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Q5RFU0 (SIAE_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Sialate O-acetylesterase

EC=3.1.1.53
Alternative name(s):
Sialic acid-specific 9-O-acetylesterase
Gene names
Name:SIAE
Synonyms:YSG2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid By similarity.

Catalytic activity

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

Subcellular location

Lysosome By similarity.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
Serine esterase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsialate O-acetylesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 523500Sialate O-acetylesterase
PRO_0000042242

Amino acid modifications

Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RFU0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: FB0D38849C48C793

FASTA52358,386
        10         20         30         40         50         60 
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF GTPGATVTVT 

        70         80         90        100        110        120 
LRQGRETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ QTLEKINFTL RVHDVLFGDV 

       130        140        150        160        170        180 
WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ SVRILSVSPT QAEQELEDLV AVDLQWSKPT 

       190        200        210        220        230        240 
SENLGHGYFK YMSAVCWLFG RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ 

       250        260        270        280        290        300 
GSVPYDSVTG PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW 

       310        320        330        340        350        360 
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV PNPKMPNTFM 

       370        380        390        400        410        420 
AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK NLTFEGPLPE KIELLAHKGL 

       430        440        450        460        470        480 
LNLTYYQQIQ VQKKDNKIFE ISCCSDRRCK WLPASMSTVS TQSLTLAIDS CRGTVVALRY 

       490        500        510        520 
AWTTWPCEYK QCPLYHPSSA LPAPPFIAFI TDQDPGHQSN VAK 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR857060 mRNA. Translation: CAH89367.1.
RefSeqNP_001124572.1. NM_001131100.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100171407.
KEGGpon:100171407.

Organism-specific databases

CTD54414.

Phylogenomic databases

HOVERGENHBG007955.
InParanoidQ5RFU0.
KOK05970.

Family and domain databases

InterProIPR005181. DUF303_acetylest.
[Graphical view]
PfamPF03629. DUF303. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIAE_PONAB
AccessionPrimary (citable) accession number: Q5RFU0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program