Q5RIH2 (Q5RIH2_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uncharacterized protein Ensembl ENSDARP00000120805

Gene names

Name:	mthfd1a Ensembl ENSDARP00000120805 ZFIN ZDB-GENE-041001-127
Synonyms:	si:dkey-1h6.1 ZFIN ZDB-GENE-041001-127

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome] Ensembl ENSDARP00000120805

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	900 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSDARP00000120805

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: InterPro methylenetetrahydrofolate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5RIH2 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 7780AB143C6095EB	FASTA	900	96,959
	10 20 30 40 50 60 MFSVSAAVLR RGVLRYRWDR CCALATVVSG NKTSQQVKQR LKEEVEQMKS QFPGFRPGLV 70 80 90 100 110 120 VLQVGDREDS NLYISMKLKA AAEIGINANH IRLPETATEN EVLRNIVAVN ENPAFHGLIV 130 140 150 160 170 180 QLPLDSINPI NTEKITNAVA PEKDVDGLTS INAGKLSRGD LGDCFIPCTP NGCMELISQT 190 200 210 220 230 240 GVSVMGKNAV VIGRSKIVGA PMHDLLLWSH ATVTTCHSKT PDLAEQVGKA DILVVGAGRA 250 260 270 280 290 300 EMVKGEWVKE GAVVIDCGIN HIPDESKASG KRVVGDVHYP SAKQRAGFIT PVPGGVGPMT 310 320 330 340 350 360 VAMLMKNTVE SAKRFLQTHT PGKWNLVYTK KRPHEPQPSD AAISSSCESK PVVQLARELG 370 380 390 400 410 420 LFSDEVESYG RSRAKIRLDA LKRMEKQPNG KYVVVTGVTS SPLGEGKRTT ALGLAQALGA 430 440 450 460 470 480 HLNTNAFACV QKSSLETCFG ARGPAVGGGY SQIIPLEEVS LQPSGQNELV SAAGRLVMDT 490 500 510 520 530 540 VKAYAHYETK LSEKALFDLL VPLREGQRCV SLAQLNRLKK LAIEKSDPLT LTEREIRRFI 550 560 570 580 590 600 RLDIDTDSAT DSFSLENEMM AVLSLSSSEE EMQHRLANII VATNKSGDPI TTEDLNVSGP 610 620 630 640 650 660 LAMLLKEALK PVLMQTVEGT PVFLHTSPLV NVAQGGPSIL ADKMALKIVG SEGFVVTESG 670 680 690 700 710 720 HGADVGLEKF FNIKCLYSGL QPDVLVMVAT IRTLKMQGGA PPIQAGLPLP KEYLQENLKQ 730 740 750 760 770 780 LERGCCHMRR QVEKAQAFGL PVIVAVNKFS SDTDAELELV CGQARQAGAF DAVQCSSWSE 790 800 810 820 830 840 GGAGALALAE TVQRAAKLPA CFKFLYDLQT PASDKLRTVA QKMYGLKDVK LSPKAKEKLA 850 860 870 880 890 900 LYTKQGFENL PVCIAKTPLS LSNDPMMKGS STDFMLPITD IKANAGAGFL CCLTGSVSFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000120805.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000120805.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX255917 Genomic DNA. No translation available.
IPI	IPI00508454.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000017895.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000141697; ENSDARP00000120805; ENSDARG00000018266.
Organism-specific databases
ZFIN	ZDB-GENE-041001-127. mthfd1a.
Phylogenomic databases
eggNOG	COG0190.
GeneTree	ENSGT00630000089817.
HOVERGEN	HBG004916.
InParanoid	Q5RIH2.
OrthoDB	EOG4GB75D.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01576. THF_DHG_CYH.
InterPro	IPR000559. Formate_THF_ligase. IPR016040. NAD(P)-bd_dom. IPR027417. P-loop_NTPase. IPR000672. THF_DH/CycHdrlase. IPR020630. THF_DH/CycHdrlase_cat_dom. IPR020867. THF_DH/CycHdrlase_CS. IPR020631. THF_DH/CycHdrlase_NAD-bd_dom. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view]
PRINTS	PR00085. THFDHDRGNASE.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00766. THF_DHG_CYH_1. 1 hit. PS00767. THF_DHG_CYH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5RIH2_DANRE

Accession

Primary (citable) accession number: Q5RIH2

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	April 3, 2007
Last modified:	May 29, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)