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Protein

Zinc finger and SCAN domain-containing protein 26

Gene

Zscan26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 26
Alternative name(s):
Zinc finger protein 187
Gene namesi
Name:Zscan26
Synonyms:Zfp187, Znf187
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:3531417. Zscan26.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073141 – 466Zinc finger and SCAN domain-containing protein 26Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5RJ54.
PeptideAtlasiQ5RJ54.
PRIDEiQ5RJ54.

PTM databases

iPTMnetiQ5RJ54.
PhosphoSitePlusiQ5RJ54.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022228.
CleanExiMM_ZFP187.
ExpressionAtlasiQ5RJ54. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi240783. 2 interactors.
IntActiQ5RJ54. 1 interactor.
STRINGi10090.ENSMUSP00000032820.

Structurei

3D structure databases

ProteinModelPortaliQ5RJ54.
SMRiQ5RJ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 242C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ5RJ54.
KOiK09230.
OMAiGKKLCES.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5RJ54.
TreeFamiTF338304.

Family and domain databases

InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RJ54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALALIHPSK RAYSLAPLNL KEELQGFKVQ GDRKGVGQEP LCKQFRQLRY
60 70 80 90 100
EESTGPREVL RRLRELCRQW LRPETHSKEQ ILELLVLEQF LTILPRDLQV
110 120 130 140 150
QVLEHHPETG EELVGILEDL QLDRGKAGEQ KDSAQRSRPT VLVGEPAPRR
160 170 180 190 200
EAREQPGCAL PQKPEERGKE TRSENGNLIA GTDSCGRMES SCTMTEPIEA
210 220 230 240 250
QCEDLSLKKN PAMPKEKTNS QCLETKERLV QNSGLIEHDR AHTGEMSWES
260 270 280 290 300
VGSQSSVAAD HQEISKDKGH PCQECGKVFQ RSSHLIRHQK IHLGEKPYQC
310 320 330 340 350
KECGKVFSQN AGLLEHLRIH TGEKPYLCIH CGKNFRRSSH LNRHQKIHSQ
360 370 380 390 400
DEPRECKECG KTFSRALLLT HHQRVHGRSK RHHCNECGKA FSLTSDLIRH
410 420 430 440 450
HRIHTGEKPF KCNVCQKAFR LNSHLDQHVR IHNEEKPYKC SECNEAFRQK
460
SGLFQHQRHH HKSKLA
Length:466
Mass (Da):53,526
Last modified:December 21, 2004 - v1
Checksum:i043A22D2F6472986
GO
Isoform 2 (identifier: Q5RJ54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):25,773
Checksum:i08A17D6930939334
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0287031 – 245Missing in isoform 2. 1 PublicationAdd BLAST245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX001068 Genomic DNA. Translation: CAI25881.1.
BC068174 mRNA. Translation: AAH68174.1.
BY139219 mRNA. No translation available.
CCDSiCCDS84009.1. [Q5RJ54-1]
RefSeqiNP_001013808.2. NM_001013786.3.
NP_001334420.1. NM_001347491.1. [Q5RJ54-1]
XP_011242620.1. XM_011244318.2. [Q5RJ54-1]
UniGeneiMm.390557.
Mm.441899.

Genome annotation databases

EnsembliENSMUST00000110485; ENSMUSP00000106111; ENSMUSG00000022228. [Q5RJ54-1]
GeneIDi432731.
KEGGimmu:432731.
UCSCiuc007pql.2. mouse. [Q5RJ54-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZSC26_MOUSE
AccessioniPrimary (citable) accession number: Q5RJ54
Secondary accession number(s): Q6NVD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot