Katanin p60 ATPase-containing subunit A1

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Q5RII9 (KTNA1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Katanin p60 ATPase-containing subunit A1
Short name=Katanin p60 subunit A1
EC=3.6.4.3

Alternative name(s):
p60 katanin

Gene names

Name:	katna1
ORF Names:	si:dkey-15j16.1, zgc:110580

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation By similarity. HAMAP-Rule MF_03023
Catalytic activity	ATP + H₂O = ADP + phosphate. HAMAP-Rule MF_03023
Enzyme regulation	ATPase activity is stimulated by microtubules, which promote homooligomerization By similarity. ATP-dependent microtubule severing is stimulated by interaction with katnb1 By similarity. HAMAP-Rule MF_03023
Subunit structure	Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules By similarity. Interacts with katnb1, which may serve as a targeting subunit By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Cytoplasm › cytoskeleton › spindle pole By similarity. Cytoplasm › cytoskeleton By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Midbody By similarity. Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 By similarity.
Sequence similarities	Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension Inferred from mutant phenotype PubMed 20829563. Source: ZFIN cell division Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic microtubule organization Inferred from mutant phenotype PubMed 20829563. Source: ZFIN mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell midbody Inferred from sequence or structural similarity. Source: UniProtKB spindle pole Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule-severing ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 485

485

Katanin p60 ATPase-containing subunit A1 HAMAP-Rule MF_03023

PRO_0000357491

Regions

Nucleotide binding

244 – 251

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q5RII9 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: F2F7A748AB4F63D1
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FASTA

485

54,882

        10         20         30         40         50         60 
MSLGEINENV KLAREYALLG NYSSAVVCYQ GVLEQIKKYL YSVRDSSLQQ KWQQVWQEIN 

        70         80         90        100        110        120 
EETKQVREIM TTLESFQMES TPSKPSSFAQ DNDIMPVHVE HRSSPCVVRK SSVPYKDSKG 

       130        140        150        160        170        180 
HGNRLSVGPR GQARPSPRVA NGDKGKPQKS KEKKENPSKP KEDKNKAEAV ETEVKRFDRG 

       190        200        210        220        230        240 
GEDKDLIDAL ERDIISQNPN VTWDDIADLE EAKKLLKEAV VLPMWMPEFF KGIRRPWKGV 

       250        260        270        280        290        300 
LMVGPPGTGK TLLAKAVATE CRTTFFNVSS STLTSKYRGE SEKLVRLLFE MARFYAPTTI 

       310        320        330        340        350        360 
FIDEIDSICS RRGTSEEHEA SRRVKAELLV QMDGVGGTSE NDPSKMVMVL AATNFPWDID 

       370        380        390        400        410        420 
EALRRRLEKR IYIPLPSAKG RVDLLKINLK ELDLANDVNM DKIAEQMEGY SGADITNVCR 

       430        440        450        460        470        480 
DASLMAMRRR IEGLTPEEIR NLPKDEMHMP TTMEDFETAL KKVSKSVSAA DLEKYEKWIA 


EFGSC

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References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX255904 Genomic DNA. Translation: CAI20705.1. BC095321 mRNA. Translation: AAH95321.1.
IPI	IPI00500630.
RefSeq	NP_001018440.1. NM_001020604.1.
UniGene	Dr.78566.
3D structure databases
HSSP	HSSP built from PDB template 1YPW based on UniProtKB Q01853.
ProteinModelPortal	Q5RII9.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000043315.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000043316; ENSDARP00000043315; ENSDARG00000021827.
GeneID	553631.
KEGG	dre:553631.
Organism-specific databases
CTD	11104.
ZFIN	ZDB-GENE-050522-514. katna1.
Phylogenomic databases
eggNOG	COG0464.
GeneTree	ENSGT00550000074466.
HOGENOM	HOG000225142.
HOVERGEN	HBG057074.
InParanoid	Q5RII9.
KO	K07767.
OMA	IMERDIL.
OrthoDB	EOG4CJVGZ.
Gene expression databases
Bgee	Q5RII9.
Family and domain databases
HAMAP	MF_03023. Katanin_p60_A1.
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR015415. Vps4_C. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF09336. Vps4_C. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20880368.

Entry information

Entry name

KTNA1_DANRE

Accession

Primary (citable) accession number: Q5RII9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents