Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Indolethylamine N-methyltransferase

Gene

INMT

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201S-adenosyl-L-methionineBy similarity
Binding sitei25 – 251S-adenosyl-L-methionineBy similarity
Binding sitei69 – 691S-adenosyl-L-methionineBy similarity
Binding sitei85 – 851S-adenosyl-L-methionineBy similarity
Binding sitei90 – 901S-adenosyl-L-methionineBy similarity
Binding sitei163 – 1631S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Indolethylamine N-methyltransferase (EC:2.1.1.49, EC:2.1.1.96)
Short name:
Indolamine N-methyltransferase
Alternative name(s):
Aromatic alkylamine N-methyltransferase
Short name:
Amine N-methyltransferase
Short name:
Arylamine N-methyltransferase
Thioether S-methyltransferase
Gene namesi
Name:INMT
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Indolethylamine N-methyltransferasePRO_0000159714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131N6-succinyllysineBy similarity
Modified residuei96 – 961N6-succinyllysineBy similarity

Proteomic databases

PRIDEiQ5RFR7.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RFR7.
SMRiQ5RFR7. Positions 5-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 642S-adenosyl-L-methionine bindingBy similarity
Regioni142 – 1432S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000011708.
HOVERGENiHBG000797.
InParanoidiQ5RFR7.
KOiK00562.
OMAiAMECACC.
OrthoDBiEOG7673B9.
TreeFamiTF313114.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025820. NNMT/PNMT/TEMT_CS.
IPR000940. NNMT_TEMT_trans.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10867. PTHR10867. 1 hit.
PfamiPF01234. NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000384. PNMTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS01100. NNMT_PNMT_TEMT. 1 hit.
PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RFR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGFTGGDE YQKHFLPRDY LATYYSFDGS PSPEAEMLKF NLECLHKTFG
60 70 80 90 100
PGGLQGDTLI DIGSGPTIYQ VLAACESFQD ITLSDFTDRN REELEKWLKK
110 120 130 140 150
EPGAYDWTPV VKFACELEGN SGQWEEKEEK LRATVKRVLK CDVHLGNPLA
160 170 180 190 200
PAVLPPADCV LTLLAMECAC CSLDAYCAAL CNLASLLKPG GHLVTTVTLR
210 220 230 240 250
LSSYMVGKRE FSCVALEKEE VEQAVLDAGF DIEQLLQSPQ SYSVTNAANN
260
GVCFIVARKK PGP
Length:263
Mass (Da):28,848
Last modified:December 21, 2004 - v1
Checksum:i05387543210CB66B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857085 mRNA. Translation: CAH89390.1.
RefSeqiNP_001124586.1. NM_001131114.1.
UniGeneiPab.12389.

Genome annotation databases

EnsembliENSPPYT00000020590; ENSPPYP00000019808; ENSPPYG00000017671.
GeneIDi100171421.
KEGGipon:100171421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857085 mRNA. Translation: CAH89390.1.
RefSeqiNP_001124586.1. NM_001131114.1.
UniGeneiPab.12389.

3D structure databases

ProteinModelPortaliQ5RFR7.
SMRiQ5RFR7. Positions 5-261.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5RFR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000020590; ENSPPYP00000019808; ENSPPYG00000017671.
GeneIDi100171421.
KEGGipon:100171421.

Organism-specific databases

CTDi11185.

Phylogenomic databases

GeneTreeiENSGT00390000011708.
HOVERGENiHBG000797.
InParanoidiQ5RFR7.
KOiK00562.
OMAiAMECACC.
OrthoDBiEOG7673B9.
TreeFamiTF313114.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025820. NNMT/PNMT/TEMT_CS.
IPR000940. NNMT_TEMT_trans.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10867. PTHR10867. 1 hit.
PfamiPF01234. NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000384. PNMTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS01100. NNMT_PNMT_TEMT. 1 hit.
PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiINMT_PONAB
AccessioniPrimary (citable) accession number: Q5RFR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.