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Q5RI56

- OPTN_DANRE

UniProt

Q5RI56 - OPTN_DANRE

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Protein

Optineurin

Gene

optn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Gene namesi
Name:optn
ORF Names:si:ch211-240l19.3, zgc:66386, zgc:77868
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-8103. optn.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517OptineurinPRO_0000058064Add
BLAST

Proteomic databases

PRIDEiQ5RI56.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020714.

Structurei

3D structure databases

ProteinModelPortaliQ5RI56.
SMRiQ5RI56. Positions 491-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 127113Sequence AnalysisAdd
BLAST
Coiled coili174 – 453280Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ5RI56.
PhylomeDBiQ5RI56.

Family and domain databases

InterProiIPR021063. NEMO_N.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5RI56-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDISHPRG SGPGNLGSLE ETLQQMNTLI KENRDLKEAL KQTNLSMKER
60 70 80 90 100
FEGLSAWKEK QKEERDFLEQ RLEEARTRLN TMDVENEALK NQVKELEKSG
110 120 130 140 150
AECLHTELEA LRGQILRIQA EKNDLVAMNS ELQLKMGQGS PSNSFIEIRI
160 170 180 190 200
ADDDLKVTKD LSSVPEASAF SMPKAESEEQ TVRQLLRSLR AETDEKERLQ
210 220 230 240 250
LTLQEARGRI AELESKLEHA DSSAQTSLPS AAETNASTEV KNLEDQLLKL
260 270 280 290 300
CNELKQAQIK LDEAESMKRN LQDRCKDLEQ DLGTLKTQLG DKQKVQAEND
310 320 330 340 350
CLKVQMESLQ AAIKLEQKKT QDEKNNLNQL KDAYTKLFED YSELQEEKKK
360 370 380 390 400
RESCVSKDDY DELQTRFATA EKALADKQQK IDEMKMELFQ KEKDLETISV
410 420 430 440 450
FQAQAEIYSS DFYAERAARE KIHEEKERLA TQLEYVKKQN SQLQEEMESL
460 470 480 490 500
GRHSMSEMQR RHVPRGANPQ GPTAPNNLPG GRGEWQQQNI PDHACPKCGE
510
VLPDLDSLQI HIMDCII
Length:517
Mass (Da):59,062
Last modified:March 29, 2005 - v2
Checksum:i5613F8B04C116795
GO
Isoform 2 (identifier: Q5RI56-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-231: Missing.

Note: No experimental confirmation available.

Show »
Length:436
Mass (Da):50,139
Checksum:iCCCB49E7AF3A1352
GO

Sequence cautioni

The sequence CAI11882.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941K → R in AAH55628. 1 PublicationCurated
Sequence conflicti325 – 3251N → S in AAH55628. 1 PublicationCurated
Sequence conflicti353 – 3531S → G in AAH55628. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei151 – 23181Missing in isoform 2. 1 PublicationVSP_013265Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321885 Genomic DNA. Translation: CAI11882.1. Sequence problems.
BC055628 mRNA. Translation: AAH55628.1.
BC063986 mRNA. Translation: AAH63986.1.
RefSeqiNP_001093536.2. NM_001100066.2.
UniGeneiDr.79390.

Genome annotation databases

GeneIDi336159.
KEGGidre:336159.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321885 Genomic DNA. Translation: CAI11882.1 . Sequence problems.
BC055628 mRNA. Translation: AAH55628.1 .
BC063986 mRNA. Translation: AAH63986.1 .
RefSeqi NP_001093536.2. NM_001100066.2.
UniGenei Dr.79390.

3D structure databases

ProteinModelPortali Q5RI56.
SMRi Q5RI56. Positions 491-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000020714.

Proteomic databases

PRIDEi Q5RI56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 336159.
KEGGi dre:336159.

Organism-specific databases

CTDi 10133.
ZFINi ZDB-GENE-030131-8103. optn.

Phylogenomic databases

eggNOGi NOG138369.
HOGENOMi HOG000231899.
HOVERGENi HBG106481.
InParanoidi Q5RI56.
PhylomeDBi Q5RI56.

Miscellaneous databases

NextBioi 20811611.
PROi Q5RI56.

Family and domain databases

InterProi IPR021063. NEMO_N.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF11577. NEMO. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: SJD.

Entry informationi

Entry nameiOPTN_DANRE
AccessioniPrimary (citable) accession number: Q5RI56
Secondary accession number(s): Q6P3H5, Q7SXF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3