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Protein

Multiple C2 and transmembrane domain-containing protein 2

Gene

Mctp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Might play a role in the development of cardiac outflow tract.By similarity

Cofactori

Ca2+By similarityNote: Binds Ca2+ via the C2 domains in absence of phospholipids.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple C2 and transmembrane domain-containing protein 2
Gene namesi
Name:Mctp2
Synonyms:Gm489
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685335. Mctp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei694 – 71421HelicalSequence analysisAdd
BLAST
Transmembranei794 – 81421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Multiple C2 and transmembrane domain-containing protein 2PRO_0000294473Add
BLAST

Proteomic databases

EPDiQ5RJH2.
PaxDbiQ5RJH2.
PRIDEiQ5RJH2.

PTM databases

iPTMnetiQ5RJH2.
PhosphoSiteiQ5RJH2.

Expressioni

Developmental stagei

Expressed at high levels in the developing heart, with high levels at 9.5 dpc that progressively decrease until 11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000032776.
CleanExiMM_MCTP2.
GenevisibleiQ5RJH2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078302.

Structurei

3D structure databases

ProteinModelPortaliQ5RJH2.
SMRiQ5RJH2. Positions 195-314, 504-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 27696C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini343 – 43694C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 59196C2 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MCTP family.Curated
Contains 3 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1030. Eukaryota.
ENOG410XRQN. LUCA.
GeneTreeiENSGT00550000074417.
HOGENOMiHOG000230810.
HOVERGENiHBG055341.
InParanoidiQ5RJH2.
OMAiHIPIGTI.
OrthoDBiEOG091G02XX.
PhylomeDBiQ5RJH2.
TreeFamiTF323373.

Family and domain databases

Gene3Di2.60.40.150. 3 hits.
InterProiIPR000008. C2_dom.
IPR013583. PRibTrfase_C.
[Graphical view]
PfamiPF00168. C2. 3 hits.
PF08372. PRT_C. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 3 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
PROSITEiPS50004. C2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RJH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDKPSVWG SLKQRTRPLL INLSKKKAKK SPSKPLDLRV QHHLDRRLSL
60 70 80 90 100
SVPDLLEAEA LAPEGRPYSG PQSSYISVPN SLSTAGIVPK SSSSSLKQSE
110 120 130 140 150
EELDWSQEEA SHVHGVDTDS EEIYASPAEE WQAFSQSALD LHKPSLGRDA
160 170 180 190 200
PEEHDKTHGN DDLNASMTSQ HFEEESTLGE ASDCVSHLPS PFAYLLTIHL
210 220 230 240 250
KEGRNLVVRD RCGTSDPYVK FKLNGKTLYK SKVIYKNLNP IWDEIVVLPI
260 270 280 290 300
QSLDQKLRVK VYDRDLTKSD FMGSAFVVLR DLELNRTTEH ILKLEDPNSL
310 320 330 340 350
EDDMGVIVLN LNLVVKQGDF KRHRWSNRKR LSASKSSLIR NLRLSESLRK
360 370 380 390 400
NQLWNGIISI TLLEGKNVSG GNMTEMFVQL KLGEQRYKSK TLCKSANPQW
410 420 430 440 450
QEQFDFHYFS DRMGILDIEV WGKDSKKHEE RLGTCKVDIS ALPLKQDNCL
460 470 480 490 500
ELPLESCQGA LLMLITLTPC TGVSISDLCV CPFEDPSERQ QISQRYAFQN
510 520 530 540 550
SLKDVKDVGI LQVKVLKASD LLAADFSGKS DPFCLLELGN DRLQTHTIYK
560 570 580 590 600
NLNPEWNKVF TFPIKDIHDV LEVTVFDEDG DKAPDFLGKV AIPLLSIRDG
610 620 630 640 650
QPNCYVLKNK DLEQAFKGLI YLELDLIYNP VKASIRTFTP REKRFVEDSR
660 670 680 690 700
KLSKKILSRD VDRVKRLTLA IWNTVQFFKS CFQWESTLRS TIAFVVFLVT
710 720 730 740 750
VWNFELYMIP LALLLLFLYN FLRPMKGKAS STQDSQESTD VEEEGKEEEK
760 770 780 790 800
ESEKKGIIER IYMVQDIVST VQNILEEVAS FGERIKNVFN WTVPFLSLLA
810 820 830 840 850
CLILAITTVI LYFIPLRYII LLWGINKFTK KLRNPYSIDN NELLDFLSRV
860 870
PSDIQKVQYA ELKLCGSHSP LRKKRSTV
Length:878
Mass (Da):100,178
Last modified:December 21, 2004 - v1
Checksum:iFAAC2F0497F4A36F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086658 mRNA. Translation: AAH86658.1.
CCDSiCCDS21361.1.
RefSeqiNP_001019874.1. NM_001024703.1.
XP_006540962.1. XM_006540899.2.
UniGeneiMm.217412.

Genome annotation databases

EnsembliENSMUST00000079323; ENSMUSP00000078302; ENSMUSG00000032776.
GeneIDi244049.
KEGGimmu:244049.
UCSCiuc009hnp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086658 mRNA. Translation: AAH86658.1.
CCDSiCCDS21361.1.
RefSeqiNP_001019874.1. NM_001024703.1.
XP_006540962.1. XM_006540899.2.
UniGeneiMm.217412.

3D structure databases

ProteinModelPortaliQ5RJH2.
SMRiQ5RJH2. Positions 195-314, 504-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078302.

PTM databases

iPTMnetiQ5RJH2.
PhosphoSiteiQ5RJH2.

Proteomic databases

EPDiQ5RJH2.
PaxDbiQ5RJH2.
PRIDEiQ5RJH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079323; ENSMUSP00000078302; ENSMUSG00000032776.
GeneIDi244049.
KEGGimmu:244049.
UCSCiuc009hnp.1. mouse.

Organism-specific databases

CTDi55784.
MGIiMGI:2685335. Mctp2.

Phylogenomic databases

eggNOGiKOG1030. Eukaryota.
ENOG410XRQN. LUCA.
GeneTreeiENSGT00550000074417.
HOGENOMiHOG000230810.
HOVERGENiHBG055341.
InParanoidiQ5RJH2.
OMAiHIPIGTI.
OrthoDBiEOG091G02XX.
PhylomeDBiQ5RJH2.
TreeFamiTF323373.

Miscellaneous databases

PROiQ5RJH2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032776.
CleanExiMM_MCTP2.
GenevisibleiQ5RJH2. MM.

Family and domain databases

Gene3Di2.60.40.150. 3 hits.
InterProiIPR000008. C2_dom.
IPR013583. PRibTrfase_C.
[Graphical view]
PfamiPF00168. C2. 3 hits.
PF08372. PRT_C. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 3 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
PROSITEiPS50004. C2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCTP2_MOUSE
AccessioniPrimary (citable) accession number: Q5RJH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.