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Protein

Indolethylamine N-methyltransferase

Gene

INMT

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20S-adenosyl-L-methionineBy similarity1
Binding sitei25S-adenosyl-L-methionineBy similarity1
Binding sitei69S-adenosyl-L-methionineBy similarity1
Binding sitei85S-adenosyl-L-methionineBy similarity1
Binding sitei90S-adenosyl-L-methionineBy similarity1
Binding sitei163S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Indolethylamine N-methyltransferase (EC:2.1.1.49, EC:2.1.1.96)
Short name:
Indolamine N-methyltransferase
Alternative name(s):
Aromatic alkylamine N-methyltransferase
Short name:
Amine N-methyltransferase
Short name:
Arylamine N-methyltransferase
Thioether S-methyltransferase
Gene namesi
Name:INMT
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597141 – 263Indolethylamine N-methyltransferaseAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13N6-succinyllysineBy similarity1
Modified residuei96N6-succinyllysineBy similarity1

Proteomic databases

PRIDEiQ5RFR7.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000019808.

Structurei

3D structure databases

ProteinModelPortaliQ5RFR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 64S-adenosyl-L-methionine bindingBy similarity2
Regioni142 – 143S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFTZ. Eukaryota.
ENOG41128ZR. LUCA.
GeneTreeiENSGT00390000011708.
HOVERGENiHBG000797.
InParanoidiQ5RFR7.
KOiK00562.
OMAiAMECACC.
OrthoDBiEOG091G0EF7.
TreeFamiTF313114.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025820. NNMT/PNMT/TEMT_CS.
IPR000940. NNMT_TEMT_trans.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10867. PTHR10867. 1 hit.
PfamiPF01234. NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000384. PNMTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS01100. NNMT_PNMT_TEMT. 1 hit.
PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RFR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGFTGGDE YQKHFLPRDY LATYYSFDGS PSPEAEMLKF NLECLHKTFG
60 70 80 90 100
PGGLQGDTLI DIGSGPTIYQ VLAACESFQD ITLSDFTDRN REELEKWLKK
110 120 130 140 150
EPGAYDWTPV VKFACELEGN SGQWEEKEEK LRATVKRVLK CDVHLGNPLA
160 170 180 190 200
PAVLPPADCV LTLLAMECAC CSLDAYCAAL CNLASLLKPG GHLVTTVTLR
210 220 230 240 250
LSSYMVGKRE FSCVALEKEE VEQAVLDAGF DIEQLLQSPQ SYSVTNAANN
260
GVCFIVARKK PGP
Length:263
Mass (Da):28,848
Last modified:December 21, 2004 - v1
Checksum:i05387543210CB66B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857085 mRNA. Translation: CAH89390.1.
RefSeqiNP_001124586.1. NM_001131114.1.
UniGeneiPab.12389.

Genome annotation databases

EnsembliENSPPYT00000020590; ENSPPYP00000019808; ENSPPYG00000017671.
GeneIDi100171421.
KEGGipon:100171421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR857085 mRNA. Translation: CAH89390.1.
RefSeqiNP_001124586.1. NM_001131114.1.
UniGeneiPab.12389.

3D structure databases

ProteinModelPortaliQ5RFR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000019808.

Proteomic databases

PRIDEiQ5RFR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000020590; ENSPPYP00000019808; ENSPPYG00000017671.
GeneIDi100171421.
KEGGipon:100171421.

Organism-specific databases

CTDi11185.

Phylogenomic databases

eggNOGiENOG410IFTZ. Eukaryota.
ENOG41128ZR. LUCA.
GeneTreeiENSGT00390000011708.
HOVERGENiHBG000797.
InParanoidiQ5RFR7.
KOiK00562.
OMAiAMECACC.
OrthoDBiEOG091G0EF7.
TreeFamiTF313114.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025820. NNMT/PNMT/TEMT_CS.
IPR000940. NNMT_TEMT_trans.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10867. PTHR10867. 1 hit.
PfamiPF01234. NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000384. PNMTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS01100. NNMT_PNMT_TEMT. 1 hit.
PS51681. SAM_MT_NNMT_PNMT_TEMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINMT_PONAB
AccessioniPrimary (citable) accession number: Q5RFR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 21, 2004
Last modified: October 5, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.