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Protein
Submitted name:

Heat shock protein 90-alpha 2

Gene

hsp90aa1.2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress responseImported

Enzyme and pathway databases

ReactomeiR-DRE-1227986. Signaling by ERBB2.
R-DRE-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-DRE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DRE-203615. eNOS activation.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-3371511. HSF1 activation.
R-DRE-3371568. Attenuation phase.
R-DRE-3371571. HSF1-dependent transactivation.
R-DRE-380259. Loss of Nlp from mitotic centrosomes.
R-DRE-380270. Recruitment of mitotic centrosome proteins and complexes.
R-DRE-3928663. EPHA-mediated growth cone collapse.
R-DRE-399954. Sema3A PAK dependent Axon repulsion.
R-DRE-4420097. VEGFA-VEGFR2 Pathway.
R-DRE-5218920. VEGFR2 mediated vascular permeability.
R-DRE-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock protein 90-alpha 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:hsp90aa1.2Imported
Synonyms:hsp90a.2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-031001-3. hsp90aa1.2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-8283650.
STRINGi7955.ENSDARP00000026065.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 192155HATPase_cInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili225 – 25329Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
KOiK04079.
OrthoDBiEOG780RM0.
TreeFamiTF300686.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RG12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAHEQQMM EDEEVETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNS
60 70 80 90 100
SDALDKIRYE SLTDPSKLDS GKDLKIEIIP NKEERTLTII DTGIGMTKAD
110 120 130 140 150
LINNLGTIAK SGTKAFMEAL QAGADISMIG QFGVGFYSAY LVAEKVTVIT
160 170 180 190 200
KHLDDEQYAW ESSAGGSFTV KVDNSEPIGR GTKVILHLKE DQTEYIEERR
210 220 230 240 250
IKEIVKKHSQ FIGYPITLFV EKERDKEVSD DEAEEEKEKE KEEEEEGEKD
260 270 280 290 300
EDKPEIEDVG SDEDDHDHGD KCGDKKKKKK KIKEKYIDQE ELNKTKPLWT
310 320 330 340 350
RNPDDITNEE YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFVPRRAP
360 370 380 390 400
FDLFENKKKK NNIKLYVRRV FIMDNCDELI PEYLNFIKGV VDSEDLPLNI
410 420 430 440 450
SREMLQQSKI LKVIRKNLVK KCLELFTELA EDKDNYKKYY EQFSKNIKLG
460 470 480 490 500
IHEDSQNRKK LSELLRYYTS ASGDEMVSLK DYVTRMKDTQ KHIYYITGET
510 520 530 540 550
KDQVANSAFV ERLRKAGLEV IYMIEPIDEY CVQQLKEFEG KNLVSVTKEG
560 570 580 590 600
LELPEDEEEK KKQEEKKSKF ENLCKIMKDI LEKKVEKVTV SNRLVSSPCC
610 620 630 640 650
IVTSTYGWTA NMERIMKAQA LRDNSTMGYM AAKKHLEINP DHPIVETLRQ
660 670 680 690 700
KAEADKNDKS VKDLVILLFE TALLSSGFTL DDPQTHSNRI YRMIKLGLGI
710 720 730
DEDDLSAEEP SSAPIEEMPP LEGDDDTSRM EEVD
Length:734
Mass (Da):84,691
Last modified:December 21, 2004 - v1
Checksum:i7E5317F059CC4BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR381646 Genomic DNA. No translation available.
BC163166 mRNA. Translation: AAI63166.1.
RefSeqiNP_001038538.1. NM_001045073.1.
UniGeneiDr.132281.

Genome annotation databases

EnsembliENSDART00000023550; ENSDARP00000026065; ENSDARG00000024746.
GeneIDi565155.
KEGGidre:565155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR381646 Genomic DNA. No translation available.
BC163166 mRNA. Translation: AAI63166.1.
RefSeqiNP_001038538.1. NM_001045073.1.
UniGeneiDr.132281.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8283650.
STRINGi7955.ENSDARP00000026065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000023550; ENSDARP00000026065; ENSDARG00000024746.
GeneIDi565155.
KEGGidre:565155.

Organism-specific databases

CTDi565155.
ZFINiZDB-GENE-031001-3. hsp90aa1.2.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
KOiK04079.
OrthoDBiEOG780RM0.
TreeFamiTF300686.

Enzyme and pathway databases

ReactomeiR-DRE-1227986. Signaling by ERBB2.
R-DRE-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-DRE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DRE-203615. eNOS activation.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-3371511. HSF1 activation.
R-DRE-3371568. Attenuation phase.
R-DRE-3371571. HSF1-dependent transactivation.
R-DRE-380259. Loss of Nlp from mitotic centrosomes.
R-DRE-380270. Recruitment of mitotic centrosome proteins and complexes.
R-DRE-3928663. EPHA-mediated growth cone collapse.
R-DRE-399954. Sema3A PAK dependent Axon repulsion.
R-DRE-4420097. VEGFA-VEGFR2 Pathway.
R-DRE-5218920. VEGFR2 mediated vascular permeability.
R-DRE-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

NextBioi20885740.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  3. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ5RG12_DANRE
AccessioniPrimary (citable) accession number: Q5RG12
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.