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Q5RIC0

- ELP3_DANRE

UniProt

Q5RIC0 - ELP3_DANRE

Protein

Elongator complex protein 3

Gene

elp3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 3 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi100 – 1001Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi110 – 1101Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi113 – 1131Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. phosphorylase kinase regulator activity Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: ZFIN
    2. regulation of protein kinase activity Source: GOC
    3. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    ReactomeiREACT_209587. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:elp3
    ORF Names:si:ch211-63o20.8, zgc:113140
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 20

    Organism-specific databases

    ZFINiZDB-GENE-050327-35. elp3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. transcription elongation factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Elongator complex protein 3PRO_0000283989Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5RIC0.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RIC0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini397 – 548152N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    GeneTreeiENSGT00390000013141.
    HOGENOMiHOG000227514.
    HOVERGENiHBG107845.
    InParanoidiQ5RIC0.
    KOiK07739.
    OMAiGYKVVSH.
    OrthoDBiEOG7V765W.
    PhylomeDBiQ5RIC0.
    TreeFamiTF105752.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 2 hits.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5RIC0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKPKKKSDL SRAELMMMTI ADVIKQLVEA HEEGKDINLN KVKTKTSAKY    50
    GLSAQPRLVD IIAAVPPHYR RALVPKLKAK PIRTASGIAV VAVMCKPHRC 100
    PHISFTGNIC VYCPGGPDSD FEYSTQSYTG YEPTSMRAIR ARYDPYLQTR 150
    HRVEQLKQLG HSVDKVEFIV MGGTFMALPE EYRDYFIRNL HDALSGHTSN 200
    NVTEAVRYSE RSNTKCVGIT IETRPDYCLK RHLSDMLGYG CTRLEIGVQS 250
    VYEDVARDTN RGHTVRAVCE SFHLAKDAGF KVVAHMMPDL PNVGMERDVE 300
    QFIEFFENPA FRPDGLKLYP TLVIRGTGLY ELWKTGRYKS YSPSALVDLV 350
    ARILALVPPW TRVYRVQRDI PMPLVSSGVE HGNLRELALA RMKDMGTECR 400
    DVRTREVGIQ EIHHKVRPYQ VELIRRDYVA NGGWETFLSY EDPEQDILIG 450
    LLRLRRCSPQ SFRPELKGGV SIVRELHVYG SVVPVSSRDP SKFQHQGFGM 500
    MLMEEAERIA RDEHGSSKLA VISGVGTRNY YRKMGYELEG PYMVKNLY 548

    Note: No experimental confirmation available.

    Length:548
    Mass (Da):62,259
    Last modified:June 12, 2007 - v3
    Checksum:i8761FBFC0FE684DE
    GO
    Isoform 2 (identifier: Q5RIC0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:533
    Mass (Da):60,589
    Checksum:i70C0C16D4E4E0129
    GO
    Isoform 3 (identifier: Q5RIC0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-93: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:455
    Mass (Da):52,132
    Checksum:i1A1227439D70C4E7
    GO

    Sequence cautioni

    The sequence CAI12039.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631H → Y in AAH91787. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9393Missing in isoform 3. 1 PublicationVSP_026085Add
    BLAST
    Alternative sequencei1 – 1515Missing in isoform 2. CuratedVSP_026084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX279523 Genomic DNA. Translation: CAI12039.1. Sequence problems.
    BC091787 mRNA. Translation: AAH91787.1.
    BC096810 mRNA. Translation: AAH96810.1.
    RefSeqiNP_001014344.2. NM_001014322.2. [Q5RIC0-1]
    UniGeneiDr.84313.

    Genome annotation databases

    EnsembliENSDART00000138226; ENSDARP00000113240; ENSDARG00000042005. [Q5RIC0-2]
    ENSDART00000152836; ENSDARP00000127220; ENSDARG00000042005. [Q5RIC0-3]
    GeneIDi541509.
    KEGGidre:541509.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX279523 Genomic DNA. Translation: CAI12039.1 . Sequence problems.
    BC091787 mRNA. Translation: AAH91787.1 .
    BC096810 mRNA. Translation: AAH96810.1 .
    RefSeqi NP_001014344.2. NM_001014322.2. [Q5RIC0-1 ]
    UniGenei Dr.84313.

    3D structure databases

    ProteinModelPortali Q5RIC0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000138226 ; ENSDARP00000113240 ; ENSDARG00000042005 . [Q5RIC0-2 ]
    ENSDART00000152836 ; ENSDARP00000127220 ; ENSDARG00000042005 . [Q5RIC0-3 ]
    GeneIDi 541509.
    KEGGi dre:541509.

    Organism-specific databases

    CTDi 55140.
    ZFINi ZDB-GENE-050327-35. elp3.

    Phylogenomic databases

    eggNOGi COG1243.
    GeneTreei ENSGT00390000013141.
    HOGENOMi HOG000227514.
    HOVERGENi HBG107845.
    InParanoidi Q5RIC0.
    KOi K07739.
    OMAi GYKVVSH.
    OrthoDBi EOG7V765W.
    PhylomeDBi Q5RIC0.
    TreeFami TF105752.

    Enzyme and pathway databases

    Reactomei REACT_209587. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 20879291.
    PROi Q5RIC0.

    Gene expression databases

    Bgeei Q5RIC0.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 2 hits.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Embryo.

    Entry informationi

    Entry nameiELP3_DANRE
    AccessioniPrimary (citable) accession number: Q5RIC0
    Secondary accession number(s): Q4V9M7, Q58ER7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3