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Q5RIC0 (ELP3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongator complex protein 3

EC=2.3.1.48
Gene names
Name:elp3
ORF Names:si:ch211-63o20.8, zgc:113140
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ELP3 family.

Contains 1 N-acetyltransferase domain.

Sequence caution

The sequence CAI12039.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5RIC0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q5RIC0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q5RIC0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Elongator complex protein 3
PRO_0000283989

Regions

Domain397 – 548152N-acetyltransferase

Sites

Metal binding1001Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1101Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1131Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Natural variations

Alternative sequence1 – 9393Missing in isoform 3.
VSP_026085
Alternative sequence1 – 1515Missing in isoform 2.
VSP_026084

Experimental info

Sequence conflict2631H → Y in AAH91787. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 12, 2007. Version 3.
Checksum: 8761FBFC0FE684DE

FASTA54862,259
        10         20         30         40         50         60 
MGKPKKKSDL SRAELMMMTI ADVIKQLVEA HEEGKDINLN KVKTKTSAKY GLSAQPRLVD 

        70         80         90        100        110        120 
IIAAVPPHYR RALVPKLKAK PIRTASGIAV VAVMCKPHRC PHISFTGNIC VYCPGGPDSD 

       130        140        150        160        170        180 
FEYSTQSYTG YEPTSMRAIR ARYDPYLQTR HRVEQLKQLG HSVDKVEFIV MGGTFMALPE 

       190        200        210        220        230        240 
EYRDYFIRNL HDALSGHTSN NVTEAVRYSE RSNTKCVGIT IETRPDYCLK RHLSDMLGYG 

       250        260        270        280        290        300 
CTRLEIGVQS VYEDVARDTN RGHTVRAVCE SFHLAKDAGF KVVAHMMPDL PNVGMERDVE 

       310        320        330        340        350        360 
QFIEFFENPA FRPDGLKLYP TLVIRGTGLY ELWKTGRYKS YSPSALVDLV ARILALVPPW 

       370        380        390        400        410        420 
TRVYRVQRDI PMPLVSSGVE HGNLRELALA RMKDMGTECR DVRTREVGIQ EIHHKVRPYQ 

       430        440        450        460        470        480 
VELIRRDYVA NGGWETFLSY EDPEQDILIG LLRLRRCSPQ SFRPELKGGV SIVRELHVYG 

       490        500        510        520        530        540 
SVVPVSSRDP SKFQHQGFGM MLMEEAERIA RDEHGSSKLA VISGVGTRNY YRKMGYELEG 


PYMVKNLY 

« Hide

Isoform 2 [UniParc].

Checksum: 70C0C16D4E4E0129
Show »

FASTA53360,589
Isoform 3 [UniParc].

Checksum: 1A1227439D70C4E7
Show »

FASTA45552,132

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX279523 Genomic DNA. Translation: CAI12039.1. Sequence problems.
BC091787 mRNA. Translation: AAH91787.1.
BC096810 mRNA. Translation: AAH96810.1.
RefSeqNP_001014344.2. NM_001014322.2.
UniGeneDr.84313.

3D structure databases

ProteinModelPortalQ5RIC0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000061557; ENSDARP00000061556; ENSDARG00000042005.
ENSDART00000138226; ENSDARP00000113240; ENSDARG00000042005. [Q5RIC0-2]
ENSDART00000152836; ENSDARP00000127220; ENSDARG00000042005. [Q5RIC0-3]
GeneID541509.
KEGGdre:541509.

Organism-specific databases

CTD55140.
ZFINZDB-GENE-050327-35. elp3.

Phylogenomic databases

eggNOGCOG1243.
GeneTreeENSGT00390000013141.
HOGENOMHOG000227514.
HOVERGENHBG107845.
InParanoidQ5RIC0.
KOK07739.
OMAGYKVVSH.
OrthoDBEOG7V765W.
PhylomeDBQ5RIC0.
TreeFamTF105752.

Gene expression databases

BgeeQ5RIC0.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 2 hits.
TIGRFAMsTIGR01211. ELP3. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20879291.
PROQ5RIC0.

Entry information

Entry nameELP3_DANRE
AccessionPrimary (citable) accession number: Q5RIC0
Secondary accession number(s): Q4V9M7, Q58ER7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 12, 2007
Last modified: April 16, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families