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Protein

Sialate O-acetylesterase

Gene

SIAE

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.By similarity

Catalytic activityi

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

GO - Molecular functioni

  1. sialate O-acetylesterase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Sialate O-acetylesterase (EC:3.1.1.53)
Alternative name(s):
Sialic acid-specific 9-O-acetylesterase
Gene namesi
Name:SIAE
Synonyms:YSG2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 523500Sialate O-acetylesterasePRO_0000042242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007955.
InParanoidiQ5RFU0.
KOiK05970.

Family and domain databases

InterProiIPR005181. DUF303_acetylest.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF03629. DUF303. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RFU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF
60 70 80 90 100
GTPGATVTVT LRQGRETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ
110 120 130 140 150
QTLEKINFTL RVHDVLFGDV WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ
160 170 180 190 200
SVRILSVSPT QAEQELEDLV AVDLQWSKPT SENLGHGYFK YMSAVCWLFG
210 220 230 240 250
RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ GSVPYDSVTG
260 270 280 290 300
PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW
310 320 330 340 350
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV
360 370 380 390 400
PNPKMPNTFM AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK
410 420 430 440 450
NLTFEGPLPE KIELLAHKGL LNLTYYQQIQ VQKKDNKIFE ISCCSDRRCK
460 470 480 490 500
WLPASMSTVS TQSLTLAIDS CRGTVVALRY AWTTWPCEYK QCPLYHPSSA
510 520
LPAPPFIAFI TDQDPGHQSN VAK
Length:523
Mass (Da):58,386
Last modified:December 20, 2004 - v1
Checksum:iFB0D38849C48C793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857060 mRNA. Translation: CAH89367.1.
RefSeqiNP_001124572.1. NM_001131100.1.

Genome annotation databases

GeneIDi100171407.
KEGGipon:100171407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857060 mRNA. Translation: CAH89367.1.
RefSeqiNP_001124572.1. NM_001131100.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100171407.
KEGGipon:100171407.

Organism-specific databases

CTDi54414.

Phylogenomic databases

HOVERGENiHBG007955.
InParanoidiQ5RFU0.
KOiK05970.

Family and domain databases

InterProiIPR005181. DUF303_acetylest.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF03629. DUF303. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiSIAE_PONAB
AccessioniPrimary (citable) accession number: Q5RFU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2005
Last sequence update: December 20, 2004
Last modified: March 31, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.