Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei194SubstrateSequence analysis1
Active sitei207Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 80NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 1By similarity
Gene namesi
Name:Dhrs7b
Synonyms:Sdr32c1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1311243. Dhrs7b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 325LumenalSequence analysisAdd BLAST287

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121081 – 325Dehydrogenase/reductase SDR family member 7BAdd BLAST325

Proteomic databases

PaxDbiQ5RJY4.
PRIDEiQ5RJY4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005360.
GenevisibleiQ5RJY4. RN.

Interactioni

Protein-protein interaction databases

BioGridi252129. 1 interactor.
IntActiQ5RJY4. 1 interactor.
STRINGi10116.ENSRNOP00000063744.

Structurei

3D structure databases

ProteinModelPortaliQ5RJY4.
SMRiQ5RJY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00900000140775.
HOVERGENiHBG107825.
InParanoidiQ5RJY4.
KOiK11166.
OMAiSMIKRRQ.
OrthoDBiEOG091G0BO9.
PhylomeDBiQ5RJY4.
TreeFamiTF313474.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RJY4-1) [UniParc]FASTAAdd to basket
Also known as: Dhrs7b.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPSSRKGM LKERAMDLVT QTTILPLLFG CLGIFSLFRL LQRTRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGKECAR VFHAAGAKVV LCGRNVKALE EFTRELADSS
110 120 130 140 150
SSQGQTHQPC VVTFDLADPG AIAPAAAEIL QCFGYVDILI NNAGISYRGA
160 170 180 190 200
ISDTIVDVDR KVMEINYFGP VALTKALLPS MVERKRGHIV AISSIQGKIS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMKDSDI EVTVISPGYI HTNLSVNAVT
260 270 280 290 300
ADGSRYGALD KNTAQGRSAV EVAQDIFDAV GKKKKDVLLT DFLPTMAVYI
310 320
RTLAPRLFFR IMASRARKER KSKNS
Length:325
Mass (Da):35,342
Last modified:December 21, 2004 - v1
Checksum:iAFC1DEA2610F2D2D
GO
Isoform 2 (identifier: Q5RJY4-2) [UniParc]FASTAAdd to basket
Also known as: Dhrs7b.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:316
Mass (Da):34,398
Checksum:i86AF3BA9E8C29D78
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297001 – 9Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF445633 mRNA. Translation: ABO31120.1.
BC086453 mRNA. Translation: AAH86453.1.
RefSeqiNP_001008507.1. NM_001008507.1. [Q5RJY4-1]
XP_006246534.1. XM_006246472.3. [Q5RJY4-2]
XP_006246535.1. XM_006246473.3. [Q5RJY4-2]
XP_006246536.1. XM_006246474.3. [Q5RJY4-2]
UniGeneiRn.203124.

Genome annotation databases

EnsembliENSRNOT00000065294; ENSRNOP00000063744; ENSRNOG00000005360. [Q5RJY4-2]
ENSRNOT00000066250; ENSRNOP00000063346; ENSRNOG00000005360. [Q5RJY4-1]
ENSRNOT00000077868; ENSRNOP00000071925; ENSRNOG00000005360. [Q5RJY4-2]
GeneIDi287380.
KEGGirno:287380.
UCSCiRGD:1311243. rat. [Q5RJY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDRS7B_RAT
AccessioniPrimary (citable) accession number: Q5RJY4
Secondary accession number(s): A4GWE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families