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Protein
Submitted name:

Prostaglandin G/H synthase 2b

Gene

ptgs2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • heme binding Source: InterPro
  • peroxidase activity Source: ZFIN
  • prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_273507. Nicotinamide salvaging.
REACT_298466. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_339986. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 2bImported
Submitted name:
Prostaglandin-endoperoxide synthase 2bImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ptgs2bImported
Synonyms:si:dkey-97o5.6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-041014-323. ptgs2b.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003684.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.
OMAiCNNVKGC.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RI06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSVLFIFL LLGFVVCTGA NPCCSHPCQN RGVCTEMGSD AYECDCTRTG
60 70 80 90 100
YYGQNCTTPE FLTWVKVSLK PSPNTVHYIL THFKSLWNII NNVSFLRNGI
110 120 130 140 150
MRYVLTSRAH LIDSPPTFNA DYGYKSWEAY SNLSYYTRTL PPVPRDCPTP
160 170 180 190 200
MGVAGKKELP DVKMLAEKLL LRRKFIPDPQ RTNLMFAFFA QHFTHQFFKS
210 220 230 240 250
DMKKGPAFTT ALNHGVDLAH IYGQNLDRQH KLRLFKDGKL RYQILDGEVY
260 270 280 290 300
PPTVSEVQVD MHYPPHVPES RRFAVGHEAF GLVPGLMMYA TIWLREHNRV
310 320 330 340 350
CDILKQEHPD WDDERLFQTS RLILIGETIK IVIEDYVQHL SGYYFKLKFD
360 370 380 390 400
PELLFNERFQ YQNRISSEFN TLYHWHPLMP DDFHIQDEVY NYQQFLFNTS
410 420 430 440 450
ILTDYGVNSL VESFNKQIAG RVAGGRNVAP AVLRVAIKSI ENSRQMRYQS
460 470 480 490 500
INAYRKRFNM KPYRSFEEMT GEKEMAAELE EMYGDVDAVE LYAGLLVEKP
510 520 530 540 550
RSNAIFGETM VEMGAPYSLK GLMGNPICSP EYWKPSTFGG KVGFEIVNSA
560 570 580 590 600
SLQNLVCNNV NGPCPMASFY VPNVKDSLPT TINASTSQSD RNVNPTVLLK

ERTSEL
Length:606
Mass (Da):69,465
Last modified:December 21, 2004 - v1
Checksum:iC0601EA49A06EA6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323056 Genomic DNA. No translation available.
BC139568 mRNA. Translation: AAI39569.1.
DQ494791 mRNA. Translation: ABF50051.1.
RefSeqiNP_001020675.1. NM_001025504.2.
UniGeneiDr.48719.

Genome annotation databases

EnsembliENSDART00000010028; ENSDARP00000003684; ENSDARG00000010276.
GeneIDi559020.
KEGGidre:559020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323056 Genomic DNA. No translation available.
BC139568 mRNA. Translation: AAI39569.1.
DQ494791 mRNA. Translation: ABF50051.1.
RefSeqiNP_001020675.1. NM_001025504.2.
UniGeneiDr.48719.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010028; ENSDARP00000003684; ENSDARG00000010276.
GeneIDi559020.
KEGGidre:559020.

Organism-specific databases

CTDi559020.
ZFINiZDB-GENE-041014-323. ptgs2b.

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.
OMAiCNNVKGC.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Enzyme and pathway databases

ReactomeiREACT_273507. Nicotinamide salvaging.
REACT_298466. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_339986. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi20882745.
PROiQ5RI06.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes."
    Ishikawa T., Griffin K.J.P., Banerjee U., Herschman H.R.
    Biochem. Biophys. Res. Commun. 352:181-187(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Singapore local strainImported.
    Tissue: EmbryoImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  4. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ5RI06_DANRE
AccessioniPrimary (citable) accession number: Q5RI06
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 22, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.