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Protein
Submitted name:

Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2

Gene

hsp90aa1.2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress responseImported

Enzyme and pathway databases

ReactomeiR-DRE-1227986. Signaling by ERBB2.
R-DRE-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-DRE-3371511. HSF1 activation.
R-DRE-3371568. Attenuation phase.
R-DRE-3371571. HSF1-dependent transactivation.
R-DRE-380259. Loss of Nlp from mitotic centrosomes.
R-DRE-380270. Recruitment of mitotic centrosome proteins and complexes.
R-DRE-380320. Recruitment of NuMA to mitotic centrosomes.
R-DRE-3928662. EPHB-mediated forward signaling.
R-DRE-399954. Sema3A PAK dependent Axon repulsion.
R-DRE-4420097. VEGFA-VEGFR2 Pathway.
R-DRE-5620912. Anchoring of the basal body to the plasma membrane.
R-DRE-6798695. Neutrophil degranulation.
R-DRE-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-DRE-8854518. AURKA Activation by TPX2.
R-DRE-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2Imported
Submitted name:
Heat shock protein 90-alpha 2Imported
Gene namesi
Name:hsp90aa1.2Imported
Synonyms:hsp90a.2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-031001-3. hsp90aa1.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000024746.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-8283650.
STRINGi7955.ENSDARP00000026065.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 192HATPase_cInterPro annotationAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 253Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
KOG0020. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00900000140936.
HOGENOMiHOG000031988.
HOVERGENiHBG007374.
OrthoDBiEOG091G0270.
TreeFamiTF300686.

Family and domain databases

CDDicd00075. HATPase_c. 1 hit.
Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiView protein in InterPro
IPR003594. HATPase_C.
IPR036890. HATPase_C_sf.
IPR019805. Heat_shock_protein_90_CS.
IPR037196. HSP90_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SUPFAMiSSF110942. SSF110942. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS00298. HSP90. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RG12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAHEQQMM EDEEVETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNS
60 70 80 90 100
SDALDKIRYE SLTDPSKLDS GKDLKIEIIP NKEERTLTII DTGIGMTKAD
110 120 130 140 150
LINNLGTIAK SGTKAFMEAL QAGADISMIG QFGVGFYSAY LVAEKVTVIT
160 170 180 190 200
KHLDDEQYAW ESSAGGSFTV KVDNSEPIGR GTKVILHLKE DQTEYIEERR
210 220 230 240 250
IKEIVKKHSQ FIGYPITLFV EKERDKEVSD DEAEEEKEKE KEEEEEGEKD
260 270 280 290 300
EDKPEIEDVG SDEDDHDHGD KCGDKKKKKK KIKEKYIDQE ELNKTKPLWT
310 320 330 340 350
RNPDDITNEE YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFVPRRAP
360 370 380 390 400
FDLFENKKKK NNIKLYVRRV FIMDNCDELI PEYLNFIKGV VDSEDLPLNI
410 420 430 440 450
SREMLQQSKI LKVIRKNLVK KCLELFTELA EDKDNYKKYY EQFSKNIKLG
460 470 480 490 500
IHEDSQNRKK LSELLRYYTS ASGDEMVSLK DYVTRMKDTQ KHIYYITGET
510 520 530 540 550
KDQVANSAFV ERLRKAGLEV IYMIEPIDEY CVQQLKEFEG KNLVSVTKEG
560 570 580 590 600
LELPEDEEEK KKQEEKKSKF ENLCKIMKDI LEKKVEKVTV SNRLVSSPCC
610 620 630 640 650
IVTSTYGWTA NMERIMKAQA LRDNSTMGYM AAKKHLEINP DHPIVETLRQ
660 670 680 690 700
KAEADKNDKS VKDLVILLFE TALLSSGFTL DDPQTHSNRI YRMIKLGLGI
710 720 730
DEDDLSAEEP SSAPIEEMPP LEGDDDTSRM EEVD
Length:734
Mass (Da):84,691
Last modified:December 21, 2004 - v1
Checksum:i7E5317F059CC4BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR381646 Genomic DNA. No translation available.
BC163166 mRNA. Translation: AAI63166.1.
RefSeqiNP_001038538.1. NM_001045073.1.
UniGeneiDr.132281.

Genome annotation databases

EnsembliENSDART00000023550; ENSDARP00000026065; ENSDARG00000024746.
GeneIDi565155.

Similar proteinsi

Entry informationi

Entry nameiQ5RG12_DANRE
AccessioniPrimary (citable) accession number: Q5RG12
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported