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Protein

Optineurin

Gene

optn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri487 – 51731CCHC NOA-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: InterPro
  • axonogenesis Source: ZFIN
  • Golgi ribbon formation Source: GO_Central
  • protein targeting to Golgi Source: GO_Central
  • regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • vesicle localization Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Gene namesi
Name:optn
ORF Names:si:ch211-240l19.3, zgc:66386, zgc:77868
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-8103. optn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517OptineurinPRO_0000058064Add
BLAST

Proteomic databases

PaxDbiQ5RI56.
PRIDEiQ5RI56.

PTM databases

iPTMnetiQ5RI56.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099052.

Structurei

3D structure databases

ProteinModelPortaliQ5RI56.
SMRiQ5RI56. Positions 491-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 127113Sequence analysisAdd
BLAST
Coiled coili174 – 453280Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC NOA-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri487 – 51731CCHC NOA-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE97. Eukaryota.
ENOG410Z0DF. LUCA.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ5RI56.
KOiK19946.
PhylomeDBiQ5RI56.

Family and domain databases

InterProiIPR032419. CC2-LZ_dom.
IPR021063. NEMO_N.
IPR032939. Optineurin.
[Graphical view]
PANTHERiPTHR31553:SF2. PTHR31553:SF2. 1 hit.
PfamiPF16516. CC2-LZ. 1 hit.
PF11577. NEMO. 1 hit.
[Graphical view]
PROSITEiPS51801. ZF_CCHC_NOA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RI56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDISHPRG SGPGNLGSLE ETLQQMNTLI KENRDLKEAL KQTNLSMKER
60 70 80 90 100
FEGLSAWKEK QKEERDFLEQ RLEEARTRLN TMDVENEALK NQVKELEKSG
110 120 130 140 150
AECLHTELEA LRGQILRIQA EKNDLVAMNS ELQLKMGQGS PSNSFIEIRI
160 170 180 190 200
ADDDLKVTKD LSSVPEASAF SMPKAESEEQ TVRQLLRSLR AETDEKERLQ
210 220 230 240 250
LTLQEARGRI AELESKLEHA DSSAQTSLPS AAETNASTEV KNLEDQLLKL
260 270 280 290 300
CNELKQAQIK LDEAESMKRN LQDRCKDLEQ DLGTLKTQLG DKQKVQAEND
310 320 330 340 350
CLKVQMESLQ AAIKLEQKKT QDEKNNLNQL KDAYTKLFED YSELQEEKKK
360 370 380 390 400
RESCVSKDDY DELQTRFATA EKALADKQQK IDEMKMELFQ KEKDLETISV
410 420 430 440 450
FQAQAEIYSS DFYAERAARE KIHEEKERLA TQLEYVKKQN SQLQEEMESL
460 470 480 490 500
GRHSMSEMQR RHVPRGANPQ GPTAPNNLPG GRGEWQQQNI PDHACPKCGE
510
VLPDLDSLQI HIMDCII
Length:517
Mass (Da):59,062
Last modified:March 29, 2005 - v2
Checksum:i5613F8B04C116795
GO
Isoform 2 (identifier: Q5RI56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-231: Missing.

Note: No experimental confirmation available.
Show »
Length:436
Mass (Da):50,139
Checksum:iCCCB49E7AF3A1352
GO

Sequence cautioni

The sequence CAI11882 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941K → R in AAH55628 (Ref. 2) Curated
Sequence conflicti325 – 3251N → S in AAH55628 (Ref. 2) Curated
Sequence conflicti353 – 3531S → G in AAH55628 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei151 – 23181Missing in isoform 2. 1 PublicationVSP_013265Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321885 Genomic DNA. Translation: CAI11882.1. Sequence problems.
BC055628 mRNA. Translation: AAH55628.1.
BC063986 mRNA. Translation: AAH63986.1.
RefSeqiNP_001093536.2. NM_001100066.2.
UniGeneiDr.79390.

Genome annotation databases

GeneIDi336159.
KEGGidre:336159.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321885 Genomic DNA. Translation: CAI11882.1. Sequence problems.
BC055628 mRNA. Translation: AAH55628.1.
BC063986 mRNA. Translation: AAH63986.1.
RefSeqiNP_001093536.2. NM_001100066.2.
UniGeneiDr.79390.

3D structure databases

ProteinModelPortaliQ5RI56.
SMRiQ5RI56. Positions 491-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099052.

PTM databases

iPTMnetiQ5RI56.

Proteomic databases

PaxDbiQ5RI56.
PRIDEiQ5RI56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi336159.
KEGGidre:336159.

Organism-specific databases

CTDi10133.
ZFINiZDB-GENE-030131-8103. optn.

Phylogenomic databases

eggNOGiENOG410IE97. Eukaryota.
ENOG410Z0DF. LUCA.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ5RI56.
KOiK19946.
PhylomeDBiQ5RI56.

Miscellaneous databases

PROiQ5RI56.

Family and domain databases

InterProiIPR032419. CC2-LZ_dom.
IPR021063. NEMO_N.
IPR032939. Optineurin.
[Graphical view]
PANTHERiPTHR31553:SF2. PTHR31553:SF2. 1 hit.
PfamiPF16516. CC2-LZ. 1 hit.
PF11577. NEMO. 1 hit.
[Graphical view]
PROSITEiPS51801. ZF_CCHC_NOA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPTN_DANRE
AccessioniPrimary (citable) accession number: Q5RI56
Secondary accession number(s): Q6P3H5, Q7SXF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.