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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene

tab2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signaling pathway. Involved in heart development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri681 – 71131RanBP2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • convergent extension involved in gastrulation Source: ZFIN
  • heart development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-1251985. Nuclear signaling by ERBB4.
R-DRE-168638. NOD1/2 Signaling Pathway.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-450302. activated TAK1 mediates p38 MAPK activation.
R-DRE-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-937042. IRAK2 mediated activation of TAK1 complex.
R-DRE-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
TGF-beta-activated kinase 1-binding protein 2
Gene namesi
Name:tab2
Synonyms:map3k7ip2
ORF Names:zgc:77446
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-040426-933. tab2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711TGF-beta-activated kinase 1 and MAP3K7-binding protein 2PRO_0000225698Add
BLAST

Proteomic databases

PaxDbiQ5RFW2.

Expressioni

Gene expression databases

BgeeiENSDARG00000021509.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116375.

Structurei

3D structure databases

ProteinModelPortaliQ5RFW2.
SMRiQ5RFW2. Positions 7-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 5144CUEPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili550 – 63081Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi240 – 373134Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CUE domain.PROSITE-ProRule annotation
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri681 – 71131RanBP2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ5RFW2.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG091G0AYA.
PhylomeDBiQ5RFW2.
TreeFamiTF332021.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RFW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGNQQIDN QVLHHLRQKF PEVPEDVVCE CVLQNKSDLA ACCEYLTKVS
60 70 80 90 100
PRFLYSEGSQ SLTDLRNHMT QLNLGVSQNT HGAVQRDAVG MNGSRTLAPS
110 120 130 140 150
VSDGPLNVPS ALSEFYQPET PSVPTHTPAS LSMESTRKPQ PPQHLGLYQV
160 170 180 190 200
GGKGHAPPQA PRFNPITVTL APNTGRNTPT SLHIHGGPQS GLNSPNSIYI
210 220 230 240 250
RPYVTQPGST RQVQCRAQYS PTSQPAQQIY QITHPAAPQS SWSQHQTSHV
260 270 280 290 300
YMPISSPTNT QAPSIPSAVA SQAVSSSPLP SSGSSFSQYN IQNISTGPRK
310 320 330 340 350
NQIEIKLESP QRGSGSSSLL RSSSAPRSAC SSTSSSCPSS CTSLASSSGS
360 370 380 390 400
STPISIGGAG LSRSQPTVYI SPSPPTAATA PSEDCALVPN TPRSQPKIYF
410 420 430 440 450
SANTSADDGG GRNPPTVYIS ANPALQGPAG LRALGSQMSM GPAYIHHHPP
460 470 480 490 500
KSRPSVGAGG TATSPRVVVT QPNTKYTFKI TVSPNKPPSV SPGVVSPTFE
510 520 530 540 550
PNNMLSLPAD HHYAEPEISQ PDPMRDKAVE PRRLSMGADD AAYTQALLVH
560 570 580 590 600
QRARMERLWH ELELKKRKLE KLKEEVNEME SDLTRRRLQR SNAFCQIPSI
610 620 630 640 650
EEMQQLRCKN RLLQIDIDCL TKEIDLLQTR GPDFNPIAIH NFYDNLGFLG
660 670 680 690 700
PVPPKPLKGP TKAEVSRTDA GVRVLSEPEE DDGVQWSCTA CTFLNHPALN
710
RCEECEFPRN F
Note: No experimental confirmation available.
Length:711
Mass (Da):76,880
Last modified:December 21, 2004 - v1
Checksum:iE26723DF30859356
GO
Isoform 2 (identifier: Q5RFW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-285: QAPSIPSAVASQAVSSSPLPSSGSS → HTHTRFTCVCARVRMPVCLIHGNGR
     286-711: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):31,163
Checksum:i058EA1A730D05A05
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei261 – 28525QAPSI…SSGSS → HTHTRFTCVCARVRMPVCLI HGNGR in isoform 2. 1 PublicationVSP_019573Add
BLAST
Alternative sequencei286 – 711426Missing in isoform 2. 1 PublicationVSP_019574Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR536610 Genomic DNA. Translation: CAI11747.1.
CR536610 Genomic DNA. Translation: CAI11748.1.
BC065982 mRNA. Translation: AAH65982.1.
RefSeqiNP_001303622.1. NM_001316693.1. [Q5RFW2-1]
UniGeneiDr.134676.
Dr.82175.

Genome annotation databases

EnsembliENSDART00000017791; ENSDARP00000019647; ENSDARG00000021509. [Q5RFW2-1]
GeneIDi494163.
KEGGidre:494163.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR536610 Genomic DNA. Translation: CAI11747.1.
CR536610 Genomic DNA. Translation: CAI11748.1.
BC065982 mRNA. Translation: AAH65982.1.
RefSeqiNP_001303622.1. NM_001316693.1. [Q5RFW2-1]
UniGeneiDr.134676.
Dr.82175.

3D structure databases

ProteinModelPortaliQ5RFW2.
SMRiQ5RFW2. Positions 7-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000116375.

Proteomic databases

PaxDbiQ5RFW2.

Protocols and materials databases

DNASUi494163.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000017791; ENSDARP00000019647; ENSDARG00000021509. [Q5RFW2-1]
GeneIDi494163.
KEGGidre:494163.

Organism-specific databases

CTDi23118.
ZFINiZDB-GENE-040426-933. tab2.

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ5RFW2.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG091G0AYA.
PhylomeDBiQ5RFW2.
TreeFamiTF332021.

Enzyme and pathway databases

ReactomeiR-DRE-1251985. Nuclear signaling by ERBB4.
R-DRE-168638. NOD1/2 Signaling Pathway.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-450302. activated TAK1 mediates p38 MAPK activation.
R-DRE-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-DRE-5357956. TNFR1-induced NFkappaB signaling pathway.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-937042. IRAK2 mediated activation of TAK1 complex.
R-DRE-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Miscellaneous databases

PROiQ5RFW2.

Gene expression databases

BgeeiENSDARG00000021509.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAB2_DANRE
AccessioniPrimary (citable) accession number: Q5RFW2
Secondary accession number(s): Q6NZS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.