-pass type II membrane protein 2 Publications

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Dehydrogenase/reductase SDR family member 7BPRO_0000312108Add
BLAST

Proteomic databases

PaxDbiQ5RJY4.
PRIDEiQ5RJY4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5RJY4. baseline.
GenevestigatoriQ5RJY4.

Interactioni

Protein-protein interaction databases

BioGridi252129. 1 interaction.
IntActiQ5RJY4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5RJY4.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini39 – 325287LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118798.
HOVERGENiHBG107825.
InParanoidiQ5RJY4.
KOiK11166.
OrthoDBiEOG7W6WM5.
PhylomeDBiQ5RJY4.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5RJY4-1) [UniParc]FASTAAdd to Basket

Also known as: Dhrs7b.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS
110 120 130 140 150
SSQGQTHQPC VVTFDLADPG AIAPAAAEIL QCFGYVDILI NNAGISYRGA
160 170 180 190 200
ISDTIVDVDR KVMEINYFGP VALTKALLPS MVERKRGHIV AISSIQGKIS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI HTNLSVNAVT
260 270 280 290 300
ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI
310 320
RTLAPRLFFR IMASRARKER KSKNS
Length:325
Mass (Da):35,342
Last modified:December 21, 2004 - v1
Checksum:iAFC1DEA2610F2D2D
GO
Isoform 2 (identifier: Q5RJY4-2) [UniParc]FASTAAdd to Basket

Also known as: Dhrs7b.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:316
Mass (Da):34,398
Checksum:i86AF3BA9E8C29D78
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99Missing in isoform 2. 1 PublicationVSP_029700

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF445633 mRNA. Translation: ABO31120.1.
BC086453 mRNA. Translation: AAH86453.1.
RefSeqiNP_001008507.1. NM_001008507.1. [Q5RJY4-1]
XP_006246534.1. XM_006246472.2. [Q5RJY4-2]
XP_006246535.1. XM_006246473.2. [Q5RJY4-2]
XP_006246536.1. XM_006246474.2. [Q5RJY4-2]
UniGeneiRn.203124.

Genome annotation databases

EnsembliENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360. [Q5RJY4-2]
GeneIDi287380.
KEGGirno:287380.
UCSCiRGD:1311243. rat. [Q5RJY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF445633 mRNA. Translation: ABO31120.1 .
BC086453 mRNA. Translation: AAH86453.1 .
RefSeqi NP_001008507.1. NM_001008507.1. [Q5RJY4-1 ]
XP_006246534.1. XM_006246472.2. [Q5RJY4-2 ]
XP_006246535.1. XM_006246473.2. [Q5RJY4-2 ]
XP_006246536.1. XM_006246474.2. [Q5RJY4-2 ]
UniGenei Rn.203124.

3D structure databases

ProteinModelPortali Q5RJY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 252129. 1 interaction.
IntActi Q5RJY4. 1 interaction.

Proteomic databases

PaxDbi Q5RJY4.
PRIDEi Q5RJY4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000066250 ; ENSRNOP00000063346 ; ENSRNOG00000005360 . [Q5RJY4-2 ]
GeneIDi 287380.
KEGGi rno:287380.
UCSCi RGD:1311243. rat. [Q5RJY4-1 ]

Organism-specific databases

CTDi 25979.
RGDi 1311243. Dhrs7b.

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00760000118798.
HOVERGENi HBG107825.
InParanoidi Q5RJY4.
KOi K11166.
OrthoDBi EOG7W6WM5.
PhylomeDBi Q5RJY4.
TreeFami TF313474.

Miscellaneous databases

NextBioi 625993.
PROi Q5RJY4.

Gene expression databases

ExpressionAtlasi Q5RJY4. baseline.
Genevestigatori Q5RJY4.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rat liver peroxisomes after fibrate treatment: a survey using quantitative mass spectrometry."
    Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A.
    J. Biol. Chem. 282:23055-23069(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  3. "Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily."
    Keller B., Meier M., Adamski J.
    Mol. Cell. Endocrinol. 301:43-46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDRS7B_RAT
AccessioniPrimary (citable) accession number: Q5RJY4
Secondary accession number(s): A4GWE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3