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Q5RII9

- KTNA1_DANRE

UniProt

Q5RII9 - KTNA1_DANRE

Protein

Katanin p60 ATPase-containing subunit A1

Gene

katna1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    Enzyme regulationi

    ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with katnb1.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi244 – 2518ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule-severing ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. axon extension Source: ZFIN
    2. cytoplasmic microtubule organization Source: ZFIN
    3. microtubule severing Source: UniProtKB-HAMAP
    4. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Katanin p60 ATPase-containing subunit A1UniRule annotation (EC:3.6.4.3UniRule annotation)
    Short name:
    Katanin p60 subunit A1UniRule annotation
    Alternative name(s):
    p60 kataninUniRule annotation
    Gene namesi
    Name:katna1
    ORF Names:si:dkey-15j16.1, zgc:110580
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 20

    Organism-specific databases

    ZFINiZDB-GENE-050522-514. katna1.

    Subcellular locationi

    Cytoplasm UniRule annotation. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome UniRule annotation. Cytoplasmcytoskeletonspindle pole UniRule annotation
    Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with katnb1.UniRule annotation

    GO - Cellular componenti

    1. centrosome Source: UniProtKB-HAMAP
    2. cytoplasm Source: UniProtKB
    3. microtubule Source: UniProtKB-KW
    4. midbody Source: UniProtKB
    5. spindle Source: UniProtKB
    6. spindle pole Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Katanin p60 ATPase-containing subunit A1PRO_0000357491Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5RII9.

    Interactioni

    Subunit structurei

    Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with katnb1, which may serve as a targeting subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000043315.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RII9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0464.
    GeneTreeiENSGT00550000074466.
    HOGENOMiHOG000225142.
    HOVERGENiHBG057074.
    InParanoidiQ5RII9.
    KOiK07767.
    OMAiSQYSDPK.
    OrthoDBiEOG7SFHWZ.
    PhylomeDBiQ5RII9.
    TreeFamiTF323170.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_03023. Katanin_p60_A1.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR028596. KATNA1.
    IPR027417. P-loop_NTPase.
    IPR015415. Vps4_C.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF09336. Vps4_C. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RII9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLGEINENV KLAREYALLG NYSSAVVCYQ GVLEQIKKYL YSVRDSSLQQ    50
    KWQQVWQEIN EETKQVREIM TTLESFQMES TPSKPSSFAQ DNDIMPVHVE 100
    HRSSPCVVRK SSVPYKDSKG HGNRLSVGPR GQARPSPRVA NGDKGKPQKS 150
    KEKKENPSKP KEDKNKAEAV ETEVKRFDRG GEDKDLIDAL ERDIISQNPN 200
    VTWDDIADLE EAKKLLKEAV VLPMWMPEFF KGIRRPWKGV LMVGPPGTGK 250
    TLLAKAVATE CRTTFFNVSS STLTSKYRGE SEKLVRLLFE MARFYAPTTI 300
    FIDEIDSICS RRGTSEEHEA SRRVKAELLV QMDGVGGTSE NDPSKMVMVL 350
    AATNFPWDID EALRRRLEKR IYIPLPSAKG RVDLLKINLK ELDLANDVNM 400
    DKIAEQMEGY SGADITNVCR DASLMAMRRR IEGLTPEEIR NLPKDEMHMP 450
    TTMEDFETAL KKVSKSVSAA DLEKYEKWIA EFGSC 485
    Length:485
    Mass (Da):54,882
    Last modified:December 21, 2004 - v1
    Checksum:iF2F7A748AB4F63D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX255904 Genomic DNA. Translation: CAI20705.1.
    BC095321 mRNA. Translation: AAH95321.1.
    RefSeqiNP_001018440.1. NM_001020604.1.
    UniGeneiDr.78566.

    Genome annotation databases

    EnsembliENSDART00000043316; ENSDARP00000043315; ENSDARG00000021827.
    GeneIDi553631.
    KEGGidre:553631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX255904 Genomic DNA. Translation: CAI20705.1 .
    BC095321 mRNA. Translation: AAH95321.1 .
    RefSeqi NP_001018440.1. NM_001020604.1.
    UniGenei Dr.78566.

    3D structure databases

    ProteinModelPortali Q5RII9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000043315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000043316 ; ENSDARP00000043315 ; ENSDARG00000021827 .
    GeneIDi 553631.
    KEGGi dre:553631.

    Organism-specific databases

    CTDi 11104.
    ZFINi ZDB-GENE-050522-514. katna1.

    Phylogenomic databases

    eggNOGi COG0464.
    GeneTreei ENSGT00550000074466.
    HOGENOMi HOG000225142.
    HOVERGENi HBG057074.
    InParanoidi Q5RII9.
    KOi K07767.
    OMAi SQYSDPK.
    OrthoDBi EOG7SFHWZ.
    PhylomeDBi Q5RII9.
    TreeFami TF323170.

    Miscellaneous databases

    NextBioi 20880368.
    PROi Q5RII9.

    Gene expression databases

    Bgeei Q5RII9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_03023. Katanin_p60_A1.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR028596. KATNA1.
    IPR027417. P-loop_NTPase.
    IPR015415. Vps4_C.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF09336. Vps4_C. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiKTNA1_DANRE
    AccessioniPrimary (citable) accession number: Q5RII9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3