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Protein
Submitted name:

Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2

Gene

hsp90aa1.2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress responseImported

Enzyme and pathway databases

ReactomeiR-DRE-1227986 Signaling by ERBB2
R-DRE-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DRE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DRE-203615 eNOS activation
R-DRE-2565942 Regulation of PLK1 Activity at G2/M Transition
R-DRE-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DRE-3371511 HSF1 activation
R-DRE-3371568 Attenuation phase
R-DRE-3371571 HSF1-dependent transactivation
R-DRE-380259 Loss of Nlp from mitotic centrosomes
R-DRE-380270 Recruitment of mitotic centrosome proteins and complexes
R-DRE-380320 Recruitment of NuMA to mitotic centrosomes
R-DRE-3928662 EPHB-mediated forward signaling
R-DRE-399954 Sema3A PAK dependent Axon repulsion
R-DRE-4420097 VEGFA-VEGFR2 Pathway
R-DRE-5218920 VEGFR2 mediated vascular permeability
R-DRE-5620912 Anchoring of the basal body to the plasma membrane
R-DRE-6798695 Neutrophil degranulation
R-DRE-8854518 AURKA Activation by TPX2
R-DRE-8863795 Downregulation of ERBB2 signaling
R-DRE-8939211 ESR-mediated signaling
R-DRE-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2Imported
Submitted name:
Heat shock protein 90-alpha 2Imported
Gene namesi
Name:hsp90aa1.2Imported
Synonyms:hsp90a.2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-031001-3 hsp90aa1.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000024746

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000026065

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 192HATPase_cInterPro annotationAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 253Sequence analysisAdd BLAST29
Coiled coili553 – 573Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
KOG0020 Eukaryota
COG0326 LUCA
GeneTreeiENSGT00920000149061
HOGENOMiHOG000031988
HOVERGENiHBG007374
KOiK04079
OrthoDBiEOG091G0270
TreeFamiTF300686

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RG12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAHEQQMM EDEEVETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNS
60 70 80 90 100
SDALDKIRYE SLTDPSKLDS GKDLKIEIIP NKEERTLTII DTGIGMTKAD
110 120 130 140 150
LINNLGTIAK SGTKAFMEAL QAGADISMIG QFGVGFYSAY LVAEKVTVIT
160 170 180 190 200
KHLDDEQYAW ESSAGGSFTV KVDNSEPIGR GTKVILHLKE DQTEYIEERR
210 220 230 240 250
IKEIVKKHSQ FIGYPITLFV EKERDKEVSD DEAEEEKEKE KEEEEEGEKD
260 270 280 290 300
EDKPEIEDVG SDEDDHDHGD KCGDKKKKKK KIKEKYIDQE ELNKTKPLWT
310 320 330 340 350
RNPDDITNEE YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFVPRRAP
360 370 380 390 400
FDLFENKKKK NNIKLYVRRV FIMDNCDELI PEYLNFIKGV VDSEDLPLNI
410 420 430 440 450
SREMLQQSKI LKVIRKNLVK KCLELFTELA EDKDNYKKYY EQFSKNIKLG
460 470 480 490 500
IHEDSQNRKK LSELLRYYTS ASGDEMVSLK DYVTRMKDTQ KHIYYITGET
510 520 530 540 550
KDQVANSAFV ERLRKAGLEV IYMIEPIDEY CVQQLKEFEG KNLVSVTKEG
560 570 580 590 600
LELPEDEEEK KKQEEKKSKF ENLCKIMKDI LEKKVEKVTV SNRLVSSPCC
610 620 630 640 650
IVTSTYGWTA NMERIMKAQA LRDNSTMGYM AAKKHLEINP DHPIVETLRQ
660 670 680 690 700
KAEADKNDKS VKDLVILLFE TALLSSGFTL DDPQTHSNRI YRMIKLGLGI
710 720 730
DEDDLSAEEP SSAPIEEMPP LEGDDDTSRM EEVD
Length:734
Mass (Da):84,691
Last modified:December 21, 2004 - v1
Checksum:i7E5317F059CC4BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR381646 Genomic DNA No translation available.
BC163166 mRNA Translation: AAI63166.1
RefSeqiNP_001038538.1, NM_001045073.1
UniGeneiDr.132281

Genome annotation databases

EnsembliENSDART00000023550; ENSDARP00000026065; ENSDARG00000024746
GeneIDi565155
KEGGidre:565155

Similar proteinsi

Entry informationi

Entry nameiQ5RG12_DANRE
AccessioniPrimary (citable) accession number: Q5RG12
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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