Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein MCM10 homolog

Gene

mcm10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA replication

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-176187. Activation of ATR in response to replication stress.
R-DRE-68962. Activation of the pre-replicative complex.
R-DRE-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MCM10 homolog
Gene namesi
Name:mcm10
ORF Names:si:ch211-206k18.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-041210-42. mcm10.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Protein MCM10 homologPRO_0000278322Add
BLAST

Proteomic databases

PaxDbiQ5RHY1.

Expressioni

Gene expression databases

BgeeiQ5RHY1.

Interactioni

Subunit structurei

Self-associates.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067338.

Structurei

3D structure databases

ProteinModelPortaliQ5RHY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 122122N-terminal domainBy similarityAdd
BLAST
Regioni202 – 360159OB-fold domainBy similarityAdd
BLAST
Regioni361 – 38626Zinc finger-like 1Add
BLAST
Regioni741 – 76020Zinc finger-like 2By similarityAdd
BLAST
Regioni774 – 79421Zinc finger-like 3By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili70 – 10839Sequence analysisAdd
BLAST

Domaini

Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.By similarity
The N-terminal domain mediates homodimerization.By similarity

Sequence similaritiesi

Belongs to the MCM10 family.Curated

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3056. Eukaryota.
ENOG41100ZT. LUCA.
GeneTreeiENSGT00390000007134.
HOGENOMiHOG000082481.
HOVERGENiHBG055312.
InParanoidiQ5RHY1.
KOiK10736.
OMAiKHCSNCG.
OrthoDBiEOG7D59N8.
PhylomeDBiQ5RHY1.
TreeFamiTF313330.

Family and domain databases

InterProiIPR015411. Rep_factor_Mcm10_C.
IPR015408. Znf_Mcm10/DnaG.
[Graphical view]
PfamiPF09332. Mcm10. 1 hit.
PF09329. zf-primase. 1 hit.
[Graphical view]
SMARTiSM01280. Mcm10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RHY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEEENLDML LSLFAESEGQ DLESPAAEEG EDNLDDLFDE DDDGEQYIEP
60 70 80 90 100
EEAEEEKEEE EEEVSPGKSS SSDLNKSKED LEAELKLMQE KMQKLQQQLE
110 120 130 140 150
ASQKTTPAQN KPAVQRQSTK SLTSPQAGVK TTPPTVRDSD GSPSNITAKL
160 170 180 190 200
KNKQRTAHQP KAASSERQIP IGQSTNQPQP MRDGAKVNSM LKSPPLIKTP
210 220 230 240 250
PTVRQPTPRL PVNQEVAVEK FSGLRLRKPR LSSIDIEQKM ASRKLIRLSQ
260 270 280 290 300
LPDRLARDNL EDSDWVTFAV IINKITPQSK NNGKTFSIWK LNDLHNLEVN
310 320 330 340 350
VSLFLFGSVH TDLWKTDTGT VIGILNPNPM KNKEGSNELS LTVDHPQKVL
360 370 380 390 400
IIGEAMDFGT CKAKKKNGDS CTQLVNLYEC QFCQYHVKAQ YKKMSSKRAE
410 420 430 440 450
LQSSFTGSAP GKGRGRGSLK ERLCQSDFHY GGMSSLACAP SMSAPQPKKQ
460 470 480 490 500
PTIQSALASI PTKKLVLNSG QVSGCSDDFR GLMSMPTPGA LNIKRHLGQS
510 520 530 540 550
KSSAVAGSSV QSVSASDLLK QQKEQHQQRM MARKKRAEEI QKRVLQSGGA
560 570 580 590 600
PVASSRPNVS RGPLLSPKAA SEGPKGSGSS LSGPAVPTLG RGFSEGEDIV
610 620 630 640 650
FDMSPPSSKS LSATKLAAVR KLQAKGSVIV KEDPNAVKRK RANSGDITGR
660 670 680 690 700
VERNIVKAKV TDENSASEEE EPAMKKRREQ LEYIQSEEFQ RILNAKSSNS
710 720 730 740 750
WMMGEIEERA MQEYFEPLVQ KEKMEEKMKS IREMKCRAVT CKTCKYTHFK
760 770 780 790 800
PADRCVEEKH DYHWHDAVKR FFKCPCGQRK ICLARMPHGA CSHCGLFKWE
810 820 830
RDGMLKEKKG PKIGGELLMP RGEEQPKFLN SLK
Length:833
Mass (Da):92,439
Last modified:December 21, 2004 - v1
Checksum:iD0E7700B2FE8B2C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323869 Genomic DNA. Translation: CAI11761.1.
RefSeqiNP_001019984.1. NM_001024813.1.
UniGeneiDr.40391.

Genome annotation databases

EnsembliENSDART00000067339; ENSDARP00000067338; ENSDARG00000045815.
GeneIDi553396.
KEGGidre:553396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323869 Genomic DNA. Translation: CAI11761.1.
RefSeqiNP_001019984.1. NM_001024813.1.
UniGeneiDr.40391.

3D structure databases

ProteinModelPortaliQ5RHY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067338.

Proteomic databases

PaxDbiQ5RHY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000067339; ENSDARP00000067338; ENSDARG00000045815.
GeneIDi553396.
KEGGidre:553396.

Organism-specific databases

CTDi55388.
ZFINiZDB-GENE-041210-42. mcm10.

Phylogenomic databases

eggNOGiKOG3056. Eukaryota.
ENOG41100ZT. LUCA.
GeneTreeiENSGT00390000007134.
HOGENOMiHOG000082481.
HOVERGENiHBG055312.
InParanoidiQ5RHY1.
KOiK10736.
OMAiKHCSNCG.
OrthoDBiEOG7D59N8.
PhylomeDBiQ5RHY1.
TreeFamiTF313330.

Enzyme and pathway databases

ReactomeiR-DRE-176187. Activation of ATR in response to replication stress.
R-DRE-68962. Activation of the pre-replicative complex.
R-DRE-69300. Removal of licensing factors from origins.

Miscellaneous databases

NextBioi20880155.
PROiQ5RHY1.

Gene expression databases

BgeeiQ5RHY1.

Family and domain databases

InterProiIPR015411. Rep_factor_Mcm10_C.
IPR015408. Znf_Mcm10/DnaG.
[Graphical view]
PfamiPF09332. Mcm10. 1 hit.
PF09329. zf-primase. 1 hit.
[Graphical view]
SMARTiSM01280. Mcm10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiMCM10_DANRE
AccessioniPrimary (citable) accession number: Q5RHY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.