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Q5RII9

- KTNA1_DANRE

UniProt

Q5RII9 - KTNA1_DANRE

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Protein

Katanin p60 ATPase-containing subunit A1

Gene
katna1, si:dkey-15j16.1, zgc:110580
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation By similarity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Enzyme regulationi

ATPase activity is stimulated by microtubules, which promote homooligomerization By similarity. ATP-dependent microtubule severing is stimulated by interaction with katnb1 By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi244 – 2518ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule-severing ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. axon extension Source: ZFIN
  2. cytoplasmic microtubule organization Source: ZFIN
  3. microtubule severing Source: UniProtKB-HAMAP
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A1 (EC:3.6.4.3)
Short name:
Katanin p60 subunit A1
Alternative name(s):
p60 katanin
Gene namesi
Name:katna1
ORF Names:si:dkey-15j16.1, zgc:110580
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050522-514. katna1.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonspindle By similarity. Midbody By similarity
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 By similarity.UniRule annotation

GO - Cellular componenti

  1. centrosome Source: UniProtKB-HAMAP
  2. cytoplasm Source: UniProtKB
  3. microtubule Source: UniProtKB-KW
  4. midbody Source: UniProtKB
  5. spindle Source: UniProtKB
  6. spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Katanin p60 ATPase-containing subunit A1UniRule annotationPRO_0000357491Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5RII9.

Interactioni

Subunit structurei

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules By similarity. Interacts with katnb1, which may serve as a targeting subunit By similarity.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043315.

Structurei

3D structure databases

ProteinModelPortaliQ5RII9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ5RII9.
KOiK07767.
OMAiSQYSDPK.
OrthoDBiEOG7SFHWZ.
PhylomeDBiQ5RII9.
TreeFamiTF323170.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RII9-1 [UniParc]FASTAAdd to Basket

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MSLGEINENV KLAREYALLG NYSSAVVCYQ GVLEQIKKYL YSVRDSSLQQ    50
KWQQVWQEIN EETKQVREIM TTLESFQMES TPSKPSSFAQ DNDIMPVHVE 100
HRSSPCVVRK SSVPYKDSKG HGNRLSVGPR GQARPSPRVA NGDKGKPQKS 150
KEKKENPSKP KEDKNKAEAV ETEVKRFDRG GEDKDLIDAL ERDIISQNPN 200
VTWDDIADLE EAKKLLKEAV VLPMWMPEFF KGIRRPWKGV LMVGPPGTGK 250
TLLAKAVATE CRTTFFNVSS STLTSKYRGE SEKLVRLLFE MARFYAPTTI 300
FIDEIDSICS RRGTSEEHEA SRRVKAELLV QMDGVGGTSE NDPSKMVMVL 350
AATNFPWDID EALRRRLEKR IYIPLPSAKG RVDLLKINLK ELDLANDVNM 400
DKIAEQMEGY SGADITNVCR DASLMAMRRR IEGLTPEEIR NLPKDEMHMP 450
TTMEDFETAL KKVSKSVSAA DLEKYEKWIA EFGSC 485
Length:485
Mass (Da):54,882
Last modified:December 21, 2004 - v1
Checksum:iF2F7A748AB4F63D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX255904 Genomic DNA. Translation: CAI20705.1.
BC095321 mRNA. Translation: AAH95321.1.
RefSeqiNP_001018440.1. NM_001020604.1.
UniGeneiDr.78566.

Genome annotation databases

EnsembliENSDART00000043316; ENSDARP00000043315; ENSDARG00000021827.
GeneIDi553631.
KEGGidre:553631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX255904 Genomic DNA. Translation: CAI20705.1 .
BC095321 mRNA. Translation: AAH95321.1 .
RefSeqi NP_001018440.1. NM_001020604.1.
UniGenei Dr.78566.

3D structure databases

ProteinModelPortali Q5RII9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000043315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000043316 ; ENSDARP00000043315 ; ENSDARG00000021827 .
GeneIDi 553631.
KEGGi dre:553631.

Organism-specific databases

CTDi 11104.
ZFINi ZDB-GENE-050522-514. katna1.

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00550000074466.
HOGENOMi HOG000225142.
HOVERGENi HBG057074.
InParanoidi Q5RII9.
KOi K07767.
OMAi SQYSDPK.
OrthoDBi EOG7SFHWZ.
PhylomeDBi Q5RII9.
TreeFami TF323170.

Miscellaneous databases

NextBioi 20880368.
PROi Q5RII9.

Gene expression databases

Bgeei Q5RII9.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_03023. Katanin_p60_A1.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiKTNA1_DANRE
AccessioniPrimary (citable) accession number: Q5RII9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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