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Q5RI06

- Q5RI06_DANRE

UniProt

Q5RI06 - Q5RI06_DANRE

Protein
Submitted name:

Prostaglandin G/H synthase 2b

Gene

ptgs2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. peroxidase activity Source: ZFIN

    GO - Biological processi

    1. cellular response to organic cyclic compound Source: ZFIN
    2. response to oxidative stress Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_181614. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
    REACT_225804. Synthesis of 15-eicosatetraenoic acid derivatives.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prostaglandin G/H synthase 2bImported
    Submitted name:
    Prostaglandin-endoperoxide synthase 2bImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:ptgs2bImported
    Synonyms:si:dkey-97o5.6Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 20

    Organism-specific databases

    ZFINiZDB-GENE-041014-323. ptgs2b.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000003684.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG39991.
    GeneTreeiENSGT00390000010743.
    HOGENOMiHOG000013149.
    HOVERGENiHBG000366.
    InParanoidiQ5RI06.
    KOiK11987.
    OMAiICNNVKG.
    OrthoDBiEOG7RFTHC.
    TreeFamiTF329675.

    Family and domain databases

    Gene3Di1.10.640.10. 1 hit.
    InterProiIPR029576. COX-2.
    IPR000742. EG-like_dom.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    [Graphical view]
    PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
    PfamiPF03098. An_peroxidase. 2 hits.
    [Graphical view]
    PRINTSiPR00457. ANPEROXIDASE.
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS50026. EGF_3. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RI06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSSVLFIFL LLGFVVCTGA NPCCSHPCQN RGVCTEMGSD AYECDCTRTG    50
    YYGQNCTTPE FLTWVKVSLK PSPNTVHYIL THFKSLWNII NNVSFLRNGI 100
    MRYVLTSRAH LIDSPPTFNA DYGYKSWEAY SNLSYYTRTL PPVPRDCPTP 150
    MGVAGKKELP DVKMLAEKLL LRRKFIPDPQ RTNLMFAFFA QHFTHQFFKS 200
    DMKKGPAFTT ALNHGVDLAH IYGQNLDRQH KLRLFKDGKL RYQILDGEVY 250
    PPTVSEVQVD MHYPPHVPES RRFAVGHEAF GLVPGLMMYA TIWLREHNRV 300
    CDILKQEHPD WDDERLFQTS RLILIGETIK IVIEDYVQHL SGYYFKLKFD 350
    PELLFNERFQ YQNRISSEFN TLYHWHPLMP DDFHIQDEVY NYQQFLFNTS 400
    ILTDYGVNSL VESFNKQIAG RVAGGRNVAP AVLRVAIKSI ENSRQMRYQS 450
    INAYRKRFNM KPYRSFEEMT GEKEMAAELE EMYGDVDAVE LYAGLLVEKP 500
    RSNAIFGETM VEMGAPYSLK GLMGNPICSP EYWKPSTFGG KVGFEIVNSA 550
    SLQNLVCNNV NGPCPMASFY VPNVKDSLPT TINASTSQSD RNVNPTVLLK 600
    ERTSEL 606
    Length:606
    Mass (Da):69,465
    Last modified:December 21, 2004 - v1
    Checksum:iC0601EA49A06EA6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX323056 Genomic DNA. No translation available.
    BC139568 mRNA. Translation: AAI39569.1.
    DQ494791 mRNA. Translation: ABF50051.1.
    RefSeqiNP_001020675.1. NM_001025504.2.
    UniGeneiDr.48719.

    Genome annotation databases

    EnsembliENSDART00000010028; ENSDARP00000003684; ENSDARG00000010276.
    GeneIDi559020.
    KEGGidre:559020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX323056 Genomic DNA. No translation available.
    BC139568 mRNA. Translation: AAI39569.1 .
    DQ494791 mRNA. Translation: ABF50051.1 .
    RefSeqi NP_001020675.1. NM_001025504.2.
    UniGenei Dr.48719.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000003684.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000010028 ; ENSDARP00000003684 ; ENSDARG00000010276 .
    GeneIDi 559020.
    KEGGi dre:559020.

    Organism-specific databases

    CTDi 559020.
    ZFINi ZDB-GENE-041014-323. ptgs2b.

    Phylogenomic databases

    eggNOGi NOG39991.
    GeneTreei ENSGT00390000010743.
    HOGENOMi HOG000013149.
    HOVERGENi HBG000366.
    InParanoidi Q5RI06.
    KOi K11987.
    OMAi ICNNVKG.
    OrthoDBi EOG7RFTHC.
    TreeFami TF329675.

    Enzyme and pathway databases

    Reactomei REACT_181614. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
    REACT_225804. Synthesis of 15-eicosatetraenoic acid derivatives.

    Miscellaneous databases

    NextBioi 20882745.
    PROi Q5RI06.

    Family and domain databases

    Gene3Di 1.10.640.10. 1 hit.
    InterProi IPR029576. COX-2.
    IPR000742. EG-like_dom.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    [Graphical view ]
    PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
    Pfami PF03098. An_peroxidase. 2 hits.
    [Graphical view ]
    PRINTSi PR00457. ANPEROXIDASE.
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS50026. EGF_3. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes."
      Ishikawa T., Griffin K.J.P., Banerjee U., Herschman H.R.
      Biochem. Biophys. Res. Commun. 352:181-187(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Singapore local strainImported.
      Tissue: EmbryoImported.
    3. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.
    4. Ensembl
      Submitted (AUG-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ5RI06_DANRE
    AccessioniPrimary (citable) accession number: Q5RI06
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3