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Q5RFU0

- SIAE_PONAB

UniProt

Q5RFU0 - SIAE_PONAB

Protein

Sialate O-acetylesterase

Gene

SIAE

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.By similarity

    Catalytic activityi

    N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

    GO - Molecular functioni

    1. sialate O-acetylesterase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialate O-acetylesterase (EC:3.1.1.53)
    Alternative name(s):
    Sialic acid-specific 9-O-acetylesterase
    Gene namesi
    Name:SIAE
    Synonyms:YSG2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 523500Sialate O-acetylesterasePRO_0000042242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG007955.
    InParanoidiQ5RFU0.
    KOiK05970.

    Family and domain databases

    InterProiIPR005181. DUF303_acetylest.
    [Graphical view]
    PfamiPF03629. DUF303. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RFU0-1 [UniParc]FASTAAdd to Basket

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    MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF    50
    GTPGATVTVT LRQGRETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ 100
    QTLEKINFTL RVHDVLFGDV WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ 150
    SVRILSVSPT QAEQELEDLV AVDLQWSKPT SENLGHGYFK YMSAVCWLFG 200
    RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ GSVPYDSVTG 250
    PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW 300
    RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV 350
    PNPKMPNTFM AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK 400
    NLTFEGPLPE KIELLAHKGL LNLTYYQQIQ VQKKDNKIFE ISCCSDRRCK 450
    WLPASMSTVS TQSLTLAIDS CRGTVVALRY AWTTWPCEYK QCPLYHPSSA 500
    LPAPPFIAFI TDQDPGHQSN VAK 523
    Length:523
    Mass (Da):58,386
    Last modified:December 21, 2004 - v1
    Checksum:iFB0D38849C48C793
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857060 mRNA. Translation: CAH89367.1.
    RefSeqiNP_001124572.1. NM_001131100.1.

    Genome annotation databases

    GeneIDi100171407.
    KEGGipon:100171407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857060 mRNA. Translation: CAH89367.1 .
    RefSeqi NP_001124572.1. NM_001131100.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100171407.
    KEGGi pon:100171407.

    Organism-specific databases

    CTDi 54414.

    Phylogenomic databases

    HOVERGENi HBG007955.
    InParanoidi Q5RFU0.
    KOi K05970.

    Family and domain databases

    InterProi IPR005181. DUF303_acetylest.
    [Graphical view ]
    Pfami PF03629. DUF303. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiSIAE_PONAB
    AccessioniPrimary (citable) accession number: Q5RFU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3