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Protein

Leucine-rich repeat-containing protein 59

Gene

Lrrc59

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 59
Alternative name(s):
Protein p34
Gene namesi
Name:Lrrc59
Synonyms:Rbp34
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305092. Lrrc59.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 244CytoplasmicSequence analysisAdd BLAST244
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 307LumenalSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002351611 – 307Leucine-rich repeat-containing protein 59Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei73N6-succinyllysineBy similarity1
Modified residuei135N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5RJR8.
PRIDEiQ5RJR8.

PTM databases

iPTMnetiQ5RJR8.
PhosphoSitePlusiQ5RJR8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003524.
GenevisibleiQ5RJR8. RN.

Interactioni

Subunit structurei

Can form homodimers. Interacts with SGO1. Interacts with FGF1.By similarity

Protein-protein interaction databases

BioGridi252266. 1 interactor.
MINTiMINT-4580716.
STRINGi10116.ENSRNOP00000004941.

Structurei

3D structure databases

ProteinModelPortaliQ5RJR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 31LRR 1Add BLAST22
Repeati40 – 62LRR 2Add BLAST23
Repeati63 – 84LRR 3Add BLAST22
Repeati86 – 107LRR 4Add BLAST22
Repeati109 – 128LRR 5Add BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili148 – 216Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi251 – 257Poly-Leu7

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0473. Eukaryota.
ENOG4111GH4. LUCA.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000073534.
HOVERGENiHBG081933.
InParanoidiQ5RJR8.
OMAiDILQWVL.
OrthoDBiEOG091G0EHN.
PhylomeDBiQ5RJR8.
TreeFamiTF316929.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RJR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATVLDLSCNK
60 70 80 90 100
LSTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNRLVTL
110 120 130 140 150
PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA
160 170 180 190 200
VQADQERERQ RRLEVEREAE KKREAKQQAK EAKERELRKR EKAEEKERRR
210 220 230 240 250
KEYDAQKASK REQEKKPKKE TNQAPKSKSG SRPRKPPPRK HNRSWAVLKG
260 270 280 290 300
LLLLLLLCVA GGLVVCRVTG LQQQPLCTSV NAIYDNAVQG LRHHEILQWV

LQTDSQQ
Length:307
Mass (Da):34,869
Last modified:December 21, 2004 - v1
Checksum:iBCAD25C593C1FE89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13623 mRNA. Translation: BAA02786.1.
BC086530 mRNA. Translation: AAH86530.1.
RefSeqiNP_001008281.1. NM_001008280.1.
UniGeneiRn.2783.

Genome annotation databases

EnsembliENSRNOT00000004941; ENSRNOP00000004941; ENSRNOG00000003524.
GeneIDi287633.
KEGGirno:287633.
UCSCiRGD:1305092. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13623 mRNA. Translation: BAA02786.1.
BC086530 mRNA. Translation: AAH86530.1.
RefSeqiNP_001008281.1. NM_001008280.1.
UniGeneiRn.2783.

3D structure databases

ProteinModelPortaliQ5RJR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252266. 1 interactor.
MINTiMINT-4580716.
STRINGi10116.ENSRNOP00000004941.

PTM databases

iPTMnetiQ5RJR8.
PhosphoSitePlusiQ5RJR8.

Proteomic databases

PaxDbiQ5RJR8.
PRIDEiQ5RJR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004941; ENSRNOP00000004941; ENSRNOG00000003524.
GeneIDi287633.
KEGGirno:287633.
UCSCiRGD:1305092. rat.

Organism-specific databases

CTDi55379.
RGDi1305092. Lrrc59.

Phylogenomic databases

eggNOGiKOG0473. Eukaryota.
ENOG4111GH4. LUCA.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000073534.
HOVERGENiHBG081933.
InParanoidiQ5RJR8.
OMAiDILQWVL.
OrthoDBiEOG091G0EHN.
PhylomeDBiQ5RJR8.
TreeFamiTF316929.

Miscellaneous databases

PROiQ5RJR8.

Gene expression databases

BgeeiENSRNOG00000003524.
GenevisibleiQ5RJR8. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC59_RAT
AccessioniPrimary (citable) accession number: Q5RJR8
Secondary accession number(s): Q63742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.