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Q5RIC0

- ELP3_DANRE

UniProt

Q5RIC0 - ELP3_DANRE

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Protein
Elongator complex protein 3
Gene
elp3, si:ch211-63o20.8, zgc:113140
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi100 – 1001Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi110 – 1101Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi113 – 1131Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphorylase kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. axonogenesis Source: ZFIN
  2. regulation of protein kinase activity Source: GOC
  3. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiREACT_209587. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elp3
ORF Names:si:ch211-63o20.8, zgc:113140
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050327-35. elp3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Elongator complex protein 3
PRO_0000283989Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5RIC0.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RIC0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini397 – 548152N-acetyltransferase
Add
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.

Phylogenomic databases

eggNOGiCOG1243.
GeneTreeiENSGT00390000013141.
HOGENOMiHOG000227514.
HOVERGENiHBG107845.
InParanoidiQ5RIC0.
KOiK07739.
OMAiGYKVVSH.
OrthoDBiEOG7V765W.
PhylomeDBiQ5RIC0.
TreeFamiTF105752.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5RIC0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGKPKKKSDL SRAELMMMTI ADVIKQLVEA HEEGKDINLN KVKTKTSAKY    50
GLSAQPRLVD IIAAVPPHYR RALVPKLKAK PIRTASGIAV VAVMCKPHRC 100
PHISFTGNIC VYCPGGPDSD FEYSTQSYTG YEPTSMRAIR ARYDPYLQTR 150
HRVEQLKQLG HSVDKVEFIV MGGTFMALPE EYRDYFIRNL HDALSGHTSN 200
NVTEAVRYSE RSNTKCVGIT IETRPDYCLK RHLSDMLGYG CTRLEIGVQS 250
VYEDVARDTN RGHTVRAVCE SFHLAKDAGF KVVAHMMPDL PNVGMERDVE 300
QFIEFFENPA FRPDGLKLYP TLVIRGTGLY ELWKTGRYKS YSPSALVDLV 350
ARILALVPPW TRVYRVQRDI PMPLVSSGVE HGNLRELALA RMKDMGTECR 400
DVRTREVGIQ EIHHKVRPYQ VELIRRDYVA NGGWETFLSY EDPEQDILIG 450
LLRLRRCSPQ SFRPELKGGV SIVRELHVYG SVVPVSSRDP SKFQHQGFGM 500
MLMEEAERIA RDEHGSSKLA VISGVGTRNY YRKMGYELEG PYMVKNLY 548

Note: No experimental confirmation available.

Length:548
Mass (Da):62,259
Last modified:June 12, 2007 - v3
Checksum:i8761FBFC0FE684DE
GO
Isoform 2 (identifier: Q5RIC0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Note: No experimental confirmation available.

Show »
Length:533
Mass (Da):60,589
Checksum:i70C0C16D4E4E0129
GO
Isoform 3 (identifier: Q5RIC0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Note: No experimental confirmation available.

Show »
Length:455
Mass (Da):52,132
Checksum:i1A1227439D70C4E7
GO

Sequence cautioni

The sequence CAI12039.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9393Missing in isoform 3.
VSP_026085Add
BLAST
Alternative sequencei1 – 1515Missing in isoform 2.
VSP_026084Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631H → Y in AAH91787. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX279523 Genomic DNA. Translation: CAI12039.1. Sequence problems.
BC091787 mRNA. Translation: AAH91787.1.
BC096810 mRNA. Translation: AAH96810.1.
RefSeqiNP_001014344.2. NM_001014322.2. [Q5RIC0-1]
UniGeneiDr.84313.

Genome annotation databases

EnsembliENSDART00000138226; ENSDARP00000113240; ENSDARG00000042005. [Q5RIC0-2]
ENSDART00000152836; ENSDARP00000127220; ENSDARG00000042005. [Q5RIC0-3]
GeneIDi541509.
KEGGidre:541509.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX279523 Genomic DNA. Translation: CAI12039.1 . Sequence problems.
BC091787 mRNA. Translation: AAH91787.1 .
BC096810 mRNA. Translation: AAH96810.1 .
RefSeqi NP_001014344.2. NM_001014322.2. [Q5RIC0-1 ]
UniGenei Dr.84313.

3D structure databases

ProteinModelPortali Q5RIC0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000138226 ; ENSDARP00000113240 ; ENSDARG00000042005 . [Q5RIC0-2 ]
ENSDART00000152836 ; ENSDARP00000127220 ; ENSDARG00000042005 . [Q5RIC0-3 ]
GeneIDi 541509.
KEGGi dre:541509.

Organism-specific databases

CTDi 55140.
ZFINi ZDB-GENE-050327-35. elp3.

Phylogenomic databases

eggNOGi COG1243.
GeneTreei ENSGT00390000013141.
HOGENOMi HOG000227514.
HOVERGENi HBG107845.
InParanoidi Q5RIC0.
KOi K07739.
OMAi GYKVVSH.
OrthoDBi EOG7V765W.
PhylomeDBi Q5RIC0.
TreeFami TF105752.

Enzyme and pathway databases

Reactomei REACT_209587. HATs acetylate histones.

Miscellaneous databases

NextBioi 20879291.
PROi Q5RIC0.

Gene expression databases

Bgeei Q5RIC0.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 2 hits.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Embryo.

Entry informationi

Entry nameiELP3_DANRE
AccessioniPrimary (citable) accession number: Q5RIC0
Secondary accession number(s): Q4V9M7, Q58ER7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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