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Q5RI56

- OPTN_DANRE

UniProt

Q5RI56 - OPTN_DANRE

Protein

Optineurin

Gene

optn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Optineurin
    Gene namesi
    Name:optn
    ORF Names:si:ch211-240l19.3, zgc:66386, zgc:77868
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-030131-8103. optn.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517OptineurinPRO_0000058064Add
    BLAST

    Proteomic databases

    PRIDEiQ5RI56.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000020714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RI56.
    SMRiQ5RI56. Positions 491-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili15 – 127113Sequence AnalysisAdd
    BLAST
    Coiled coili174 – 453280Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG138369.
    HOGENOMiHOG000231899.
    HOVERGENiHBG106481.
    InParanoidiQ5RI56.
    PhylomeDBiQ5RI56.

    Family and domain databases

    InterProiIPR021063. NEMO_N.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF11577. NEMO. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5RI56-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGDISHPRG SGPGNLGSLE ETLQQMNTLI KENRDLKEAL KQTNLSMKER    50
    FEGLSAWKEK QKEERDFLEQ RLEEARTRLN TMDVENEALK NQVKELEKSG 100
    AECLHTELEA LRGQILRIQA EKNDLVAMNS ELQLKMGQGS PSNSFIEIRI 150
    ADDDLKVTKD LSSVPEASAF SMPKAESEEQ TVRQLLRSLR AETDEKERLQ 200
    LTLQEARGRI AELESKLEHA DSSAQTSLPS AAETNASTEV KNLEDQLLKL 250
    CNELKQAQIK LDEAESMKRN LQDRCKDLEQ DLGTLKTQLG DKQKVQAEND 300
    CLKVQMESLQ AAIKLEQKKT QDEKNNLNQL KDAYTKLFED YSELQEEKKK 350
    RESCVSKDDY DELQTRFATA EKALADKQQK IDEMKMELFQ KEKDLETISV 400
    FQAQAEIYSS DFYAERAARE KIHEEKERLA TQLEYVKKQN SQLQEEMESL 450
    GRHSMSEMQR RHVPRGANPQ GPTAPNNLPG GRGEWQQQNI PDHACPKCGE 500
    VLPDLDSLQI HIMDCII 517
    Length:517
    Mass (Da):59,062
    Last modified:March 29, 2005 - v2
    Checksum:i5613F8B04C116795
    GO
    Isoform 2 (identifier: Q5RI56-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         151-231: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:436
    Mass (Da):50,139
    Checksum:iCCCB49E7AF3A1352
    GO

    Sequence cautioni

    The sequence CAI11882.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941K → R in AAH55628. 1 PublicationCurated
    Sequence conflicti325 – 3251N → S in AAH55628. 1 PublicationCurated
    Sequence conflicti353 – 3531S → G in AAH55628. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei151 – 23181Missing in isoform 2. 1 PublicationVSP_013265Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX321885 Genomic DNA. Translation: CAI11882.1. Sequence problems.
    BC055628 mRNA. Translation: AAH55628.1.
    BC063986 mRNA. Translation: AAH63986.1.
    RefSeqiNP_001093536.2. NM_001100066.2.
    UniGeneiDr.79390.

    Genome annotation databases

    GeneIDi336159.
    KEGGidre:336159.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX321885 Genomic DNA. Translation: CAI11882.1 . Sequence problems.
    BC055628 mRNA. Translation: AAH55628.1 .
    BC063986 mRNA. Translation: AAH63986.1 .
    RefSeqi NP_001093536.2. NM_001100066.2.
    UniGenei Dr.79390.

    3D structure databases

    ProteinModelPortali Q5RI56.
    SMRi Q5RI56. Positions 491-517.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000020714.

    Proteomic databases

    PRIDEi Q5RI56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 336159.
    KEGGi dre:336159.

    Organism-specific databases

    CTDi 10133.
    ZFINi ZDB-GENE-030131-8103. optn.

    Phylogenomic databases

    eggNOGi NOG138369.
    HOGENOMi HOG000231899.
    HOVERGENi HBG106481.
    InParanoidi Q5RI56.
    PhylomeDBi Q5RI56.

    Miscellaneous databases

    NextBioi 20811611.
    PROi Q5RI56.

    Family and domain databases

    InterProi IPR021063. NEMO_N.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF11577. NEMO. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: SJD.

    Entry informationi

    Entry nameiOPTN_DANRE
    AccessioniPrimary (citable) accession number: Q5RI56
    Secondary accession number(s): Q6P3H5, Q7SXF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3