SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5RFU0

- SIAE_PONAB

UniProt

Q5RFU0 - SIAE_PONAB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Sialate O-acetylesterase
Gene
SIAE, YSG2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid By similarity.

Catalytic activityi

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

GO - Molecular functioni

  1. sialate O-acetylesterase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Sialate O-acetylesterase (EC:3.1.1.53)
Alternative name(s):
Sialic acid-specific 9-O-acetylesterase
Gene namesi
Name:SIAE
Synonyms:YSG2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 523500Sialate O-acetylesterase
PRO_0000042242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi422 – 4221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007955.
InParanoidiQ5RFU0.
KOiK05970.

Family and domain databases

InterProiIPR005181. DUF303_acetylest.
[Graphical view]
PfamiPF03629. DUF303. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFU0-1 [UniParc]FASTAAdd to Basket

« Hide

MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF    50
GTPGATVTVT LRQGRETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ 100
QTLEKINFTL RVHDVLFGDV WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ 150
SVRILSVSPT QAEQELEDLV AVDLQWSKPT SENLGHGYFK YMSAVCWLFG 200
RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ GSVPYDSVTG 250
PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW 300
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV 350
PNPKMPNTFM AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK 400
NLTFEGPLPE KIELLAHKGL LNLTYYQQIQ VQKKDNKIFE ISCCSDRRCK 450
WLPASMSTVS TQSLTLAIDS CRGTVVALRY AWTTWPCEYK QCPLYHPSSA 500
LPAPPFIAFI TDQDPGHQSN VAK 523
Length:523
Mass (Da):58,386
Last modified:December 21, 2004 - v1
Checksum:iFB0D38849C48C793
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857060 mRNA. Translation: CAH89367.1.
RefSeqiNP_001124572.1. NM_001131100.1.

Genome annotation databases

GeneIDi100171407.
KEGGipon:100171407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR857060 mRNA. Translation: CAH89367.1 .
RefSeqi NP_001124572.1. NM_001131100.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100171407.
KEGGi pon:100171407.

Organism-specific databases

CTDi 54414.

Phylogenomic databases

HOVERGENi HBG007955.
InParanoidi Q5RFU0.
KOi K05970.

Family and domain databases

InterProi IPR005181. DUF303_acetylest.
[Graphical view ]
Pfami PF03629. DUF303. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiSIAE_PONAB
AccessioniPrimary (citable) accession number: Q5RFU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi