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Protein

Zinc finger and SCAN domain-containing protein 26

Gene

Zscan26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 26
Alternative name(s):
Zinc finger protein 187
Gene namesi
Name:Zscan26
Synonyms:Zfp187, Znf187
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:3531417. Zscan26.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073141 – 466Zinc finger and SCAN domain-containing protein 26Add BLAST466

Proteomic databases

PaxDbiQ5RJ54.
PeptideAtlasiQ5RJ54.
PRIDEiQ5RJ54.

PTM databases

PhosphoSitePlusiQ5RJ54.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022228.
CleanExiMM_ZFP187.
ExpressionAtlasiQ5RJ54. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi240783. 2 interactors.
IntActiQ5RJ54. 1 interactor.
STRINGi10090.ENSMUSP00000032820.

Structurei

3D structure databases

ProteinModelPortaliQ5RJ54.
SMRiQ5RJ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133839.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ5RJ54.
OMAiGKKLCES.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5RJ54.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RJ54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALALIHPSK RAYSLAPLNL KEELQGFKVQ GDRKGVGQEP LCKQFRQLRY
60 70 80 90 100
EESTGPREVL RRLRELCRQW LRPETHSKEQ ILELLVLEQF LTILPRDLQV
110 120 130 140 150
QVLEHHPETG EELVGILEDL QLDRGKAGEQ KDSAQRSRPT VLVGEPAPRR
160 170 180 190 200
EAREQPGCAL PQKPEERGKE TRSENGNLIA GTDSCGRMES SCTMTEPIEA
210 220 230 240 250
QCEDLSLKKN PAMPKEKTNS QCLETKERLV QNSGLIEHDR AHTGEMSWES
260 270 280 290 300
VGSQSSVAAD HQEISKDKGH PCQECGKVFQ RSSHLIRHQK IHLGEKPYQC
310 320 330 340 350
KECGKVFSQN AGLLEHLRIH TGEKPYLCIH CGKNFRRSSH LNRHQKIHSQ
360 370 380 390 400
DEPRECKECG KTFSRALLLT HHQRVHGRSK RHHCNECGKA FSLTSDLIRH
410 420 430 440 450
HRIHTGEKPF KCNVCQKAFR LNSHLDQHVR IHNEEKPYKC SECNEAFRQK
460
SGLFQHQRHH HKSKLA
Length:466
Mass (Da):53,526
Last modified:December 21, 2004 - v1
Checksum:i043A22D2F6472986
GO
Isoform 2 (identifier: Q5RJ54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):25,773
Checksum:i08A17D6930939334
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0287031 – 245Missing in isoform 2. 1 PublicationAdd BLAST245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX001068 Genomic DNA. Translation: CAI25881.1.
BC068174 mRNA. Translation: AAH68174.1.
BY139219 mRNA. No translation available.
RefSeqiXP_006516773.1. XM_006516710.3. [Q5RJ54-1]
XP_011242620.1. XM_011244318.2. [Q5RJ54-1]
UniGeneiMm.441899.

Genome annotation databases

EnsembliENSMUST00000110485; ENSMUSP00000106111; ENSMUSG00000022228. [Q5RJ54-1]
GeneIDi432731.
UCSCiuc007pql.2. mouse. [Q5RJ54-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX001068 Genomic DNA. Translation: CAI25881.1.
BC068174 mRNA. Translation: AAH68174.1.
BY139219 mRNA. No translation available.
RefSeqiXP_006516773.1. XM_006516710.3. [Q5RJ54-1]
XP_011242620.1. XM_011244318.2. [Q5RJ54-1]
UniGeneiMm.441899.

3D structure databases

ProteinModelPortaliQ5RJ54.
SMRiQ5RJ54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240783. 2 interactors.
IntActiQ5RJ54. 1 interactor.
STRINGi10090.ENSMUSP00000032820.

PTM databases

PhosphoSitePlusiQ5RJ54.

Proteomic databases

PaxDbiQ5RJ54.
PeptideAtlasiQ5RJ54.
PRIDEiQ5RJ54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110485; ENSMUSP00000106111; ENSMUSG00000022228. [Q5RJ54-1]
GeneIDi432731.
UCSCiuc007pql.2. mouse. [Q5RJ54-1]

Organism-specific databases

CTDi7741.
MGIiMGI:3531417. Zscan26.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133839.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ5RJ54.
OMAiGKKLCES.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5RJ54.
TreeFamiTF338304.

Miscellaneous databases

PROiQ5RJ54.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022228.
CleanExiMM_ZFP187.
ExpressionAtlasiQ5RJ54. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSC26_MOUSE
AccessioniPrimary (citable) accession number: Q5RJ54
Secondary accession number(s): Q6NVD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.