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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei194SubstrateSequence analysis1
Active sitei207Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 80NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 1By similarity
Gene namesi
Name:Dhrs7b
Synonyms:Sdr32c1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1311243 Dhrs7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 325LumenalSequence analysisAdd BLAST287

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121081 – 325Dehydrogenase/reductase SDR family member 7BAdd BLAST325

Proteomic databases

PaxDbiQ5RJY4
PRIDEiQ5RJY4

Expressioni

Gene expression databases

BgeeiENSRNOG00000005360
GenevisibleiQ5RJY4 RN

Interactioni

Protein-protein interaction databases

BioGridi252129, 1 interactor
IntActiQ5RJY4, 1 interactor
STRINGi10116.ENSRNOP00000063744

Structurei

3D structure databases

ProteinModelPortaliQ5RJY4
SMRiQ5RJY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000143991
HOVERGENiHBG107825
InParanoidiQ5RJY4
KOiK11166
OMAiSMIKRRQ
OrthoDBiEOG091G0BO9
PhylomeDBiQ5RJY4
TreeFamiTF313474

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RJY4-1) [UniParc]FASTAAdd to basket
Also known as: Dhrs7b.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS
110 120 130 140 150
SSQGQTHQPC VVTFDLADPG AIAPAAAEIL QCFGYVDILI NNAGISYRGA
160 170 180 190 200
ISDTIVDVDR KVMEINYFGP VALTKALLPS MVERKRGHIV AISSIQGKIS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI HTNLSVNAVT
260 270 280 290 300
ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI
310 320
RTLAPRLFFR IMASRARKER KSKNS
Length:325
Mass (Da):35,342
Last modified:December 21, 2004 - v1
Checksum:iAFC1DEA2610F2D2D
GO
Isoform 2 (identifier: Q5RJY4-2) [UniParc]FASTAAdd to basket
Also known as: Dhrs7b.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:316
Mass (Da):34,398
Checksum:i86AF3BA9E8C29D78
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297001 – 9Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF445633 mRNA Translation: ABO31120.1
BC086453 mRNA Translation: AAH86453.1
RefSeqiNP_001008507.1, NM_001008507.1 [Q5RJY4-1]
XP_006246534.1, XM_006246472.3 [Q5RJY4-2]
XP_006246535.1, XM_006246473.3 [Q5RJY4-2]
XP_006246536.1, XM_006246474.3 [Q5RJY4-2]
UniGeneiRn.203124

Genome annotation databases

EnsembliENSRNOT00000065294; ENSRNOP00000063744; ENSRNOG00000005360 [Q5RJY4-2]
ENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360 [Q5RJY4-1]
ENSRNOT00000077868; ENSRNOP00000071925; ENSRNOG00000005360 [Q5RJY4-2]
GeneIDi287380
KEGGirno:287380
UCSCiRGD:1311243 rat [Q5RJY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDRS7B_RAT
AccessioniPrimary (citable) accession number: Q5RJY4
Secondary accession number(s): A4GWE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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