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Protein

Elongator complex protein 3

Gene

elp3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. Involved in acetylation of alpha-tubulin (By similarity). May also have a methyltransferase activity (By similarity). Involved in neurogenesis (PubMed:18996918).1 PublicationBy similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi110Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi113Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: ZFIN
  • regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processNeurogenesis, Transcription, Transcription regulation
LigandIron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elp3
ORF Names:si:ch211-63o20.8, zgc:113140
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050327-35 elp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

ELP3 morpholino knockdown in embryos at 27 hpf results in abnormal motor neuron axonal branching and length.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002839891 – 548Elongator complex protein 3Add BLAST548

Proteomic databases

PaxDbiQ5RIC0
PRIDEiQ5RIC0

Expressioni

Gene expression databases

BgeeiENSDARG00000042005

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061556

Structurei

3D structure databases

ProteinModelPortaliQ5RIC0
SMRiQ5RIC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini397 – 548N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.Curated

Phylogenomic databases

eggNOGiKOG2535 Eukaryota
COG1243 LUCA
GeneTreeiENSGT00390000013141
HOGENOMiHOG000227514
HOVERGENiHBG107845
InParanoidiQ5RIC0
KOiK07739
OMAiSYTGKEP
OrthoDBiEOG091G03ZS
PhylomeDBiQ5RIC0
TreeFamiTF105752

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RIC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKPKKKSDL SRAELMMMTI ADVIKQLVEA HEEGKDINLN KVKTKTSAKY
60 70 80 90 100
GLSAQPRLVD IIAAVPPHYR RALVPKLKAK PIRTASGIAV VAVMCKPHRC
110 120 130 140 150
PHISFTGNIC VYCPGGPDSD FEYSTQSYTG YEPTSMRAIR ARYDPYLQTR
160 170 180 190 200
HRVEQLKQLG HSVDKVEFIV MGGTFMALPE EYRDYFIRNL HDALSGHTSN
210 220 230 240 250
NVTEAVRYSE RSNTKCVGIT IETRPDYCLK RHLSDMLGYG CTRLEIGVQS
260 270 280 290 300
VYEDVARDTN RGHTVRAVCE SFHLAKDAGF KVVAHMMPDL PNVGMERDVE
310 320 330 340 350
QFIEFFENPA FRPDGLKLYP TLVIRGTGLY ELWKTGRYKS YSPSALVDLV
360 370 380 390 400
ARILALVPPW TRVYRVQRDI PMPLVSSGVE HGNLRELALA RMKDMGTECR
410 420 430 440 450
DVRTREVGIQ EIHHKVRPYQ VELIRRDYVA NGGWETFLSY EDPEQDILIG
460 470 480 490 500
LLRLRRCSPQ SFRPELKGGV SIVRELHVYG SVVPVSSRDP SKFQHQGFGM
510 520 530 540
MLMEEAERIA RDEHGSSKLA VISGVGTRNY YRKMGYELEG PYMVKNLY
Note: No experimental confirmation available.
Length:548
Mass (Da):62,259
Last modified:June 12, 2007 - v3
Checksum:i8761FBFC0FE684DE
GO
Isoform 2 (identifier: Q5RIC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):60,589
Checksum:i70C0C16D4E4E0129
GO
Isoform 3 (identifier: Q5RIC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):52,132
Checksum:i1A1227439D70C4E7
GO

Sequence cautioni

The sequence CAI12039 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263H → Y in AAH91787 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260851 – 93Missing in isoform 3. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0260841 – 15Missing in isoform 2. CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX279523 Genomic DNA Translation: CAI12039.1 Sequence problems.
BC091787 mRNA Translation: AAH91787.1
BC096810 mRNA Translation: AAH96810.1
RefSeqiNP_001014344.2, NM_001014322.2 [Q5RIC0-1]
UniGeneiDr.84313

Genome annotation databases

EnsembliENSDART00000138226; ENSDARP00000113240; ENSDARG00000042005 [Q5RIC0-2]
ENSDART00000152836; ENSDARP00000127220; ENSDARG00000042005 [Q5RIC0-3]
GeneIDi541509
KEGGidre:541509

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELP3_DANRE
AccessioniPrimary (citable) accession number: Q5RIC0
Secondary accession number(s): Q4V9M7, Q58ER7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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