Q5RFV3 (Q5RFV3_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
A disintegrin and metalloproteinase domain 17a Ensembl ENSDARP00000063436

Submitted name:
Novel protein (Zgc:63886) EMBL CAI20731.1

Gene names

Name:	adam17a ZFIN ZDB-GENE-030131-2862 Ensembl ENSDARP00000063436
Synonyms:	DKEY-174C12.1 EMBL CAI20731.1
ORF Names:	DKEY-174C12.1-001 EMBL CAI20731.1, zgc:63886 ZFIN ZDB-GENE-030131-2862

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL CAI20731.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	842 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 disintegrin domain. SAAS SAAS002870 Contains 1 peptidase M12B domain. SAAS SAAS002870 RuleBase RU004141

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS002870 Zinc SAAS SAAS001762
Molecular function	Hydrolase Metalloprotease SAAS SAAS002870 Protease
PTM	Disulfide bond SAAS SAAS002870
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5RFV3 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 634C9D1BF5FDBFB2	FASTA	842	94,113
	10 20 30 40 50 60 MKPCIFYLVL LAPLFAHCAV KPVSVEEVSR NEEELQEFDA LNSLLSDFEV LPASGLQLHS 70 80 90 100 110 120 VRKRDADAHS HVERLVSFTA LQRNFKLYLT TNTQLFTENF SAVFVDENGK EDQFDVQIQN 130 140 150 160 170 180 YFKGHVVGEE HSRVQAHIDG DEFSAHIITE ETEYNVEPLW RFTETPPDGR LLVYRSEDIK 190 200 210 220 230 240 NISRLSSPKV CGYVNADAQE LLPEEARAAE EMEEMKEEPH NRERRSTHDQ KKNTCTLLLV 250 260 270 280 290 300 ADHRFYKHMG RAEESTTLNY LIELIDRVDD IYRNTSWDDD FKGYGVQIQQ IIINKDPTKV 310 320 330 340 350 360 APGEFHYNMD GSPTGRKDGV WDVKKLLEQF SYDIAANASR ACLAHLFTYQ DFDDGTLGLA 370 380 390 400 410 420 YVAPSKPGLG GLCPKPYYPS QSVKKPSYLN TGLTSTMNYG KTILTKEADL VTTHELGHNF 430 440 450 460 470 480 GAEHDPDNIA SCAPSDDQGG KYVMYPIAVS GDHVNNKHFS TCSKISVSKT LRIKVNQCFV 490 500 510 520 530 540 ERSSKLCGNS RVEEDEDCDP GLLHINDDPC CTSNCKFRKQ AQCSDRNSPC CKNCMFESAD 550 560 570 580 590 600 KVCQEVITAT CKGTSQCTGN SSECPTPGNL EDNTECVDKG RCQNGQCRPF CEAVHNLESC 610 620 630 640 650 660 ACNETENSCK VCCRKDELCT PFLNGGSFLY LRKGKPCTVG FCDGAGKCMK QVQDVIERLW 670 680 690 700 710 720 DFIDKLNINT FGKFLADNIV GSVVVFSLLF WIPISILVHC VDKRLDEQYE ENTKMMYPSS 730 740 750 760 770 780 GEILSSLESV PVRIVKAHHV HSPAARPQLS MAPTGPGSTP AQETLGGPGH PSLSAAPKAD 790 800 810 820 830 840 QLRMATIEED PSGDSFHPDE EEGFRLSGTA ARSFEDLTEQ ATPSHKRRLK RQARIESKET EC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Dyer L. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000063436.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000063436.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR556709 Genomic DNA. Translation: CAI20731.1.
IPI	IPI00495996.
UniGene	Dr.59760.
3D structure databases
ProteinModelPortal	Q5RFV3.
SMR	Q5RFV3. Positions 229-486.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5RFV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000063437; ENSDARP00000063436; ENSDARG00000043213.
Organism-specific databases
ZFIN	ZDB-GENE-030131-2862. adam17a.
Phylogenomic databases
eggNOG	fiNOG12363.
HOGENOM	HBG315430.
HOVERGEN	HBG050457.
InParanoid	Q5RFV3.
OMA	YHIEPSW.
OrthoDB	EOG40P468.
PhylomeDB	Q5RFV3.
Gene expression databases
ArrayExpress	Q5RFV3.
Bgee	Q5RFV3.
Family and domain databases
InterPro	IPR001762. Blood-coag_inhib_Disintegrin. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit. G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit.
Pfam	PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
SMART	SM00050. DISIN. 1 hit. [Graphical view]
SUPFAM	SSF57552. Disintegrin. 1 hit.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5RFV3_DANRE

Accession

Primary (citable) accession number: Q5RFV3

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)