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Q5RJY4

- DRS7B_RAT

UniProt

Q5RJY4 - DRS7B_RAT

Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Putative oxidoreductase.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei194 – 1941SubstrateSequence Analysis
    Active sitei207 – 2071Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
    Gene namesi
    Name:Dhrs7b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1311243. Dhrs7b.

    Subcellular locationi

    Endoplasmic reticulum membrane 2 Publications; Single-pass type II membrane protein 2 Publications

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Dehydrogenase/reductase SDR family member 7BPRO_0000312108Add
    BLAST

    Proteomic databases

    PaxDbiQ5RJY4.
    PRIDEiQ5RJY4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5RJY4.

    Interactioni

    Protein-protein interaction databases

    BioGridi252129. 1 interaction.
    IntActiQ5RJY4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RJY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 325287LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    GeneTreeiENSGT00740000115336.
    HOVERGENiHBG107825.
    InParanoidiQ5RJY4.
    KOiK11166.
    OrthoDBiEOG7W6WM5.
    PhylomeDBiQ5RJY4.
    TreeFamiTF313474.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5RJY4-1) [UniParc]FASTAAdd to Basket

    Also known as: Dhrs7b.1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL    50
    RNAVVVVTGA TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS 100
    SSQGQTHQPC VVTFDLADPG AIAPAAAEIL QCFGYVDILI NNAGISYRGA 150
    ISDTIVDVDR KVMEINYFGP VALTKALLPS MVERKRGHIV AISSIQGKIS 200
    IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI HTNLSVNAVT 250
    ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI 300
    RTLAPRLFFR IMASRARKER KSKNS 325
    Length:325
    Mass (Da):35,342
    Last modified:December 21, 2004 - v1
    Checksum:iAFC1DEA2610F2D2D
    GO
    Isoform 2 (identifier: Q5RJY4-2) [UniParc]FASTAAdd to Basket

    Also known as: Dhrs7b.2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:316
    Mass (Da):34,398
    Checksum:i86AF3BA9E8C29D78
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99Missing in isoform 2. 1 PublicationVSP_029700

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF445633 mRNA. Translation: ABO31120.1.
    BC086453 mRNA. Translation: AAH86453.1.
    RefSeqiNP_001008507.1. NM_001008507.1. [Q5RJY4-1]
    XP_006246532.1. XM_006246470.1. [Q5RJY4-2]
    XP_006246533.1. XM_006246471.1. [Q5RJY4-2]
    XP_006246534.1. XM_006246472.1. [Q5RJY4-2]
    XP_006246535.1. XM_006246473.1. [Q5RJY4-2]
    XP_006246536.1. XM_006246474.1. [Q5RJY4-2]
    UniGeneiRn.203124.

    Genome annotation databases

    EnsembliENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360. [Q5RJY4-2]
    GeneIDi287380.
    KEGGirno:287380.
    UCSCiRGD:1311243. rat. [Q5RJY4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF445633 mRNA. Translation: ABO31120.1 .
    BC086453 mRNA. Translation: AAH86453.1 .
    RefSeqi NP_001008507.1. NM_001008507.1. [Q5RJY4-1 ]
    XP_006246532.1. XM_006246470.1. [Q5RJY4-2 ]
    XP_006246533.1. XM_006246471.1. [Q5RJY4-2 ]
    XP_006246534.1. XM_006246472.1. [Q5RJY4-2 ]
    XP_006246535.1. XM_006246473.1. [Q5RJY4-2 ]
    XP_006246536.1. XM_006246474.1. [Q5RJY4-2 ]
    UniGenei Rn.203124.

    3D structure databases

    ProteinModelPortali Q5RJY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 252129. 1 interaction.
    IntActi Q5RJY4. 1 interaction.

    Proteomic databases

    PaxDbi Q5RJY4.
    PRIDEi Q5RJY4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000066250 ; ENSRNOP00000063346 ; ENSRNOG00000005360 . [Q5RJY4-2 ]
    GeneIDi 287380.
    KEGGi rno:287380.
    UCSCi RGD:1311243. rat. [Q5RJY4-1 ]

    Organism-specific databases

    CTDi 25979.
    RGDi 1311243. Dhrs7b.

    Phylogenomic databases

    eggNOGi COG1028.
    GeneTreei ENSGT00740000115336.
    HOVERGENi HBG107825.
    InParanoidi Q5RJY4.
    KOi K11166.
    OrthoDBi EOG7W6WM5.
    PhylomeDBi Q5RJY4.
    TreeFami TF313474.

    Miscellaneous databases

    NextBioi 625993.
    PROi Q5RJY4.

    Gene expression databases

    Genevestigatori Q5RJY4.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat liver peroxisomes after fibrate treatment: a survey using quantitative mass spectrometry."
      Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A.
      J. Biol. Chem. 282:23055-23069(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ovary.
    3. "Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily."
      Keller B., Meier M., Adamski J.
      Mol. Cell. Endocrinol. 301:43-46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDRS7B_RAT
    AccessioniPrimary (citable) accession number: Q5RJY4
    Secondary accession number(s): A4GWE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3