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Protein

Zinc finger protein 467

Gene

Znf467

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 18223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 467
Gene namesi
Name:Znf467
Synonyms:Zfp467
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1561603. Zfp467.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Zinc finger protein 467PRO_0000247519Add
BLAST

Proteomic databases

PaxDbiQ5RJR4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5RJR4. baseline and differential.
GenevisibleiQ5RJR4. RN.

Interactioni

Subunit structurei

Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010377.

Structurei

3D structure databases

ProteinModelPortaliQ5RJR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 18223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130023.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5RJR4.
OMAiERSFFCP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5RJR4.
TreeFamiTF326846.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RJR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRETLEALNS LGFSVGQPEM APQSEPRDGF SNPQEKMSSR DESTLHSCSG
60 70 80 90 100
PETPGQKEGI HTEQAEAPCM GSQACIPQKA EPASSVPGEE WMIRKVKVED
110 120 130 140 150
EDQEAEEEVE WPQHLSFLPS PFPTPDLGQL AVAYKLEPGT PGTLGGIALS
160 170 180 190 200
GWAPIPEKPY GCEECERRFR DQLTLRLHQR LHRGEGPCAC PDCGRSFTQR
210 220 230 240 250
AHMLLHQRSH RGERPFPCSE CDKRFSKKAH LTRHLRTHTG ERPYPCAECG
260 270 280 290 300
KRFSQKIHLG SHQKTHTGER PFPCTECEKR FRKKTHLIRH QRIHTGERPY
310 320 330 340 350
QCTQCTRSFT HKQHLVRHQR VHDAASRTRS SPDIPATPHP PTASLAPSPT
360 370 380 390 400
GPKPFACSHC GQSFGWKKNL ATHQSLHLTE GRPFGCDECA LGTNVDPAAE
410 420 430 440 450
PSACTPHAPD CGPGSGPVAP QRTTSSERSF FCPDCGRGFA HGQHLARHRR
460 470 480 490 500
VHTGERPFAC AQCGRRFGSR PNLVAHSRAH SGARPFACAQ CGRRFSRKSH
510 520 530 540 550
LGRHQAVHTG SRPHACAVCA RCFSSKTNLV RHQAIHTGSR PFSCPQCAKS
560 570 580 590
FSRKTHLVRH QRIHGEAALP ASASNLSAPA WSNPSEVVPP PIFF
Length:594
Mass (Da):65,753
Last modified:December 21, 2004 - v1
Checksum:i9AC61F71F72AEC84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086534 mRNA. Translation: AAH86534.1.
RefSeqiNP_001019498.1. NM_001024327.1.
XP_006236493.1. XM_006236431.2.
XP_006236494.1. XM_006236432.2.
XP_006236495.1. XM_006236433.2.
XP_006236496.1. XM_006236434.2.
UniGeneiRn.27249.

Genome annotation databases

EnsembliENSRNOT00000010377; ENSRNOP00000010377; ENSRNOG00000007707.
GeneIDi500110.
KEGGirno:500110.
UCSCiRGD:1561603. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086534 mRNA. Translation: AAH86534.1.
RefSeqiNP_001019498.1. NM_001024327.1.
XP_006236493.1. XM_006236431.2.
XP_006236494.1. XM_006236432.2.
XP_006236495.1. XM_006236433.2.
XP_006236496.1. XM_006236434.2.
UniGeneiRn.27249.

3D structure databases

ProteinModelPortaliQ5RJR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010377.

Proteomic databases

PaxDbiQ5RJR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010377; ENSRNOP00000010377; ENSRNOG00000007707.
GeneIDi500110.
KEGGirno:500110.
UCSCiRGD:1561603. rat.

Organism-specific databases

CTDi68910.
RGDi1561603. Zfp467.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130023.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5RJR4.
OMAiERSFFCP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5RJR4.
TreeFamiTF326846.

Miscellaneous databases

NextBioi705106.
PROiQ5RJR4.

Gene expression databases

ExpressionAtlasiQ5RJR4. baseline and differential.
GenevisibleiQ5RJR4. RN.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN467_RAT
AccessioniPrimary (citable) accession number: Q5RJR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.