Q5RIQ8 (Q5RIQ8_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
A disintegrin and metallopeptidase domain 17b Ensembl ENSDARP00000121508

Submitted name:
Novel protein similar to vertebrate disintegrin and metalloproteinase domain 17 (Tumor necrosis factor, alpha, converting enzyme) (ADAM17) EMBL CAI21236.1

Gene names

Name:	adam17b Ensembl ENSDARP00000121508 ZFIN ZDB-GENE-041001-199
Synonyms:	adam17 ZFIN ZDB-GENE-041001-199, si:dkey-81b15.2 ZFIN ZDB-GENE-041001-199
ORF Names:	DKEY-81B15.2-001 EMBL CAI21236.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL CAI21236.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	809 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 1 disintegrin domain. SAAS SAAS002870 Contains 1 peptidase M12B domain. SAAS SAAS002870 RuleBase RU004141

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS002870 Zinc SAAS SAAS001762
Molecular function	Hydrolase Integrin EMBL CAI21236.1 Metalloprotease SAAS SAAS002870 Protease
PTM	Disulfide bond SAAS SAAS002870
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAI21236.1 Ensembl ENSDARP00000121508

Sequences

	Sequence		Length	Mass (Da)
	Q5RIQ8 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 6A82FC6267D462BC	FASTA	809	90,323
	10 20 30 40 50 60 DHLSSLLSDF DVLQLSSLQQ HSVRKRDVQS QTHAERLLGF TALQRHFKLY LTTNTELFTH 70 80 90 100 110 120 DFKAVVVGED GAQEVYEVQR ENFFTGHVIG EENSRVQAHI GDNDFTAHIL TDEAEYNIEP 130 140 150 160 170 180 LWRFTENTHD SRLLVYRSED IRNVSRLAAT KVCGYVSADA SEVLPESVRV SRALDEDHQE 190 200 210 220 230 240 EEGQVRERRQ TVDHSKNTCP LLLVADYRFF KHMGRKEEST TLNYLIELID RVDDIYRNTS 250 260 270 280 290 300 WDDEYKGYGV QIQQIIINMT PTQVEPGGAH FNMKGTPVKD KYVWDVKKLL EQFSIDIADN 310 320 330 340 350 360 ASQVCLAHLF TYQDFDEGTL GLAYVAPSKP GFPGECPPSG NDNRAIYLNT GLTSTKNYGK 370 380 390 400 410 420 TILTKEADLV TTHELGHNFG AVHDPDDMSY CAPREDQGGK YVMYPIAVSG DHTNNKLFSN 430 440 450 460 470 480 CSKMSIAKRL RAKASTCFKE RNSNVCGNSR VEEGEECDPG LLHLNSDLCC TANCKLKPGV 490 500 510 520 530 540 QCSDRNSPCC KDCRFEKQNK VCQEPMEATC KGRSNCSGYG SECPPPENLP NKTICVDNGR 550 560 570 580 590 600 CLNGECIPFC EAVKNLQSCA CNETHNSCKV CCKDKNGVCA PYIGDKGSPL FLRKGKPCTV 610 620 630 640 650 660 GFCDGAGKCM KQVQDVIERL WDFIEKLDIN TFGKFLADNI VGSVVVFSLL FWIPLSILVH 670 680 690 700 710 720 CVDKKLDQQY ELSTKPLFYP SNAELLSSLE SASVRIFKPP SSAGSSVVPR FHACGPLQTS 730 740 750 760 770 780 TPPVSISQVA PAPIQTPTPC PLPNIEPQRM ATIKEDPSYD SHLDQVLGED FPTSGSVSRS 790 800 FDDLTENREN AMSFRVNRHP QSNSKETEC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith M. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000121508.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000121508.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248136 Genomic DNA. Translation: CAI21236.1.
IPI	IPI00495617.
3D structure databases
ProteinModelPortal	Q5RIQ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5RIQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000135391; ENSDARP00000121508; ENSDARG00000093093.
Organism-specific databases
ZFIN	ZDB-GENE-041001-199. adam17b.
Phylogenomic databases
eggNOG	fiNOG15213.
HOGENOM	HBG315430.
HOVERGEN	HBG050457.
InParanoid	Q5RIQ8.
OrthoDB	EOG40P468.
Family and domain databases
InterPro	IPR001762. Blood-coag_inhib_Disintegrin. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit. G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit.
Pfam	PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
SMART	SM00050. DISIN. 1 hit. [Graphical view]
SUPFAM	SSF57552. Disintegrin. 1 hit.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5RIQ8_DANRE

Accession

Primary (citable) accession number: Q5RIQ8

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)