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Protein

Multiple C2 and transmembrane domain-containing protein 2

Gene

Mctp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Might play a role in the development of cardiac outflow tract.By similarity

Cofactori

Ca2+By similarityNote: Binds Ca2+ via the C2 domains in absence of phospholipids.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple C2 and transmembrane domain-containing protein 2
Gene namesi
Name:Mctp2
Synonyms:Gm489
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685335 Mctp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei694 – 714HelicalSequence analysisAdd BLAST21
Transmembranei794 – 814HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944731 – 878Multiple C2 and transmembrane domain-containing protein 2Add BLAST878

Proteomic databases

EPDiQ5RJH2
PaxDbiQ5RJH2
PRIDEiQ5RJH2

PTM databases

iPTMnetiQ5RJH2
PhosphoSitePlusiQ5RJH2

Expressioni

Developmental stagei

Expressed at high levels in the developing heart, with high levels at 9.5 dpc that progressively decrease until 11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000032776
CleanExiMM_MCTP2
ExpressionAtlasiQ5RJH2 baseline and differential
GenevisibleiQ5RJH2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078302

Structurei

3D structure databases

ProteinModelPortaliQ5RJH2
SMRiQ5RJH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 276C2 1PROSITE-ProRule annotationAdd BLAST96
Domaini343 – 436C2 2PROSITE-ProRule annotationAdd BLAST94
Domaini496 – 591C2 3PROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the MCTP family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1030 Eukaryota
ENOG410XRQN LUCA
GeneTreeiENSGT00550000074417
HOGENOMiHOG000230810
HOVERGENiHBG055341
InParanoidiQ5RJH2
OMAiPNCYVLK
OrthoDBiEOG091G02XX
PhylomeDBiQ5RJH2
TreeFamiTF323373

Family and domain databases

Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR013583 PRibTrfase_C
PfamiView protein in Pfam
PF00168 C2, 3 hits
PF08372 PRT_C, 1 hit
SMARTiView protein in SMART
SM00239 C2, 3 hits
PROSITEiView protein in PROSITE
PS50004 C2, 3 hits

Sequencei

Sequence statusi: Complete.

Q5RJH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDKPSVWG SLKQRTRPLL INLSKKKAKK SPSKPLDLRV QHHLDRRLSL
60 70 80 90 100
SVPDLLEAEA LAPEGRPYSG PQSSYISVPN SLSTAGIVPK SSSSSLKQSE
110 120 130 140 150
EELDWSQEEA SHVHGVDTDS EEIYASPAEE WQAFSQSALD LHKPSLGRDA
160 170 180 190 200
PEEHDKTHGN DDLNASMTSQ HFEEESTLGE ASDCVSHLPS PFAYLLTIHL
210 220 230 240 250
KEGRNLVVRD RCGTSDPYVK FKLNGKTLYK SKVIYKNLNP IWDEIVVLPI
260 270 280 290 300
QSLDQKLRVK VYDRDLTKSD FMGSAFVVLR DLELNRTTEH ILKLEDPNSL
310 320 330 340 350
EDDMGVIVLN LNLVVKQGDF KRHRWSNRKR LSASKSSLIR NLRLSESLRK
360 370 380 390 400
NQLWNGIISI TLLEGKNVSG GNMTEMFVQL KLGEQRYKSK TLCKSANPQW
410 420 430 440 450
QEQFDFHYFS DRMGILDIEV WGKDSKKHEE RLGTCKVDIS ALPLKQDNCL
460 470 480 490 500
ELPLESCQGA LLMLITLTPC TGVSISDLCV CPFEDPSERQ QISQRYAFQN
510 520 530 540 550
SLKDVKDVGI LQVKVLKASD LLAADFSGKS DPFCLLELGN DRLQTHTIYK
560 570 580 590 600
NLNPEWNKVF TFPIKDIHDV LEVTVFDEDG DKAPDFLGKV AIPLLSIRDG
610 620 630 640 650
QPNCYVLKNK DLEQAFKGLI YLELDLIYNP VKASIRTFTP REKRFVEDSR
660 670 680 690 700
KLSKKILSRD VDRVKRLTLA IWNTVQFFKS CFQWESTLRS TIAFVVFLVT
710 720 730 740 750
VWNFELYMIP LALLLLFLYN FLRPMKGKAS STQDSQESTD VEEEGKEEEK
760 770 780 790 800
ESEKKGIIER IYMVQDIVST VQNILEEVAS FGERIKNVFN WTVPFLSLLA
810 820 830 840 850
CLILAITTVI LYFIPLRYII LLWGINKFTK KLRNPYSIDN NELLDFLSRV
860 870
PSDIQKVQYA ELKLCGSHSP LRKKRSTV
Length:878
Mass (Da):100,178
Last modified:December 21, 2004 - v1
Checksum:iFAAC2F0497F4A36F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086658 mRNA Translation: AAH86658.1
CCDSiCCDS21361.1
RefSeqiNP_001019874.1, NM_001024703.1
XP_006540962.1, XM_006540899.2
UniGeneiMm.217412

Genome annotation databases

EnsembliENSMUST00000079323; ENSMUSP00000078302; ENSMUSG00000032776
GeneIDi244049
KEGGimmu:244049
UCSCiuc009hnp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMCTP2_MOUSE
AccessioniPrimary (citable) accession number: Q5RJH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health