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Q5RJB0

- BHA09_MOUSE

UniProt

Q5RJB0 - BHA09_MOUSE

Protein

Class A basic helix-loop-helix protein 9

Gene

Bhlha9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Putative transcription factor, which may play a role in limb development.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class A basic helix-loop-helix protein 9
    Short name:
    bHLHa9
    Alternative name(s):
    Class B basic helix-loop-helix factor 42
    Short name:
    bHLHf42
    Gene namesi
    Name:Bhlha9
    Synonyms:Bhlhf42
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2444198. Bhlha9.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Class A basic helix-loop-helix protein 9PRO_0000341378Add
    BLAST

    Proteomic databases

    PRIDEiQ5RJB0.

    PTM databases

    PhosphoSiteiQ5RJB0.

    Expressioni

    Developmental stagei

    At 10.5 dpc, expressed in forelimb and hindlimb buds, in the distal mesenchyme below the apical ectodermal ridge. At 11.5 dpc, expression is restricted to the subridge mesenchymal layer, as well as in the dorsal and ventral regions of the developing limbs.1 Publication

    Gene expression databases

    BgeeiQ5RJB0.
    GenevestigatoriQ5RJB0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RJB0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 11353bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG82328.
    GeneTreeiENSGT00390000002453.
    HOGENOMiHOG000095226.
    InParanoidiQ5RJB0.
    OMAiIHRITAL.
    OrthoDBiEOG7C5M9C.
    PhylomeDBiQ5RJB0.
    TreeFamiTF337642.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RJB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRGTPGLGL GGLNRAEDFV EDLGRSCSEA GRNFGVLRRS SLDEAEEAAG    50
    RKRERPTRSK ARRMAANVRE RKRILDYNEA FNALRRALQH DLGGKRLSKI 100
    ATLRRAIHRI TALSLVLRAS PAPRWPCGHL ECHGQAAQGS STGNSSFSVP 150
    RSAPSPIAPS LTRRDIASPL VPPTPRCASC SPHSHLGRPR VMAEVPNLAQ 200
    TSGGNWRQCP GAPPVRPVSW RWGSGLGYQH S 231
    Length:231
    Mass (Da):25,115
    Last modified:February 20, 2007 - v1
    Checksum:iD25ACC159CF730D1
    GO

    Sequence cautioni

    The sequence AAH48728.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC31704.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661A → G in BAC31704. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX000359 Genomic DNA. Translation: CAI25286.2.
    BC048728 mRNA. Translation: AAH48728.1. Different initiation.
    AK043927 mRNA. Translation: BAC31704.1. Different initiation.
    CCDSiCCDS25068.2.
    RefSeqiNP_796156.3. NM_177182.4.
    UniGeneiMm.131585.

    Genome annotation databases

    EnsembliENSMUST00000056184; ENSMUSP00000050516; ENSMUSG00000044243.
    GeneIDi320522.
    KEGGimmu:320522.
    UCSCiuc007kfx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX000359 Genomic DNA. Translation: CAI25286.2 .
    BC048728 mRNA. Translation: AAH48728.1 . Different initiation.
    AK043927 mRNA. Translation: BAC31704.1 . Different initiation.
    CCDSi CCDS25068.2.
    RefSeqi NP_796156.3. NM_177182.4.
    UniGenei Mm.131585.

    3D structure databases

    ProteinModelPortali Q5RJB0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5RJB0.

    Proteomic databases

    PRIDEi Q5RJB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056184 ; ENSMUSP00000050516 ; ENSMUSG00000044243 .
    GeneIDi 320522.
    KEGGi mmu:320522.
    UCSCi uc007kfx.1. mouse.

    Organism-specific databases

    CTDi 727857.
    MGIi MGI:2444198. Bhlha9.

    Phylogenomic databases

    eggNOGi NOG82328.
    GeneTreei ENSGT00390000002453.
    HOGENOMi HOG000095226.
    InParanoidi Q5RJB0.
    OMAi IHRITAL.
    OrthoDBi EOG7C5M9C.
    PhylomeDBi Q5RJB0.
    TreeFami TF337642.

    Miscellaneous databases

    NextBioi 396897.
    PROi Q5RJB0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5RJB0.
    Genevestigatori Q5RJB0.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-231.
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    4. Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiBHA09_MOUSE
    AccessioniPrimary (citable) accession number: Q5RJB0
    Secondary accession number(s): Q80ZL8, Q8BLP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3