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Protein

Succinate dehydrogenase assembly factor 2, mitochondrial

Gene

Sdhaf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase assembly factor 2, mitochondrialUniRule annotation
Short name:
SDH assembly factor 2UniRule annotation
Short name:
SDHAF2UniRule annotation
Gene namesi
Name:Sdhaf2UniRule annotation
Synonyms:Pgl2UniRule annotation, Sdh5UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309216. Sdhaf2.

Subcellular locationi

  • Mitochondrion matrix UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionSequence analysisAdd
BLAST
Chaini28 – 164137Succinate dehydrogenase assembly factor 2, mitochondrialPRO_0000294360Add
BLAST

Proteomic databases

PaxDbiQ5RJQ7.
PRIDEiQ5RJQ7.

PTM databases

PhosphoSiteiQ5RJQ7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020646.
GenevisibleiQ5RJQ7. RN.

Interactioni

Subunit structurei

Interacts with SDHA within the SDH catalytic dimer.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028028.

Structurei

3D structure databases

ProteinModelPortaliQ5RJQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDHAF2 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3326. Eukaryota.
COG2938. LUCA.
GeneTreeiENSGT00390000001149.
HOGENOMiHOG000230636.
InParanoidiQ5RJQ7.
KOiK18168.
OMAiYLFEKPH.
OrthoDBiEOG091G0VSZ.
PhylomeDBiQ5RJQ7.
TreeFamiTF300175.

Family and domain databases

Gene3Di1.10.150.250. 1 hit.
HAMAPiMF_03057. SDHAF2. 1 hit.
InterProiIPR005631. SDH.
IPR028882. SDHAF2.
[Graphical view]
PfamiPF03937. Sdh5. 1 hit.
[Graphical view]
SUPFAMiSSF109910. SSF109910. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RJQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVTLIPTL ARVLSKHSLL SPLLSVTSFR RFYRGDSPTD SQKDMIEIPL
60 70 80 90 100
PPWQERTDES IETKRARLLY ESRKRGMLEN CILLSLFAKE YLHNMTEKQL
110 120 130 140 150
NLYDRLINEP SNDWDIYYWA TEAKPAPEIF ENEVMELLRE FTKNKNKEQR
160
LRAPDLEYLF EKPR
Length:164
Mass (Da):19,524
Last modified:December 21, 2004 - v1
Checksum:i9CBE582352281AA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086542 mRNA. Translation: AAH86542.1.
RefSeqiNP_001008372.1. NM_001008371.1.
UniGeneiRn.228653.

Genome annotation databases

EnsembliENSRNOT00000028028; ENSRNOP00000028028; ENSRNOG00000020646.
GeneIDi361726.
KEGGirno:361726.
UCSCiRGD:1309216. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086542 mRNA. Translation: AAH86542.1.
RefSeqiNP_001008372.1. NM_001008371.1.
UniGeneiRn.228653.

3D structure databases

ProteinModelPortaliQ5RJQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028028.

PTM databases

PhosphoSiteiQ5RJQ7.

Proteomic databases

PaxDbiQ5RJQ7.
PRIDEiQ5RJQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028028; ENSRNOP00000028028; ENSRNOG00000020646.
GeneIDi361726.
KEGGirno:361726.
UCSCiRGD:1309216. rat.

Organism-specific databases

CTDi54949.
RGDi1309216. Sdhaf2.

Phylogenomic databases

eggNOGiKOG3326. Eukaryota.
COG2938. LUCA.
GeneTreeiENSGT00390000001149.
HOGENOMiHOG000230636.
InParanoidiQ5RJQ7.
KOiK18168.
OMAiYLFEKPH.
OrthoDBiEOG091G0VSZ.
PhylomeDBiQ5RJQ7.
TreeFamiTF300175.

Miscellaneous databases

PROiQ5RJQ7.

Gene expression databases

BgeeiENSRNOG00000020646.
GenevisibleiQ5RJQ7. RN.

Family and domain databases

Gene3Di1.10.150.250. 1 hit.
HAMAPiMF_03057. SDHAF2. 1 hit.
InterProiIPR005631. SDH.
IPR028882. SDHAF2.
[Graphical view]
PfamiPF03937. Sdh5. 1 hit.
[Graphical view]
SUPFAMiSSF109910. SSF109910. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSDHF2_RAT
AccessioniPrimary (citable) accession number: Q5RJQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.