Sialate O-acetylesterase precursor - Pongo abelii (Sumatran orangutan)

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Q5RFU0 (SIAE_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 35. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Sialate O-acetylesterase
EC=3.1.1.53

Alternative name(s):
Sialic acid-specific 9-O-acetylesterase

Gene names

Name:	SIAE
Synonyms:	YSG2

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid By similarity.
Catalytic activity	N-acetyl-O-acetylneuraminate + H₂O = N-acetylneuraminate + acetate.
Subcellular location	Lysosome By similarity.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Serine esterase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW sialate O-acetylesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

23

Potential

Chain

500

Sialate O-acetylesterase

PRO_0000042242

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q5RFU0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: FB0D38849C48C793
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523

58,386

        10         20         30         40         50         60 
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF GTPGATVTVT 

        70         80         90        100        110        120 
LRQGRETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ QTLEKINFTL RVHDVLFGDV 

       130        140        150        160        170        180 
WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ SVRILSVSPT QAEQELEDLV AVDLQWSKPT 

       190        200        210        220        230        240 
SENLGHGYFK YMSAVCWLFG RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ 

       250        260        270        280        290        300 
GSVPYDSVTG PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW 

       310        320        330        340        350        360 
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV PNPKMPNTFM 

       370        380        390        400        410        420 
AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK NLTFEGPLPE KIELLAHKGL 

       430        440        450        460        470        480 
LNLTYYQQIQ VQKKDNKIFE ISCCSDRRCK WLPASMSTVS TQSLTLAIDS CRGTVVALRY 

       490        500        510        520 
AWTTWPCEYK QCPLYHPSSA LPAPPFIAFI TDQDPGHQSN VAK

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR857060 mRNA. Translation: CAH89367.1.
RefSeq	NP_001124572.1. NM_001131100.1.
UniGene	Pab.19556.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100171407.
KEGG	pon:100171407.
Organism-specific databases
CTD	54414.
Phylogenomic databases
HOVERGEN	HBG007955.
InParanoid	Q5RFU0.
KO	K05970.
Family and domain databases
InterPro	IPR005181. DUF303_acetylest. [Graphical view]
Pfam	PF03629. DUF303. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIAE_PONAB

Accession

Primary (citable) accession number: Q5RFU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info