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Protein

Katanin p60 ATPase-containing subunit A1

Gene

katna1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Enzyme regulationi

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with katnb1.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi244 – 2518ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule-severing ATPase activity Source: GO_Central

GO - Biological processi

  1. axon extension Source: ZFIN
  2. cell division Source: UniProtKB-KW
  3. cytoplasmic microtubule organization Source: ZFIN
  4. metabolic process Source: GOC
  5. microtubule severing Source: UniProtKB-HAMAP
  6. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A1UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A1UniRule annotation
Alternative name(s):
p60 kataninUniRule annotation
Gene namesi
Name:katna1
ORF Names:si:dkey-15j16.1, zgc:110580
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050522-514. katna1.

Subcellular locationi

Cytoplasm UniRule annotation. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome UniRule annotation. Cytoplasmcytoskeletonspindle pole UniRule annotation
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with katnb1.UniRule annotation

GO - Cellular componenti

  1. centrosome Source: UniProtKB-HAMAP
  2. cytoplasm Source: UniProtKB
  3. microtubule Source: UniProtKB-KW
  4. midbody Source: UniProtKB
  5. nucleus Source: GO_Central
  6. spindle Source: UniProtKB
  7. spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Katanin p60 ATPase-containing subunit A1PRO_0000357491Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5RII9.

Interactioni

Subunit structurei

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with katnb1, which may serve as a targeting subunit.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043315.

Structurei

3D structure databases

ProteinModelPortaliQ5RII9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ5RII9.
KOiK07767.
OMAiSQYSDPK.
OrthoDBiEOG7SFHWZ.
PhylomeDBiQ5RII9.
TreeFamiTF323170.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RII9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGEINENV KLAREYALLG NYSSAVVCYQ GVLEQIKKYL YSVRDSSLQQ
60 70 80 90 100
KWQQVWQEIN EETKQVREIM TTLESFQMES TPSKPSSFAQ DNDIMPVHVE
110 120 130 140 150
HRSSPCVVRK SSVPYKDSKG HGNRLSVGPR GQARPSPRVA NGDKGKPQKS
160 170 180 190 200
KEKKENPSKP KEDKNKAEAV ETEVKRFDRG GEDKDLIDAL ERDIISQNPN
210 220 230 240 250
VTWDDIADLE EAKKLLKEAV VLPMWMPEFF KGIRRPWKGV LMVGPPGTGK
260 270 280 290 300
TLLAKAVATE CRTTFFNVSS STLTSKYRGE SEKLVRLLFE MARFYAPTTI
310 320 330 340 350
FIDEIDSICS RRGTSEEHEA SRRVKAELLV QMDGVGGTSE NDPSKMVMVL
360 370 380 390 400
AATNFPWDID EALRRRLEKR IYIPLPSAKG RVDLLKINLK ELDLANDVNM
410 420 430 440 450
DKIAEQMEGY SGADITNVCR DASLMAMRRR IEGLTPEEIR NLPKDEMHMP
460 470 480
TTMEDFETAL KKVSKSVSAA DLEKYEKWIA EFGSC
Length:485
Mass (Da):54,882
Last modified:December 21, 2004 - v1
Checksum:iF2F7A748AB4F63D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255904 Genomic DNA. Translation: CAI20705.1.
BC095321 mRNA. Translation: AAH95321.1.
RefSeqiNP_001018440.1. NM_001020604.1.
XP_009292937.1. XM_009294662.1.
UniGeneiDr.78566.

Genome annotation databases

EnsembliENSDART00000043316; ENSDARP00000043315; ENSDARG00000021827.
GeneIDi553631.
KEGGidre:553631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255904 Genomic DNA. Translation: CAI20705.1.
BC095321 mRNA. Translation: AAH95321.1.
RefSeqiNP_001018440.1. NM_001020604.1.
XP_009292937.1. XM_009294662.1.
UniGeneiDr.78566.

3D structure databases

ProteinModelPortaliQ5RII9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000043316; ENSDARP00000043315; ENSDARG00000021827.
GeneIDi553631.
KEGGidre:553631.

Organism-specific databases

CTDi11104.
ZFINiZDB-GENE-050522-514. katna1.

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ5RII9.
KOiK07767.
OMAiSQYSDPK.
OrthoDBiEOG7SFHWZ.
PhylomeDBiQ5RII9.
TreeFamiTF323170.

Miscellaneous databases

NextBioi20880368.
PROiQ5RII9.

Gene expression databases

BgeeiQ5RII9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiKTNA1_DANRE
AccessioniPrimary (citable) accession number: Q5RII9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.