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Q5RII9 (KTNA1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Katanin p60 ATPase-containing subunit A1

Short name=Katanin p60 subunit A1
EC=3.6.4.3
Alternative name(s):
p60 katanin
Gene names
Name:katna1
ORF Names:si:dkey-15j16.1, zgc:110580
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation By similarity. HAMAP-Rule MF_03023

Catalytic activity

ATP + H2O = ADP + phosphate. HAMAP-Rule MF_03023

Enzyme regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization By similarity. ATP-dependent microtubule severing is stimulated by interaction with katnb1 By similarity. HAMAP-Rule MF_03023

Subunit structure

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules By similarity. Interacts with katnb1, which may serve as a targeting subunit By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonspindle By similarity. Midbody By similarity. Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 By similarity. HAMAP-Rule MF_03023

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Katanin p60 ATPase-containing subunit A1 HAMAP-Rule MF_03023
PRO_0000357491

Regions

Nucleotide binding244 – 2518ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RII9 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: F2F7A748AB4F63D1

FASTA48554,882
        10         20         30         40         50         60 
MSLGEINENV KLAREYALLG NYSSAVVCYQ GVLEQIKKYL YSVRDSSLQQ KWQQVWQEIN 

        70         80         90        100        110        120 
EETKQVREIM TTLESFQMES TPSKPSSFAQ DNDIMPVHVE HRSSPCVVRK SSVPYKDSKG 

       130        140        150        160        170        180 
HGNRLSVGPR GQARPSPRVA NGDKGKPQKS KEKKENPSKP KEDKNKAEAV ETEVKRFDRG 

       190        200        210        220        230        240 
GEDKDLIDAL ERDIISQNPN VTWDDIADLE EAKKLLKEAV VLPMWMPEFF KGIRRPWKGV 

       250        260        270        280        290        300 
LMVGPPGTGK TLLAKAVATE CRTTFFNVSS STLTSKYRGE SEKLVRLLFE MARFYAPTTI 

       310        320        330        340        350        360 
FIDEIDSICS RRGTSEEHEA SRRVKAELLV QMDGVGGTSE NDPSKMVMVL AATNFPWDID 

       370        380        390        400        410        420 
EALRRRLEKR IYIPLPSAKG RVDLLKINLK ELDLANDVNM DKIAEQMEGY SGADITNVCR 

       430        440        450        460        470        480 
DASLMAMRRR IEGLTPEEIR NLPKDEMHMP TTMEDFETAL KKVSKSVSAA DLEKYEKWIA 


EFGSC 

« Hide

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX255904 Genomic DNA. Translation: CAI20705.1.
BC095321 mRNA. Translation: AAH95321.1.
RefSeqNP_001018440.1. NM_001020604.1.
UniGeneDr.78566.

3D structure databases

ProteinModelPortalQ5RII9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000043315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000043316; ENSDARP00000043315; ENSDARG00000021827.
GeneID553631.
KEGGdre:553631.

Organism-specific databases

CTD11104.
ZFINZDB-GENE-050522-514. katna1.

Phylogenomic databases

eggNOGCOG0464.
GeneTreeENSGT00550000074466.
HOGENOMHOG000225142.
HOVERGENHBG057074.
InParanoidQ5RII9.
KOK07767.
OMASQYSDPK.
OrthoDBEOG7SFHWZ.
PhylomeDBQ5RII9.
TreeFamTF323170.

Gene expression databases

BgeeQ5RII9.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_03023. Katanin_p60_A1.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20880368.
PROQ5RII9.

Entry information

Entry nameKTNA1_DANRE
AccessionPrimary (citable) accession number: Q5RII9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families