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Protein

Acyl-CoA-binding domain-containing protein 6

Gene

Acbd6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95Acyl-CoABy similarity1
Binding sitei114Acyl-CoABy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 6
Gene namesi
Name:Acbd6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1305030. Acbd6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328811 – 282Acyl-CoA-binding domain-containing protein 6Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei106PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5RJK8.
PRIDEiQ5RJK8.

PTM databases

iPTMnetiQ5RJK8.
PhosphoSitePlusiQ5RJK8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003550.
GenevisibleiQ5RJK8. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004772.

Structurei

3D structure databases

ProteinModelPortaliQ5RJK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 127ACBPROSITE-ProRule annotationAdd BLAST86
Repeati191 – 220ANK 1Add BLAST30
Repeati224 – 253ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 73Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00820000127112.
HOGENOMiHOG000241133.
HOVERGENiHBG080775.
InParanoidiQ5RJK8.
OMAiPGWNPQS.
OrthoDBiEOG091G0NXJ.
PhylomeDBiQ5RJK8.
TreeFamiTF329102.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
PR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF47027. SSF47027. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RJK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPFLPAGA TTGDSGGELS SGDDSGDLES FQTPEAEATR SLAELFEKAA
60 70 80 90 100
AHVQGLVQVA SREQLLYLYA RYKQVKVGNC NIPKPNFFDF EGKQKWEAWK
110 120 130 140 150
ALGDSSPSQA MQEYIAAVKK LDPGWNPQVS EKKGKEGSSG FGGPVVSSLY
160 170 180 190 200
HEETIREEDK NIFDYCRENN IDHITKAIKS KTVDVNMTDE EGRALLHWAC
210 220 230 240 250
DRGHKELVKV LLQCEAGINC QDNEGQTALH YAAACEFSDI VELLLQSGAD
260 270 280
PTLRDQDGCL PEEVTGCKAV SLVLQLHRAG KA
Length:282
Mass (Da):30,810
Last modified:December 21, 2004 - v1
Checksum:i67486B4E629C02A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086598 mRNA. Translation: AAH86598.1.
RefSeqiNP_001011906.1. NM_001011906.1.
UniGeneiRn.27349.

Genome annotation databases

EnsembliENSRNOT00000004772; ENSRNOP00000004772; ENSRNOG00000003550.
GeneIDi289125.
KEGGirno:289125.
UCSCiRGD:1305030. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086598 mRNA. Translation: AAH86598.1.
RefSeqiNP_001011906.1. NM_001011906.1.
UniGeneiRn.27349.

3D structure databases

ProteinModelPortaliQ5RJK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004772.

PTM databases

iPTMnetiQ5RJK8.
PhosphoSitePlusiQ5RJK8.

Proteomic databases

PaxDbiQ5RJK8.
PRIDEiQ5RJK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004772; ENSRNOP00000004772; ENSRNOG00000003550.
GeneIDi289125.
KEGGirno:289125.
UCSCiRGD:1305030. rat.

Organism-specific databases

CTDi84320.
RGDi1305030. Acbd6.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00820000127112.
HOGENOMiHOG000241133.
HOVERGENiHBG080775.
InParanoidiQ5RJK8.
OMAiPGWNPQS.
OrthoDBiEOG091G0NXJ.
PhylomeDBiQ5RJK8.
TreeFamiTF329102.

Enzyme and pathway databases

ReactomeiR-RNO-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

PROiQ5RJK8.

Gene expression databases

BgeeiENSRNOG00000003550.
GenevisibleiQ5RJK8. RN.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
PR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF47027. SSF47027. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBD6_RAT
AccessioniPrimary (citable) accession number: Q5RJK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.