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Protein

Cytochrome c oxidase protein 20 homolog

Gene

COX20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase protein 20 homolog
Gene namesi
Name:COX20
Synonyms:FAM36A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26970. COX20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5118HelicalSequence analysisAdd
BLAST
Transmembranei61 – 7717HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

MalaCardsiCOX20.
Orphaneti254905. Isolated cytochrome C oxidase deficiency.
PharmGKBiPA134976890.

Polymorphism and mutation databases

BioMutaiCOX20.
DMDMi71151875.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 118117Cytochrome c oxidase protein 20 homologPRO_0000186815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5RI15.
MaxQBiQ5RI15.
PaxDbiQ5RI15.
PeptideAtlasiQ5RI15.
PRIDEiQ5RI15.

PTM databases

iPTMnetiQ5RI15.
PhosphoSiteiQ5RI15.

Expressioni

Gene expression databases

BgeeiQ5RI15.
CleanExiHS_FAM36A.
ExpressionAtlasiQ5RI15. baseline and differential.
GenevisibleiQ5RI15. HS.

Organism-specific databases

HPAiHPA043617.
HPA045490.

Interactioni

Protein-protein interaction databases

BioGridi125491. 9 interactions.
IntActiQ5RI15. 2 interactions.
STRINGi9606.ENSP00000406327.

Structurei

3D structure databases

ProteinModelPortaliQ5RI15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3VJ. Eukaryota.
ENOG4111Y8F. LUCA.
GeneTreeiENSGT00390000016158.
HOGENOMiHOG000008535.
HOVERGENiHBG054540.
InParanoidiQ5RI15.
KOiK18184.
OMAiCGTIAYW.
OrthoDBiEOG754HRR.
PhylomeDBiQ5RI15.
TreeFamiTF323844.

Family and domain databases

InterProiIPR022533. Cox20/FAM36A.
IPR023242. FAM36A.
[Graphical view]
PfamiPF12597. DUF3767. 1 hit.
[Graphical view]
PRINTSiPR02049. PROTEINF36A.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RI15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPEPGEP EERKSLKLLG FLDVENTPCA RHSILYGSLG SVVAGFGHFL
60 70 80 90 100
FTSRIRRSCD VGVGGFILVT LGCWFHCRYN YAKQRIQERI AREEIKKKIL
110
YEGTHLDPER KHNGSSSN
Length:118
Mass (Da):13,291
Last modified:July 19, 2005 - v2
Checksum:i8D413FD148382A94
GO
Isoform 2 (identifier: Q5RI15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: K → KASCTSLHLSYWK

Note: Gene prediction confirmed by EST data.
Show »
Length:130
Mass (Da):14,669
Checksum:i4913B08459483B9B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei14 – 141K → KASCTSLHLSYWK in isoform 2. CuratedVSP_014855

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323046 Genomic DNA. Translation: CAI11052.1.
BX323046 Genomic DNA. Translation: CAI11053.1.
BC018519 mRNA. Translation: AAH18519.1.
BC062419 mRNA. Translation: AAH62419.1.
BC095486 mRNA. Translation: AAH95486.1.
CCDSiCCDS31080.1. [Q5RI15-1]
RefSeqiNP_001299800.1. NM_001312871.1. [Q5RI15-1]
NP_932342.1. NM_198076.5. [Q5RI15-1]
UniGeneiHs.411490.

Genome annotation databases

EnsembliENST00000366528; ENSP00000355486; ENSG00000203667. [Q5RI15-2]
ENST00000411948; ENSP00000406327; ENSG00000203667. [Q5RI15-1]
GeneIDi116228.
KEGGihsa:116228.
UCSCiuc001iar.5. human. [Q5RI15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323046 Genomic DNA. Translation: CAI11052.1.
BX323046 Genomic DNA. Translation: CAI11053.1.
BC018519 mRNA. Translation: AAH18519.1.
BC062419 mRNA. Translation: AAH62419.1.
BC095486 mRNA. Translation: AAH95486.1.
CCDSiCCDS31080.1. [Q5RI15-1]
RefSeqiNP_001299800.1. NM_001312871.1. [Q5RI15-1]
NP_932342.1. NM_198076.5. [Q5RI15-1]
UniGeneiHs.411490.

3D structure databases

ProteinModelPortaliQ5RI15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125491. 9 interactions.
IntActiQ5RI15. 2 interactions.
STRINGi9606.ENSP00000406327.

PTM databases

iPTMnetiQ5RI15.
PhosphoSiteiQ5RI15.

Polymorphism and mutation databases

BioMutaiCOX20.
DMDMi71151875.

Proteomic databases

EPDiQ5RI15.
MaxQBiQ5RI15.
PaxDbiQ5RI15.
PeptideAtlasiQ5RI15.
PRIDEiQ5RI15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366528; ENSP00000355486; ENSG00000203667. [Q5RI15-2]
ENST00000411948; ENSP00000406327; ENSG00000203667. [Q5RI15-1]
GeneIDi116228.
KEGGihsa:116228.
UCSCiuc001iar.5. human. [Q5RI15-1]

Organism-specific databases

CTDi116228.
GeneCardsiCOX20.
H-InvDBHIX0001752.
HGNCiHGNC:26970. COX20.
HPAiHPA043617.
HPA045490.
MalaCardsiCOX20.
MIMi614698. gene.
neXtProtiNX_Q5RI15.
Orphaneti254905. Isolated cytochrome C oxidase deficiency.
PharmGKBiPA134976890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3VJ. Eukaryota.
ENOG4111Y8F. LUCA.
GeneTreeiENSGT00390000016158.
HOGENOMiHOG000008535.
HOVERGENiHBG054540.
InParanoidiQ5RI15.
KOiK18184.
OMAiCGTIAYW.
OrthoDBiEOG754HRR.
PhylomeDBiQ5RI15.
TreeFamiTF323844.

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiCOX20. human.
GenomeRNAii116228.
PROiQ5RI15.
SOURCEiSearch...

Gene expression databases

BgeeiQ5RI15.
CleanExiHS_FAM36A.
ExpressionAtlasiQ5RI15. baseline and differential.
GenevisibleiQ5RI15. HS.

Family and domain databases

InterProiIPR022533. Cox20/FAM36A.
IPR023242. FAM36A.
[Graphical view]
PfamiPF12597. DUF3767. 1 hit.
[Graphical view]
PRINTSiPR02049. PROTEINF36A.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Prostate and Uterus.
  3. "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."
    Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M., van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P., Nijtmans L.G., Huynen M.A.
    Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX20_HUMAN
AccessioniPrimary (citable) accession number: Q5RI15
Secondary accession number(s): Q8WV86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 6, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.