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Q5RI06

- Q5RI06_DANRE

UniProt

Q5RI06 - Q5RI06_DANRE

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Protein
Submitted name:

Prostaglandin G/H synthase 2b

Gene

ptgs2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: ZFIN
  3. prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

  1. cellular response to organic cyclic compound Source: ZFIN
  2. cyclooxygenase pathway Source: InterPro
  3. inflammatory response Source: InterPro
  4. regulation of blood pressure Source: InterPro
  5. response to oxidative stress Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_181614. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_225804. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_241815. Nicotinamide salvaging.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 2bImported
Submitted name:
Prostaglandin-endoperoxide synthase 2bImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ptgs2bImported
Synonyms:si:dkey-97o5.6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-041014-323. ptgs2b.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003684.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.
OMAiICNNVKG.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RI06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSSVLFIFL LLGFVVCTGA NPCCSHPCQN RGVCTEMGSD AYECDCTRTG
60 70 80 90 100
YYGQNCTTPE FLTWVKVSLK PSPNTVHYIL THFKSLWNII NNVSFLRNGI
110 120 130 140 150
MRYVLTSRAH LIDSPPTFNA DYGYKSWEAY SNLSYYTRTL PPVPRDCPTP
160 170 180 190 200
MGVAGKKELP DVKMLAEKLL LRRKFIPDPQ RTNLMFAFFA QHFTHQFFKS
210 220 230 240 250
DMKKGPAFTT ALNHGVDLAH IYGQNLDRQH KLRLFKDGKL RYQILDGEVY
260 270 280 290 300
PPTVSEVQVD MHYPPHVPES RRFAVGHEAF GLVPGLMMYA TIWLREHNRV
310 320 330 340 350
CDILKQEHPD WDDERLFQTS RLILIGETIK IVIEDYVQHL SGYYFKLKFD
360 370 380 390 400
PELLFNERFQ YQNRISSEFN TLYHWHPLMP DDFHIQDEVY NYQQFLFNTS
410 420 430 440 450
ILTDYGVNSL VESFNKQIAG RVAGGRNVAP AVLRVAIKSI ENSRQMRYQS
460 470 480 490 500
INAYRKRFNM KPYRSFEEMT GEKEMAAELE EMYGDVDAVE LYAGLLVEKP
510 520 530 540 550
RSNAIFGETM VEMGAPYSLK GLMGNPICSP EYWKPSTFGG KVGFEIVNSA
560 570 580 590 600
SLQNLVCNNV NGPCPMASFY VPNVKDSLPT TINASTSQSD RNVNPTVLLK

ERTSEL
Length:606
Mass (Da):69,465
Last modified:December 21, 2004 - v1
Checksum:iC0601EA49A06EA6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323056 Genomic DNA. No translation available.
BC139568 mRNA. Translation: AAI39569.1.
DQ494791 mRNA. Translation: ABF50051.1.
RefSeqiNP_001020675.1. NM_001025504.2.
UniGeneiDr.48719.

Genome annotation databases

EnsembliENSDART00000010028; ENSDARP00000003684; ENSDARG00000010276.
GeneIDi559020.
KEGGidre:559020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323056 Genomic DNA. No translation available.
BC139568 mRNA. Translation: AAI39569.1 .
DQ494791 mRNA. Translation: ABF50051.1 .
RefSeqi NP_001020675.1. NM_001025504.2.
UniGenei Dr.48719.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000003684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000010028 ; ENSDARP00000003684 ; ENSDARG00000010276 .
GeneIDi 559020.
KEGGi dre:559020.

Organism-specific databases

CTDi 559020.
ZFINi ZDB-GENE-041014-323. ptgs2b.

Phylogenomic databases

eggNOGi NOG39991.
GeneTreei ENSGT00390000010743.
HOGENOMi HOG000013149.
HOVERGENi HBG000366.
KOi K11987.
OMAi ICNNVKG.
OrthoDBi EOG7RFTHC.
TreeFami TF329675.

Enzyme and pathway databases

Reactomei REACT_181614. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_225804. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_241815. Nicotinamide salvaging.

Miscellaneous databases

NextBioi 20882745.
PROi Q5RI06.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
Pfami PF03098. An_peroxidase. 2 hits.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes."
    Ishikawa T., Griffin K.J.P., Banerjee U., Herschman H.R.
    Biochem. Biophys. Res. Commun. 352:181-187(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Singapore local strainImported.
    Tissue: EmbryoImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  4. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ5RI06_DANRE
AccessioniPrimary (citable) accession number: Q5RI06
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3