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Protein

Leucine-rich repeat-containing protein 59

Gene

Lrrc59

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 59
Alternative name(s):
Protein p34
Cleaved into the following chain:
Gene namesi
Name:Lrrc59
Synonyms:Rbp34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305092 Lrrc59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 244CytoplasmicSequence analysisAdd BLAST243
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 307LumenalSequence analysisAdd BLAST42

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004417411 – 307Leucine-rich repeat-containing protein 59Add BLAST307
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00002351612 – 307Leucine-rich repeat-containing protein 59, N-terminally processedAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Leucine-rich repeat-containing protein 59, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei73N6-succinyllysineBy similarity1
Modified residuei135N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RJR8
PRIDEiQ5RJR8

PTM databases

iPTMnetiQ5RJR8
PhosphoSitePlusiQ5RJR8

Expressioni

Gene expression databases

BgeeiENSRNOG00000003524
GenevisibleiQ5RJR8 RN

Interactioni

Subunit structurei

Can form homodimers. Interacts with SGO1. Interacts with FGF1.By similarity

Protein-protein interaction databases

BioGridi252266, 1 interactor
STRINGi10116.ENSRNOP00000004941

Structurei

3D structure databases

ProteinModelPortaliQ5RJR8
SMRiQ5RJR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 31LRR 1Add BLAST22
Repeati40 – 62LRR 2Add BLAST23
Repeati63 – 84LRR 3Add BLAST22
Repeati86 – 107LRR 4Add BLAST22
Repeati109 – 128LRR 5Add BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili148 – 216Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi251 – 257Poly-Leu7

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0473 Eukaryota
ENOG4111GH4 LUCA
GeneTreeiENSGT00390000017385
HOGENOMiHOG000073534
HOVERGENiHBG081933
InParanoidiQ5RJR8
OMAiKAAGDCL
OrthoDBiEOG091G0EHN
PhylomeDBiQ5RJR8
TreeFamiTF316929

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RJR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATVLDLSCNK
60 70 80 90 100
LSTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNRLVTL
110 120 130 140 150
PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA
160 170 180 190 200
VQADQERERQ RRLEVEREAE KKREAKQQAK EAKERELRKR EKAEEKERRR
210 220 230 240 250
KEYDAQKASK REQEKKPKKE TNQAPKSKSG SRPRKPPPRK HNRSWAVLKG
260 270 280 290 300
LLLLLLLCVA GGLVVCRVTG LQQQPLCTSV NAIYDNAVQG LRHHEILQWV

LQTDSQQ
Length:307
Mass (Da):34,869
Last modified:December 21, 2004 - v1
Checksum:iBCAD25C593C1FE89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13623 mRNA Translation: BAA02786.1
BC086530 mRNA Translation: AAH86530.1
RefSeqiNP_001008281.1, NM_001008280.1
UniGeneiRn.2783

Genome annotation databases

EnsembliENSRNOT00000004941; ENSRNOP00000004941; ENSRNOG00000003524
GeneIDi287633
KEGGirno:287633
UCSCiRGD:1305092 rat

Similar proteinsi

Entry informationi

Entry nameiLRC59_RAT
AccessioniPrimary (citable) accession number: Q5RJR8
Secondary accession number(s): Q63742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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