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Q5RFR7

- INMT_PONAB

UniProt

Q5RFR7 - INMT_PONAB

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Protein

Indolethylamine N-methyltransferase

Gene

INMT

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201S-adenosyl-L-methionineBy similarity
Binding sitei25 – 251S-adenosyl-L-methionineBy similarity
Binding sitei69 – 691S-adenosyl-L-methionineBy similarity
Binding sitei85 – 851S-adenosyl-L-methionineBy similarity
Binding sitei90 – 901S-adenosyl-L-methionineBy similarity
Binding sitei163 – 1631S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

  1. amine N-methyltransferase activity Source: UniProtKB
  2. thioether S-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. amine metabolic process Source: UniProtKB
  2. methylation Source: UniProtKB
  3. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Indolethylamine N-methyltransferase (EC:2.1.1.49, EC:2.1.1.96)
Short name:
Indolamine N-methyltransferase
Alternative name(s):
Aromatic alkylamine N-methyltransferase
Short name:
Amine N-methyltransferase
Short name:
Arylamine N-methyltransferase
Thioether S-methyltransferase
Gene namesi
Name:INMT
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 7

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Indolethylamine N-methyltransferasePRO_0000159714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131N6-succinyllysineBy similarity
Modified residuei96 – 961N6-succinyllysineBy similarity

Proteomic databases

PRIDEiQ5RFR7.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RFR7.
SMRiQ5RFR7. Positions 5-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 642S-adenosyl-L-methionine bindingBy similarity
Regioni142 – 1432S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000011708.
HOVERGENiHBG000797.
InParanoidiQ5RFR7.
KOiK00562.
OMAiAMECACC.
OrthoDBiEOG7673B9.
TreeFamiTF313114.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025817. Amine_MeTrfase.
IPR025820. NNMT/PNMT/TEMT_CS.
IPR000940. NNMT_TEMT_trans.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10867. PTHR10867. 1 hit.
PfamiPF01234. NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000384. PNMTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS01100. NNMT_PNMT_TEMT. 1 hit.
PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RFR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGGFTGGDE YQKHFLPRDY LATYYSFDGS PSPEAEMLKF NLECLHKTFG
60 70 80 90 100
PGGLQGDTLI DIGSGPTIYQ VLAACESFQD ITLSDFTDRN REELEKWLKK
110 120 130 140 150
EPGAYDWTPV VKFACELEGN SGQWEEKEEK LRATVKRVLK CDVHLGNPLA
160 170 180 190 200
PAVLPPADCV LTLLAMECAC CSLDAYCAAL CNLASLLKPG GHLVTTVTLR
210 220 230 240 250
LSSYMVGKRE FSCVALEKEE VEQAVLDAGF DIEQLLQSPQ SYSVTNAANN
260
GVCFIVARKK PGP
Length:263
Mass (Da):28,848
Last modified:December 21, 2004 - v1
Checksum:i05387543210CB66B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857085 mRNA. Translation: CAH89390.1.
RefSeqiNP_001124586.1. NM_001131114.1.
UniGeneiPab.12389.

Genome annotation databases

EnsembliENSPPYT00000020590; ENSPPYP00000019808; ENSPPYG00000017671.
GeneIDi100171421.
KEGGipon:100171421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857085 mRNA. Translation: CAH89390.1 .
RefSeqi NP_001124586.1. NM_001131114.1.
UniGenei Pab.12389.

3D structure databases

ProteinModelPortali Q5RFR7.
SMRi Q5RFR7. Positions 5-261.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5RFR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000020590 ; ENSPPYP00000019808 ; ENSPPYG00000017671 .
GeneIDi 100171421.
KEGGi pon:100171421.

Organism-specific databases

CTDi 11185.

Phylogenomic databases

GeneTreei ENSGT00390000011708.
HOVERGENi HBG000797.
InParanoidi Q5RFR7.
KOi K00562.
OMAi AMECACC.
OrthoDBi EOG7673B9.
TreeFami TF313114.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025817. Amine_MeTrfase.
IPR025820. NNMT/PNMT/TEMT_CS.
IPR000940. NNMT_TEMT_trans.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10867. PTHR10867. 1 hit.
Pfami PF01234. NNMT_PNMT_TEMT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000384. PNMTase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS01100. NNMT_PNMT_TEMT. 1 hit.
PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiINMT_PONAB
AccessioniPrimary (citable) accession number: Q5RFR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3