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Protein

Class A basic helix-loop-helix protein 9

Gene

Bhlha9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor, which may play a role in limb development.By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Class A basic helix-loop-helix protein 9
Short name:
bHLHa9
Alternative name(s):
Class B basic helix-loop-helix factor 42
Short name:
bHLHf42
Gene namesi
Name:Bhlha9
Synonyms:Bhlhf42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444198. Bhlha9.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Class A basic helix-loop-helix protein 9PRO_0000341378Add
BLAST

Proteomic databases

PRIDEiQ5RJB0.

PTM databases

PhosphoSiteiQ5RJB0.

Expressioni

Developmental stagei

At 10.5 dpc, expressed in forelimb and hindlimb buds, in the distal mesenchyme below the apical ectodermal ridge. At 11.5 dpc, expression is restricted to the subridge mesenchymal layer, as well as in the dorsal and ventral regions of the developing limbs.1 Publication

Gene expression databases

BgeeiQ5RJB0.
GenevestigatoriQ5RJB0.

Structurei

3D structure databases

ProteinModelPortaliQ5RJB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 11353bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG82328.
GeneTreeiENSGT00390000002453.
HOGENOMiHOG000095226.
InParanoidiQ5RJB0.
OMAiPCGHLEC.
OrthoDBiEOG7C5M9C.
PhylomeDBiQ5RJB0.
TreeFamiTF337642.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RJB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGTPGLGL GGLNRAEDFV EDLGRSCSEA GRNFGVLRRS SLDEAEEAAG
60 70 80 90 100
RKRERPTRSK ARRMAANVRE RKRILDYNEA FNALRRALQH DLGGKRLSKI
110 120 130 140 150
ATLRRAIHRI TALSLVLRAS PAPRWPCGHL ECHGQAAQGS STGNSSFSVP
160 170 180 190 200
RSAPSPIAPS LTRRDIASPL VPPTPRCASC SPHSHLGRPR VMAEVPNLAQ
210 220 230
TSGGNWRQCP GAPPVRPVSW RWGSGLGYQH S
Length:231
Mass (Da):25,115
Last modified:February 19, 2007 - v1
Checksum:iD25ACC159CF730D1
GO

Sequence cautioni

The sequence AAH48728.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC31704.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661A → G in BAC31704 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX000359 Genomic DNA. Translation: CAI25286.2.
BC048728 mRNA. Translation: AAH48728.1. Different initiation.
AK043927 mRNA. Translation: BAC31704.1. Different initiation.
CCDSiCCDS25068.2.
RefSeqiNP_796156.3. NM_177182.4.
UniGeneiMm.131585.

Genome annotation databases

EnsembliENSMUST00000056184; ENSMUSP00000050516; ENSMUSG00000044243.
GeneIDi320522.
KEGGimmu:320522.
UCSCiuc007kfx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX000359 Genomic DNA. Translation: CAI25286.2.
BC048728 mRNA. Translation: AAH48728.1. Different initiation.
AK043927 mRNA. Translation: BAC31704.1. Different initiation.
CCDSiCCDS25068.2.
RefSeqiNP_796156.3. NM_177182.4.
UniGeneiMm.131585.

3D structure databases

ProteinModelPortaliQ5RJB0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ5RJB0.

Proteomic databases

PRIDEiQ5RJB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056184; ENSMUSP00000050516; ENSMUSG00000044243.
GeneIDi320522.
KEGGimmu:320522.
UCSCiuc007kfx.1. mouse.

Organism-specific databases

CTDi727857.
MGIiMGI:2444198. Bhlha9.

Phylogenomic databases

eggNOGiNOG82328.
GeneTreeiENSGT00390000002453.
HOGENOMiHOG000095226.
InParanoidiQ5RJB0.
OMAiPCGHLEC.
OrthoDBiEOG7C5M9C.
PhylomeDBiQ5RJB0.
TreeFamiTF337642.

Miscellaneous databases

NextBioi396897.
PROiQ5RJB0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5RJB0.
GenevestigatoriQ5RJB0.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-231.
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  4. Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiBHA09_MOUSE
AccessioniPrimary (citable) accession number: Q5RJB0
Secondary accession number(s): Q80ZL8, Q8BLP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 9, 2008
Last sequence update: February 19, 2007
Last modified: January 6, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.