##gff-version 3 Q5RJI5 UniProtKB Chain 1 778 . . . ID=PRO_0000260829;Note=Serine/threonine-protein kinase BRSK1 Q5RJI5 UniProtKB Domain 34 285 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q5RJI5 UniProtKB Domain 314 356 . . . Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 Q5RJI5 UniProtKB Region 1 29 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Region 362 548 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Region 560 588 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Region 719 778 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Compositional bias 362 401 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Compositional bias 426 453 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Compositional bias 488 510 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Compositional bias 512 529 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5RJI5 UniProtKB Active site 156 156 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 Q5RJI5 UniProtKB Binding site 40 48 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q5RJI5 UniProtKB Binding site 63 63 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5RJI5 UniProtKB Modified residue 189 189 . . . Note=Phosphothreonine%3B by LKB1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17482548;Dbxref=PMID:17482548 Q5RJI5 UniProtKB Modified residue 399 399 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 443 443 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 447 447 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 450 450 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 466 466 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q5RJI5 UniProtKB Modified residue 481 481 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q5RJI5 UniProtKB Modified residue 484 484 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q5RJI5 UniProtKB Modified residue 498 498 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q5RJI5 UniProtKB Modified residue 508 508 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8TDC3 Q5RJI5 UniProtKB Modified residue 525 525 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q5RJI5 UniProtKB Modified residue 529 529 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 535 535 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 550 550 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q5RJI5 UniProtKB Modified residue 583 583 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q5RJI5 UniProtKB Modified residue 586 586 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B2DD29 Q5RJI5 UniProtKB Modified residue 587 587 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B2DD29 Q5RJI5 UniProtKB Modified residue 601 601 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B2DD29 Q5RJI5 UniProtKB Alternative sequence 1 45 . . . ID=VSP_041743;Note=In isoform 4. MSSGSKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQT->MQKFGIEEM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19648910;Dbxref=PMID:19648910 Q5RJI5 UniProtKB Alternative sequence 344 778 . . . ID=VSP_041745;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:19648910;Dbxref=PMID:19648910 Q5RJI5 UniProtKB Mutagenesis 63 63 . . . Note=Abolishes kinase activity and ability to regulate centrosome duplication. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19648910;Dbxref=PMID:19648910 Q5RJI5 UniProtKB Mutagenesis 189 189 . . . Note=Abolishes activation by STK11/LKB1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17482548;Dbxref=PMID:17482548 Q5RJI5 UniProtKB Sequence conflict 18 19 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5RJI5 UniProtKB Sequence conflict 23 24 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5RJI5 UniProtKB Beta strand 598 602 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Beta strand 605 614 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Helix 617 630 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Beta strand 634 640 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Beta strand 643 648 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Helix 649 651 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Beta strand 654 658 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Beta strand 661 669 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Beta strand 688 697 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI Q5RJI5 UniProtKB Helix 699 714 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IRI