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Protein

Optineurin

Gene

optn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri487 – 517CCHC NOA-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: InterPro
  • axonogenesis Source: ZFIN
  • Golgi ribbon formation Source: GO_Central
  • regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • vesicle localization Source: ZFIN
  • vesicle-mediated transport Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Gene namesi
Name:optn
ORF Names:si:ch211-240l19.3, zgc:66386, zgc:77868
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-8103 optn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580641 – 517OptineurinAdd BLAST517

Proteomic databases

PaxDbiQ5RI56

PTM databases

iPTMnetiQ5RI56

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099052

Structurei

3D structure databases

ProteinModelPortaliQ5RI56
SMRiQ5RI56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 127Sequence analysisAdd BLAST113
Coiled coili174 – 453Sequence analysisAdd BLAST280

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri487 – 517CCHC NOA-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE97 Eukaryota
ENOG410Z0DF LUCA
HOGENOMiHOG000231899
HOVERGENiHBG106481
InParanoidiQ5RI56
KOiK19946
PhylomeDBiQ5RI56

Family and domain databases

InterProiView protein in InterPro
IPR032419 CC2-LZ_dom
IPR021063 NEMO_N
IPR034735 NEMO_ZF
IPR032939 Optineurin
PANTHERiPTHR31553:SF2 PTHR31553:SF2, 1 hit
PfamiView protein in Pfam
PF16516 CC2-LZ, 1 hit
PF11577 NEMO, 1 hit
PROSITEiView protein in PROSITE
PS51801 ZF_CCHC_NOA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RI56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDISHPRG SGPGNLGSLE ETLQQMNTLI KENRDLKEAL KQTNLSMKER
60 70 80 90 100
FEGLSAWKEK QKEERDFLEQ RLEEARTRLN TMDVENEALK NQVKELEKSG
110 120 130 140 150
AECLHTELEA LRGQILRIQA EKNDLVAMNS ELQLKMGQGS PSNSFIEIRI
160 170 180 190 200
ADDDLKVTKD LSSVPEASAF SMPKAESEEQ TVRQLLRSLR AETDEKERLQ
210 220 230 240 250
LTLQEARGRI AELESKLEHA DSSAQTSLPS AAETNASTEV KNLEDQLLKL
260 270 280 290 300
CNELKQAQIK LDEAESMKRN LQDRCKDLEQ DLGTLKTQLG DKQKVQAEND
310 320 330 340 350
CLKVQMESLQ AAIKLEQKKT QDEKNNLNQL KDAYTKLFED YSELQEEKKK
360 370 380 390 400
RESCVSKDDY DELQTRFATA EKALADKQQK IDEMKMELFQ KEKDLETISV
410 420 430 440 450
FQAQAEIYSS DFYAERAARE KIHEEKERLA TQLEYVKKQN SQLQEEMESL
460 470 480 490 500
GRHSMSEMQR RHVPRGANPQ GPTAPNNLPG GRGEWQQQNI PDHACPKCGE
510
VLPDLDSLQI HIMDCII
Length:517
Mass (Da):59,062
Last modified:March 29, 2005 - v2
Checksum:i5613F8B04C116795
GO
Isoform 2 (identifier: Q5RI56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-231: Missing.

Note: No experimental confirmation available.
Show »
Length:436
Mass (Da):50,139
Checksum:iCCCB49E7AF3A1352
GO

Sequence cautioni

The sequence CAI11882 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94K → R in AAH55628 (Ref. 2) Curated1
Sequence conflicti325N → S in AAH55628 (Ref. 2) Curated1
Sequence conflicti353S → G in AAH55628 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013265151 – 231Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321885 Genomic DNA Translation: CAI11882.1 Sequence problems.
BC055628 mRNA Translation: AAH55628.1
BC063986 mRNA Translation: AAH63986.1
RefSeqiNP_001093536.2, NM_001100066.2
UniGeneiDr.79390

Genome annotation databases

GeneIDi336159
KEGGidre:336159

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOPTN_DANRE
AccessioniPrimary (citable) accession number: Q5RI56
Secondary accession number(s): Q6P3H5, Q7SXF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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