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Q5RFR7

- INMT_PONAB

UniProt

Q5RFR7 - INMT_PONAB

Protein

Indolethylamine N-methyltransferase

Gene

INMT

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the N-methylation of tryptamine and structurally related compounds By similarity. Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
    S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201S-adenosyl-L-methionineBy similarity
    Binding sitei25 – 251S-adenosyl-L-methionineBy similarity
    Binding sitei69 – 691S-adenosyl-L-methionineBy similarity
    Binding sitei85 – 851S-adenosyl-L-methionineBy similarity
    Binding sitei90 – 901S-adenosyl-L-methionineBy similarity
    Binding sitei163 – 1631S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. amine N-methyltransferase activity Source: UniProtKB
    2. thioether S-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. amine metabolic process Source: UniProtKB
    2. methylation Source: UniProtKB
    3. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Detoxification

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Indolethylamine N-methyltransferase (EC:2.1.1.49, EC:2.1.1.96)
    Short name:
    Indolamine N-methyltransferase
    Alternative name(s):
    Aromatic alkylamine N-methyltransferase
    Short name:
    Amine N-methyltransferase
    Short name:
    Arylamine N-methyltransferase
    Thioether S-methyltransferase
    Gene namesi
    Name:INMT
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 7

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Indolethylamine N-methyltransferasePRO_0000159714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei13 – 131N6-succinyllysineBy similarity
    Modified residuei96 – 961N6-succinyllysineBy similarity

    Proteomic databases

    PRIDEiQ5RFR7.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RFR7.
    SMRiQ5RFR7. Positions 5-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 642S-adenosyl-L-methionine bindingBy similarity
    Regioni142 – 1432S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000011708.
    HOVERGENiHBG000797.
    InParanoidiQ5RFR7.
    KOiK00562.
    OMAiAMECACC.
    OrthoDBiEOG7673B9.
    TreeFamiTF313114.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025817. Amine_MeTrfase.
    IPR025820. NNMT/PNMT/TEMT_CS.
    IPR000940. NNMT_TEMT_trans.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10867. PTHR10867. 1 hit.
    PfamiPF01234. NNMT_PNMT_TEMT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000384. PNMTase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS01100. NNMT_PNMT_TEMT. 1 hit.
    PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RFR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGFTGGDE YQKHFLPRDY LATYYSFDGS PSPEAEMLKF NLECLHKTFG    50
    PGGLQGDTLI DIGSGPTIYQ VLAACESFQD ITLSDFTDRN REELEKWLKK 100
    EPGAYDWTPV VKFACELEGN SGQWEEKEEK LRATVKRVLK CDVHLGNPLA 150
    PAVLPPADCV LTLLAMECAC CSLDAYCAAL CNLASLLKPG GHLVTTVTLR 200
    LSSYMVGKRE FSCVALEKEE VEQAVLDAGF DIEQLLQSPQ SYSVTNAANN 250
    GVCFIVARKK PGP 263
    Length:263
    Mass (Da):28,848
    Last modified:December 21, 2004 - v1
    Checksum:i05387543210CB66B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857085 mRNA. Translation: CAH89390.1.
    RefSeqiNP_001124586.1. NM_001131114.1.
    UniGeneiPab.12389.

    Genome annotation databases

    EnsembliENSPPYT00000020590; ENSPPYP00000019808; ENSPPYG00000017671.
    GeneIDi100171421.
    KEGGipon:100171421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR857085 mRNA. Translation: CAH89390.1 .
    RefSeqi NP_001124586.1. NM_001131114.1.
    UniGenei Pab.12389.

    3D structure databases

    ProteinModelPortali Q5RFR7.
    SMRi Q5RFR7. Positions 5-261.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RFR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000020590 ; ENSPPYP00000019808 ; ENSPPYG00000017671 .
    GeneIDi 100171421.
    KEGGi pon:100171421.

    Organism-specific databases

    CTDi 11185.

    Phylogenomic databases

    GeneTreei ENSGT00390000011708.
    HOVERGENi HBG000797.
    InParanoidi Q5RFR7.
    KOi K00562.
    OMAi AMECACC.
    OrthoDBi EOG7673B9.
    TreeFami TF313114.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025817. Amine_MeTrfase.
    IPR025820. NNMT/PNMT/TEMT_CS.
    IPR000940. NNMT_TEMT_trans.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10867. PTHR10867. 1 hit.
    Pfami PF01234. NNMT_PNMT_TEMT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000384. PNMTase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS01100. NNMT_PNMT_TEMT. 1 hit.
    PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiINMT_PONAB
    AccessioniPrimary (citable) accession number: Q5RFR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3